Published in Genes Dev on May 19, 2014
CD44 Acts as a Signaling Platform Controlling Tumor Progression and Metastasis. Front Immunol (2015) 1.00
Defective control of pre-messenger RNA splicing in human disease. J Cell Biol (2016) 0.96
The hnRNP family: insights into their role in health and disease. Hum Genet (2016) 0.94
Functional roles of alternative splicing factors in human disease. Wiley Interdiscip Rev RNA (2015) 0.92
RNA splicing factors as oncoproteins and tumour suppressors. Nat Rev Cancer (2016) 0.92
Rbfox Proteins Regulate Splicing as Part of a Large Multiprotein Complex LASR. Cell (2016) 0.89
Telomere-regulating genes and the telomere interactome in familial cancers. Mol Cancer Res (2014) 0.87
The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development. Elife (2015) 0.86
Aberrant Splicing of Estrogen Receptor, HER2, and CD44 Genes in Breast Cancer. Genet Epigenet (2015) 0.85
Wrecked regulation of intrinsically disordered proteins in diseases: pathogenicity of deregulated regulators. Front Mol Biosci (2014) 0.82
Direct Regulation of Alternative Splicing by SMAD3 through PCBP1 Is Essential to the Tumor-Promoting Role of TGF-β. Mol Cell (2016) 0.81
Alternative splicing of DNA damage response genes and gastrointestinal cancers. World J Gastroenterol (2014) 0.80
Actin cytoskeletal control during epithelial to mesenchymal transition: focus on the pancreas and intestinal tract. Br J Cancer (2015) 0.80
Restraint of the G2/M transition by the SR/RRM family mRNA shuttling binding protein SNXAHRB1 in Aspergillus nidulans. Genetics (2014) 0.79
Epigenetic regulation of ZEB1-RAB25/ESRP1 axis plays a critical role in phenylbutyrate treatment-resistant breast cancer. Oncotarget (2016) 0.78
Splicing-factor alterations in cancers. RNA (2016) 0.78
Determination of a Comprehensive Alternative Splicing Regulatory Network and Combinatorial Regulation by Key Factors during the Epithelial-to-Mesenchymal Transition. Mol Cell Biol (2016) 0.77
Dysregulation of splicing proteins in head and neck squamous cell carcinoma. Cancer Biol Ther (2016) 0.77
Muscleblind-like 1 suppresses breast cancer metastatic colonization and stabilizes metastasis suppressor transcripts. Genes Dev (2016) 0.77
The Alternative Splicing of Cytoplasmic Polyadenylation Element Binding Protein 2 Drives Anoikis Resistance and the Metastasis of Triple Negative Breast Cancer. J Biol Chem (2015) 0.77
Heterogeneous nuclear ribonucleoprotein M associates with mTORC2 and regulates muscle differentiation. Sci Rep (2017) 0.75
Methods for Characterization of Alternative RNA Splicing. Methods Mol Biol (2016) 0.75
The role of splicing factors in deregulation of alternative splicing during oncogenesis and tumor progression. Mol Cell Oncol (2014) 0.75
Splicing Regulators and Their Roles in Cancer Biology and Therapy. Biomed Res Int (2015) 0.75
The Genome-Wide Analysis of Carcinoembryonic Antigen Signaling by Colorectal Cancer Cells Using RNA Sequencing. PLoS One (2016) 0.75
Metformin treatment reduces temozolomide resistance of glioblastoma cells. Oncotarget (2016) 0.75
Internalized CD44s splice isoform attenuates EGFR degradation by targeting Rab7A. Proc Natl Acad Sci U S A (2017) 0.75
Akt signaling is sustained by a CD44 splice isoform-mediated positive feedback loop. Cancer Res (2017) 0.75
The clinical and prognostic correlation of HRNPM and SLC1A5 in pathogenesis and prognosis in epithelial ovarian cancer. PLoS One (2017) 0.75
miR18a and miR19a Recruit Specific Proteins for Splicing in Thyroid Cancer Cells. Cancer Genomics Proteomics (2017) 0.75
Molecular portraits of human breast tumours. Nature (2000) 94.14
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A (2001) 71.82
Gene expression profiling predicts clinical outcome of breast cancer. Nature (2002) 71.36
Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A (2003) 59.17
The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell (2008) 46.08
Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol (2006) 23.04
Genes that mediate breast cancer metastasis to lung. Nature (2005) 19.85
Identification of pancreatic cancer stem cells. Cancer Res (2007) 18.36
Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell (2008) 14.80
Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis. J Natl Cancer Inst (2006) 14.60
Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci U S A (2007) 13.58
The prognostic role of a gene signature from tumorigenic breast-cancer cells. N Engl J Med (2007) 13.39
Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. Proc Natl Acad Sci U S A (2007) 11.94
Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor. Cancer Res (1992) 9.02
Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res (2008) 7.91
Epithelial-mesenchymal transition in breast cancer relates to the basal-like phenotype. Cancer Res (2008) 6.95
Regulatory networks defining EMT during cancer initiation and progression. Nat Rev Cancer (2013) 6.13
Targeting of CD44 eradicates human acute myeloid leukemic stem cells. Nat Med (2006) 5.92
Deconstructing the molecular portraits of breast cancer. Mol Oncol (2010) 5.37
Identification of molecular apocrine breast tumours by microarray analysis. Oncogene (2005) 5.27
ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing. Mol Cell (2009) 5.03
Homologues of the Caenorhabditis elegans Fox-1 protein are neuronal splicing regulators in mammals. Mol Cell Biol (2005) 5.03
RNA binding specificity of hnRNP proteins: a subset bind to the 3' end of introns. EMBO J (1988) 4.26
Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein. Mol Cell Biol (2000) 4.12
A vertebrate RNA-binding protein Fox-1 regulates tissue-specific splicing via the pentanucleotide GCAUG. EMBO J (2003) 3.44
Signal-dependent regulation of splicing via phosphorylation of Sam68. Nature (2002) 3.17
A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicing. Proc Natl Acad Sci U S A (2000) 3.11
An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype. PLoS Genet (2011) 2.99
CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression. J Clin Invest (2011) 2.90
Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system. Neuron (1993) 2.81
Integrative genome-wide analysis reveals cooperative regulation of alternative splicing by hnRNP proteins. Cell Rep (2012) 2.76
Accurate identification of A-to-I RNA editing in human by transcriptome sequencing. Genome Res (2011) 2.73
An ESRP-regulated splicing programme is abrogated during the epithelial-mesenchymal transition. EMBO J (2010) 2.42
Functional diversity of the hnRNPs: past, present and perspectives. Biochem J (2010) 2.29
Cancer stem-like cell marker CD44 promotes bone metastases by enhancing tumorigenicity, cell motility, and hyaluronan production. Cancer Res (2013) 2.21
MATS: a Bayesian framework for flexible detection of differential alternative splicing from RNA-Seq data. Nucleic Acids Res (2012) 2.09
The hnRNP F protein: unique primary structure, nucleic acid-binding properties, and subcellular localization. Nucleic Acids Res (1994) 2.01
Regulation of CD44 alternative splicing by SRm160 and its potential role in tumor cell invasion. Mol Cell Biol (2006) 1.99
A systems view of epithelial-mesenchymal transition signaling states. Clin Exp Metastasis (2010) 1.95
The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation. Nat Struct Mol Biol (2012) 1.88
Activation of CD44, a receptor for extracellular matrix components, protects chronic lymphocytic leukemia cells from spontaneous and drug induced apoptosis through MCL-1. Leuk Lymphoma (2011) 1.68
Prediction of future metastasis and molecular characterization of head and neck squamous-cell carcinoma based on transcriptome and genome analysis by microarrays. Oncogene (2008) 1.63
hnRNP H and hnRNP F complex with Fox2 to silence fibroblast growth factor receptor 2 exon IIIc. Mol Cell Biol (2008) 1.60
A positive feedback loop couples Ras activation and CD44 alternative splicing. Genes Dev (2006) 1.60
Sam68 regulates EMT through alternative splicing-activated nonsense-mediated mRNA decay of the SF2/ASF proto-oncogene. J Cell Biol (2010) 1.55
TGF-β drives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP. Oncogene (2011) 1.53
Systematical optimization of reverse-phase chromatography for shotgun proteomics. J Proteome Res (2009) 1.53
Genome-wide determination of a broad ESRP-regulated posttranscriptional network by high-throughput sequencing. Mol Cell Biol (2012) 1.49
Rbfox proteins regulate alternative mRNA splicing through evolutionarily conserved RNA bridges. Nat Struct Mol Biol (2013) 1.49
The human hnRNP M proteins: identification of a methionine/arginine-rich repeat motif in ribonucleoproteins. Nucleic Acids Res (1993) 1.48
Evolution of SR protein and hnRNP splicing regulatory factors. Wiley Interdiscip Rev RNA (2011) 1.37
Oncogenic splicing factor SRSF1 is a critical transcriptional target of MYC. Cell Rep (2012) 1.36
CD44s regulates the TGF-β-mediated mesenchymal phenotype and is associated with poor prognosis in patients with hepatocellular carcinoma. Cancer Res (2012) 1.31
Heterogeneous ribonucleoprotein m is a splicing regulatory protein that can enhance or silence splicing of alternatively spliced exons. J Biol Chem (2007) 1.23
RBFOX2 is an important regulator of mesenchymal tissue-specific splicing in both normal and cancer tissues. Mol Cell Biol (2012) 1.22
Identification of allele-specific alternative mRNA processing via transcriptome sequencing. Nucleic Acids Res (2012) 1.16
Patho-biological aspects of basal-like breast cancer. Breast Cancer Res Treat (2008) 1.09
ERalpha-CITED1 co-regulated genes expressed during pubertal mammary gland development: implications for breast cancer prognosis. Oncogene (2007) 1.06
Snail represses the splicing regulator epithelial splicing regulatory protein 1 to promote epithelial-mesenchymal transition. J Biol Chem (2012) 1.06
HnRNP A1 controls a splicing regulatory circuit promoting mesenchymal-to-epithelial transition. Nucleic Acids Res (2013) 1.00
Prediction of lymph node metastasis in patients with endometrioid endometrial cancer using expression microarray. Clin Cancer Res (2006) 0.96
CD44 regulates the apoptotic response and promotes disease development in chronic lymphocytic leukemia. Blood (2013) 0.92
Carcinoembryonic antigen (CEA) and its receptor hnRNP M are mediators of metastasis and the inflammatory response in the liver. Clin Exp Metastasis (2011) 0.88