Published in Elife on September 15, 2015
Genetic insights into the mechanisms of Fgf signaling. Genes Dev (2016) 0.79
Splicing-factor alterations in cancers. RNA (2016) 0.78
Transcriptome sequencing reveals aberrant alternative splicing in Huntington's disease. Hum Mol Genet (2016) 0.78
The FaceBase Consortium: a comprehensive resource for craniofacial researchers. Development (2016) 0.78
Determination of a Comprehensive Alternative Splicing Regulatory Network and Combinatorial Regulation by Key Factors during the Epithelial-to-Mesenchymal Transition. Mol Cell Biol (2016) 0.77
rMAPS: RNA map analysis and plotting server for alternative exon regulation. Nucleic Acids Res (2016) 0.77
Ablation of the epithelial-specific splicing factor Esrp1 results in ureteric branching defects and reduced nephron number. Dev Dyn (2016) 0.75
Downregulation of Lnc-Spry1 mediates TGF-β-induced epithelial-mesenchymal transition by transcriptional and posttranscriptional regulatory mechanisms. Cell Death Differ (2017) 0.75
EMT and stemness: flexible processes tuned by alternative splicing in development and cancer progression. Mol Cancer (2017) 0.75
Offspring genes indirectly influence sibling and maternal behavioural strategies over resource share. Proc Biol Sci (2017) 0.75
Genome-wide signatures of complex introgression and adaptive evolution in the big cats. Sci Adv (2017) 0.75
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc (2009) 137.99
Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Nat Biotechnol (2010) 75.21
Alternative isoform regulation in human tissue transcriptomes. Nature (2008) 52.76
Epithelial-mesenchymal transitions in development and disease. Cell (2009) 39.17
Large-scale analysis of the human and mouse transcriptomes. Proc Natl Acad Sci U S A (2002) 25.47
Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing. Nat Genet (2008) 24.51
Alternative splicing: increasing diversity in the proteomic world. Trends Genet (2001) 10.44
CLIP identifies Nova-regulated RNA networks in the brain. Science (2003) 8.88
Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches. Nat Rev Mol Cell Biol (2009) 7.11
Nova regulates brain-specific splicing to shape the synapse. Nat Genet (2005) 6.58
Klf4 is a transcription factor required for establishing the barrier function of the skin. Nat Genet (1999) 5.91
Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. J Biol Chem (2006) 5.78
Cleft lip and palate: understanding genetic and environmental influences. Nat Rev Genet (2011) 5.41
A two-step mechanism for stem cell activation during hair regeneration. Cell Stem Cell (2009) 5.40
ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing. Mol Cell (2009) 5.03
A compendium of RNA-binding motifs for decoding gene regulation. Nature (2013) 4.91
Scratching the surface of skin development. Nature (2007) 4.61
An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis. Development (2000) 4.33
Molecular dissection of mesenchymal-epithelial interactions in the hair follicle. PLoS Biol (2005) 4.27
Epidermal barrier formation and recovery in skin disorders. J Clin Invest (2006) 4.14
Expression of 24,426 human alternative splicing events and predicted cis regulation in 48 tissues and cell lines. Nat Genet (2008) 3.78
Identification of alternative splicing regulators by RNA interference in Drosophila. Proc Natl Acad Sci U S A (2004) 3.58
Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development. Development (2004) 3.46
A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart. Proc Natl Acad Sci U S A (2008) 3.33
Functional consequences of developmentally regulated alternative splicing. Nat Rev Genet (2011) 3.27
FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development. Biochem Biophys Res Commun (2000) 3.08
Developmental localization of the splicing alternatives of fibroblast growth factor receptor-2 (FGFR2). Dev Biol (1993) 2.96
A comprehensive guide for the recognition and classification of distinct stages of hair follicle morphogenesis. J Invest Dermatol (1999) 2.92
Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction. Development (1998) 2.90
CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression. J Clin Invest (2011) 2.90
Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate. J Clin Invest (2004) 2.72
MBNL proteins repress ES-cell-specific alternative splicing and reprogramming. Nature (2013) 2.49
An ESRP-regulated splicing programme is abrogated during the epithelial-mesenchymal transition. EMBO J (2010) 2.42
Pre-mRNA splicing in disease and therapeutics. Trends Mol Med (2012) 2.23
Lessons from loricrin-deficient mice: compensatory mechanisms maintaining skin barrier function in the absence of a major cornified envelope protein. J Cell Biol (2000) 2.22
Fibroblast growth factor receptor 2-IIIb acts upstream of Shh and Fgf4 and is required for limb bud maintenance but not for the induction of Fgf8, Fgf10, Msx1, or Bmp4. Dev Biol (2001) 2.21
Context-dependent control of alternative splicing by RNA-binding proteins. Nat Rev Genet (2014) 2.17
The splicing regulator Rbfox1 (A2BP1) controls neuronal excitation in the mammalian brain. Nat Genet (2011) 2.10
An intronic splicing silencer causes skipping of the IIIb exon of fibroblast growth factor receptor 2 through involvement of polypyrimidine tract binding protein. Mol Cell Biol (2000) 2.08
Function of alternative splicing. Gene (2012) 2.00
Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate. Development (2008) 1.96
A crucial role for Fgfr2-IIIb signalling in epidermal development and hair follicle patterning. Development (2003) 1.79
Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain. Genes Dev (2012) 1.70
The NF2 tumor suppressor, Merlin, regulates epidermal development through the establishment of a junctional polarity complex. Dev Cell (2010) 1.67
Regulation of alternative splicing by the core spliceosomal machinery. Genes Dev (2011) 1.60
hnRNP H and hnRNP F complex with Fox2 to silence fibroblast growth factor receptor 2 exon IIIc. Mol Cell Biol (2008) 1.60
The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4. Dev Biol (2006) 1.58
The epithelial splicing factors ESRP1 and ESRP2 positively and negatively regulate diverse types of alternative splicing events. RNA Biol (2009) 1.57
Genome-wide determination of a broad ESRP-regulated posttranscriptional network by high-throughput sequencing. Mol Cell Biol (2012) 1.49
rMATS: robust and flexible detection of differential alternative splicing from replicate RNA-Seq data. Proc Natl Acad Sci U S A (2014) 1.47
Alternative splicing in fibroblast growth factor receptor 2 is associated with induced epithelial-mesenchymal transition in rat bladder carcinoma cells. Mol Biol Cell (1994) 1.46
Perturbed desmosomal cadherin expression in grainy head-like 1-null mice. EMBO J (2008) 1.42
Mouse genetic models of cleft lip with or without cleft palate. Birth Defects Res A Clin Mol Teratol (2008) 1.41
Alternative splicing regulation during C. elegans development: splicing factors as regulated targets. PLoS Genet (2008) 1.41
Alcian blue/alizarin red staining of cartilage and bone in mouse. Cold Spring Harb Protoc (2009) 1.37
The human epidermal differentiation complex: cornified envelope precursors, S100 proteins and the 'fused genes' family. Exp Dermatol (2012) 1.29
Mouse Sprr locus: a tandem array of coordinately regulated genes. Mamm Genome (2003) 1.24
The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation. Elife (2014) 1.19
A novel intronic cis element, ISE/ISS-3, regulates rat fibroblast growth factor receptor 2 splicing through activation of an upstream exon and repression of a downstream exon containing a noncanonical branch point sequence. Mol Cell Biol (2005) 1.19
Compound loss of muscleblind-like function in myotonic dystrophy. EMBO Mol Med (2013) 1.19
Characterization of a novel ectodermal signaling center regulating Tbx2 and Shh in the vertebrate limb. Dev Biol (2006) 1.13
Regenerating the skin: a task for the heterogeneous stem cell pool and surrounding niche. Nat Rev Mol Cell Biol (2013) 1.13
Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing. Genes Dev (2014) 1.11
Endothelial, epithelial, and fibroblast cells exhibit specific splicing programs independently of their tissue of origin. Genome Res (2013) 1.06
Loss of the multifunctional RNA-binding protein RBM47 as a source of selectable metastatic traits in breast cancer. Elife (2014) 1.06
The impact of alternative splicing in vivo: mouse models show the way. RNA (2007) 1.03
The cardiotonic steroid digitoxin regulates alternative splicing through depletion of the splicing factors SRSF3 and TRA2B. RNA (2012) 1.00
RBM24 is a major regulator of muscle-specific alternative splicing. Dev Cell (2014) 0.99
Functional roles of alternative splicing factors in human disease. Wiley Interdiscip Rev RNA (2015) 0.92
Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development. Genes Dev (2015) 0.92
Transcriptome-wide landscape of pre-mRNA alternative splicing associated with metastatic colonization. Mol Cancer Res (2014) 0.91
fusilli, an essential gene with a maternal role in Drosophila embryonic dorsal-ventral patterning. Dev Biol (2001) 0.89
CD44 regulates tight-junction assembly and barrier function. J Invest Dermatol (2010) 0.88
Loss of Grainy head-like 1 is associated with disruption of the epidermal barrier and squamous cell carcinoma of the skin. PLoS One (2014) 0.85
During embryogenesis, esrp1 expression is restricted to a subset of epithelial cells and is associated with splicing of a number of developmentally important genes. Dev Dyn (2013) 0.80