Published in Br J Cancer on May 29, 2014
From plant extract to molecular panacea: a commentary on Stone (1763) 'An account of the success of the bark of the willow in the cure of the agues'. Philos Trans R Soc Lond B Biol Sci (2015) 0.94
Arresting amyloid with coulomb's law: acetylation of ALS-linked SOD1 by aspirin impedes aggregation. Biophys J (2015) 0.88
Cyclin A2 and CDK2 as Novel Targets of Aspirin and Salicylic Acid: A Potential Role in Cancer Prevention. Mol Cancer Res (2015) 0.84
Aspirin in combination with TACE in treatment of unresectable HCC: a matched-pairs analysis. Am J Cancer Res (2016) 0.82
Transcriptomic analysis of pancreatic cancer cells in response to metformin and aspirin: an implication of synergy. Sci Rep (2015) 0.81
Aspirin blocks growth of breast tumor cells and tumor-initiating cells and induces reprogramming factors of mesenchymal to epithelial transition. Lab Invest (2015) 0.81
Aspirin Reduces Plasma Concentrations of the Oncometabolite 2-Hydroxyglutarate: Results of a Randomized, Double-Blind, Crossover Trial. Cancer Epidemiol Biomarkers Prev (2015) 0.80
Aspirin inhibits glucose‑6‑phosphate dehydrogenase activity in HCT 116 cells through acetylation: Identification of aspirin-acetylated sites. Mol Med Rep (2016) 0.79
Aspirin and P2Y12 inhibition attenuate platelet-induced ovarian cancer cell invasion. BMC Cancer (2015) 0.79
Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis. Carcinogenesis (2015) 0.78
Aspirin Protects against Acinar Cells Necrosis in Severe Acute Pancreatitis in Mice. Biomed Res Int (2016) 0.77
Unlocking Aspirin's Chemopreventive Activity: Role of Irreversibly Inhibiting Platelet Cyclooxygenase-1. Cancer Prev Res (Phila) (2016) 0.76
Cytotoxic Activity of Salicylic Acid-Containing Drug Models with Ionic and Covalent Binding. ACS Med Chem Lett (2015) 0.75
A Second WNT for Old Drugs: Drug Repositioning against WNT-Dependent Cancers. Cancers (Basel) (2016) 0.75
Proteome-wide prediction of targets for aspirin: new insight into the molecular mechanism of aspirin. PeerJ (2016) 0.75
Effects of Aspirin on Endothelial Function and Hypertension. Curr Hypertens Rep (2016) 0.75
Prostate Cancer and Aspirin Use: Synopsis of the Proposed Molecular Mechanisms. Front Pharmacol (2017) 0.75
Aspirin induces cell death by directly modulating mitochondrial voltage-dependent anion channel (VDAC). Sci Rep (2017) 0.75
Understanding why aspirin prevents cancer and why consuming very hot beverages and foods increases esophageal cancer risk. Controlling the division rates of stem cells is an important strategy to prevent cancer. Oncoscience (2015) 0.75
Therapeutic dosages of aspirin counteract the IL-6 induced pro-tumorigenic effects by slowing down the ribosome biogenesis rate. Oncotarget (2016) 0.75
Chemoprevention of Low-Molecular-Weight Citrus Pectin (LCP) in Gastrointestinal Cancer Cells. Int J Biol Sci (2016) 0.75
Aspirin Prevention of Colorectal Cancer: Focus on NF-κB Signalling and the Nucleolus. Biomedicines (2017) 0.75
Salicylic acid metabolites and derivatives inhibit CDK activity: Novel insights into aspirin's chemopreventive effects against colorectal cancer. Int J Oncol (2017) 0.75
Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol (1971) 37.53
ras oncogenes in human cancer: a review. Cancer Res (1989) 22.03
Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science (2009) 20.49
Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials. Lancet (2010) 11.00
Regulation of cellular metabolism by protein lysine acetylation. Science (2010) 10.55
Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology (1994) 8.79
Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli. Nat Chem Biol (2009) 8.36
Inhibition of NF-kappa B by sodium salicylate and aspirin. Science (1994) 7.60
Aspirin use, tumor PIK3CA mutation, and colorectal-cancer survival. N Engl J Med (2012) 7.47
Aspirin use and survival after diagnosis of colorectal cancer. JAMA (2009) 6.93
The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta. Nature (1998) 6.69
RNA structure analysis at single nucleotide resolution by selective 2'-hydroxyl acylation and primer extension (SHAPE). J Am Chem Soc (2005) 6.46
Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux. Science (2010) 6.04
RNA-binding proteins: modular design for efficient function. Nat Rev Mol Cell Biol (2007) 5.33
Acetylation of prostaglandin synthase by aspirin. Proc Natl Acad Sci U S A (1975) 4.92
Aspirin intake and survival after breast cancer. J Clin Oncol (2010) 4.50
Contribution of platelets to tumour metastasis. Nat Rev Cancer (2011) 4.16
Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions. Proc Natl Acad Sci U S A (1995) 3.72
Nonsteroidal anti-inflammatory drug use, chronic liver disease, and hepatocellular carcinoma. J Natl Cancer Inst (2012) 3.69
Aspirin, ibuprofen, and other non-steroidal anti-inflammatory drugs in cancer prevention: a critical review of non-selective COX-2 blockade (review). Oncol Rep (2005) 2.96
The role of aspirin in cancer prevention. Nat Rev Clin Oncol (2012) 2.94
Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis. Proc Natl Acad Sci U S A (1998) 2.83
Histone acetyltransferases: function, structure, and catalysis. Curr Opin Genet Dev (2001) 2.14
Aspirin is associated with lower melanoma risk among postmenopausal Caucasian women: the Women's Health Initiative. Cancer (2013) 2.14
Aspirin and salicylate induce apoptosis and activation of caspases in B-cell chronic lymphocytic leukemia cells. Blood (1998) 1.93
RNA catalyses nuclear pre-mRNA splicing. Nature (2013) 1.86
Suppression of inducible cyclooxygenase 2 gene transcription by aspirin and sodium salicylate. Proc Natl Acad Sci U S A (1999) 1.60
Use of aspirin postdiagnosis improves survival for colon cancer patients. Br J Cancer (2012) 1.54
The mechanisms of RNA SHAPE chemistry. J Am Chem Soc (2012) 1.52
Structure and function of histone acetyltransferases. Cell Mol Life Sci (2001) 1.51
In vitro acetylation of plasma proteins, enzymes and DNA by aspirin. Nature (1968) 1.51
Nonsteroidal antiinflammatory drugs inhibit the proliferation of colon adenocarcinoma cells: effects on cell cycle and apoptosis. Exp Cell Res (1996) 1.51
Histone acetylation and cancer. Curr Opin Genet Dev (1999) 1.50
A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles. Nat Methods (2013) 1.48
Protein-reactive natural products. Angew Chem Int Ed Engl (2005) 1.47
Cyclooxygenase inhibitors suppress angiogenesis and reduce tumor growth in vivo. Lab Invest (1999) 1.45
NSAIDs and chemoprevention. Curr Cancer Drug Targets (2004) 1.44
Determining target engagement in living systems. Nat Chem Biol (2013) 1.41
Cyclooxygenase-2 inhibitors decrease vascular endothelial growth factor expression in colon cancer cells by enhanced degradation of Sp1 and Sp4 proteins. Mol Pharmacol (2005) 1.36
Functional lysine modification by an intrinsically reactive primary glycolytic metabolite. Science (2013) 1.31
Aspirin use and potential mechanisms for colorectal cancer prevention. J Clin Invest (1997) 1.25
Direct Raman measurement of an elevated base pKa in the active site of a small ribozyme in a precatalytic conformation. J Am Chem Soc (2009) 1.20
Aspirin activates the NF-kappaB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer. Carcinogenesis (2006) 1.16
Histone acetylation and the cell-cycle in cancer. Front Biosci (2001) 1.16
Mode of action of aspirin as a chemopreventive agent. Recent Results Cancer Res (2013) 1.15
Aspirin induces apoptosis through the inhibition of proteasome function. J Biol Chem (2006) 1.14
Acetylation of human serum albumin by acetylsalicylic acid. Science (1968) 1.13
Investigation of adenosine base ionization in the hairpin ribozyme by nucleotide analog interference mapping. RNA (2001) 1.11
Aspirin, NSAIDS, and colon cancer prevention: mechanisms? Gastroenterology (1998) 1.11
Effect of aspirin on the Wnt/beta-catenin pathway is mediated via protein phosphatase 2A. Oncogene (2006) 1.10
Aspirin inhibits colon cancer cell and tumor growth and downregulates specificity protein (Sp) transcription factors. PLoS One (2012) 1.06
Use of aspirin, but not other non-steroidal anti-inflammatory drugs is associated with decreased prostate cancer risk at the population level. Eur J Cancer (2012) 1.05
The pK(a)'s of 2'-hydroxyl group in nucleosides and nucleotides. J Am Chem Soc (2001) 1.04
Prostanoids, ornithine decarboxylase, and polyamines in primary chemoprevention of familial adenomatous polyposis. Gastroenterology (2004) 1.01
Cell proliferation depends on mitochondrial Ca2+ uptake: inhibition by salicylate. J Physiol (2005) 1.00
An alkyne-aspirin chemical reporter for the detection of aspirin-dependent protein modification in living cells. J Am Chem Soc (2013) 1.00
Aspirin inhibits camptothecin-induced p21CIP1 levels and potentiates apoptosis in human breast cancer cells. Int J Oncol (2009) 0.99
Preadministration of high-dose salicylates, suppressors of NF-kappaB activation, may increase the chemosensitivity of many cancers: an example of proapoptotic signal modulation therapy. Integr Cancer Ther (2006) 0.99
Aspirin induces apoptosis through release of cytochrome c from mitochondria. Neoplasia (2001) 0.97
Mechanistic aspects of COX-2 expression in colorectal neoplasia. Recent Results Cancer Res (2013) 0.95
Aspirin acetylates multiple cellular proteins in HCT-116 colon cancer cells: Identification of novel targets. Int J Oncol (2011) 0.95
Acetylsalicylic acid and salicylic acid decrease tumor cell viability and glucose metabolism modulating 6-phosphofructo-1-kinase structure and activity. Biochem Pharmacol (2008) 0.94
Non-steroidal anti-inflammatory drugs suppress the ERK signaling pathway via block of Ras/c-Raf interaction and activation of MAP kinase phosphatases. Cell Signal (2008) 0.92
Does aspirin acetylate multiple cellular proteins? (Review). Mol Med Rep (2011) 0.91
Reaction of aspirin with cysteinyl residues of lens gamma-crystallins: a mechanism for the proposed anti-cataract effect of aspirin. Biochim Biophys Acta (1993) 0.90
The acetylation of hemoglobin by aspirin. In vitro and in vivo. J Clin Invest (1975) 0.90
Protein lysine acetylation guards metabolic homeostasis to fight against cancer. Oncogene (2013) 0.89
Aspirin acetylates fibrinogen and enhances fibrinolysis. Fibrinolytic effect is independent of changes in plasminogen activator levels. J Pharmacol Exp Ther (1989) 0.88
Will an aspirin a day keep cancer away? Science (2012) 0.87
Presence of acetylsalicylic acid in plasma following oral ingestion of aspirin. Proc Soc Exp Biol Med (1962) 0.86
Platelet activation in patients with colorectal cancer. Prostaglandins Leukot Essent Fatty Acids (2005) 0.84
Cyclooxygenase inhibitors: drugs for cancer prevention. Curr Opin Pharmacol (2003) 0.83
Histone acetylation and cancer. Acta Oncol (2003) 0.83
Aspirin and the prevention of colorectal cancer. Best Pract Res Clin Gastroenterol (2012) 0.83
Salicylate-induced growth arrest is associated with inhibition of p70s6k and down-regulation of c-myc, cyclin D1, cyclin A, and proliferating cell nuclear antigen. J Biol Chem (2000) 0.82
Evaluation of chemopreventive agents in different mechanistic classes using a rat tracheal epithelial cell culture transformation assay. Cancer Res (1995) 0.81
Human tissue transglutaminase is inhibited by pharmacologic and chemical acetylation. Protein Sci (2010) 0.79
Aspirin, protein transacetylation and inhibition of prostaglandin synthetase in the kidney. Br J Pharmacol (1978) 0.79
Distribution of the acetyl compared with the salicyl moiety of acetylsalicylic acid. Acetylation of macromolecules in organs wherein side-effects are manifest. Biochem Pharmacol (1983) 0.79
Computational prediction of RNA secondary structure. Methods Enzymol (2013) 0.79
An introduction to aspirin, NSAids, and COX-2 inhibitors for the primary prevention of cardiovascular events and cancer and their potential preventive role in bladder carcinogenesis: part II. Semin Urol Oncol (2001) 0.76