ATM regulates insulin-like growth factor 1-secretory clusterin (IGF-1-sCLU) expression that protects cells against senescence.

PubWeight™: 0.85‹?›

🔗 View Article (PMC 4061041)

Published in PLoS One on June 17, 2014

Authors

Xiuquan Luo1, Masatoshi Suzuki1, Shanaz A Ghandhi2, Sally A Amundson2, David A Boothman1

Author Affiliations

1: Departments of Pharmacology and Radiation Oncology, Laboratory of Molecular Cell Stress Responses, Program in Cell Stress and Cancer Nanomedicine, Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.
2: Center for Radiological Research, Columbia University Medical Center, New York, New York, United States of America.

Articles cited by this

Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol (2007) 16.55

ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer (2003) 16.06

Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell (2005) 12.73

Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proc Natl Acad Sci U S A (2001) 7.93

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat Cell Biol (2009) 7.74

Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1. Nature (2007) 6.82

Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol Cell (2004) 6.48

Senescent human fibroblasts increase the early growth of xenograft tumors via matrix metalloproteinase secretion. Cancer Res (2007) 2.94

Oxidative DNA damage and senescence of human diploid fibroblast cells. Proc Natl Acad Sci U S A (1995) 2.89

Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer. Nat Cell Biol (2011) 2.69

Clusterin inhibits apoptosis by interacting with activated Bax. Nat Cell Biol (2005) 2.30

Human cell senescence as a DNA damage response. Mech Ageing Dev (2005) 2.26

Challenge and promise: roles for clusterin in pathogenesis, progression and therapy of cancer. Cell Death Differ (2006) 1.83

The ATM-dependent DNA damage signaling pathway. Cold Spring Harb Symp Quant Biol (2005) 1.83

Subcytotoxic H2O2 stress triggers a release of transforming growth factor-beta 1, which induces biomarkers of cellular senescence of human diploid fibroblasts. J Biol Chem (2000) 1.71

Clusterin/apolipoprotein J in human aging and cancer. Int J Biochem Cell Biol (2002) 1.70

The shock of aging: molecular chaperones and the heat shock response in longevity and aging--a mini-review. Gerontology (2009) 1.69

Oxidative stress induces an ATM-independent senescence pathway through p38 MAPK-mediated lamin B1 accumulation. EMBO J (2012) 1.60

Silencing expression of the clusterin/apolipoprotein j gene in human cancer cells using small interfering RNA induces spontaneous apoptosis, reduced growth ability, and cell sensitization to genotoxic and oxidative stress. Cancer Res (2004) 1.55

Clusterin plays an important role in hepatocellular carcinoma metastasis. Oncogene (2006) 1.45

Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence. Proc Natl Acad Sci U S A (2008) 1.41

Heat shock protein Hsp72 controls oncogene-induced senescence pathways in cancer cells. Mol Cell Biol (2008) 1.37

Delayed activation of insulin-like growth factor-1 receptor/Src/MAPK/Egr-1 signaling regulates clusterin expression, a pro-survival factor. J Biol Chem (2005) 1.36

Uncoupling the senescent phenotype from telomere shortening in hydrogen peroxide-treated fibroblasts. Exp Cell Res (2001) 1.35

High levels of heat shock protein Hsp72 in cancer cells suppress default senescence pathways. Cancer Res (2007) 1.24

Hsp27 modulates p53 signaling and suppresses cellular senescence. Cancer Res (2007) 1.22

ATM protein kinase: the linchpin of cellular defenses to stress. Cell Mol Life Sci (2011) 1.17

Signal transduction in H2O2-induced senescence-like phenotype in human diploid fibroblasts. Free Radic Biol Med (2002) 1.13

c-Jun-deficient cells undergo premature senescence as a result of spontaneous DNA damage accumulation. Mol Cell Biol (2004) 1.13

Caveolin-1 expression is required for the development of pulmonary emphysema through activation of the ATM-p53-p21 pathway. J Biol Chem (2008) 1.06

Stress-induced premature senescence (SIPS)--influence of SIPS on radiotherapy. J Radiat Res (2008) 1.06

Ataxia telangiectasia mutated (ATM)-mediated DNA damage response in oxidative stress-induced vascular endothelial cell senescence. J Biol Chem (2010) 1.04

Caveolin-1, cellular senescence and pulmonary emphysema. Aging (Albany NY) (2009) 1.00

Premature senescence of mesothelial cells is associated with non-telomeric DNA damage. Biochem Biophys Res Commun (2007) 0.95

ATM-dependent IGF-1 induction regulates secretory clusterin expression after DNA damage and in genetic instability. Oncogene (2011) 0.95

Induction of premature senescence by hsp90 inhibition in small cell lung cancer. PLoS One (2010) 0.94

Stress-induced premature senescence in hTERT-expressing ataxia telangiectasia fibroblasts. J Biol Chem (2003) 0.93

Clusterin/apolipoprotein J is a novel biomarker of cellular senescence that does not affect the proliferative capacity of human diploid fibroblasts. FEBS Lett (2001) 0.90

Differential regulation of the clusterin gene by Ha-ras and c-myc oncogenes and during apoptosis. J Cell Physiol (1998) 0.88

Proteomic analysis of plasma proteins in Japanese semisuper centenarians. Exp Gerontol (2010) 0.87

Never-ageing cellular senescence. Eur J Cancer (2011) 0.85