Follistatin, an activin antagonist, ameliorates renal interstitial fibrosis in a rat model of unilateral ureteral obstruction.

The basics of epithelial-mesenchymal transition. J Clin Invest (2009) 32.82

Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest (2002) 12.22

BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat Med (2003) 7.91

Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention. J Am Soc Nephrol (2004) 5.43

Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction. J Clin Invest (2003) 4.58

Macrophage diversity in renal injury and repair. J Clin Invest (2008) 4.41

Cellular and molecular mechanisms of renal fibrosis. Nat Rev Nephrol (2011) 3.68

Activin-binding protein from rat ovary is follistatin. Science (1990) 2.38

The transforming growth factor-beta superfamily of receptors. Cytokine Growth Factor Rev (2004) 2.15

Overexpression of activin A in the skin of transgenic mice reveals new activities of activin in epidermal morphogenesis, dermal fibrosis and wound repair. EMBO J (1999) 1.84

Impaired wound healing in transgenic mice overexpressing the activin antagonist follistatin in the epidermis. EMBO J (2001) 1.46

TGF-β/Smad signaling in kidney disease. Semin Nephrol (2012) 1.36

Bone morphogenetic protein (BMP) ligands and receptors in bovine ovarian follicle cells: actions of BMP-4, -6 and -7 on granulosa cells and differential modulation of Smad-1 phosphorylation by follistatin. Reproduction (2004) 1.30

Roles of activin in tissue repair, fibrosis, and inflammatory disease. Cytokine Growth Factor Rev (2006) 1.30

Strong induction of activin expression after injury suggests an important role of activin in wound repair. Dev Biol (1996) 1.29

Activin and related proteins in inflammation: not just interested bystanders. Cytokine Growth Factor Rev (2009) 1.23

Attenuation of bleomycin-induced pulmonary fibrosis by follistatin. Am J Respir Crit Care Med (2005) 1.15

A novel role of follistatin, an activin-binding protein, in the inhibition of activin action in rat pituitary cells. Endocytotic degradation of activin and its acceleration by follistatin associated with cell-surface heparan sulfate. J Biol Chem (1997) 1.13

Follistatin regulates bone morphogenetic protein-7 (BMP-7) activity to stimulate embryonic muscle growth. Dev Biol (2002) 1.08

Therapeutic potential of follistatin for colonic inflammation in mice. Gastroenterology (2005) 1.07

Activin A induces dendritic cell migration through the polarized release of CXC chemokine ligands 12 and 14. Blood (2009) 1.05

Activin A is an autocrine activator of rat pancreatic stellate cells: potential therapeutic role of follistatin for pancreatic fibrosis. Gut (2003) 1.01

Follistatin, an activin-binding protein, associates with heparan sulfate chains of proteoglycans on follicular granulosa cells. J Biol Chem (1991) 1.01

Activin A induces cell proliferation of fibroblast-like synoviocytes in rheumatoid arthritis. Arthritis Rheum (2003) 1.01

Activin A is a potent activator of renal interstitial fibroblasts. J Am Soc Nephrol (2004) 1.00

Expression of immunoreactive activin A protein in remodeling lesions associated with interstitial pulmonary fibrosis. Am J Pathol (1996) 0.97

Activin A stimulates type IV collagenase (matrix metalloproteinase-2) production in mouse peritoneal macrophages. J Immunol (2000) 0.95

The dependence of transforming growth factor-beta-induced collagen production on autocrine factor activin A in hepatic stellate cells. Endocrinology (2004) 0.91

Expression of activin A is increased in cirrhotic and fibrotic rat livers. Gastroenterology (1998) 0.90

Role of activin A in murine mast cells: modulation of cell growth, differentiation, and migration. J Leukoc Biol (2003) 0.86

Activin A: autocrine regulator of kidney development and repair. Endocr J (2007) 0.85

Involvement of the activin-follistatin system in tubular regeneration after renal ischemia in rats. J Am Soc Nephrol (2001) 0.83

The role of the activin-follistatin system in the developmental and regeneration processes of the kidney. Cytokine Growth Factor Rev (2001) 0.83

Expression of immunoreactive and bioactive activin A protein in adult murine lung after bleomycin treatment. Am J Respir Cell Mol Biol (1995) 0.80

Involvement of N-type Ca(2+) channels in the fibrotic process of the kidney in rats. Am J Physiol Renal Physiol (2013) 0.80

Regenerative medicine for the kidney: renotropic factors, renal stem/progenitor cells, and stem cell therapy. Biomed Res Int (2014) 0.84

Diverse Cell Populations Involved in Regeneration of Renal Tubular Epithelium following Acute Kidney Injury. Stem Cells Int (2015) 0.76