Recent applications of metabolomics toward cyanobacteria.

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Published in Metabolites on February 04, 2013

Authors

Doreen Schwarz1, Isabel Orf2, Joachim Kopka3, Martin Hagemann4

Author Affiliations

1: Institut Biowissenschaften, Pflanzenphysiologie, Universität Rostock, Albert-Einstein-Str. 3, D-18059 Rostock, Germany. doreen.schwarz@uni-rostock.de.
2: Max-Planck-Institut für Molekulare Pflanzenphysiologie, Am Mühlenberg 1, 14476 Golm, Germany. orf@mpimp-golm.mpg.de.
3: Max-Planck-Institut für Molekulare Pflanzenphysiologie, Am Mühlenberg 1, 14476 Golm, Germany. kopka@mpimp-golm.mpg.de.
4: Institut Biowissenschaften, Pflanzenphysiologie, Universität Rostock, Albert-Einstein-Str. 3, D-18059 Rostock, Germany. martin.hagemann@uni-rostock.de.

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Metabolomics--the link between genotypes and phenotypes. Plant Mol Biol (2002) 11.36

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Proposed minimum reporting standards for chemical analysis Chemical Analysis Working Group (CAWG) Metabolomics Standards Initiative (MSI). Metabolomics (2007) 6.93

Gas chromatography mass spectrometry-based metabolite profiling in plants. Nat Protoc (2006) 6.33

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Technical advance: simultaneous analysis of metabolites in potato tuber by gas chromatography-mass spectrometry. Plant J (2000) 4.64

Biochemical basis of obligate autotrophy in blue-green algae and thiobacilli. J Bacteriol (1967) 4.63

VANTED: a system for advanced data analysis and visualization in the context of biological networks. BMC Bioinformatics (2006) 4.38

Potential of metabolomics as a functional genomics tool. Trends Plant Sci (2004) 4.10

Cyanobacteria secondary metabolites--the cyanotoxins. J Appl Bacteriol (1992) 3.70

High-throughput classification of yeast mutants for functional genomics using metabolic footprinting. Nat Biotechnol (2003) 3.48

MetaboLights--an open-access general-purpose repository for metabolomics studies and associated meta-data. Nucleic Acids Res (2012) 3.32

GC-MS libraries for the rapid identification of metabolites in complex biological samples. FEBS Lett (2005) 3.29

Metabolism of glucose by unicellular blue-green algae. Arch Mikrobiol (1972) 3.20

TagFinder for the quantitative analysis of gas chromatography--mass spectrometry (GC-MS)-based metabolite profiling experiments. Bioinformatics (2008) 3.01

CSB.DB: a comprehensive systems-biology database. Bioinformatics (2004) 2.98

An experimentally anchored map of transcriptional start sites in the model cyanobacterium Synechocystis sp. PCC6803. Proc Natl Acad Sci U S A (2011) 2.84

Plant metabolomics: large-scale phytochemistry in the functional genomics era. Phytochemistry (2003) 2.84

The metabolism of acetate by the blue-green algae, Anabaena variabilis and Anacystis nidulans. J Gen Microbiol (1967) 2.80

Fatty acid production in genetically modified cyanobacteria. Proc Natl Acad Sci U S A (2011) 2.77

Combining genomics, metabolome analysis, and biochemical modelling to understand metabolic networks. Comp Funct Genomics (2001) 2.68

The path of carbon in photosynthesis. Science (1962) 2.52

Engineering cyanobacteria to generate high-value products. Trends Biotechnol (2011) 2.31

The tricarboxylic acid cycle in cyanobacteria. Science (2011) 2.14

High rate of uptake of organic nitrogen compounds by Prochlorococcus cyanobacteria as a key to their dominance in oligotrophic oceanic waters. Appl Environ Microbiol (2003) 2.03

Cyanobacteria perceive nitrogen status by sensing intracellular 2-oxoglutarate levels. J Biol Chem (2001) 2.01

The incomplete tricarboxylic acid cycle in the blue-green alga Anabaena variabilis. J Gen Microbiol (1969) 2.00

Construction and application of a mass spectral and retention time index database generated from plant GC/EI-TOF-MS metabolite profiles. Phytochemistry (2003) 1.99

Photosynthetic and dark carbon metabolism in unicellular blue-green algae. Arch Mikrobiol (1972) 1.97

Alterations in global patterns of gene expression in Synechocystis sp. PCC 6803 in response to inorganic carbon limitation and the inactivation of ndhR, a LysR family regulator. J Biol Chem (2003) 1.94

Release of Dissolved Organic Nitrogen by Marine Diazotrophic Cyanobacteria, Trichodesmium spp. Appl Environ Microbiol (1994) 1.93

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Metabolome analysis: the potential of in vivo labeling with stable isotopes for metabolite profiling. Trends Biotechnol (2005) 1.59

Evolution of photosynthesis. Annu Rev Plant Biol (2011) 1.56

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Decision tree supported substructure prediction of metabolites from GC-MS profiles. Metabolomics (2010) 1.51

Molecular biology of cyanobacterial salt acclimation. FEMS Microbiol Rev (2011) 1.49

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Nitrogen assimilation and nitrogen control in cyanobacteria. Biochem Soc Trans (2005) 1.46

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Cyanobacterial toxins: biosynthetic routes and evolutionary roots. FEMS Microbiol Rev (2012) 1.40

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Applications of mass isotopomer analysis to nutrition research. Annu Rev Nutr (1997) 1.33

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PaVESy: Pathway Visualization and Editing System. Bioinformatics (2004) 0.93

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Cyanobacterial systematics and nomenclature as featured in the International Bulletin of Bacteriological Nomenclature and Taxonomy / International Journal of Systematic Bacteriology / International Journal of Systematic and Evolutionary Microbiology. Int J Syst Evol Microbiol (2010) 0.89

Plant metabolomics and its potential for systems biology research background concepts, technology, and methodology. Methods Enzymol (2011) 0.88

Sequence conservation among the glucose transporter from the cyanobacterium Synechocystis sp. PCC 6803 and mammalian glucose transporters. Plant Mol Biol (1990) 0.88

Applications of MALDI-TOF MS analysis in cyanotoxin research. Environ Toxicol (2002) 0.86

TagFinder: preprocessing software for the fingerprinting and the profiling of gas chromatography-mass spectrometry based metabolome analyses. Methods Mol Biol (2012) 0.85

Comparison of analytical tools and biological assays for detection of paralytic shellfish poisoning toxins. Anal Bioanal Chem (2010) 0.85

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Comparative analysis of 126 cyanobacterial genomes reveals evidence of functional diversity among homologs of the redox-regulated CP12 protein. Plant Physiol (2012) 0.81

Methods, applications and concepts of metabolite profiling: primary metabolism. EXS (2007) 0.80

Rapid detection of cyanobacterial toxins in precursor ion mode by liquid chromatography tandem mass spectrometry. J Mass Spectrom (2007) 0.80