Molecular chaperones in protein folding and proteostasis.

The hallmarks of aging. Cell (2013) 14.29

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases. Nature (2013) 3.55

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers. Nat Struct Mol Biol (2015) 2.53

Chaperone machines for protein folding, unfolding and disaggregation. Nat Rev Mol Cell Biol (2013) 2.24

Essential oils in food preservation: mode of action, synergies, and interactions with food matrix components. Front Microbiol (2012) 2.18

Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP. Nat Struct Mol Biol (2013) 2.14

Stress-independent activation of XBP1s and/or ATF6 reveals three functionally diverse ER proteostasis environments. Cell Rep (2013) 1.87

Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease. Nature (2011) 1.87

Structural basis for protein antiaggregation activity of the trigger factor chaperone. Science (2014) 1.86

Widespread regulation of translation by elongation pausing in heat shock. Mol Cell (2013) 1.85

Cotranslational response to proteotoxic stress by elongation pausing of ribosomes. Mol Cell (2013) 1.83

Proteostatic control of telomerase function through TRiC-mediated folding of TCAB1. Cell (2014) 1.82

The molecular architecture of the eukaryotic chaperonin TRiC/CCT. Structure (2012) 1.80

Principles of cotranslational ubiquitination and quality control at the ribosome. Mol Cell (2013) 1.76

Atomic structure and hierarchical assembly of a cross-β amyloid fibril. Proc Natl Acad Sci U S A (2013) 1.75

The mammalian disaggregase machinery: Hsp110 synergizes with Hsp70 and Hsp40 to catalyze protein disaggregation and reactivation in a cell-free system. PLoS One (2011) 1.74

Axis of ageing: telomeres, p53 and mitochondria. Nat Rev Mol Cell Biol (2012) 1.74

Small heat shock proteins and α-crystallins: dynamic proteins with flexible functions. Trends Biochem Sci (2011) 1.74

Mechanisms that regulate stem cell aging and life span. Cell Stem Cell (2013) 1.73

Interaction of p53 with the CCT complex promotes protein folding and wild-type p53 activity. Mol Cell (2013) 1.72

An interdomain energetic tug-of-war creates the allosterically active state in Hsp70 molecular chaperones. Cell (2012) 1.67

HDAC inhibitor-based therapies: can we interpret the code? Mol Oncol (2012) 1.67

Pharmacological approaches to restore mitochondrial function. Nat Rev Drug Discov (2013) 1.66

Aneuploidy causes proteotoxic stress in yeast. Genes Dev (2012) 1.66

Dissecting heterogeneous molecular chaperone complexes using a mass spectrum deconvolution approach. Chem Biol (2012) 1.66

A cotranslational ubiquitination pathway for quality control of misfolded proteins. Mol Cell (2013) 1.65

Control of protein quality and stoichiometries by N-terminal acetylation and the N-end rule pathway. Mol Cell (2013) 1.64

A cellular system that degrades misfolded proteins and protects against neurodegeneration. Mol Cell (2014) 1.63

Metazoan Hsp70 machines use Hsp110 to power protein disaggregation. EMBO J (2012) 1.62

The ribosome as a hub for protein quality control. Mol Cell (2013) 1.53

Diversity in the origins of proteostasis networks--a driver for protein function in evolution. Nat Rev Mol Cell Biol (2013) 1.51

Widespread Proteome Remodeling and Aggregation in Aging C. elegans. Cell (2015) 1.50

The cotranslational function of ribosome-associated Hsp70 in eukaryotic protein homeostasis. Cell (2013) 1.46

Mechanisms of protein-folding diseases at a glance. Dis Model Mech (2014) 1.45

Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome. Elife (2013) 1.44

SNPeffect 4.0: on-line prediction of molecular and structural effects of protein-coding variants. Nucleic Acids Res (2011) 1.44

α-Synuclein oligomers and clinical implications for Parkinson disease. Ann Neurol (2012) 1.42

HJURP uses distinct CENP-A surfaces to recognize and to stabilize CENP-A/histone H4 for centromere assembly. Dev Cell (2012) 1.41

The N-terminal methionine of cellular proteins as a degradation signal. Cell (2013) 1.32

Intrinsic unfoldase/foldase activity of the chaperonin GroEL directly demonstrated using multinuclear relaxation-based NMR. Proc Natl Acad Sci U S A (2015) 1.32

The structural basis of substrate recognition by the eukaryotic chaperonin TRiC/CCT. Cell (2014) 1.31

Protein rescue from aggregates by powerful molecular chaperone machines. Nat Rev Mol Cell Biol (2013) 1.31

DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity. Nat Cell Biol (2013) 1.30

Hsp70 proteins bind Hsp100 regulatory M domains to activate AAA+ disaggregase at aggregate surfaces. Nat Struct Mol Biol (2012) 1.26

Direct three-dimensional visualization of membrane disruption by amyloid fibrils. Proc Natl Acad Sci U S A (2012) 1.24

Widespread aggregation and neurodegenerative diseases are associated with supersaturated proteins. Cell Rep (2013) 1.20

Defining Hsp70 Subnetworks in Dengue Virus Replication Reveals Key Vulnerability in Flavivirus Infection. Cell (2015) 1.20

Sorting out the trash: the spatial nature of eukaryotic protein quality control. Curr Opin Cell Biol (2014) 1.17

A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease. Cell Rep (2014) 1.17

Structural asymmetry in the closed state of mitochondrial Hsp90 (TRAP1) supports a two-step ATP hydrolysis mechanism. Mol Cell (2014) 1.17

Novel roles for α-crystallins in retinal function and disease. Prog Retin Eye Res (2012) 1.17

Structure, function, and assembly of heme centers in mitochondrial respiratory complexes. Biochim Biophys Acta (2012) 1.16

Visualizing GroEL/ES in the act of encapsulating a folding protein. Cell (2013) 1.16

Protein quality control acts on folding intermediates to shape the effects of mutations on organismal fitness. Mol Cell (2012) 1.16

Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation. J Biol Chem (2013) 1.16

Global regulation of mRNA translation and stability in the early Drosophila embryo by the Smaug RNA-binding protein. Genome Biol (2014) 1.15

Transcriptional response to stress in the dynamic chromatin environment of cycling and mitotic cells. Proc Natl Acad Sci U S A (2013) 1.15

How hsp70 molecular machines interact with their substrates to mediate diverse physiological functions. J Mol Biol (2015) 1.15

The venom-gland transcriptome of the eastern diamondback rattlesnake (Crotalus adamanteus). BMC Genomics (2012) 1.14

Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers. Proc Natl Acad Sci U S A (2012) 1.13

Functional analysis of Hsp70 inhibitors. PLoS One (2013) 1.13

Nutrient signaling in protein homeostasis: an increase in quantity at the expense of quality. Sci Signal (2013) 1.12

Quantitative proteomics reveals that Hsp90 inhibition preferentially targets kinases and the DNA damage response. Mol Cell Proteomics (2011) 1.12

Plasmodium falciparum heat shock protein 110 stabilizes the asparagine repeat-rich parasite proteome during malarial fevers. Nat Commun (2012) 1.12

Selective targeting of the stress chaperome as a therapeutic strategy. Trends Pharmacol Sci (2014) 1.12

Glycation-altered proteolysis as a pathobiologic mechanism that links dietary glycemic index, aging, and age-related disease (in nondiabetics). Aging Cell (2011) 1.12

Compartment-specific aggregases direct distinct nuclear and cytoplasmic aggregate deposition. EMBO J (2015) 1.11

The structured core domain of αB-crystallin can prevent amyloid fibrillation and associated toxicity. Proc Natl Acad Sci U S A (2014) 1.11

Hsp90-Tau complex reveals molecular basis for specificity in chaperone action. Cell (2014) 1.11

Molecular mechanism of mutant p53 stabilization: the role of HSP70 and MDM2. PLoS One (2012) 1.11

Heat shock protein (Hsp) 70 is an activator of the Hsp104 motor. Proc Natl Acad Sci U S A (2013) 1.10

Cysteine reactivity distinguishes redox sensing by the heat-inducible and constitutive forms of heat shock protein 70. Chem Biol (2012) 1.10

Protein aggregation and degradation mechanisms in neurodegenerative diseases. Am J Neurodegener Dis (2013) 1.09

Cellular strategies for regulating functional and nonfunctional protein aggregation. Cell Rep (2012) 1.08

Gedunin inactivates the co-chaperone p23 protein causing cancer cell death by apoptosis. J Biol Chem (2013) 1.07

Small molecule-mediated refolding and activation of myosin motor function. Elife (2014) 1.06

Regulated structural transitions unleash the chaperone activity of αB-crystallin. Proc Natl Acad Sci U S A (2013) 1.06

Development of a Grp94 inhibitor. J Am Chem Soc (2012) 1.06

Global analysis of chaperone effects using a reconstituted cell-free translation system. Proc Natl Acad Sci U S A (2012) 1.05

Protein aggregation can inhibit clathrin-mediated endocytosis by chaperone competition. Proc Natl Acad Sci U S A (2014) 1.05

A network of ubiquitin ligases is important for the dynamics of misfolded protein aggregates in yeast. J Biol Chem (2012) 1.05

Intrinsic disorder modulates protein self-assembly and aggregation. Proc Natl Acad Sci U S A (2012) 1.05

The nuclear lamina is mechano-responsive to ECM elasticity in mature tissue. J Cell Sci (2014) 1.04

Folding the proteome. Trends Biochem Sci (2013) 1.03

Molecular chaperones and proteostasis regulation during redox imbalance. Redox Biol (2014) 1.03

Perspectives on deciphering mechanisms underlying plant heat stress response and thermotolerance. Front Plant Sci (2013) 1.02

The role of saposin C in Gaucher disease. Mol Genet Metab (2012) 1.02

Targeting protein aggregation for the treatment of degenerative diseases. Nat Rev Drug Discov (2015) 1.02

Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro. J Biol Chem (2013) 1.01

The mitochondrial Hsp70 chaperone Ssq1 facilitates Fe/S cluster transfer from Isu1 to Grx5 by complex formation. Mol Biol Cell (2013) 1.01

Gelsolin amyloidosis: genetics, biochemistry, pathology and possible strategies for therapeutic intervention. Crit Rev Biochem Mol Biol (2012) 1.01

Reshaping of the conformational search of a protein by the chaperone trigger factor. Nature (2013) 1.01

Experimental free energy surfaces reveal the mechanisms of maintenance of protein solubility. Proc Natl Acad Sci U S A (2011) 1.01

HSP70 sequestration by free α-globin promotes ineffective erythropoiesis in β-thalassaemia. Nature (2014) 1.01

Hsp70 protein complexes as drug targets. Curr Pharm Des (2013) 1.00

Aneuploidy: implications for protein homeostasis and disease. Dis Model Mech (2014) 1.00

Interaction of the molecular chaperone DNAJB6 with growing amyloid-beta 42 (Aβ42) aggregates leads to sub-stoichiometric inhibition of amyloid formation. J Biol Chem (2014) 0.99

Thinking laterally about neurodegenerative proteinopathies. J Clin Invest (2013) 0.99

FoldEco: a model for proteostasis in E. coli. Cell Rep (2012) 0.98

Inefficient SRP interaction with a nascent chain triggers a mRNA quality control pathway. Cell (2014) 0.98

Molecular chaperones in the cytosol: from nascent chain to folded protein. Science (2002) 15.09

Converging concepts of protein folding in vitro and in vivo. Nat Struct Mol Biol (2009) 5.47

Proteome-wide analysis of chaperonin-dependent protein folding in Escherichia coli. Cell (2005) 4.78

Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions. Cell (2011) 3.98

Molecular chaperone functions in protein folding and proteostasis. Annu Rev Biochem (2013) 3.56

Structural features of the GroEL-GroES nano-cage required for rapid folding of encapsulated protein. Cell (2006) 3.45

Structural basis for the cooperation of Hsp70 and Hsp110 chaperones in protein folding. Cell (2008) 2.80

Molecular chaperones of the Hsp110 family act as nucleotide exchange factors of Hsp70s. EMBO J (2006) 2.58

Structural probing of a protein phosphatase 2A network by chemical cross-linking and mass spectrometry. Science (2012) 2.34

Real-time observation of trigger factor function on translating ribosomes. Nature (2006) 2.23

Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation. Mol Cell (2004) 2.19

Structure and function of RbcX, an assembly chaperone for hexadecameric Rubisco. Cell (2007) 2.11

Regulation of Hsp70 function by HspBP1: structural analysis reveals an alternate mechanism for Hsp70 nucleotide exchange. Mol Cell (2005) 1.94

Function of trigger factor and DnaK in multidomain protein folding: increase in yield at the expense of folding speed. Cell (2004) 1.85

The molecular architecture of the eukaryotic chaperonin TRiC/CCT. Structure (2012) 1.80

PolyQ proteins interfere with nuclear degradation of cytosolic proteins by sequestering the Sis1p chaperone. Cell (2013) 1.76

The matrix protein VP40 from Ebola virus octamerizes into pore-like structures with specific RNA binding properties. Structure (2003) 1.75

Protein folding in the cytoplasm and the heat shock response. Cold Spring Harb Perspect Biol (2010) 1.71

Coupled chaperone action in folding and assembly of hexadecameric Rubisco. Nature (2010) 1.63

Mitigation of chlorine-induced lung injury by low-molecular-weight antioxidants. Am J Physiol Lung Cell Mol Physiol (2008) 1.58

The proteasomal subunit Rpn6 is a molecular clamp holding the core and regulatory subcomplexes together. Proc Natl Acad Sci U S A (2011) 1.57

Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11. Proc Natl Acad Sci U S A (2014) 1.57

DnaK functions as a central hub in the E. coli chaperone network. Cell Rep (2012) 1.52

Retracted L25 functions as a conserved ribosomal docking site shared by nascent chain-associated complex and signal-recognition particle. EMBO Rep (2006) 1.51

Monitoring protein conformation along the pathway of chaperonin-assisted folding. Cell (2008) 1.45

Chaperonin-catalyzed rescue of kinetically trapped states in protein folding. Cell (2010) 1.36

Firefly luciferase mutants as sensors of proteome stress. Nat Methods (2011) 1.35

Essential role of the chaperonin folding compartment in vivo. EMBO J (2008) 1.29

Structure and function of the AAA+ protein CbbX, a red-type Rubisco activase. Nature (2011) 1.20

Maintaining photosynthetic CO2 fixation via protein remodelling: the Rubisco activases. Photosynth Res (2013) 1.16

Mechanisms and modification of chlorine-induced lung injury in animals. Proc Am Thorac Soc (2010) 1.09

Biosynthesis of pteridines. Reaction mechanism of GTP cyclohydrolase I. J Mol Biol (2003) 1.06

The protein import motor of mitochondria: a targeted molecular ratchet driving unfolding and translocation. EMBO J (2002) 1.06

Pathogenic mutations located in the hydrophobic core of the prion protein interfere with folding and attachment of the glycosylphosphatidylinositol anchor. J Biol Chem (2004) 1.05

Post-exposure antioxidant treatment in rats decreases airway hyperplasia and hyperreactivity due to chlorine inhalation. Am J Respir Cell Mol Biol (2011) 1.05

SnapShot: molecular chaperones, Part I. Cell (2007) 1.05

Structure of green-type Rubisco activase from tobacco. Nat Struct Mol Biol (2011) 1.05

Structure of a halophilic nucleoside diphosphate kinase from Halobacterium salinarum. FEBS Lett (2005) 1.02

Crystal structure of an archaeal actin homolog. J Mol Biol (2006) 1.00

Crystal structure of the GABA(A)-receptor-associated protein, GABARAP. EMBO Rep (2002) 0.98

Structural plasticity and noncovalent substrate binding in the GroEL apical domain. A study using electrospay ionization mass spectrometry and fluorescence binding studies. J Biol Chem (2002) 0.98

Large FK506-binding proteins shape the pharmacology of rapamycin. Mol Cell Biol (2013) 0.98

Folding of large multidomain proteins by partial encapsulation in the chaperonin TRiC/CCT. Proc Natl Acad Sci U S A (2012) 0.95

Crystal structure of a chaperone-bound assembly intermediate of form I Rubisco. Nat Struct Mol Biol (2011) 0.95

Interaction of the Hsp110 molecular chaperones from S. cerevisiae with substrate protein. J Mol Biol (2010) 0.94

Fes1p acts as a nucleotide exchange factor for the ribosome-associated molecular chaperone Ssb1p. Biol Chem (2006) 0.93

Differential substrate specificity of group I and group II chaperonins in the archaeon Methanosarcina mazei. Mol Microbiol (2009) 0.93

SnapShot: molecular chaperones, Part II. Cell (2007) 0.93

Coexistence of group I and group II chaperonins in the archaeon Methanosarcina mazei. J Biol Chem (2003) 0.93

Combination of dacarbazine and dimethylfumarate efficiently reduces melanoma lymph node metastasis. J Invest Dermatol (2009) 0.87

Chaperonin cofactors, Cpn10 and Cpn20, of green algae and plants function as hetero-oligomeric ring complexes. J Biol Chem (2012) 0.87

Hsp90 structure: when two ends meet. Nat Struct Mol Biol (2006) 0.86

Structure and function of Hip, an attenuator of the Hsp70 chaperone cycle. Nat Struct Mol Biol (2013) 0.86

Increasing the efficiency of ligands for FK506-binding protein 51 by conformational control. J Med Chem (2013) 0.83

Exploration of pipecolate sulfonamides as binders of the FK506-binding proteins 51 and 52. J Med Chem (2012) 0.82

Evaluation of synthetic FK506 analogues as ligands for the FK506-binding proteins 51 and 52. J Med Chem (2012) 0.82

A mobile loop order-disorder transition modulates the speed of chaperonin cycling. Protein Sci (2004) 0.82

Structural basis for subunit assembly in UDP-glucose pyrophosphorylase from Saccharomyces cerevisiae. J Mol Biol (2006) 0.81

A c-kit mutation in exon 18 in familial mastocytosis. J Invest Dermatol (2012) 0.81

Reaction mechanism of GTP cyclohydrolase I: single turnover experiments using a kinetically competent reaction intermediate. J Mol Biol (2002) 0.79

How to orient the functional GroEL-SR1 mutant for atomic force microscopy investigations. Biochem Biophys Res Commun (2005) 0.78

Wnt1 is anti-lymphangiogenic in a melanoma mouse model. J Invest Dermatol (2012) 0.78

Functional characterization of an archaeal GroEL/GroES chaperonin system: significance of substrate encapsulation. J Biol Chem (2003) 0.78

Towards a complete structure of Hsp90. Structure (2005) 0.75

L25 functions as a conserved ribosomal docking site shared by nascent chain-associated complex and signal-recognition particle. EMBO Rep (2007) 0.75

The first chaperonin. Nat Rev Mol Cell Biol (2013) 0.75

Rational design and asymmetric synthesis of potent and neurotrophic ligands for FK506-binding proteins (FKBPs). Angew Chem Int Ed Engl (2014) 0.75

Stereoselective construction of the 5-hydroxy diazabicyclo[4.3.1]decane-2-one scaffold, a privileged motif for FK506-binding proteins. Org Lett (2014) 0.75