Published in Calcif Tissue Int on October 08, 2013
MicroRNAs in the control of metastatic bone disease. Trends Endocrinol Metab (2014) 0.92
Minireview: complexity of hematopoietic stem cell regulation in the bone marrow microenvironment. Mol Endocrinol (2014) 0.86
CD44 standard and CD44v10 isoform expression on leukemia cells distinctly influences niche embedding of hematopoietic stem cells. J Hematol Oncol (2014) 0.80
Notch signaling in the malignant bone marrow microenvironment: implications for a niche-based model of oncogenesis. Ann N Y Acad Sci (2014) 0.80
Targeting the molecular and cellular interactions of the bone marrow niche in immunologic disease. Curr Allergy Asthma Rep (2014) 0.76
Intra-Bone Marrow Transplantation of Endosteal Bone Marrow Cells Facilitates Allogeneic Hematopoietic and Stromal Cells Engraftment Dependent on Early Expression of CXCL-12. Med Sci Monit (2015) 0.75
SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell (2005) 24.00
Osteoblastic cells regulate the haematopoietic stem cell niche. Nature (2003) 19.60
Identification of the haematopoietic stem cell niche and control of the niche size. Nature (2003) 18.17
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature (2010) 15.28
Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell (2004) 12.67
Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Science (1996) 12.54
Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. Immunity (2006) 11.28
Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment. Cell (2007) 10.13
Little evidence for developmental plasticity of adult hematopoietic stem cells. Science (2002) 9.63
Socializing with the neighbors: stem cells and their niche. Cell (2004) 9.40
Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell (2002) 9.36
The relationship between the spleen colony-forming cell and the haemopoietic stem cell. Blood Cells (1978) 8.80
Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4. Science (1999) 8.43
Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature (2007) 7.55
Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow. Cell (2006) 7.23
Physiological migration of hematopoietic stem and progenitor cells. Science (2001) 7.02
Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche. Nature (2008) 6.61
Endothelial and perivascular cells maintain haematopoietic stem cells. Nature (2012) 6.60
Haematopoietic stem cell release is regulated by circadian oscillations. Nature (2008) 6.50
G-CSF induces stem cell mobilization by decreasing bone marrow SDF-1 and up-regulating CXCR4. Nat Immunol (2002) 6.22
Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis. Immunity (2012) 6.18
Forcing cells to change lineages. Nature (2009) 5.99
c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation. Genes Dev (2004) 5.83
Definitive hematopoiesis is autonomously initiated by the AGM region. Cell (1996) 5.75
Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor. Nature (2005) 5.54
Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter. Nature (2009) 5.34
Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells. Nat Med (2006) 5.33
Regulation of the HIF-1alpha level is essential for hematopoietic stem cells. Cell Stem Cell (2010) 4.90
Endogenous bone marrow MSCs are dynamic, fate-restricted participants in bone maintenance and regeneration. Cell Stem Cell (2012) 4.67
Hematopoiesis is severely altered in mice with an induced osteoblast deficiency. Blood (2004) 4.56
Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells. Cell Stem Cell (2009) 4.52
Identification of stromal cell precursors in human bone marrow by a novel monoclonal antibody, STRO-1. Blood (1991) 4.49
Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow. J Clin Invest (2011) 4.43
Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche. Cell Stem Cell (2007) 4.31
Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells. Cell Stem Cell (2010) 4.21
Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment. Nature (2009) 4.14
Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches. Nature (2013) 4.11
Detection of functional haematopoietic stem cell niche using real-time imaging. Nature (2008) 4.06
Of lineage and legacy: the development of mammalian hematopoietic stem cells. Nat Immunol (2008) 4.04
Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche. Cell (2011) 4.04
CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance. Nature (2013) 4.04
Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche. J Exp Med (2011) 3.88
Therapeutic targeting of a stem cell niche. Nat Biotechnol (2007) 3.88
Spatial localization of transplanted hemopoietic stem cells: inferences for the localization of stem cell niches. Blood (2001) 3.76
The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development. J Clin Invest (2007) 3.76
G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow. Blood (2005) 3.76
Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide. J Clin Invest (2003) 3.52
Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells. Nat Cell Biol (2010) 3.51
Germline stem cells anchored by adherens junctions in the Drosophila ovary niches. Science (2002) 3.42
Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells. Cell Stem Cell (2007) 3.39
Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoietic progenitor cells. Science (2008) 3.39
Cord-blood engraftment with ex vivo mesenchymal-cell coculture. N Engl J Med (2012) 3.39
Activated parathyroid hormone/parathyroid hormone-related protein receptor in osteoblastic cells differentially affects cortical and trabecular bone. J Clin Invest (2001) 3.37
Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs. Blood (2010) 3.26
Restoration and reversible expansion of the osteoblastic hematopoietic stem cell niche after marrow radioablation. Blood (2009) 3.04
Stem cell states, fates, and the rules of attraction. Cell Stem Cell (2009) 2.96
TGF-beta as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation. Blood (2008) 2.64
Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma. Blood (2009) 2.61
CXCR4 is required for the quiescence of primitive hematopoietic cells. J Exp Med (2008) 2.41
Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and in vivo. J Immunol (2008) 2.39
Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche. Cell (2012) 2.36
Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment. Nat Cell Biol (2013) 2.34
Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance. Nat Med (2012) 2.33
Superior ex vivo cord blood expansion following co-culture with bone marrow-derived mesenchymal stem cells. Bone Marrow Transplant (2006) 2.29
Functional inhibition of osteoblastic cells in an in vivo mouse model of myeloid leukemia. Blood (2011) 2.27
CD169⁺ macrophages provide a niche promoting erythropoiesis under homeostasis and stress. Nat Med (2013) 2.26
An empty Drosophila stem cell niche reactivates the proliferation of ectopic cells. Proc Natl Acad Sci U S A (2003) 2.26
Marrow fat and the bone microenvironment: developmental, functional, and pathological implications. Crit Rev Eukaryot Gene Expr (2009) 2.26
The HIF signaling pathway in osteoblasts directly modulates erythropoiesis through the production of EPO. Cell (2012) 2.25
Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization. Blood (2009) 2.25
Hematopoietic development: a balancing act. Curr Opin Genet Dev (2001) 2.21
Human osteoblasts support hematopoiesis through the production of granulocyte colony-stimulating factor. J Exp Med (1994) 2.14
Drosophila stem cell niches: a decade of discovery suggests a unified view of stem cell regulation. Dev Cell (2011) 2.10
Prostaglandin E2 enhances human cord blood stem cell xenotransplants and shows long-term safety in preclinical nonhuman primate transplant models. Cell Stem Cell (2011) 2.04
Characterization of hematopoietic progenitor mobilization in protease-deficient mice. Blood (2004) 2.01
A cell-autonomous requirement for CXCR4 in long-term lymphoid and myeloid reconstitution. Proc Natl Acad Sci U S A (1999) 1.97
Expression of the G-CSF receptor in monocytic cells is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice. J Exp Med (2011) 1.96
PDGFRα and CD51 mark human nestin+ sphere-forming mesenchymal stem cells capable of hematopoietic progenitor cell expansion. J Exp Med (2013) 1.95
Adipogenesis and aging: does aging make fat go MAD? Exp Gerontol (2002) 1.90
Adiponectin and its receptors are expressed in bone-forming cells. Bone (2004) 1.86
Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization. J Exp Med (2011) 1.79
Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells. Blood (2010) 1.78
The relative spatial distributions of CFUs and CFUc in the normal mouse femur. Blood (1975) 1.77
Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model. J Bone Miner Res (2011) 1.76
Silencing of parathyroid hormone (PTH) receptor 1 in T cells blunts the bone anabolic activity of PTH. Proc Natl Acad Sci U S A (2012) 1.68
Expression of the G-CSF receptor on hematopoietic progenitor cells is not required for their mobilization by G-CSF. Blood (2000) 1.66
Human osteoblasts support human hematopoietic progenitor cells in vitro bone marrow cultures. Blood (1996) 1.65
Regulation of hematopoietic stem and progenitor cell mobilization by cholesterol efflux pathways. Cell Stem Cell (2012) 1.62
Strontium can increase some osteoblasts without increasing hematopoietic stem cells. Blood (2007) 1.61
Marrow fat and bone--new perspectives. J Clin Endocrinol Metab (2013) 1.60
CD150- cells are transiently reconstituting multipotent progenitors with little or no stem cell activity. Blood (2008) 1.57
PTH expands short-term murine hemopoietic stem cells through T cells. Blood (2012) 1.53
A role of CXC chemokine ligand 12/stromal cell-derived factor-1/pre-B cell growth stimulating factor and its receptor CXCR4 in fetal and adult T cell development in vivo. J Immunol (2003) 1.52
CD34 expression by stromal precursors in normal human adult bone marrow. Blood (1991) 1.52
Annexin II expressed by osteoblasts and endothelial cells regulates stem cell adhesion, homing, and engraftment following transplantation. Blood (2007) 1.48
Blood cells and blood cell development in the animal kingdom. Annu Rev Cell Dev Biol (2006) 1.45
DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. Nature (2008) 38.13
Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med (2009) 33.09
Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing. Nature (2012) 14.33
DNMT3A mutations in acute myeloid leukemia. N Engl J Med (2010) 14.07
The origin and evolution of mutations in acute myeloid leukemia. Cell (2012) 9.66
Clonal architecture of secondary acute myeloid leukemia. N Engl J Med (2012) 6.71
Acquired copy number alterations in adult acute myeloid leukemia genomes. Proc Natl Acad Sci U S A (2009) 4.17
Use of whole-genome sequencing to diagnose a cryptic fusion oncogene. JAMA (2011) 4.11
CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance. Nature (2013) 4.04
Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes. Nat Genet (2011) 4.02
Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia. Blood (2008) 3.89
G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow. Blood (2005) 3.76
The number of endothelial progenitor cell colonies in the blood is increased in patients with angiographically significant coronary artery disease. J Am Coll Cardiol (2006) 3.17
Rapid mobilization of functional donor hematopoietic cells without G-CSF using AMD3100, an antagonist of the CXCR4/SDF-1 interaction. Blood (2008) 3.11
G-CSF is an essential regulator of neutrophil trafficking from the bone marrow to the blood. Immunity (2002) 2.72
High throughput digital quantification of mRNA abundance in primary human acute myeloid leukemia samples. J Clin Invest (2009) 2.66
CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow. J Clin Invest (2010) 2.38
Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization. Blood (2009) 2.25
STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils. Blood (2006) 2.12
Characterization of hematopoietic progenitor mobilization in protease-deficient mice. Blood (2004) 2.01
Expression of the G-CSF receptor in monocytic cells is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice. J Exp Med (2011) 1.96
Mutations of the ELA2 gene found in patients with severe congenital neutropenia induce the unfolded protein response and cellular apoptosis. Blood (2007) 1.92
Regulation of neutrophil homeostasis. Curr Opin Hematol (2007) 1.87
CXCR4 is a key regulator of neutrophil release from the bone marrow under basal and stress granulopoiesis conditions. Blood (2009) 1.83
Next-generation sequencing identifies the natural killer cell microRNA transcriptome. Genome Res (2010) 1.75
A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid leukemia cell genomes. Proc Natl Acad Sci U S A (2003) 1.69
G-CSF and AMD3100 mobilize monocytes into the blood that stimulate angiogenesis in vivo through a paracrine mechanism. Blood (2006) 1.66
Prevalence of mutations in ELANE, GFI1, HAX1, SBDS, WAS and G6PC3 in patients with severe congenital neutropenia. Br J Haematol (2009) 1.59
Mutations of the SBDS gene are present in most patients with Shwachman-Diamond syndrome. Blood (2004) 1.58
A mouse-based strategy for cyclophosphamide pharmacogenomic discovery. J Appl Physiol (1985) (2003) 1.55
Identification of somatic JAK1 mutations in patients with acute myeloid leukemia. Blood (2007) 1.55
Mechanisms of mobilization of hematopoietic progenitors with granulocyte colony-stimulating factor. Curr Opin Hematol (2002) 1.48
Pivotal role of granulocyte colony-stimulating factor in the development of progenitors in the common myeloid pathway. Blood (2003) 1.44
Granulocyte colony-stimulating factor induces osteoblast apoptosis and inhibits osteoblast differentiation. J Bone Miner Res (2008) 1.42
Genomics of AML: clinical applications of next-generation sequencing. Hematology Am Soc Hematol Educ Program (2011) 1.41
Csf3r mutations in mice confer a strong clonal HSC advantage via activation of Stat5. J Clin Invest (2008) 1.41
Revascularization of ischemic limbs after transplantation of human bone marrow cells with high aldehyde dehydrogenase activity. Blood (2009) 1.40
The many causes of severe congenital neutropenia. N Engl J Med (2009) 1.40
Neutrophil elastase mutations and risk of leukaemia in severe congenital neutropenia. Br J Haematol (2007) 1.37
N-cadherin in osteolineage cells is not required for maintenance of hematopoietic stem cells. Blood (2012) 1.33
Angiogenic cells can be rapidly mobilized and efficiently harvested from the blood following treatment with AMD3100. Blood (2006) 1.29
Lentiviral-mediated RNAi inhibition of Sbds in murine hematopoietic progenitors impairs their hematopoietic potential. Blood (2007) 1.25
Activation of Tyk2 and Stat3 is required for the apoptotic actions of interferon-beta in primary pro-B cells. J Biol Chem (2006) 1.23
Recruitment of the inflammatory subset of monocytes to sites of ischemia induces angiogenesis in a monocyte chemoattractant protein-1-dependent fashion. J Leukoc Biol (2008) 1.20
Contribution of granulocyte colony-stimulating factor to the acute mobilization of endothelial precursor cells by vascular disrupting agents. Cancer Res (2009) 1.20
Commonly dysregulated genes in murine APL cells. Blood (2006) 1.18
Stable long-term risk of leukaemia in patients with severe congenital neutropenia maintained on G-CSF therapy. Br J Haematol (2010) 1.17
A truncation mutant of Csf3r cooperates with PML-RARα to induce acute myeloid leukemia in mice. Exp Hematol (2011) 1.17
Regulation of hematopoietic stem cell activity by inflammation. Front Immunol (2013) 1.17
Complete characterization of the microRNAome in a patient with acute myeloid leukemia. Blood (2010) 1.16
Mice expressing a neutrophil elastase mutation derived from patients with severe congenital neutropenia have normal granulopoiesis. Blood (2002) 1.09
Src family kinases are important negative regulators of G-CSF-dependent granulopoiesis. Blood (2006) 1.07
Regulation of systemic and local neutrophil responses by G-CSF during pulmonary Pseudomonas aeruginosa infection. Blood (2006) 1.06
Regulation of neutrophil trafficking from the bone marrow. Cell Mol Life Sci (2011) 1.03
Tumor-induced STAT3 activation in monocytic myeloid-derived suppressor cells enhances stemness and mesenchymal properties in human pancreatic cancer. Cancer Immunol Immunother (2014) 0.96
Activation of the unfolded protein response is associated with impaired granulopoiesis in transgenic mice expressing mutant Elane. Blood (2011) 0.93
Dicer and outcomes in patients with acute myeloid leukemia (AML). Leuk Res (2009) 0.91
Dual functions of cell-autonomous and non-cell-autonomous ADAM10 activity in granulopoiesis. Blood (2011) 0.90
Kruppel-like factor 7 overexpression suppresses hematopoietic stem and progenitor cell function. Blood (2012) 0.90
Inherited bone marrow failure syndromes in adolescents and young adults. Ann Med (2014) 0.88
Severe congenital neutropenia and the unfolded protein response. Curr Opin Hematol (2008) 0.87
Systemic levels of G-CSF and interleukin-6 determine the angiogenic potential of bone marrow resident monocytes. J Leukoc Biol (2010) 0.86
The diversity of mutations and clinical outcomes for ELANE-associated neutropenia. Curr Opin Hematol (2015) 0.86
Niche competition and cancer metastasis to bone. J Clin Invest (2011) 0.85
Acquired copy number alterations of miRNA genes in acute myeloid leukemia are uncommon. Blood (2013) 0.84
5. Mechanisms of disordered granulopoiesis in congenital neutropenia. Curr Top Dev Biol (2006) 0.79
Enhancing hematopoietic growth factor performance. Nat Med (2012) 0.78
p120 nucleolar-proliferating antigen is a direct target of G-CSF signaling during myeloid differentiation. J Leukoc Biol (2006) 0.77
CXCR2 is the Tpo of the iceberg. Blood (2011) 0.76
Divergent pathways in COS-7 cells mediate defective internalization and intracellular routing of truncated G-CSFR forms in SCN/AML. PLoS One (2008) 0.76
A comparison of cyclic neutropenia in childhood and severe congenital neutropenia. Haematologica (2005) 0.75
Neutrophil differentiation. Haematologica (2005) 0.75