Published in J Biol Chem on June 02, 2014
Expression of baculovirus P35 prevents cell death in Drosophila. Development (1994) 7.16
The protein structures that shape caspase activity, specificity, activation and inhibition. Biochem J (2004) 4.85
The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis. Cell (2012) 4.29
Human caspases: activation, specificity, and regulation. J Biol Chem (2009) 3.67
Characterization and use of the Drosophila metallothionein promoter in cultured Drosophila melanogaster cells. Nucleic Acids Res (1988) 3.66
Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathway. Nat Cell Biol (1999) 3.45
Caspase-9 can be activated without proteolytic processing. J Biol Chem (1999) 3.20
Cell killing by the Drosophila gene reaper. Science (1996) 3.11
Drosophila immune deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosis. Dev Cell (2001) 2.68
Activation of the Drosophila NF-kappaB factor Relish by rapid endoproteolytic cleavage. EMBO Rep (2000) 2.49
The Drosophila caspase DRONC is regulated by DIAP1. EMBO J (2000) 2.46
Caspase-mediated processing of the Drosophila NF-kappaB factor Relish. Proc Natl Acad Sci U S A (2003) 2.42
An exegesis of IAPs: salvation and surprises from BIR motifs. Trends Cell Biol (1999) 2.33
PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan. Nat Immunol (2006) 2.12
Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation. J Biol Chem (2010) 1.99
Mutation of a self-processing site in caspase-8 compromises its apoptotic but not its nonapoptotic functions in bacterial artificial chromosome-transgenic mice. J Immunol (2008) 1.90
Dredd, a novel effector of the apoptosis activators reaper, grim, and hid in Drosophila. Dev Biol (1998) 1.89
The Drosophila caspase DRONC cleaves following glutamate or aspartate and is regulated by DIAP1, HID, and GRIM. J Biol Chem (2000) 1.81
Caspase-dependent cell death in Drosophila. Annu Rev Cell Dev Biol (2006) 1.73
The Drosophila immune defense against gram-negative infection requires the death protein dFADD. Immunity (2002) 1.66
FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity. Biochem J (2011) 1.64
The Apaf-1*procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer. EMBO J (2009) 1.57
Covalent inhibition revealed by the crystal structure of the caspase-8/p35 complex. Nature (2001) 1.51
Interaction of the baculovirus anti-apoptotic protein p35 with caspases. Specificity, kinetics, and characterization of the caspase/p35 complex. Biochemistry (1998) 1.48
Pathogen-derived effectors trigger protective immunity via activation of the Rac2 enzyme and the IMD or Rip kinase signaling pathway. Immunity (2011) 1.45
NF-κB/Rel proteins and the humoral immune responses of Drosophila melanogaster. Curr Top Microbiol Immunol (2011) 1.45
Caspase-mediated cleavage, IAP binding, and ubiquitination: linking three mechanisms crucial for Drosophila NF-kappaB signaling. Mol Cell (2010) 1.36
Expression of adenovirus E1B mutant phenotypes is dependent on the host cell and on synthesis of E1A proteins. J Virol (1987) 1.35
The Drosophila caspases Strica and Dronc function redundantly in programmed cell death during oogenesis. Cell Death Differ (2007) 1.34
Two roles for the Drosophila IKK complex in the activation of Relish and the induction of antimicrobial peptide genes. Proc Natl Acad Sci U S A (2009) 1.30
Rudra interrupts receptor signaling complexes to negatively regulate the IMD pathway. PLoS Pathog (2008) 1.30
Apoptotic caspase activation and activity. Methods Mol Biol (2008) 1.26
The Drosophila IMD pathway in the activation of the humoral immune response. Dev Comp Immunol (2013) 1.21
Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)-mediated inhibition of caspase 9. Biochem J (2007) 1.20
dFADD, a novel death domain-containing adapter protein for the Drosophila caspase DREDD. J Biol Chem (2000) 1.17
Cell death regulation in Drosophila: conservation of mechanism and unique insights. J Cell Biol (2000) 1.09
Ubiquitylation of the initiator caspase DREDD is required for innate immune signalling. EMBO J (2012) 1.03
Drosophila caspases involved in developmentally regulated programmed cell death of peptidergic neurons during early metamorphosis. J Comp Neurol (2011) 0.90
The protein Dredd is an essential component of the c-Jun N-terminal kinase pathway in the Drosophila immune response. J Biol Chem (2011) 0.80