Published in Mol Cell on May 29, 2014
Arsenic trioxide sensitizes glioblastoma to a myc inhibitor. PLoS One (2015) 1.41
Characterization of the loss of SUMO pathway function on cancer cells and tumor proliferation. PLoS One (2015) 0.87
UbSRD: The Ubiquitin Structural Relational Database. J Mol Biol (2015) 0.86
A comprehensive compilation of SUMO proteomics. Nat Rev Mol Cell Biol (2016) 0.84
The function, regulation and therapeutic implications of the tumor suppressor protein, PML. Cell Biosci (2015) 0.82
The life cycle of the 26S proteasome: from birth, through regulation and function, and onto its death. Cell Res (2016) 0.80
Comparative ultrastructure of CRM1-Nucleolar bodies (CNoBs), Intranucleolar bodies (INBs) and hybrid PML/p62 bodies uncovers new facets of nuclear body dynamic and diversity. Nucleus (2015) 0.79
PML nuclear bodies: assembly and oxidative stress-sensitive sumoylation. Nucleus (2014) 0.79
Assembly of Epstein-Barr Virus Capsid in Promyelocytic Leukemia Nuclear Bodies. J Virol (2015) 0.78
Repair or Destruction: An Intimate Liaison Between Ubiquitin Ligases and Molecular Chaperones in Proteostasis. FEBS Lett (2017) 0.77
Engineering therapeutic protein disaggregases. Mol Biol Cell (2016) 0.76
PML, SUMO, and RNF4: guardians of nuclear protein quality. Mol Cell (2014) 0.76
Enhanced Degradation of Misfolded Proteins Promotes Tumorigenesis. Cell Rep (2017) 0.75
Ataxin-3 consolidates the MDC1-dependent DNA double-strand break response by counteracting the SUMO-targeted ubiquitin ligase RNF4. EMBO J (2017) 0.75
Ubiquitin-dependent and independent roles of SUMO in proteostasis. Am J Physiol Cell Physiol (2016) 0.75
Analysis of Small Ubiquitin-Like Modifier (SUMO) Targets Reflects the Essential Nature of Protein SUMOylation and Provides Insight to Elucidate the Role of SUMO in Plant Development. Plant Physiol (2015) 0.75
Undoing SUMO aids polyQ AR. Oncotarget (2015) 0.75
Protein quality control in the nucleus. Curr Opin Cell Biol (2016) 0.75
PML regulates neuroprotective innate immunity and neuroblast commitment in a hypoxic-ischemic encephalopathy model. Cell Death Dis (2016) 0.75
The human cytomegalovirus IE1 protein antagonizes PML nuclear body mediated intrinsic immunity via the inhibition of PML de novo SUMOylation. J Virol (2016) 0.75
Protein folding and misfolding. Nature (2003) 14.92
Adapting proteostasis for disease intervention. Science (2008) 13.22
Protein degradation and protection against misfolded or damaged proteins. Nature (2003) 10.19
Trinucleotide repeat disorders. Annu Rev Neurosci (2007) 9.45
Molecular chaperones in protein folding and proteostasis. Nature (2011) 8.63
Hsp104, Hsp70, and Hsp40: a novel chaperone system that rescues previously aggregated proteins. Cell (1998) 7.69
RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation. Nat Cell Biol (2008) 5.90
Toxic proteins in neurodegenerative disease. Science (2002) 5.82
Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies. Nat Rev Mol Cell Biol (2007) 5.79
Folding proteins in fatal ways. Nature (2003) 5.58
Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3. J Biol Chem (2000) 5.30
Substrate specificity of the DnaK chaperone determined by screening cellulose-bound peptide libraries. EMBO J (1997) 4.28
TRIM family proteins and their emerging roles in innate immunity. Nat Rev Immunol (2008) 4.21
SUMO modification of Huntingtin and Huntington's disease pathology. Science (2004) 3.85
Role of PML in cell growth and the retinoic acid pathway. Science (1998) 3.82
Cellular strategies for controlling protein aggregation. Nat Rev Mol Cell Biol (2010) 3.54
Protein quality control in the cytosol and the endoplasmic reticulum: brothers in arms. Mol Cell (2010) 3.23
Mechanisms, regulation and consequences of protein SUMOylation. Biochem J (2010) 3.22
Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures. Nature (1997) 3.16
Degradation-mediated protein quality control in the nucleus. Cell (2005) 3.10
SCA1 transgenic mice: a model for neurodegeneration caused by an expanded CAG trinucleotide repeat. Cell (1995) 2.96
TAR DNA-binding protein 43 in neurodegenerative disease. Nat Rev Neurol (2010) 2.81
Conserved function of RNF4 family proteins in eukaryotes: targeting a ubiquitin ligase to SUMOylated proteins. EMBO J (2007) 2.59
Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice. Neuron (1999) 2.25
Substrate recognition by the AAA+ chaperone ClpB. Nat Struct Mol Biol (2004) 2.19
Purkinje cell expression of a mutant allele of SCA1 in transgenic mice leads to disparate effects on motor behaviors, followed by a progressive cerebellar dysfunction and histological alterations. J Neurosci (1997) 1.99
Emerging extranuclear roles of protein SUMOylation in neuronal function and dysfunction. Nat Rev Neurosci (2007) 1.97
Spatially regulated ubiquitin ligation by an ER/nuclear membrane ligase. Nature (2006) 1.78
Essential role of coiled coils for aggregation and activity of Q/N-rich prions and PolyQ proteins. Cell (2010) 1.76
Aggregate formation inhibits proteasomal degradation of polyglutamine proteins. Hum Mol Genet (2002) 1.73
Firefly luciferase mutants as sensors of proteome stress. Nat Methods (2011) 1.35
SUMO fusion technology for enhanced protein production in prokaryotic and eukaryotic expression systems. Methods Mol Biol (2009) 1.33
SUMO E3 ligase activity of TRIM proteins. Oncogene (2010) 1.26
Intranuclear degradation of polyglutamine aggregates by the ubiquitin-proteasome system. J Biol Chem (2009) 1.26
Quality control of a transcriptional regulator by SUMO-targeted degradation. Mol Cell Biol (2009) 1.25
Identification of RING finger protein 4 (RNF4) as a modulator of DNA demethylation through a functional genomics screen. Proc Natl Acad Sci U S A (2010) 1.22
SUMOylation of the polyglutamine repeat protein, ataxin-1, is dependent on a functional nuclear localization signal. J Biol Chem (2005) 1.15
Differential Roles of PML Isoforms. Front Oncol (2013) 1.13
PML clastosomes prevent nuclear accumulation of mutant ataxin-7 and other polyglutamine proteins. J Cell Biol (2006) 1.12
Partial loss of Tip60 slows mid-stage neurodegeneration in a spinocerebellar ataxia type 1 (SCA1) mouse model. Hum Mol Genet (2011) 1.02
PML nuclear bodies and neuronal intranuclear inclusion in polyglutamine diseases. Neurobiol Dis (2003) 0.96
Enhanced Degradation of Misfolded Proteins Promotes Tumorigenesis. Cell Rep (2017) 0.75