Published in Brain Sci on April 22, 2013
Reperfusion injury and reactive oxygen species: The evolution of a concept. Redox Biol (2015) 1.19
Nox2 knockout delays infarct progression and increases vascular recovery through angiogenesis in mice following ischaemic stroke with reperfusion. PLoS One (2014) 0.78
NADPH Oxidase Contributes to Photoreceptor Degeneration in Constitutively Active RAC1 Mice. Invest Ophthalmol Vis Sci (2016) 0.76
Chronic Pancreatitis Correlates With Increased Risk of Cerebrovascular Disease: A Retrospective Population-Based Cohort Study in Taiwan. Medicine (Baltimore) (2016) 0.75
Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent. J Clin Invest (1973) 17.56
Mechanisms and functional implications of adult neurogenesis. Cell (2008) 14.50
NOX enzymes and the biology of reactive oxygen. Nat Rev Immunol (2004) 12.93
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci (2007) 11.24
1,026 experimental treatments in acute stroke. Ann Neurol (2006) 7.23
Update of the stroke therapy academic industry roundtable preclinical recommendations. Stroke (2009) 6.79
Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? Lancet (1994) 6.71
Cell transformation by the superoxide-generating oxidase Mox1. Nature (1999) 6.23
Recommendations for standards regarding preclinical neuroprotective and restorative drug development. Stroke (1999) 6.18
Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant. Hypertension (2007) 5.80
Reactive oxygen radicals in signaling and damage in the ischemic brain. J Cereb Blood Flow Metab (2001) 5.06
Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases. Cell Signal (2005) 4.74
Leukocyte oxidase: defective activity in chronic granulomatous disease. Science (1967) 4.25
Identification of renox, an NAD(P)H oxidase in kidney. Proc Natl Acad Sci U S A (2000) 4.24
Defective superoxide production by granulocytes from patients with chronic granulomatous disease. N Engl J Med (1974) 4.21
Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5. Gene (2001) 3.97
Superoxide production and expression of nox family proteins in human atherosclerosis. Circulation (2002) 3.95
Evidence for the efficacy of NXY-059 in experimental focal cerebral ischaemia is confounded by study quality. Stroke (2008) 3.87
The neutrophil NADPH oxidase. Arch Biochem Biophys (2002) 3.71
NXY-059 for the treatment of acute ischemic stroke. N Engl J Med (2007) 3.70
Nox proteins in signal transduction. Free Radic Biol Med (2009) 3.47
Regulation of Nox and Duox enzymatic activity and expression. Free Radic Biol Med (2007) 3.44
Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic. Lancet Neurol (2009) 3.27
Novel competitive inhibitor of NAD(P)H oxidase assembly attenuates vascular O(2)(-) and systolic blood pressure in mice. Circ Res (2001) 3.24
Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol. Am J Respir Cell Mol Biol (1994) 3.23
The superoxide-generating NADPH oxidase: structural aspects and activation mechanism. Cell Mol Life Sci (2002) 3.22
Acute ischemic stroke: overview of major experimental rodent models, pathophysiology, and therapy of focal cerebral ischemia. Pharmacol Biochem Behav (2007) 3.19
Xanthine oxidoreductase and cardiovascular disease: molecular mechanisms and pathophysiological implications. J Physiol (2003) 3.19
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species. FEBS J (2008) 3.04
Bench to bedside: the quest for quality in experimental stroke research. J Cereb Blood Flow Metab (2006) 2.99
Empirical evidence of bias in the design of experimental stroke studies: a metaepidemiologic approach. Stroke (2008) 2.98
T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation. Nat Immunol (2004) 2.96
Role of angiogenesis in patients with cerebral ischemic stroke. Stroke (1994) 2.96
Cerebral ischemia and reperfusion: the pathophysiologic concept as a basis for clinical therapy. J Cereb Blood Flow Metab (2004) 2.94
A fatal granulomatosus of childhood: the clinical study of a new syndrome. Minn Med (1957) 2.92
Human fibroblasts release reactive oxygen species in response to interleukin-1 or tumour necrosis factor-alpha. Biochem J (1989) 2.85
Poldip2, a novel regulator of Nox4 and cytoskeletal integrity in vascular smooth muscle cells. Circ Res (2009) 2.83
NADPH oxidases: functions and pathologies in the vasculature. Arterioscler Thromb Vasc Biol (2009) 2.83
Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration. PLoS Biol (2010) 2.72
Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family. J Biol Chem (2000) 2.70
Three distinct mechanisms generate oxygen free radicals in neurons and contribute to cell death during anoxia and reoxygenation. J Neurosci (2007) 2.69
Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction. J Neurosci (1998) 2.65
NADPH oxidase deficiency in X-linked chronic granulomatous disease. J Clin Invest (1975) 2.62
NADPH oxidases of the brain: distribution, regulation, and function. Antioxid Redox Signal (2006) 2.56
A Ca(2+)-activated NADPH oxidase in testis, spleen, and lymph nodes. J Biol Chem (2001) 2.56
NADPH oxidase-mediated redox signaling: roles in cellular stress response, stress tolerance, and tissue repair. Pharmacol Rev (2011) 2.53
Oxidative innate immune defenses by Nox/Duox family NADPH oxidases. Contrib Microbiol (2008) 2.50
A syndrome of recurrent infection and infiltration of viscera by pigmented lipid histiocytes. Pediatrics (1957) 2.44
Redox signaling in angiogenesis: role of NADPH oxidase. Cardiovasc Res (2006) 2.42
Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox. J Cell Biol (2001) 2.40
Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency. J Neurosci (1998) 2.39
NOX enzymes in the central nervous system: from signaling to disease. Antioxid Redox Signal (2009) 2.38
Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cdnas. J Biol Chem (1999) 2.37
NOX3, a superoxide-generating NADPH oxidase of the inner ear. J Biol Chem (2004) 2.36
The phagocytes: neutrophils and monocytes. Blood (2008) 2.25
Nox4 acts as a switch between differentiation and proliferation in preadipocytes. Arterioscler Thromb Vasc Biol (2008) 2.21
Ischemic stroke injury is reduced in mice lacking a functional NADPH oxidase. Stroke (1997) 2.14
NADPH oxidase plays a central role in blood-brain barrier damage in experimental stroke. Stroke (2007) 2.13
Oxidants, antioxidants and the ischemic brain. J Exp Biol (2004) 2.05
Inhibition of NADPH oxidase is neuroprotective after ischemia-reperfusion. J Cereb Blood Flow Metab (2009) 2.02
Temporal profile of angiogenesis and expression of related genes in the brain after ischemia. J Cereb Blood Flow Metab (2003) 2.00
Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia. Stroke (1994) 1.99
Role of gp91phox (Nox2)-containing NAD(P)H oxidase in angiogenesis in response to hindlimb ischemia. Circulation (2005) 1.98
Redox regulation of glial inflammatory response to lipopolysaccharide and interferongamma. J Neurosci Res (2004) 1.97
Biological roles for the NOX family NADPH oxidases. J Biol Chem (2008) 1.96
Endothelium-derived hyperpolarizing factor synthase (Cytochrome P450 2C9) is a functionally significant source of reactive oxygen species in coronary arteries. Circ Res (2001) 1.94
NOX enzymes as novel targets for drug development. Semin Immunopathol (2008) 1.90
Antioxidants in central nervous system diseases: preclinical promise and translational challenges. J Alzheimers Dis (2008) 1.88
Collateral growth and angiogenesis around cortical stroke. Stroke (2001) 1.87
Glucose and NADPH oxidase drive neuronal superoxide formation in stroke. Ann Neurol (2008) 1.86
Point mutations in the proline-rich region of p22phox are dominant inhibitors of Nox1- and Nox2-dependent reactive oxygen generation. J Biol Chem (2005) 1.85
Local immune responses in the rat cerebral cortex after middle cerebral artery occlusion. J Neuroimmunol (1994) 1.85
Neuronal expression of the NADPH oxidase NOX4, and its regulation in mouse experimental brain ischemia. Neuroscience (2005) 1.84
Reduction of CuZn-superoxide dismutase activity exacerbates neuronal cell injury and edema formation after transient focal cerebral ischemia. J Neurosci (1997) 1.84
Nox2-derived reactive oxygen species mediate neurovascular dysregulation in the aging mouse brain. J Cereb Blood Flow Metab (2007) 1.79
Apocynin protects against global cerebral ischemia-reperfusion-induced oxidative stress and injury in the gerbil hippocampus. Brain Res (2006) 1.78
NADPH oxidase immunoreactivity in the mouse brain. Brain Res (2003) 1.74
Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: a key role for reactive oxygen species in ischemic brain injury. J Pharmacol Exp Ther (1998) 1.73
Expression and modulation of an NADPH oxidase in mammalian astrocytes. J Neurosci (2005) 1.71
Antioxidant strategies in the treatment of stroke. Free Radic Biol Med (2005) 1.70
Nox2 redox signaling maintains essential cell populations in the brain. Nat Chem Biol (2010) 1.70
Translational stroke research of the combination of thrombolysis and antioxidant therapy. Stroke (2011) 1.69
NADPH-oxidase-derived reactive oxygen species mediate the cerebrovascular dysfunction induced by the amyloid beta peptide. J Neurosci (2005) 1.68
Metabolic activation of natural phenols into selective oxidative burst agonists by activated human neutrophils. Free Radic Biol Med (1990) 1.68
NADPH oxidase activity and function are profoundly greater in cerebral versus systemic arteries. Circ Res (2005) 1.65
VEGF signaling through NADPH oxidase-derived ROS. Antioxid Redox Signal (2007) 1.61
Synaptic localization of a functional NADPH oxidase in the mouse hippocampus. Mol Cell Neurosci (2005) 1.61
Effects of NXY-059 in experimental stroke: an individual animal meta-analysis. Br J Pharmacol (2009) 1.60
Oxidative processes and antioxidative defense mechanisms in the aging brain. FASEB J (1995) 1.60
Apocynin improves outcome in experimental stroke with a narrow dose range. Neuroscience (2008) 1.59
Induction and activation by zinc of NADPH oxidase in cultured cortical neurons and astrocytes. J Neurosci (2000) 1.59
NADPH oxidases in the vasculature: molecular features, roles in disease and pharmacological inhibition. Pharmacol Ther (2008) 1.58
NOXO1, regulation of lipid binding, localization, and activation of Nox1 by the Phox homology (PX) domain. J Biol Chem (2003) 1.56
Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia. J Cell Physiol (2011) 1.54
Role of nox2-based NADPH oxidase in bone marrow and progenitor cell function involved in neovascularization induced by hindlimb ischemia. Circ Res (2008) 1.52
Astrocytes protect neurons from hydrogen peroxide toxicity. J Neurosci (1996) 1.51
The protective role of ROS in autoimmune disease. Trends Immunol (2009) 1.49
The NADPH oxidase subunit NOX4 is a new target gene of the hypoxia-inducible factor-1. Mol Biol Cell (2010) 1.49
The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activators. J Biol Chem (2005) 1.48
Effects of edaravone, a free radical scavenger, on serum levels of inflammatory biomarkers in acute brain infarction. J Stroke Cerebrovasc Dis (2011) 1.48