Published in Mol Cell on May 21, 2004
The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol (2010) 7.58
Four faces of cellular senescence. J Cell Biol (2011) 6.86
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature (2008) 6.02
The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing. Nat Cell Biol (2010) 3.29
Accumulation of senescent cells in mitotic tissue of aging primates. Mech Ageing Dev (2006) 3.14
Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation. Nat Cell Biol (2012) 3.03
Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence. Nat Commun (2012) 2.90
Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence. PLoS Biol (2007) 2.78
Endoreplication: polyploidy with purpose. Genes Dev (2009) 2.78
Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer. Nat Cell Biol (2011) 2.69
POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end. EMBO J (2005) 2.69
Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis. EMBO J (2007) 2.61
What has senescence got to do with cancer? Cancer Cell (2005) 2.55
Telomere dysfunction and tumour suppression: the senescence connection. Nat Rev Cancer (2008) 2.54
p53 isoforms Delta133p53 and p53beta are endogenous regulators of replicative cellular senescence. Nat Cell Biol (2009) 2.46
A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen. PLoS One (2010) 2.38
Cellular senescence and its effector programs. Genes Dev (2014) 2.37
DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion. J Cell Sci (2010) 2.34
Senescent cells as a source of inflammatory factors for tumor progression. Cancer Metastasis Rev (2010) 2.32
Telomeric DNA in ALT cells is characterized by free telomeric circles and heterogeneous t-loops. Mol Cell Biol (2004) 2.23
Distinct tumor suppressor mechanisms evolve in rodent species that differ in size and lifespan. Aging Cell (2008) 2.21
Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation of mouse cells. Cancer Cell (2012) 2.21
Ulcerative colitis is a disease of accelerated colon aging: evidence from telomere attrition and DNA damage. Gastroenterology (2008) 2.14
In vivo stoichiometry of shelterin components. J Biol Chem (2009) 2.12
Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype. J Biol Chem (2011) 2.11
DNA damage, cellular senescence and organismal ageing: causal or correlative? Nucleic Acids Res (2007) 2.09
Telomere maintenance and human bone marrow failure. Blood (2008) 2.09
Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16(INK4a). Proc Natl Acad Sci U S A (2006) 2.06
Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan. Nat Cell Biol (2012) 1.94
Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging. Gene (2007) 1.92
Cellular senescence and organismal aging. Mech Ageing Dev (2008) 1.92
Downregulation of Wnt signaling is a trigger for formation of facultative heterochromatin and onset of cell senescence in primary human cells. Mol Cell (2007) 1.87
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. Science (2015) 1.83
MDC1 accelerates nonhomologous end-joining of dysfunctional telomeres. Genes Dev (2006) 1.81
Role of oxidatively induced DNA lesions in human pathogenesis. Mutat Res (2010) 1.78
DNA damage signaling and p53-dependent senescence after prolonged beta-interferon stimulation. Mol Biol Cell (2006) 1.78
Replicon dynamics, dormant origin firing, and terminal fork integrity after double-strand break formation. Cell (2009) 1.78
SIRT6 protects human endothelial cells from DNA damage, telomere dysfunction, and senescence. Cardiovasc Res (2012) 1.74
Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions. EMBO J (2012) 1.71
The p400 E1A-associated protein is a novel component of the p53 --> p21 senescence pathway. Genes Dev (2005) 1.70
Human regulatory T cells induce T-lymphocyte senescence. Blood (2012) 1.70
Cigarette smoke induces cellular senescence. Am J Respir Cell Mol Biol (2006) 1.66
Comparative analysis of human mesenchymal stem cells from bone marrow, adipose tissue, and umbilical cord blood as sources of cell therapy. Int J Mol Sci (2013) 1.64
Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements. Aging Cell (2013) 1.62
New insights into p53 signaling and cancer cell response to DNA damage: implications for cancer therapy. J Biomed Biotechnol (2012) 1.57
Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin. Aging (Albany NY) (2012) 1.57
Human cancer cells harbor T-stumps, a distinct class of extremely short telomeres. Mol Cell (2007) 1.56
Death by transposition - the enemy within? Bioessays (2013) 1.53
Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence. Epigenetics Chromatin (2008) 1.50
Shorter telomeres associate with a reduced risk of melanoma development. Cancer Res (2011) 1.49
InTERTpreting telomerase structure and function. Nucleic Acids Res (2010) 1.47
Five dysfunctional telomeres predict onset of senescence in human cells. EMBO Rep (2011) 1.45
BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping. Nat Struct Mol Biol (2010) 1.44
RNA-Binding Protein FXR1 Regulates p21 and TERC RNA to Bypass p53-Mediated Cellular Senescence in OSCC. PLoS Genet (2016) 1.42
Critical Role for Telomerase in the Mechanism of Flow-Mediated Dilation in the Human Microcirculation. Circ Res (2015) 1.42
Hepatocytes with extensive telomere deprotection and fusion remain viable and regenerate liver mass through endoreduplication. Genes Dev (2006) 1.42
DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse. Mol Cell Biol (2006) 1.39
Spreading of mammalian DNA-damage response factors studied by ChIP-chip at damaged telomeres. EMBO J (2007) 1.38
Accelerated telomere shortening and replicative senescence in human fibroblasts overexpressing mutant and wild-type lamin A. Exp Cell Res (2007) 1.36
Dyskeratosis congenita as a disorder of telomere maintenance. Mutat Res (2011) 1.35
Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response. Aging Cell (2012) 1.35
Age-associated increase in heterochromatic marks in murine and primate tissues. Aging Cell (2010) 1.33
MLL associates with telomeres and regulates telomeric repeat-containing RNA transcription. Mol Cell Biol (2009) 1.33
Regulation of ploidy and senescence by the AMPK-related kinase NUAK1. EMBO J (2009) 1.33
ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation. Mol Cell Biol (2005) 1.31
Tetrahymena POT1a regulates telomere length and prevents activation of a cell cycle checkpoint. Mol Cell Biol (2006) 1.24
A role for monoubiquitinated FANCD2 at telomeres in ALT cells. Nucleic Acids Res (2009) 1.24
DNA damage responses in neural cells: Focus on the telomere. Neuroscience (2007) 1.23
Vertebrate POT1 restricts G-overhang length and prevents activation of a telomeric DNA damage checkpoint but is dispensable for overhang protection. Mol Cell Biol (2006) 1.23
Pot1 and cell cycle progression cooperate in telomere length regulation. Nat Struct Mol Biol (2007) 1.23
Smurf2 up-regulation activates telomere-dependent senescence. Genes Dev (2004) 1.23
Ulcerative colitis-associated colorectal cancer arises in a field of short telomeres, senescence, and inflammation. Cancer Res (2011) 1.23
Is telomerase a viable target in cancer? Mutat Res (2011) 1.23
Senescence and apoptosis: dueling or complementary cell fates? EMBO Rep (2014) 1.21
Multiple facets of histone variant H2AX: a DNA double-strand-break marker with several biological functions. Nucleic Acids Res (2015) 1.19
The relative contributions of the p53 and pRb pathways in oncogene-induced melanocyte senescence. Aging (Albany NY) (2009) 1.19
p53-dependent integration of telomere and growth factor deprivation signals. Proc Natl Acad Sci U S A (2007) 1.18
Assessing cell and organ senescence biomarkers. Circ Res (2012) 1.17
Involvement of Akt and mTOR in chemotherapeutic- and hormonal-based drug resistance and response to radiation in breast cancer cells. Cell Cycle (2011) 1.17
CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms. Mol Cell Biol (2007) 1.16
Epigenetic factors in aging and longevity. Pflugers Arch (2009) 1.15
Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence. Nat Cell Biol (2010) 1.14
Telomere dysfunction and cell survival: roles for distinct TIN2-containing complexes. J Cell Biol (2008) 1.14
Higher-order unfolding of satellite heterochromatin is a consistent and early event in cell senescence. J Cell Biol (2013) 1.13
Lifestyle impacts on the aging-associated expression of biomarkers of DNA damage and telomere dysfunction in human blood. Aging Cell (2010) 1.13
Klotho, phosphate and FGF-23 in ageing and disturbed mineral metabolism. Nat Rev Nephrol (2013) 1.12
Analysis of cell cycle phases and progression in cultured mammalian cells. Methods (2007) 1.12
p53 mediates senescence-like arrest induced by chronic replicational stress. Mol Cell Biol (2007) 1.11
Fanconi anemia proteins and endogenous stresses. Mutat Res (2009) 1.11
Telomere structure and telomerase in health and disease (review). Int J Oncol (2012) 1.11
Tumor-derived γδ regulatory T cells suppress innate and adaptive immunity through the induction of immunosenescence. J Immunol (2013) 1.10
Senescence mediates pituitary hypoplasia and restrains pituitary tumor growth. Cancer Res (2007) 1.09
Inflammatory signaling and cellular senescence. Cell Signal (2008) 1.08
Short telomeres: from dyskeratosis congenita to sporadic aplastic anemia and malignancy. Transl Res (2013) 1.08
Impairment of osteoblast differentiation due to proliferation-independent telomere dysfunction in mouse models of accelerated aging. Aging Cell (2012) 1.07
PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice. Proc Natl Acad Sci U S A (2014) 1.06
Cellular senescence and chromatin organisation. Br J Cancer (2007) 1.06
Telomeric DNA induces apoptosis and senescence of human breast carcinoma cells. Breast Cancer Res (2007) 1.06
The N-terminus of hTERT contains a DNA-binding domain and is required for telomerase activity and cellular immortalization. Nucleic Acids Res (2009) 1.05
Maternal and genetic factors determine early life telomere length. Proc Biol Sci (2015) 1.05
Cellular senescence in aging primates. Science (2006) 6.24
Genomic instability in laminopathy-based premature aging. Nat Med (2005) 4.54
Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks. Genes Dev (2002) 3.83
Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks. J Biol Chem (2005) 3.19
Accumulation of senescent cells in mitotic tissue of aging primates. Mech Ageing Dev (2006) 3.14
The endless tale of non-homologous end-joining. Cell Res (2008) 3.03
Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinase. J Biol Chem (2005) 3.02
Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks. J Cell Biol (2007) 2.92
A large scale genetic analysis of c-Myc-regulated gene expression patterns. J Biol Chem (2003) 2.69
Role of non-homologous end joining (NHEJ) in maintaining genomic integrity. DNA Repair (Amst) (2006) 2.67
Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break. J Biol Chem (2006) 2.66
Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells. J Cell Biol (2005) 2.64
A functional screen for Myc-responsive genes reveals serine hydroxymethyltransferase, a major source of the one-carbon unit for cell metabolism. Mol Cell Biol (2002) 2.27
Two essential but distinct functions of the mammalian abasic endonuclease. Proc Natl Acad Sci U S A (2005) 2.26
Cryo-EM structure of the DNA-dependent protein kinase catalytic subunit at subnanometer resolution reveals alpha helices and insight into DNA binding. Structure (2008) 2.17
Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks. Mol Cell (2011) 2.16
Role of DNA-PK in the cellular response to DNA double-strand breaks. DNA Repair (Amst) (2004) 2.13
Global regulation of nucleotide biosynthetic genes by c-Myc. PLoS One (2008) 2.12
The oncogene c-Myc coordinates regulation of metabolic networks to enable rapid cell cycle entry. Cell Cycle (2008) 2.09
Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression. Mol Cell (2003) 2.09
Reduced c-Myc signaling triggers telomere-independent senescence by regulating Bmi-1 and p16(INK4a). Proc Natl Acad Sci U S A (2006) 2.06
MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair. Mol Cell Biol (2010) 2.03
Ku recruits XLF to DNA double-strand breaks. EMBO Rep (2007) 2.00
Homologous recombination and nonhomologous end-joining repair pathways regulate fragile site stability. Genes Dev (2005) 1.97
Proteomic profiling of bone marrow mesenchymal stem cells upon transforming growth factor beta1 stimulation. J Biol Chem (2004) 1.96
DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination. Proc Natl Acad Sci U S A (2002) 1.92
Cellular senescence and organismal aging. Mech Ageing Dev (2008) 1.92
Ku and DNA-dependent protein kinase dynamic conformations and assembly regulate DNA binding and the initial non-homologous end joining complex. J Biol Chem (2009) 1.91
Ex vivo expanded hematopoietic stem cells overcome the MHC barrier in allogeneic transplantation. Cell Stem Cell (2011) 1.91
Genome-scale expression profiling of Hutchinson-Gilford progeria syndrome reveals widespread transcriptional misregulation leading to mesodermal/mesenchymal defects and accelerated atherosclerosis. Aging Cell (2004) 1.87
ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damage. Sci Signal (2010) 1.86
Targeted inactivation of p53 in human cells does not result in aneuploidy. Cancer Res (2002) 1.86
A DNA-PKcs mutation in a radiosensitive T-B- SCID patient inhibits Artemis activation and nonhomologous end-joining. J Clin Invest (2008) 1.82
Proteomic profiling of Myc-associated proteins. Cell Cycle (2010) 1.80
A human breast cell model of preinvasive to invasive transition. Cancer Res (2008) 1.79
Solution structure of the C-terminal domain of Ku80 suggests important sites for protein-protein interactions. Structure (2004) 1.78
DNA-PK phosphorylates histone H2AX during apoptotic DNA fragmentation in mammalian cells. DNA Repair (Amst) (2006) 1.75
Suppression of nonhomologous end joining repair by overexpression of HMGA2. Cancer Res (2009) 1.73
ATR-dependent phosphorylation of DNA-dependent protein kinase catalytic subunit in response to UV-induced replication stress. Mol Cell Biol (2006) 1.73
Somatic mutations in the tyrosine kinase domain of epidermal growth factor receptor (EGFR) abrogate EGFR-mediated radioprotection in non-small cell lung carcinoma. Cancer Res (2007) 1.68
Unrepaired clustered DNA lesions induce chromosome breakage in human cells. Proc Natl Acad Sci U S A (2011) 1.64
Involvement of the nuclear proteasome activator PA28γ in the cellular response to DNA double-strand breaks. Cell Cycle (2011) 1.63
Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements. Aging Cell (2013) 1.62
DNA double strand break repair via non-homologous end-joining. Transl Cancer Res (2013) 1.61
RKIP sensitizes prostate and breast cancer cells to drug-induced apoptosis. J Biol Chem (2004) 1.61
Complex formation by the human Rad51B and Rad51C DNA repair proteins and their activities in vitro. J Biol Chem (2002) 1.60
DNA-PKcs function regulated specifically by protein phosphatase 5. Proc Natl Acad Sci U S A (2004) 1.60
Essential role for DNA-PK-mediated phosphorylation of NR4A nuclear orphan receptors in DNA double-strand break repair. Genes Dev (2011) 1.60
Evidence for formation of DNA repair centers and dose-response nonlinearity in human cells. Proc Natl Acad Sci U S A (2011) 1.58
WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing. Nat Struct Mol Biol (2006) 1.55
Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites. J Cell Biol (2009) 1.55
Loss of Raf kinase inhibitor protein promotes cell proliferation and migration of human hepatoma cells. Gastroenterology (2006) 1.49
Gene expression profiles of normal human fibroblasts after exposure to ionizing radiation: a comparative study of low and high doses. Radiat Res (2005) 1.48
DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys? J Cell Biol (2007) 1.48
Involvement of Matrin 3 and SFPQ/NONO in the DNA damage response. Cell Cycle (2010) 1.48
Stress response gene ATF3 is a target of c-myc in serum-induced cell proliferation. EMBO J (2005) 1.41
Room-temperature single-nucleotide polymorphism and multiallele DNA detection using fluorescent nanocrystals and microarrays. Anal Chem (2003) 1.40
Defining interactions between DNA-PK and ligase IV/XRCC4. DNA Repair (Amst) (2002) 1.40
Repair of HZE-particle-induced DNA double-strand breaks in normal human fibroblasts. Radiat Res (2008) 1.37
Retracted DNA-PKcs-PIDDosome: a nuclear caspase-2-activating complex with role in G2/M checkpoint maintenance. Cell (2009) 1.37
DNA double-strand break formation upon UV-induced replication stress activates ATM and DNA-PKcs kinases. J Mol Biol (2008) 1.36
Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair. J Cell Biol (2011) 1.36
Loss of protooncogene c-Myc function impedes G1 phase progression both before and after the restriction point. Mol Biol Cell (2003) 1.34
Cellular responses to DNA double-strand breaks after low-dose gamma-irradiation. Nucleic Acids Res (2009) 1.34
Age-associated increase in heterochromatic marks in murine and primate tissues. Aging Cell (2010) 1.33
Genomic analysis of smooth muscle cells in 3-dimensional collagen matrix. FASEB J (2002) 1.33
Phosphoproteome profiling of human skin fibroblast cells in response to low- and high-dose irradiation. J Proteome Res (2006) 1.33
Abolition of cyclin-dependent kinase inhibitor p16Ink4a and p21Cip1/Waf1 functions permits Ras-induced anchorage-independent growth in telomerase-immortalized human fibroblasts. Mol Cell Biol (2003) 1.32
MDC1 regulates DNA-PK autophosphorylation in response to DNA damage. J Biol Chem (2004) 1.32
Deletion of Brca2 exon 27 causes hypersensitivity to DNA crosslinks, chromosomal instability, and reduced life span in mice. Genes Chromosomes Cancer (2003) 1.31
DNA-PK and ATM phosphorylation sites in XLF/Cernunnos are not required for repair of DNA double strand breaks. DNA Repair (Amst) (2008) 1.29
Involvement of the INK4a/Arf gene locus in senescence. Aging Cell (2003) 1.28
Human Rad51C deficiency destabilizes XRCC3, impairs recombination, and radiosensitizes S/G2-phase cells. J Biol Chem (2004) 1.27
DNA-PKcs and ATM co-regulate DNA double-strand break repair. DNA Repair (Amst) (2009) 1.27
The interaction of CtIP and Nbs1 connects CDK and ATM to regulate HR-mediated double-strand break repair. PLoS Genet (2013) 1.27
Downregulation of human DAB2IP gene expression in prostate cancer cells results in resistance to ionizing radiation. Cancer Res (2010) 1.26
Formation of higher-order nuclear Rad51 structures is functionally linked to p21 expression and protection from DNA damage-induced apoptosis. J Cell Sci (2002) 1.26
Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues. Aging (Albany NY) (2013) 1.26
Regulation of growth arrest in senescence: telomere damage is not the end of the story. Mech Ageing Dev (2005) 1.25
Artemis deficiency confers a DNA double-strand break repair defect and Artemis phosphorylation status is altered by DNA damage and cell cycle progression. DNA Repair (Amst) (2005) 1.25
Differential regulation of Rho GTPases by beta1 and beta3 integrins: the role of an extracellular domain of integrin in intracellular signaling. J Cell Sci (2002) 1.24
The number of p16INK4a positive cells in human skin reflects biological age. Aging Cell (2012) 1.23
DNA damage-induced apoptosis requires the DNA-dependent protein kinase, and is mediated by the latent population of p53. EMBO J (2002) 1.21
Mechanism of cluster DNA damage repair in response to high-atomic number and energy particles radiation. Mutat Res (2010) 1.20
Engineered bacterial outer membrane vesicles with enhanced functionality. J Mol Biol (2008) 1.20
Ku is a novel transcriptional recycling coactivator of the androgen receptor in prostate cancer cells. J Biol Chem (2005) 1.19
Live cell imaging of XLF and XRCC4 reveals a novel view of protein assembly in the non-homologous end-joining pathway. Cell Cycle (2008) 1.19
Molecular characterization of human telomerase reverse transcriptase-immortalized human fibroblasts by gene expression profiling: activation of the epiregulin gene. Cancer Res (2003) 1.18
Evidence for the direct binding of phosphorylated p53 to sites of DNA breaks in vivo. Cancer Res (2005) 1.16