Published in Mol Cell Biol on October 01, 2005
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation. Nat Cell Biol (2008) 5.19
Reactive oxygen species in cancer. Free Radic Res (2010) 3.20
Protein kinase D1 regulates cofilin-mediated F-actin reorganization and cell motility through slingshot. Nat Cell Biol (2009) 2.31
Oxidative stress in the regulation of normal and neoplastic hematopoiesis. Antioxid Redox Signal (2008) 1.81
Low-level laser therapy activates NF-kB via generation of reactive oxygen species in mouse embryonic fibroblasts. PLoS One (2011) 1.76
FOXO signaling is required for disuse muscle atrophy and is directly regulated by Hsp70. Am J Physiol Cell Physiol (2009) 1.64
Forkhead homeobox type O transcription factors in the responses to oxidative stress. Antioxid Redox Signal (2010) 1.59
Protein kinase D1 regulates matrix metalloproteinase expression and inhibits breast cancer cell invasion. Breast Cancer Res (2009) 1.55
FOXO3a promotes tumor cell invasion through the induction of matrix metalloproteinases. Mol Cell Biol (2009) 1.35
Protein kinase D: coupling extracellular stimuli to the regulation of cell physiology. EMBO Rep (2011) 1.30
HSV infection induces production of ROS, which potentiate signaling from pattern recognition receptors: role for S-glutathionylation of TRAF3 and 6. PLoS Pathog (2011) 1.26
Protein kinase D as a potential new target for cancer therapy. Biochim Biophys Acta (2010) 1.25
Mechanisms by which docosahexaenoic acid and related fatty acids reduce colon cancer risk and inflammatory disorders of the intestine. Chem Phys Lipids (2008) 1.23
Unique functions for protein kinase D1 and protein kinase D2 in mammalian cells. Biochem J (2010) 1.16
Loss of cell-cell contacts induces NF-kappaB via RhoA-mediated activation of protein kinase D1. J Cell Biochem (2009) 1.14
Role of protein kinase D signaling in pancreatic cancer. Biochem Pharmacol (2010) 1.14
Regulation of protein kinase D1 activity. Mol Pharmacol (2011) 1.13
Protein kinase D regulates cofilin activity through p21-activated kinase 4. J Biol Chem (2011) 1.10
Inhibition of IkappaB kinase alpha (IKKα) or IKKbeta (IKKβ) plus forkhead box O (Foxo) abolishes skeletal muscle atrophy. Biochem Biophys Res Commun (2011) 1.09
Lysophospholipid receptor activation of RhoA and lipid signaling pathways. Biochim Biophys Acta (2012) 1.07
Revisited and revised: is RhoA always a villain in cardiac pathophysiology? J Cardiovasc Transl Res (2010) 1.05
Mitochondrial diacylglycerol initiates protein-kinase D1-mediated ROS signaling. J Cell Sci (2009) 1.05
Mitochondrial H2O2 generated from electron transport chain complex I stimulates muscle differentiation. Cell Res (2011) 1.04
Ros-mediated activation of NF-kappaB and Foxo during muscle disuse. Muscle Nerve (2010) 1.01
SB202190-induced cell type-specific vacuole formation and defective autophagy do not depend on p38 MAP kinase inhibition. PLoS One (2011) 1.00
Design, Synthesis, and Biological Evaluation of PKD Inhibitors. Pharmaceutics (2011) 0.99
Maintenance of manganese superoxide dismutase (SOD2)-mediated delayed radioprotection induced by repeated administration of the free thiol form of amifostine. Radiat Res (2008) 0.98
Hsp27 inhibits IKKbeta-induced NF-kappaB activity and skeletal muscle atrophy. FASEB J (2009) 0.97
Global detection of protein kinase D-dependent phosphorylation events in nocodazole-treated human cells. Mol Cell Proteomics (2012) 0.95
G protein-coupled receptor Ca2+-linked mitochondrial reactive oxygen species are essential for endothelial/leukocyte adherence. Mol Cell Biol (2007) 0.94
Modulation of T Cell Metabolism and Function through Calcium Signaling. Front Immunol (2013) 0.93
The involvement of specific PKC isoenzymes in phorbol ester-mediated regulation of steroidogenic acute regulatory protein expression and steroid synthesis in mouse Leydig cells. Endocrinology (2010) 0.93
Ultraviolet B irradiation and activation of protein kinase D in primary mouse epidermal keratinocytes. Oncogene (2010) 0.92
Protein kinase d as a potential chemotherapeutic target for colorectal cancer. Mol Cancer Ther (2014) 0.92
Protein kinase D2 is a novel regulator of glioblastoma growth and tumor formation. Neuro Oncol (2011) 0.91
Differential cerebral cortex transcriptomes of baboon neonates consuming moderate and high docosahexaenoic acid formulas. PLoS One (2007) 0.91
PLCε, PKD1, and SSH1L transduce RhoA signaling to protect mitochondria from oxidative stress in the heart. Sci Signal (2013) 0.90
Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions. Cell Rep (2016) 0.90
PKD prevents H2O2-induced apoptosis via NF-kappaB and p38 MAPK in RIE-1 cells. Biochem Biophys Res Commun (2008) 0.89
Cell survival from chemotherapy depends on NF-kappaB transcriptional up-regulation of coenzyme Q biosynthesis. PLoS One (2009) 0.89
Reactive oxygen species-mediated regulation of mitochondrial biogenesis in the yeast Saccharomyces cerevisiae. J Biol Chem (2009) 0.89
Protein kinase D1: a new component in TLR9 signaling. J Immunol (2008) 0.89
Chronic oxidative stress increases growth and tumorigenic potential of MCF-7 breast cancer cells. PLoS One (2014) 0.88
Protein kinase Cmu plays an essential role in hypertonicity-induced heat shock protein 70 expression. Exp Mol Med (2008) 0.88
Mitochondria Retrograde Signaling and the UPR mt: Where Are We in Mammals? Int J Mol Sci (2015) 0.87
Protein kinase D enzymes are dispensable for proliferation, survival and antigen receptor-regulated NFkappaB activity in vertebrate B-cells. FEBS Lett (2007) 0.86
Mitochondrial DNA-depleted A549 cells are resistant to bleomycin. Am J Physiol Lung Cell Mol Physiol (2012) 0.86
Sense-antisense gene pairs: sequence, transcription, and structure are not conserved between human and mouse. Front Genet (2013) 0.85
Protein kinase D1 (PKD1) activation mediates a compensatory protective response during early stages of oxidative stress-induced neuronal degeneration. Mol Neurodegener (2011) 0.84
Association of SOD2, a mitochondrial antioxidant enzyme, with gray matter volume shrinkage in alcoholics. Neuropsychopharmacology (2009) 0.83
Protein kinase D1 (PKD1) phosphorylation promotes dopaminergic neuronal survival during 6-OHDA-induced oxidative stress. PLoS One (2014) 0.83
Protein kinase D1 is essential for Ras-induced senescence and tumor suppression by regulating senescence-associated inflammation. Proc Natl Acad Sci U S A (2014) 0.83
Interactions of the major metabolite of the cancer chemopreventive drug oltipraz with cytochrome c: a novel pathway for cancer chemoprevention. Free Radic Biol Med (2007) 0.82
Association between rs2981582 polymorphism in the FGFR2 gene and the risk of breast cancer in Mexican women. Arch Med Res (2013) 0.82
Aging and calorie restriction oppositely affect mitochondrial biogenesis through TFAM binding at both origins of mitochondrial DNA replication in rat liver. PLoS One (2013) 0.82
Protein kinase D orchestrates the activation of DRAK2 in response to TCR-induced Ca2+ influx and mitochondrial reactive oxygen generation. J Immunol (2010) 0.81
Yeast apurinic/apyrimidinic endonuclease Apn1 protects mammalian neuronal cell line from oxidative stress. J Neurochem (2007) 0.81
Protein kinase D2 is an essential regulator of murine myoblast differentiation. PLoS One (2011) 0.81
Functional and therapeutic significance of protein kinase D enzymes in invasive breast cancer. Cell Mol Life Sci (2015) 0.80
The C-terminus of the long AKAP13 isoform (AKAP-Lbc) is critical for development of compensatory cardiac hypertrophy. J Mol Cell Cardiol (2013) 0.80
The adaptor protein SH2B1β reduces hydrogen peroxide-induced cell death in PC12 cells and hippocampal neurons. J Mol Signal (2010) 0.80
Protein Kinase D1 Signaling in Angiogenic Gene Expression and VEGF-Mediated Angiogenesis. Front Cell Dev Biol (2016) 0.80
UV radiation induces delayed hyperrecombination associated with hypermutation in human cells. Mol Cell Biol (2006) 0.78
PKD1 protein is involved in reactive oxygen species-mediated mitochondrial depolarization in cooperation with protein kinase Cδ (PKCδ). J Biol Chem (2015) 0.78
KRas, ROS and the initiation of pancreatic cancer. Small GTPases (2016) 0.78
Roles of the kinase TAK1 in CD40-mediated effects on vascular oxidative stress and neointima formation after vascular injury. PLoS One (2014) 0.78
Different regulation of physiological and tumor angiogenesis in zebrafish by protein kinase D1 (PKD1). PLoS One (2013) 0.77
β-adrenergic signaling inhibits Gq-dependent protein kinase D activation by preventing protein kinase D translocation. Circ Res (2014) 0.77
A time frame permissive for Protein Kinase D2 activity to direct angiogenesis in mouse embryonic stem cells. Sci Rep (2015) 0.76
Administration of rat acute-phase protein α(2)-macroglobulin before total-body irradiation initiates cytoprotective mechanisms in the liver. Radiat Environ Biophys (2010) 0.76
Striatal Mitochondrial Disruption following Severe Traumatic Brain Injury. J Neurotrauma (2016) 0.76
Photobiomodulation reduces oral mucositis by modulating NF-kB. J Biomed Opt (2015) 0.76
Protein kinase D1 deficiency promotes differentiation in epidermal keratinocytes. J Dermatol Sci (2014) 0.75
Emergency Spatiotemporal Shift: The Response of Protein Kinase D to Stress Signals in the Cardiovascular System. Front Pharmacol (2017) 0.75
Mitochondrial and Oxidative Stress-Mediated Activation of Protein Kinase D1 and Its Importance in Pancreatic Cancer. Front Oncol (2017) 0.75
Protein kinase D at the Golgi controls NLRP3 inflammasome activation. J Exp Med (2017) 0.75
Potein Kinase D Signaling in Cancer: A Friend or Foe? Biochim Biophys Acta (2017) 0.75
The protein kinase complement of the human genome. Science (2002) 35.36
A system for stable expression of short interfering RNAs in mammalian cells. Science (2002) 35.21
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell (1999) 32.32
Oxidants, oxidative stress and the biology of ageing. Nature (2000) 23.21
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science (2004) 17.38
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature (2002) 7.88
Neurodegenerative diseases and oxidative stress. Nat Rev Drug Discov (2004) 5.82
The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor. Cell (1995) 5.08
Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway. Science (2002) 4.88
Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production. J Biol Chem (2002) 4.48
Protein kinase D regulates the fission of cell surface destined transport carriers from the trans-Golgi network. Cell (2001) 3.19
Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha. Cell (1996) 3.00
Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathway. EMBO J (2003) 2.68
Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network. Nat Cell Biol (2004) 2.59
Protein kinase Cdelta selectively regulates protein kinase D-dependent activation of NF-kappaB in oxidative stress signaling. Mol Cell Biol (2004) 2.51
PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid. EMBO J (1995) 2.14
Regulation of cytochrome c oxidase activity by c-Src in osteoclasts. J Cell Biol (2003) 1.90
A mitochondrial paradigm for degenerative diseases and ageing. Novartis Found Symp (2001) 1.63
Structural requirements for localization and activation of protein kinase C mu (PKC mu) at the Golgi compartment. J Cell Biol (2002) 1.57
Spatial and temporal regulation of protein kinase D (PKD). EMBO J (2000) 1.38
Intracellular location and cell context-dependent function of protein kinase D. Immunity (2003) 1.33
Targeting of protein kinase C delta to mitochondria in the oxidative stress response. Cell Growth Differ (2001) 1.31
Targeting of the c-Abl tyrosine kinase to mitochondria in the necrotic cell death response to oxidative stress. J Biol Chem (2001) 1.21
Transcriptional activation of the human manganese superoxide dismutase gene mediated by tetradecanoylphorbol acetate. J Biol Chem (1999) 1.20
Sequence analysis of mutations and translocations across breast cancer subtypes. Nature (2012) 7.76
A rapid method for determining protein kinase phosphorylation specificity. Nat Methods (2004) 5.04
Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT. Mol Cell (2005) 3.78
Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4 kinase IIIbeta at the Golgi complex. Nat Cell Biol (2005) 3.20
The role of NFAT transcription factors in integrin-mediated carcinoma invasion. Nat Cell Biol (2002) 3.05
Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction. Nat Cell Biol (2009) 2.76
Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathway. EMBO J (2003) 2.68
Protein kinase Cdelta selectively regulates protein kinase D-dependent activation of NF-kappaB in oxidative stress signaling. Mol Cell Biol (2004) 2.51
Protein kinase D1 regulates cofilin-mediated F-actin reorganization and cell motility through slingshot. Nat Cell Biol (2009) 2.31
NFAT proteins: emerging roles in cancer progression. Nat Rev Cancer (2009) 2.18
mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR. Mol Cell (2011) 2.03
A phosphorylation state-specific antibody recognizes Hsp27, a novel substrate of protein kinase D. J Biol Chem (2005) 2.03
A secreted form of ADAM9 promotes carcinoma invasion through tumor-stromal interactions. Cancer Res (2005) 1.87
Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer. Cell Signal (2008) 1.81
Regulation of novel protein kinase C epsilon by phosphorylation. Biochem J (2002) 1.65
Calcium-dependent regulation of protein kinase D revealed by a genetically encoded kinase activity reporter. J Biol Chem (2006) 1.56
Protein kinase D1 regulates matrix metalloproteinase expression and inhibits breast cancer cell invasion. Breast Cancer Res (2009) 1.55
NFAT induces breast cancer cell invasion by promoting the induction of cyclooxygenase-2. J Biol Chem (2006) 1.55
Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-κB and MMPs. J Cell Biol (2013) 1.54
The actin-bundling protein palladin is an Akt1-specific substrate that regulates breast cancer cell migration. Mol Cell (2010) 1.53
Tyrosine phosphorylation of protein kinase D in the pleckstrin homology domain leads to activation. J Biol Chem (2003) 1.47
3-Phosphoinositide-dependent kinase 1 potentiates upstream lesions on the phosphatidylinositol 3-kinase pathway in breast carcinoma. Cancer Res (2009) 1.43
Akt/PKB signaling in cancer: a function in cell motility and invasion. Cell Cycle (2006) 1.42
Acetylation-dependent regulation of Skp2 function. Cell (2012) 1.40
FOXO3a promotes tumor cell invasion through the induction of matrix metalloproteinases. Mol Cell Biol (2009) 1.35
Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction. Mol Cell (2010) 1.34
Loss of cell-cell contacts induces NF-kappaB via RhoA-mediated activation of protein kinase D1. J Cell Biochem (2009) 1.14
Activation loop phosphorylation controls protein kinase D-dependent activation of nuclear factor kappaB. Mol Pharmacol (2004) 1.13
Protein kinase D regulates cofilin activity through p21-activated kinase 4. J Biol Chem (2011) 1.10
Regulation of oxysterol-binding protein Golgi localization through protein kinase D-mediated phosphorylation. Mol Biol Cell (2010) 1.09
3'-phosphoinositide-dependent kinase-1 (PDK-1) in PI 3-kinase signaling. Front Biosci (2002) 1.09
NFAT promotes carcinoma invasive migration through glypican-6. Biochem J (2011) 1.09
Phosphorylation of the Par-1 polarity kinase by protein kinase D regulates 14-3-3 binding and membrane association. Proc Natl Acad Sci U S A (2008) 1.08
Akt/protein kinase b and glycogen synthase kinase-3beta signaling pathway regulates cell migration through the NFAT1 transcription factor. Mol Cancer Res (2009) 1.07
Targeting Akt3 signaling in triple-negative breast cancer. Cancer Res (2013) 1.06
Mitochondrial diacylglycerol initiates protein-kinase D1-mediated ROS signaling. J Cell Sci (2009) 1.05
Pharmacologic reversion of epigenetic silencing of the PRKD1 promoter blocks breast tumor cell invasion and metastasis. Breast Cancer Res (2013) 1.03
Akt isoform-specific signaling in breast cancer: uncovering an anti-migratory role for palladin. Cell Adh Migr (2011) 1.01
The adherens junction protein afadin is an AKT substrate that regulates breast cancer cell migration. Mol Cancer Res (2013) 0.98
Protein kinase D1 maintains the epithelial phenotype by inducing a DNA-bound, inactive SNAI1 transcriptional repressor complex. PLoS One (2012) 0.97
Functional dichotomy of A20 in apoptotic and necrotic cell death. Biochem J (2005) 0.95
Effect of overexpression of constitutively active PKCalpha on rat lacrimal gland protein secretion. Invest Ophthalmol Vis Sci (2004) 0.94
Secreted and membrane-bound isoforms of protease ADAM9 have opposing effects on breast cancer cell migration. Cancer Res (2010) 0.94
NF-kappaB signaling--an alternate pathway for oxidative stress responses. Cell Cycle (2003) 0.91
PKD controls αvβ3 integrin recycling and tumor cell invasive migration through its substrate Rabaptin-5. Dev Cell (2012) 0.90
Akt2 regulates expression of the actin-bundling protein palladin. FEBS Lett (2010) 0.89
Protein kinase D-mediated phosphorylation at Ser99 regulates localization of p21-activated kinase 4. Biochem J (2013) 0.89
RhoB differentially controls Akt function in tumor cells and stromal endothelial cells during breast tumorigenesis. Cancer Res (2012) 0.85
Using phospho-motif antibodies to determine kinase substrates. Curr Protoc Mol Biol (2013) 0.78
Effect of overexpression of protein kinase C alpha on rat lacrimal gland protein secretion. Adv Exp Med Biol (2002) 0.75