Published in Nat Rev Immunol on November 01, 2008
Population genomics of parallel adaptation in threespine stickleback using sequenced RAD tags. PLoS Genet (2010) 7.05
Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I. Cell Host Microbe (2009) 5.12
Interferon-stimulated genes: a complex web of host defenses. Annu Rev Immunol (2014) 3.47
MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. Mol Cell (2010) 3.28
TRIM proteins and cancer. Nat Rev Cancer (2011) 2.84
Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium. Ann Neurol (2011) 2.37
Obesity related methylation changes in DNA of peripheral blood leukocytes. BMC Med (2010) 2.24
KAP1 protein: an enigmatic master regulator of the genome. J Biol Chem (2011) 2.15
TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition. Dev Cell (2014) 1.92
TRIM79α, an interferon-stimulated gene product, restricts tick-borne encephalitis virus replication by degrading the viral RNA polymerase. Cell Host Microbe (2011) 1.84
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Independent evolution of striated muscles in cnidarians and bilaterians. Nature (2012) 1.81
Type I interferons: crucial participants in disease amplification in autoimmunity. Nat Rev Rheumatol (2010) 1.73
Gene disruption study reveals a nonredundant role for TRIM21/Ro52 in NF-kappaB-dependent cytokine expression in fibroblasts. J Immunol (2009) 1.73
The E3-ligase TRIM family of proteins regulates signaling pathways triggered by innate immune pattern-recognition receptors. Immunity (2013) 1.69
IRF8 regulates myeloid and B lymphoid lineage diversification. Immunol Res (2009) 1.68
Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength. PLoS Genet (2012) 1.64
A cellular system that degrades misfolded proteins and protects against neurodegeneration. Mol Cell (2014) 1.63
Active site remodeling switches HIV specificity of antiretroviral TRIMCyp. Nat Struct Mol Biol (2009) 1.53
Human immunodeficiency virus type 1 mediates global disruption of innate antiviral signaling and immune defenses within infected cells. J Virol (2009) 1.53
Promyelocytic leukemia isoform IV confers resistance to encephalomyocarditis virus via the sequestration of 3D polymerase in nuclear bodies. J Virol (2011) 1.49
Identification of residues within the L2 region of rhesus TRIM5alpha that are required for retroviral restriction and cytoplasmic body localization. Virology (2010) 1.49
Novel approaches to inhibiting HIV-1 replication. Antiviral Res (2009) 1.48
TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity. J Virol (2012) 1.47
Comparative transcriptome analysis of two oysters, Crassostrea gigas and Crassostrea hongkongensis provides insights into adaptation to hypo-osmotic conditions. PLoS One (2014) 1.46
Amplification of TRIM44: pairing a prognostic target with potential therapeutic strategy. J Natl Cancer Inst (2014) 1.43
Regulation of innate immune signalling pathways by the tripartite motif (TRIM) family proteins. EMBO Mol Med (2011) 1.42
TRIM68 negatively regulates IFN-β production by degrading TRK fused gene, a novel driver of IFN-β downstream of anti-viral detection systems. PLoS One (2014) 1.39
SUMO E3 ligase activity of TRIM proteins. Oncogene (2010) 1.26
TGF-β control of stem cell differentiation genes. FEBS Lett (2012) 1.25
TRIMmunity: the roles of the TRIM E3-ubiquitin ligase family in innate antiviral immunity. J Mol Biol (2013) 1.25
Interleukin-27 inhibition of HIV-1 involves an intermediate induction of type I interferon. Blood (2009) 1.23
Tripartite motif-containing protein 28 is a small ubiquitin-related modifier E3 ligase and negative regulator of IFN regulatory factor 7. J Immunol (2011) 1.21
Genome analysis and signature discovery for diving and sensory properties of the endangered Chinese alligator. Cell Res (2013) 1.18
MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling. Nat Commun (2013) 1.16
Structure of the rhesus monkey TRIM5α PRYSPRY domain, the HIV capsid recognition module. Proc Natl Acad Sci U S A (2012) 1.15
Rhesus TRIM5α disrupts the HIV-1 capsid at the inter-hexamer interfaces. PLoS Pathog (2011) 1.15
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TRIM22 inhibits influenza A virus infection by targeting the viral nucleoprotein for degradation. J Virol (2013) 1.08
p62/sequestosome-1 associates with and sustains the expression of retroviral restriction factor TRIM5alpha. J Virol (2010) 1.08
Systems analysis of a RIG-I agonist inducing broad spectrum inhibition of virus infectivity. PLoS Pathog (2013) 1.07
TRIM56 is a virus- and interferon-inducible E3 ubiquitin ligase that restricts pestivirus infection. J Virol (2011) 1.05
Ubiquitination-deubiquitination by the TRIM27-USP7 complex regulates tumor necrosis factor alpha-induced apoptosis. Mol Cell Biol (2013) 1.05
Association of TRIM22 with the type 1 interferon response and viral control during primary HIV-1 infection. J Virol (2010) 1.02
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TRIM14 is a mitochondrial adaptor that facilitates retinoic acid-inducible gene-I-like receptor-mediated innate immune response. Proc Natl Acad Sci U S A (2013) 1.01
Origin and evolution of TRIM proteins: new insights from the complete TRIM repertoire of zebrafish and pufferfish. PLoS One (2011) 1.01
TRIM22: A Diverse and Dynamic Antiviral Protein. Mol Biol Int (2012) 1.01
Innate immune evasion strategies of influenza viruses. Future Microbiol (2010) 1.00
Epigenetics and obesity: the devil is in the details. BMC Med (2010) 0.99
Fas-associated death domain (FADD) and the E3 ubiquitin-protein ligase TRIM21 interact to negatively regulate virus-induced interferon production. J Biol Chem (2010) 0.99
Inflammasomes and their activation. Crit Rev Immunol (2010) 0.98
The specificity of TRIM5 alpha-mediated restriction is influenced by its coiled-coil domain. J Virol (2010) 0.98
TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal degradation. PLoS One (2012) 0.98
IFN-α mediates the development of autoimmunity both by direct tissue toxicity and through immune cell recruitment mechanisms. J Immunol (2011) 0.98
Genome-wide association studies in Sjögren's syndrome: What do the genes tell us about disease pathogenesis? Autoimmun Rev (2014) 0.96
Crystal structure of TRIM20 C-terminal coiled-coil/B30.2 fragment: implications for the recognition of higher order oligomers. Sci Rep (2015) 0.95
Variable prevalence and functional diversity of the antiretroviral restriction factor TRIMCyp in Macaca fascicularis. J Virol (2011) 0.95
Implication of PMLIV in both intrinsic and innate immunity. PLoS Pathog (2014) 0.94
Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2β. Proc Natl Acad Sci U S A (2011) 0.93
Phosphatidylinositol-3-kinase C2β and TRIM27 function to positively and negatively regulate IgE receptor activation of mast cells. Mol Cell Biol (2012) 0.92
Host Factors and HIV-1 Replication: Clinical Evidence and Potential Therapeutic Approaches. Front Immunol (2013) 0.92
Collaboration of Toll-like and RIG-I-like receptors in human dendritic cells: tRIGgering antiviral innate immune responses. Am J Clin Exp Immunol (2013) 0.92
Evolution of the antiretroviral restriction factor TRIMCyp in Old World primates. PLoS One (2010) 0.92
Regulatory role of TRIM21 in the type-I interferon pathway in Japanese encephalitis virus-infected human microglial cells. J Neuroinflammation (2014) 0.90
Regulation of the psoriatic chemokine CCL20 by E3 ligases Trim32 and Piasy in keratinocytes. J Invest Dermatol (2010) 0.89
Vicious circle: systemic autoreactivity in Ro52/TRIM21-deficient mice. J Exp Med (2009) 0.89
TRIM56 is an essential component of the TLR3 antiviral signaling pathway. J Biol Chem (2012) 0.88
Origin and diversification of TRIM ubiquitin ligases. PLoS One (2012) 0.88
Systems-level analysis of innate immunity. Annu Rev Immunol (2014) 0.88
The MHC-II transactivator CIITA, a restriction factor against oncogenic HTLV-1 and HTLV-2 retroviruses: similarities and differences in the inhibition of Tax-1 and Tax-2 viral transactivators. Front Microbiol (2013) 0.88
Adenovirus E4orf3 targets transcriptional intermediary factor 1γ for proteasome-dependent degradation during infection. J Virol (2011) 0.88
Proton-driven assembly of the Rous Sarcoma virus capsid protein results in the formation of icosahedral particles. J Biol Chem (2010) 0.88
Membrane Repair: Mechanisms and Pathophysiology. Physiol Rev (2015) 0.88
TRIM26 negatively regulates interferon-β production and antiviral response through polyubiquitination and degradation of nuclear IRF3. PLoS Pathog (2015) 0.87
Negative regulation of NF-κB activity by brain-specific TRIpartite Motif protein 9. Nat Commun (2014) 0.87
Hare TRIM5α restricts divergent retroviruses and exhibits significant sequence variation from closely related lagomorpha TRIM5 genes. J Virol (2010) 0.87
Ovine TRIM5α can restrict visna/maedi virus. J Virol (2012) 0.87
TRIM30α Is a Negative-Feedback Regulator of the Intracellular DNA and DNA Virus-Triggered Response by Targeting STING. PLoS Pathog (2015) 0.86
Clinical and pathological roles of Ro/SSA autoantibody system. Clin Dev Immunol (2012) 0.86
TRIM29 suppresses TWIST1 and invasive breast cancer behavior. Cancer Res (2014) 0.86
Leukocyte Ig-like receptor B4 (LILRB4) is a potent inhibitor of FcgammaRI-mediated monocyte activation via dephosphorylation of multiple kinases. J Biol Chem (2009) 0.86
Role of inflammasome activation in development and exacerbation of asthma. Asia Pac Allergy (2014) 0.85
Current pathophysiological concepts in cerebral small vessel disease. Front Aging Neurosci (2014) 0.85
Transcriptome profiling of immune responses to cardiomyopathy syndrome (CMS) in Atlantic salmon. BMC Genomics (2011) 0.85
TRIM11 negatively regulates IFNβ production and antiviral activity by targeting TBK1. PLoS One (2013) 0.85
Autoantigen TRIM21/Ro52 as a Possible Target for Treatment of Systemic Lupus Erythematosus. Int J Rheumatol (2012) 0.85
Insights into the antiviral immunity against grass carp (Ctenopharyngodon idella) reovirus (GCRV) in grass carp. J Immunol Res (2015) 0.85
Common minor histocompatibility antigen discovery based upon patient clinical outcomes and genomic data. PLoS One (2011) 0.84
Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-fungal Immunity and Intestinal Inflammation. Immunity (2015) 0.84
Homology-based identification of capsid determinants that protect HIV1 from human TRIM5α restriction. J Biol Chem (2010) 0.84
Identification of TRIML2, a novel p53 target, that enhances p53 SUMOylation and regulates the transactivation of proapoptotic genes. Mol Cancer Res (2014) 0.84
TRIM3 regulates the motility of the kinesin motor protein KIF21B. PLoS One (2013) 0.84
Human dendritic cells exhibit a pronounced type I IFN signature following Leishmania major infection that is required for IL-12 induction. J Immunol (2014) 0.84
Interaction with the Bardet-Biedl gene product TRIM32/BBS11 modifies the half-life and localization of Glis2/NPHP7. J Biol Chem (2014) 0.84
Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross. PLoS Genet (2015) 0.84
TRIM5α-Mediated Ubiquitin Chain Conjugation Is Required for Inhibition of HIV-1 Reverse Transcription and Capsid Destabilization. J Virol (2015) 0.83
Adenovirus E4-ORF3-dependent relocalization of TIF1α and TIF1γ relies on access to the Coiled-Coil motif. Virology (2011) 0.83
Interferon alpha (IFNα)-induced TRIM22 interrupts HCV replication by ubiquitinating NS5A. Cell Mol Immunol (2015) 0.83
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Expression of the cyclin-dependent kinase inhibitor p27 and its deregulation in mouse B cell lymphomas. Leuk Res (2005) 0.96
Langerhans cells are generated by two distinct PU.1-dependent transcriptional networks. J Exp Med (2013) 0.94
Eef1a2 promotes cell growth, inhibits apoptosis and activates JAK/STAT and AKT signaling in mouse plasmacytomas. PLoS One (2010) 0.94
IFN regulatory factor 8 regulates MDM2 in germinal center B cells. J Immunol (2009) 0.94
Differential expression of IRF8 in subsets of macrophages and dendritic cells and effects of IRF8 deficiency on splenic B cell and macrophage compartments. Immunol Res (2009) 0.93
Ebolavirus VP35 interacts with the cytoplasmic dynein light chain 8. J Virol (2009) 0.93
Identification and characterization of two related murine genes, Eat2a and Eat2b, encoding single SH2-domain adapters. Immunogenetics (2006) 0.92
Green tomato extract attenuates high-fat-diet-induced obesity through activation of the AMPK pathway in C57BL/6 mice. J Nutr Biochem (2012) 0.92
Routes to covalent catalysis by reactive selection for nascent protein nucleophiles. J Am Chem Soc (2007) 0.90
Conditional inactivation of p53 in mature B cells promotes generation of nongerminal center-derived B-cell lymphomas. Proc Natl Acad Sci U S A (2013) 0.90
A mutant collagen XIII alters intestinal expression of immune response genes and predisposes transgenic mice to develop B-cell lymphomas. Cancer Res (2008) 0.88
Identification of genes differentially regulated by the P210 BCR/ABL1 fusion oncogene using cDNA microarrays. Exp Hematol (2004) 0.88
Evidence for selective transformation of autoreactive immature plasma cells in mice deficient in Fasl. J Exp Med (2004) 0.88
Mouse model of endemic Burkitt translocations reveals the long-range boundaries of Ig-mediated oncogene deregulation. Proc Natl Acad Sci U S A (2012) 0.88
ICSBP/IRF-8 differentially regulates antigen uptake during dendritic-cell development and affects antigen presentation to CD4+ T cells. Blood (2006) 0.88
MHC class I family proteins retard systemic lupus erythematosus autoimmunity and B cell lymphomagenesis. J Immunol (2011) 0.87
Expression of plasma cell alloantigen 1 defines layered development of B-1a B-cell subsets with distinct innate-like functions. Proc Natl Acad Sci U S A (2012) 0.87
PAX5 activates the transcription of the human telomerase reverse transcriptase gene in B cells. J Pathol (2010) 0.87
CD19 signaling pathways play a major role for murine AIDS induction and progression. J Immunol (2002) 0.87
Dysregulated TCL1 requires the germinal center and genome instability for mature B-cell transformation. Blood (2006) 0.86
Catalytic activity of autoantibodies toward myelin basic protein correlates with the scores on the multiple sclerosis expanded disability status scale. Immunol Lett (2005) 0.86
Induction of a protein-targeted catalytic response in autoimmune prone mice: antibody-mediated cleavage of HIV-1 glycoprotein GP120. Biochemistry (2006) 0.85
Temporal expression changes during differentiation of neural stem cells derived from mouse embryonic stem cell. J Cell Biochem (2004) 0.84
Transitional B cells lose their ability to receptor edit but retain their potential for positive and negative selection. J Immunol (2007) 0.84
Hydroxychloroquine-inhibited dengue virus is associated with host defense machinery. J Interferon Cytokine Res (2014) 0.84
Identification of murine B cell lines that undergo somatic hypermutation focused to A:T and G:C residues. Eur J Immunol (2008) 0.83
Characterization of a novel murine retrovirus mixture that facilitates hematopoiesis. J Virol (2002) 0.83
IL-21 is a double-edged sword in the systemic lupus erythematosus-like disease of BXSB.Yaa mice. J Immunol (2013) 0.83
Alloimmunization against RBC or PLT antigens is independent of TRIM21 expression in a murine model. Mol Immunol (2011) 0.83
Virus-induced differential expression of nuclear receptors and coregulators in dendritic cells: implication to interferon production. FEBS Lett (2011) 0.83