Validation of blood phosphatidylethanol as an alcohol consumption biomarker in patients with chronic liver disease.

PubWeight™: 0.98‹?› | Rank: Top 15%

🔗 View Article (PMC 4409698)

Published in Alcohol Clin Exp Res on May 21, 2014

Authors

Scott H Stewart1, David G Koch, Ira R Willner, Raymond F Anton, Adrian Reuben

Author Affiliations

1: Division of General Internal Medicine, University at Buffalo, Buffalo, New York.

Articles citing this

Comparison of self-reported alcohol consumption to phosphatidylethanol measurement among HIV-infected patients initiating antiretroviral treatment in southwestern Uganda. PLoS One (2014) 1.10

Comparison of Traditional and Novel Self-Report Measures to an Alcohol Biomarker for Quantifying Alcohol Consumption Among HIV-Infected Adults in Sub-Saharan Africa. Alcohol Clin Exp Res (2015) 0.84

Biomolecules and Biomarkers Used in Diagnosis of Alcohol Drinking and in Monitoring Therapeutic Interventions. Biomolecules (2015) 0.82

The Formation, Elimination, Interpretation, and Future Research Needs of Phosphatidylethanol for Research Studies and Clinical Practice. Alcohol Clin Exp Res (2016) 0.81

Phosphatidylethanol Detects Moderate-to-Heavy Alcohol Use in Liver Transplant Recipients. Alcohol Clin Exp Res (2017) 0.75

Relationship of Abnormal Chromatographic Pattern for Carbohydrate-Deficient Transferrin with Severe Liver Disease. Alcohol Alcohol (2016) 0.75

Identification of non-steroidal anti-inflammatory drug use disorder: A case report. Addict Behav (2017) 0.75

Biomarkers for detection of alcohol consumption in liver transplantation. World J Gastroenterol (2016) 0.75

High prevalence of unhealthy alcohol use and comparison of self-reported alcohol consumption to phosphatidylethanol among women engaged in sex work and their male clients in Cambodia. Drug Alcohol Depend (2016) 0.75

Phosphatidylethanol (PEth) as a Biomarker of Alcohol Consumption in HIV-Infected Young Russian Women: Comparison to Self-Report Assessments of Alcohol Use. AIDS Behav (2017) 0.75

Cut-point Levels of Phosphatidylethanol to Identify Alcohol Misuse in a Mixed Cohort including Critically Ill Patients. Alcohol Clin Exp Res (2017) 0.75

Articles cited by this

A model to predict survival in patients with end-stage liver disease. Hepatology (2001) 18.06

PHosphatidylethanol (PEth) concentrations in blood are correlated to reported alcohol intake in alcohol-dependent patients. Alcohol Alcohol (2006) 1.58

Monitoring of the alcohol biomarkers PEth, CDT and EtG/EtS in an outpatient treatment setting. Alcohol Alcohol (2012) 1.57

Phosphatidylethanol as a sensitive and specific biomarker: comparison with gamma-glutamyl transpeptidase, mean corpuscular volume and carbohydrate-deficient transferrin. Addict Biol (2007) 1.42

Phosphatidylethanol (PEth) as a biomarker of alcohol consumption in HIV-positive patients in sub-Saharan Africa. Alcohol Clin Exp Res (2011) 1.33

Phosphatidylethanol and alcohol consumption in reproductive age women. Alcohol Clin Exp Res (2009) 1.19

Urinary ethyl glucuronide as a novel screening tool in patients pre- and post-liver transplantation improves detection of alcohol consumption. Hepatology (2011) 1.18

Blood phosphatidylethanol as a marker of alcohol abuse: levels in alcoholic males during withdrawal. Alcohol Clin Exp Res (1997) 1.15

Phosphatidylethanol: normalization during detoxification, gender aspects and correlation with other biomarkers and self-reports. Addict Biol (2010) 1.15

Preliminary evaluation of phosphatidylethanol and alcohol consumption in patients with liver disease and hypertension. Alcohol Alcohol (2009) 1.13

ESBRA 1994 Award Lecture. Phosphatidylethanol formation: specific effects of ethanol mediated via phospholipase D. Alcohol Alcohol (1995) 1.12

Combined use of fatty acid ethyl esters and ethyl glucuronide in hair for diagnosis of alcohol abuse: interpretation and advantages. Forensic Sci Int (2010) 1.12

Phosphatidylethanol in blood as a marker of ethanol consumption in healthy volunteers: comparison with other markers. Alcohol Clin Exp Res (1998) 1.09

Improved HPLC method for carbohydrate-deficient transferrin in serum. Clin Chem (2003) 1.09

Formation of phosphatidylethanol and its subsequent elimination during an extensive drinking experiment over 5 days. Alcohol Clin Exp Res (2012) 1.06

An abnormal phospholipid in rat organs after ethanol treatment. FEBS Lett (1983) 1.03

Forensic confirmatory analysis of ethyl sulfate--a new marker for alcohol consumption--by liquid-chromatography/electrospray ionization/tandem mass spectrometry. J Am Soc Mass Spectrom (2004) 0.99

Emerging biomarkers: new directions and clinical applications. Alcohol Clin Exp Res (2005) 0.97

A review of clinical diagnostic applications of liquid chromatography-tandem mass spectrometry. Mass Spectrom Rev (2010) 0.96

Sensitivity and specificity of urinary ethyl glucuronide and ethyl sulfate in liver disease patients. Alcohol Clin Exp Res (2012) 0.93

LC-MS/MS analysis of phosphatidylethanol in dried blood spots versus conventional blood specimens. Anal Bioanal Chem (2011) 0.93

Determination of ethyl glucuronide in hair samples by liquid chromatography/electrospray tandem mass spectrometry. J Mass Spectrom (2006) 0.91

Assessing the drinking status of liver transplant patients with alcoholic liver disease. Liver Transpl (2013) 0.86

Atypical serum transferrin isoform distribution in liver cirrhosis studied by HPLC, capillary electrophoresis and transferrin genotyping. Clin Chim Acta (2008) 0.85

Liver disease and HPLC quantification of disialotransferrin for heavy alcohol use: a case series. Alcohol Clin Exp Res (2010) 0.83

Phosphatidylethanol: the potential role in further evaluating low positive urinary ethyl glucuronide and ethyl sulfate results. Alcohol Clin Exp Res (2013) 0.81

Hair ethyl glucuronide is highly sensitive and specific for detecting moderate-to-heavy drinking in patients with liver disease. Alcohol Alcohol (2012) 0.81

Articles by these authors

Topiramate for treating alcohol dependence: a randomized controlled trial. JAMA (2007) 6.81

A closely packed system of low-mass, low-density planets transiting Kepler-11. Nature (2011) 3.59

Kepler-9: a system of multiple planets transiting a Sun-like star, confirmed by timing variations. Science (2010) 2.87

Differential brain activity in alcoholics and social drinkers to alcohol cues: relationship to craving. Neuropsychopharmacology (2004) 2.69

Prediction of esophageal varices in patients with cirrhosis. J Clin Gastroenterol (2002) 2.45

Drug-induced acute liver failure: results of a U.S. multicenter, prospective study. Hepatology (2010) 2.26

Interaction of FKBP5 with childhood adversity on risk for post-traumatic stress disorder. Neuropsychopharmacology (2010) 2.16

Interactive effect of stressful life events and the serotonin transporter 5-HTTLPR genotype on posttraumatic stress disorder diagnosis in 2 independent populations. Arch Gen Psychiatry (2009) 1.97

Kepler-36: a pair of planets with neighboring orbits and dissimilar densities. Science (2012) 1.92

Effect of naltrexone and ondansetron on alcohol cue-induced activation of the ventral striatum in alcohol-dependent people. Arch Gen Psychiatry (2008) 1.80

Two Earth-sized planets orbiting Kepler-20. Nature (2011) 1.79

Rare nonsynonymous variants in alpha-4 nicotinic acetylcholine receptor gene protect against nicotine dependence. Biol Psychiatry (2011) 1.76

Functional neuroimaging studies of alcohol cue reactivity: a quantitative meta-analysis and systematic review. Addict Biol (2012) 1.63

Toward standardization of carbohydrate-deficient transferrin (CDT) measurements: I. Analyte definition and proposal of a candidate reference method. Clin Chem Lab Med (2007) 1.63

Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes. Neuropsychopharmacology (2010) 1.58

Sertraline in the treatment of co-occurring alcohol dependence and posttraumatic stress disorder. Alcohol Clin Exp Res (2005) 1.35

Improvement of physical health and quality of life of alcohol-dependent individuals with topiramate treatment: US multisite randomized controlled trial. Arch Intern Med (2008) 1.34

Serum apoptosis markers in acute liver failure: a pilot study. Clin Gastroenterol Hepatol (2007) 1.29

Adverse childhood events as risk factors for substance dependence: partial mediation by mood and anxiety disorders. Addict Behav (2009) 1.27

What role does measuring medication compliance play in evaluating the efficacy of naltrexone? Alcohol Clin Exp Res (2007) 1.26

Results of a double-blind, placebo-controlled pharmacotherapy trial in alcoholism conducted in Germany and comparison with the US COMBINE study. Addict Biol (2012) 1.24

Cold pressor task reactivity: predictors of alcohol use among alcohol-dependent individuals with and without comorbid posttraumatic stress disorder. Alcohol Clin Exp Res (2006) 1.22

KOI-126: a triply eclipsing hierarchical triple with two low-mass stars. Science (2011) 1.20

The role of the Asn40Asp polymorphism of the mu opioid receptor gene (OPRM1) on alcoholism etiology and treatment: a critical review. Alcohol Clin Exp Res (2011) 1.18

Transiting circumbinary planets Kepler-34 b and Kepler-35 b. Nature (2012) 1.15

A clinical laboratory paradigm for evaluating medication effects on alcohol consumption: naltrexone and nalmefene. Neuropsychopharmacology (2002) 1.14

Treatment of patients with substance use disorders, second edition. American Psychiatric Association. Am J Psychiatry (2007) 1.14

Preliminary evaluation of phosphatidylethanol and alcohol consumption in patients with liver disease and hypertension. Alcohol Alcohol (2009) 1.13

Mechanism of regulation of bcl-2 mRNA by nucleolin and A+U-rich element-binding factor 1 (AUF1). J Biol Chem (2010) 1.12

OPRM1 Asn40Asp predicts response to naltrexone treatment: a haplotype-based approach. Alcohol Clin Exp Res (2008) 1.12

Effects of naltrexone and nalmefene on subjective response to alcohol among non-treatment-seeking alcoholics and social drinkers. Alcohol Clin Exp Res (2004) 1.12

Combined pharmacotherapies and behavioral interventions for alcohol dependence (The COMBINE Study): examination of posttreatment drinking outcomes. J Stud Alcohol Drugs (2008) 1.12

Long-term outcomes for patients with post-liver transplant anastomotic biliary strictures treated by endoscopic stent placement. Gastrointest Endosc (2003) 1.10

Array-based profiling of DNA methylation changes associated with alcohol dependence. Alcohol Clin Exp Res (2012) 1.09

A review of genetic, biological, pharmacological, and clinical factors that affect carbohydrate-deficient transferrin levels. Alcohol Clin Exp Res (2004) 1.07

Association of markers in the 3' region of the GluR5 kainate receptor subunit gene to alcohol dependence. Alcohol Clin Exp Res (2009) 1.07

5-HTTLPR as a potential moderator of the effects of adverse childhood experiences on risk of antisocial personality disorder. Psychiatr Genet (2011) 1.05

Reversal of activation of human myofibroblast-like cells by culture on a basement membrane-like substrate. J Hepatol (2002) 1.05

Factors associated with advanced liver disease in adults with alpha1-antitrypsin deficiency. Clin Gastroenterol Hepatol (2005) 1.04

Interacting effects of naltrexone and OPRM1 and DAT1 variation on the neural response to alcohol cues. Neuropsychopharmacology (2012) 1.03

Depression and coronary artery atherosclerosis and reactivity in female cynomolgus monkeys. Psychosom Med (2002) 1.01

Sertraline and cognitive behavioral therapy for depressed alcoholics: results of a placebo-controlled trial. J Clin Psychopharmacol (2003) 1.01

The impact of alcohol dependence and posttraumatic stress disorder on cold pressor task response. J Stud Alcohol (2006) 1.01

Pro-opiomelanocortin gene variation related to alcohol or drug dependence: evidence and replications across family- and population-based studies. Biol Psychiatry (2009) 1.00

Following alcohol consumption, nontreatment-seeking alcoholics report greater stimulation but similar sedation compared with social drinkers. J Stud Alcohol (2004) 0.99

Methods to analyze treatment effects in the presence of missing data for a continuous heavy drinking outcome measure when participants drop out from treatment in alcohol clinical trials. Alcohol Clin Exp Res (2014) 0.98

Stability of fMRI striatal response to alcohol cues: a hierarchical linear modeling approach. Neuroimage (2011) 0.97

Kepler-47: a transiting circumbinary multiplanet system. Science (2012) 0.97

Effectiveness of naltrexone in a community treatment program. Alcohol Clin Exp Res (2004) 0.97

Outcomes in Adults With Acute Liver Failure Between 1998 and 2013: An Observational Cohort Study. Ann Intern Med (2016) 0.97

Childhood adversity increases risk for nicotine dependence and interacts with α5 nicotinic acetylcholine receptor genotype specifically in males. Neuropsychopharmacology (2011) 0.95

Biochemical alcohol screening in primary health care. Addict Behav (2004) 0.95

Alleles of a functional serotonin transporter promoter polymorphism are associated with major depression in alcoholics. Alcohol Clin Exp Res (2003) 0.95

Alcohol treatment effects on secondary nondrinking outcomes and quality of life: the COMBINE study. J Stud Alcohol Drugs (2009) 0.95

A double-blind trial of gabapentin versus lorazepam in the treatment of alcohol withdrawal. Alcohol Clin Exp Res (2009) 0.94

Editorial commentary: alcohol biomarker papers. Alcohol Clin Exp Res (2010) 0.94

Treatment of patients with substance use disorders, second edition. American Psychiatic Association. Am J Psychiatry (2006) 0.93

Prospective evaluation of a 3.1-mm battery-powered esophagoscope in screening for esophageal varices in cirrhotic patients. Am J Gastroenterol (2003) 0.93

The effect of aripiprazole on cue-induced brain activation and drinking parameters in alcoholics. J Clin Psychopharmacol (2010) 0.93

Sensitivity and specificity of urinary ethyl glucuronide and ethyl sulfate in liver disease patients. Alcohol Clin Exp Res (2012) 0.93

Blood pressure reduction during treatment for alcohol dependence: results from the Combining Medications and Behavioral Interventions for Alcoholism (COMBINE) study. Addiction (2008) 0.92

Excessive alcohol consumption and hypertension: clinical implications of current research. J Clin Hypertens (Greenwich) (2005) 0.91

The biopsy GAVE the diagnosis. Clin Gastroenterol Hepatol (2011) 0.91

A CRHR1 haplotype moderates the effect of adverse childhood experiences on lifetime risk of major depressive episode in African-American women. Am J Med Genet B Neuropsychiatr Genet (2011) 0.91

Design and analysis of trials of combination therapies. J Stud Alcohol Suppl (2005) 0.90

Aripiprazole: a drug with a novel mechanism of action and possible efficacy for alcohol dependence. CNS Neurol Disord Drug Targets (2010) 0.90

Advanced gestational age increases serum carbohydrate-deficient transferrin levels in abstinent pregnant women. Alcohol Alcohol (2012) 0.89

Two-year outcomes in initial survivors with acute liver failure: results from a prospective, multicentre study. Liver Int (2014) 0.89

GABRG1 and GABRA2 variation associated with alcohol dependence in African Americans. Alcohol Clin Exp Res (2011) 0.88

Posttransplantation lymphoproliferative disorder--the great mimic in liver transplantation: appraisal of the clinicopathologic spectrum and the role of Epstein-Barr virus. Liver Transpl (2007) 0.88

Confirmatory analysis of the adolescent obsessive compulsive drinking scale (A-OCDS): a measure of 'craving' and problem drinking in adolescents/young adults. J Natl Med Assoc (2002) 0.87

Toward standardization of carbohydrate-deficient transferrin (CDT) measurements: II. Performance of a laboratory network running the HPLC candidate reference measurement procedure and evaluation of a candidate reference material. Clin Chem Lab Med (2010) 0.87

Subtypes of major depression in substance dependence. Addiction (2009) 0.87

Hypermethylation of OPRM1 promoter region in European Americans with alcohol dependence. J Hum Genet (2012) 0.86

Variation in the gene encoding the serotonin transporter is associated with a measure of sociopathy in alcoholics. Addict Biol (2011) 0.85

Varenicline effects on drinking, craving and neural reward processing among non-treatment-seeking alcohol-dependent individuals. Psychopharmacology (Berl) (2014) 0.85

Association of COL25A1 with comorbid antisocial personality disorder and substance dependence. Biol Psychiatry (2012) 0.84

Autonomic dysfunction and gastroparesis in cirrhosis. J Clin Gastroenterol (2004) 0.83

The differential effects of medication on mood, sleep disturbance, and work ability in outpatient alcohol detoxification. Am J Addict (2002) 0.83

Liver disease and HPLC quantification of disialotransferrin for heavy alcohol use: a case series. Alcohol Clin Exp Res (2010) 0.83

Collagen binding alpha2beta1 and alpha1beta1 integrins play contrasting roles in regulation of Ets-1 expression in human liver myofibroblasts. Mol Cell Biochem (2006) 0.83

Variation in regulator of G-protein signaling 17 gene (RGS17) is associated with multiple substance dependence diagnoses. Behav Brain Funct (2012) 0.82

Needles in haystacks. Am J Gastroenterol (2007) 0.82

Modeling longitudinal drinking data in clinical trials: an application to the COMBINE study. Drug Alcohol Depend (2013) 0.82

Genetic basis for predicting response to naltrexone in the treatment of alcohol dependence. Pharmacogenomics (2008) 0.82

Expression of oncostatin M and its receptors in normal and cirrhotic human liver. J Hepatol (2005) 0.82

Pulmonary hypertension after liver transplantation: case presentation and review of the literature. Liver Transpl (2009) 0.82

The COMBINE Study-: An Overview of the Largest Pharmacotherapy Study to Date for Treating Alcohol Dependence. Psychiatry (Edgmont) (2006) 0.81

Hair ethyl glucuronide is highly sensitive and specific for detecting moderate-to-heavy drinking in patients with liver disease. Alcohol Alcohol (2012) 0.81

Alcohol and the liver. Curr Opin Gastroenterol (2005) 0.81

Recessive genetic mode of an ADH4 variant in substance dependence in African-Americans: A model of utility of the HWD test. Behav Brain Funct (2008) 0.81

Alcohol biomarker screening in medical and surgical settings. Alcohol Clin Exp Res (2006) 0.81

Agitated depression in substance dependence. Drug Alcohol Depend (2011) 0.80

Does comorbid anxiety or depression affect clinical outcomes in patients with post-traumatic stress disorder and alcohol use disorders? Compr Psychiatry (2004) 0.80