Published in Wiley Interdiscip Rev RNA on January 28, 2015
Defective control of pre-messenger RNA splicing in human disease. J Cell Biol (2016) 0.96
The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development. Elife (2015) 0.86
Systematic characterization of lncRNAs' cell-to-cell expression heterogeneity in glioblastoma cells. Oncotarget (2016) 0.78
Alternative splicing and the evolution of phenotypic novelty. Philos Trans R Soc Lond B Biol Sci (2017) 0.76
EMT and stemness: flexible processes tuned by alternative splicing in development and cancer progression. Mol Cancer (2017) 0.75
Transcriptome-Wide Analysis Reveals Modulation of Human Macrophage Inflammatory Phenotype Through Alternative Splicing. Arterioscler Thromb Vasc Biol (2016) 0.75
Targeting Splicing in the Treatment of Human Disease. Genes (Basel) (2017) 0.75
Identification of biomarkers of intrahepatic cholangiocarcinoma via integrated analysis of mRNA and miRNA microarray data. Mol Med Rep (2017) 0.75
BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis. Nat Commun (2017) 0.75
Bronchial Epithelial Cells from Asthmatic Patients Display Less Functional HLA-G Isoform Expression. Front Immunol (2017) 0.75
JMJD6 and U2AF65 co-regulate alternative splicing in both JMJD6 enzymatic activity dependent and independent manner. Nucleic Acids Res (2016) 0.75
The impact of RABL2B gene (rs144944885) on human male infertility in patients with oligoasthenoteratozoospermia and immotile short tail sperm defects. J Assist Reprod Genet (2017) 0.75
Fine-tuning and autoregulation of the intestinal determinant and tumor suppressor homeobox gene CDX2 by alternative splicing. Cell Death Differ (2017) 0.75
A new role for FBP21 as regulator of Brr2 helicase activity. Nucleic Acids Res (2017) 0.75
Domestication reduces alternative splicing expression variations in sorghum. PLoS One (2017) 0.75
Alternative isoform regulation in human tissue transcriptomes. Nature (2008) 52.76
The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell (2008) 46.08
Epithelial-mesenchymal transitions in development and disease. Cell (2009) 39.17
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science (2006) 27.96
Strong association of de novo copy number mutations with autism. Science (2007) 27.84
Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing. Nat Genet (2008) 24.51
Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS. Neuron (2011) 20.15
A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD. Neuron (2011) 18.73
Listening to silence and understanding nonsense: exonic mutations that affect splicing. Nat Rev Genet (2002) 16.29
bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell (1993) 14.39
Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis. Science (2009) 13.45
Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6. Science (2009) 12.99
Mechanical devices of the spliceosome: motors, clocks, springs, and things. Cell (1998) 10.95
Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer. Breast Cancer Res (2010) 10.90
Transcriptomic analysis of autistic brain reveals convergent molecular pathology. Nature (2011) 10.16
Pre-mRNA splicing: awash in a sea of proteins. Mol Cell (2003) 8.28
RNA and disease. Cell (2009) 7.98
Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features. Proc Natl Acad Sci U S A (2009) 7.95
Splicing in disease: disruption of the splicing code and the decoding machinery. Nat Rev Genet (2007) 7.42
Amyotrophic lateral sclerosis. N Engl J Med (2001) 7.37
Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches. Nat Rev Mol Cell Biol (2009) 7.11
Disruption of splicing regulated by a CUG-binding protein in myotonic dystrophy. Science (1998) 6.67
The gene encoding the splicing factor SF2/ASF is a proto-oncogene. Nat Struct Mol Biol (2007) 6.16
Regulatory networks defining EMT during cancer initiation and progression. Nat Rev Cancer (2013) 6.13
Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43. Nat Neurosci (2011) 6.01
A muscleblind knockout model for myotonic dystrophy. Science (2003) 5.93
Unconventional translation of C9ORF72 GGGGCC expansion generates insoluble polypeptides specific to c9FTD/ALS. Neuron (2013) 5.91
Amyotrophic lateral sclerosis. Lancet (2011) 5.86
Myotonic dystrophy in transgenic mice expressing an expanded CUG repeat. Science (2000) 5.85
Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1. Cancer Cell (2012) 5.53
Characterizing the RNA targets and position-dependent splicing regulation by TDP-43. Nat Neurosci (2011) 5.24
ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing. Mol Cell (2009) 5.03
Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged. Genes Dev (2010) 4.75
Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. Cancer Cell (2012) 4.51
An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis. Development (2000) 4.33
Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2. Genes Dev (2008) 4.24
Neuronal intranuclear inclusions in a new cerebellar tremor/ataxia syndrome among fragile X carriers. Brain (2002) 4.05
Cancer stem cells and epithelial-mesenchymal transition: concepts and molecular links. Semin Cancer Biol (2012) 3.98
Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule. Science (1994) 3.98
The ins and outs of the epithelial to mesenchymal transition in health and disease. Annu Rev Cell Dev Biol (2011) 3.80
A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart. Proc Natl Acad Sci U S A (2008) 3.33
Functional consequences of developmentally regulated alternative splicing. Nat Rev Genet (2011) 3.27
Increased steady-state levels of CUGBP1 in myotonic dystrophy 1 are due to PKC-mediated hyperphosphorylation. Mol Cell (2007) 3.26
Cytogenetic and molecular characterization of A2BP1/FOX1 as a candidate gene for autism. Am J Med Genet B Neuropsychiatr Genet (2007) 3.11
Reversal of RNA missplicing and myotonia after muscleblind overexpression in a mouse poly(CUG) model for myotonic dystrophy. Proc Natl Acad Sci U S A (2006) 3.09
Splicing in action: assessing disease causing sequence changes. J Med Genet (2005) 3.07
An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype. PLoS Genet (2011) 2.99
Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs. Nat Neurosci (2012) 2.93
CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression. J Clin Invest (2011) 2.90
Cell motility is controlled by SF2/ASF through alternative splicing of the Ron protooncogene. Mol Cell (2005) 2.85
HITS-CLIP: panoramic views of protein-RNA regulation in living cells. Wiley Interdiscip Rev RNA (2010) 2.59
Mutations in ribonucleic acid binding protein gene cause familial dilated cardiomyopathy. J Am Coll Cardiol (2009) 2.53
Understanding the role of TDP-43 and FUS/TLS in ALS and beyond. Curr Opin Neurobiol (2011) 2.48
Sam68 sequestration and partial loss of function are associated with splicing alterations in FXTAS patients. EMBO J (2010) 2.43
An ESRP-regulated splicing programme is abrogated during the epithelial-mesenchymal transition. EMBO J (2010) 2.42
Advances in clinical and molecular understanding of the FMR1 premutation and fragile X-associated tremor/ataxia syndrome. Lancet Neurol (2013) 2.41
RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia. Proc Natl Acad Sci U S A (2013) 2.31
Pre-mRNA splicing in disease and therapeutics. Trends Mol Med (2012) 2.23
EMT as the ultimate survival mechanism of cancer cells. Semin Cancer Biol (2012) 2.22
The splicing regulator Rbfox1 (A2BP1) controls neuronal excitation in the mammalian brain. Nat Genet (2011) 2.10
Effect of a rapid response system for patients in shock on time to treatment and mortality during 5 years. Crit Care Med (2007) 2.04
Association of TALS developmental disorder with defect in minor splicing component U4atac snRNA. Science (2011) 2.04
Function of alternative splicing. Gene (2012) 2.00
RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing. Nat Med (2012) 1.97
Identification of both shared and distinct proteins in the major and minor spliceosomes. Science (1999) 1.96
Hexanucleotide repeats in ALS/FTD form length-dependent RNA foci, sequester RNA binding proteins, and are neurotoxic. Cell Rep (2013) 1.96
The genetic basis of myelodysplasia and its clinical relevance. Blood (2013) 1.95
The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation. Nat Struct Mol Biol (2012) 1.88
Exon-level microarray analyses identify alternative splicing programs in breast cancer. Mol Cancer Res (2010) 1.84
Muscleblind-like 2-mediated alternative splicing in the developing brain and dysregulation in myotonic dystrophy. Neuron (2012) 1.78
HITS-CLIP and integrative modeling define the Rbfox splicing-regulatory network linked to brain development and autism. Cell Rep (2014) 1.78
A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype. Mol Cell Biol (1996) 1.65
Hallmarks of alternative splicing in cancer. Oncogene (2013) 1.61
Identification of RNA-protein interaction networks using PAR-CLIP. Wiley Interdiscip Rev RNA (2011) 1.61
iCLIP: protein-RNA interactions at nucleotide resolution. Methods (2013) 1.61
The epithelial splicing factors ESRP1 and ESRP2 positively and negatively regulate diverse types of alternative splicing events. RNA Biol (2009) 1.57
Sam68 regulates EMT through alternative splicing-activated nonsense-mediated mRNA decay of the SF2/ASF proto-oncogene. J Cell Biol (2010) 1.55
Global profiling and molecular characterization of alternative splicing events misregulated in lung cancer. Mol Cell Biol (2010) 1.53
Identification of novel mutations in RBM20 in patients with dilated cardiomyopathy. Clin Transl Sci (2010) 1.52
RBFOX1 regulates both splicing and transcriptional networks in human neuronal development. Hum Mol Genet (2012) 1.51
Breast cancer epithelial-to-mesenchymal transition: examining the functional consequences of plasticity. Breast Cancer Res (2011) 1.50
Genome-wide determination of a broad ESRP-regulated posttranscriptional network by high-throughput sequencing. Mol Cell Biol (2012) 1.49
ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43. Proc Natl Acad Sci U S A (2013) 1.48
RBM5, 6, and 10 differentially regulate NUMB alternative splicing to control cancer cell proliferation. Mol Cell (2013) 1.47
CUGBP1 overexpression in mouse skeletal muscle reproduces features of myotonic dystrophy type 1. Hum Mol Genet (2010) 1.44
New connections between splicing and human disease. Trends Genet (2012) 1.39
Misregulation of pre-mRNA alternative splicing in cancer. Cancer Discov (2013) 1.39
Pre-mRNA splicing and retinitis pigmentosa. Mol Vis (2006) 1.32
Titin is a major human disease gene. Circulation (2013) 1.29
ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects. J Clin Invest (2014) 1.23
RBFOX2 is an important regulator of mesenchymal tissue-specific splicing in both normal and cancer tissues. Mol Cell Biol (2012) 1.22
MicroRNAs coordinate an alternative splicing network during mouse postnatal heart development. Genes Dev (2010) 1.22
Pathological mechanisms underlying TDP-43 driven neurodegeneration in FTLD-ALS spectrum disorders. Hum Mol Genet (2013) 1.21
Mutation that dramatically alters rat titin isoform expression and cardiomyocyte passive tension. J Mol Cell Cardiol (2008) 1.20
The alternative splicing side of cancer. Semin Cell Dev Biol (2014) 1.18
Titin isoform changes in rat myocardium during development. Mech Dev (2004) 1.18
Developments in RNA splicing and disease. Cold Spring Harb Perspect Biol (2011) 1.18
The RNA-binding protein QKI suppresses cancer-associated aberrant splicing. PLoS Genet (2014) 1.15
Complex changes in alternative pre-mRNA splicing play a central role in the epithelial-to-mesenchymal transition (EMT). Semin Cancer Biol (2012) 1.13
Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing. Genes Dev (2014) 1.11
ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing. Mol Cell (2009) 5.03
A compendium of RNA-binding motifs for decoding gene regulation. Nature (2013) 4.91
An ESRP-regulated splicing programme is abrogated during the epithelial-mesenchymal transition. EMBO J (2010) 2.42
MATS: a Bayesian framework for flexible detection of differential alternative splicing from RNA-Seq data. Nucleic Acids Res (2012) 2.09
The epithelial splicing factors ESRP1 and ESRP2 positively and negatively regulate diverse types of alternative splicing events. RNA Biol (2009) 1.57
Splicing program of human MENA produces a previously undescribed isoform associated with invasive, mesenchymal-like breast tumors. Proc Natl Acad Sci U S A (2012) 1.36
A Non-sequence-specific double-stranded RNA structural element regulates splicing of two mutually exclusive exons of fibroblast growth factor receptor 2 (FGFR2). J Biol Chem (2002) 1.28
Heterogeneous ribonucleoprotein m is a splicing regulatory protein that can enhance or silence splicing of alternatively spliced exons. J Biol Chem (2007) 1.23
A novel intronic cis element, ISE/ISS-3, regulates rat fibroblast growth factor receptor 2 splicing through activation of an upstream exon and repression of a downstream exon containing a noncanonical branch point sequence. Mol Cell Biol (2005) 1.19
An optimized protocol for protein purification in cultured mammalian cells using a tandem affinity purification approach. Nat Protoc (2006) 1.13
MADS+: discovery of differential splicing events from Affymetrix exon junction array data. Bioinformatics (2009) 1.13
Complex changes in alternative pre-mRNA splicing play a central role in the epithelial-to-mesenchymal transition (EMT). Semin Cancer Biol (2012) 1.13
The 3' untranslated region complex involved in stabilization of human alpha-globin mRNA assembles in the nucleus and serves an independent role as a splice enhancer. Mol Cell Biol (2007) 0.96
Characterization of sequences and mechanisms through which ISE/ISS-3 regulates FGFR2 splicing. Nucleic Acids Res (2006) 0.93
The RNA binding protein RBM38 (RNPC1) regulates splicing during late erythroid differentiation. PLoS One (2013) 0.90
Identification of a putative network of actin-associated cytoskeletal proteins in glomerular podocytes defined by co-purified mRNAs. PLoS One (2009) 0.85
Two methods for improved purification of full-length mammalian proteins that have poor expression and/or solubility using standard Escherichia coli procedures. Protein Expr Purif (2006) 0.79
Genome-wide activities of RNA binding proteins that regulate cellular changes in the epithelial to mesenchymal transition (EMT). Adv Exp Med Biol (2014) 0.78
Dynamic fluorescent and luminescent reporters for cell-based splicing screens. Methods Mol Biol (2012) 0.76