NADPH oxidase activity and function are profoundly greater in cerebral versus systemic arteries.

PubWeight™: 1.65‹?› | Rank: Top 3%

🔗 View Article (PMID 16210546)

Published in Circ Res on October 06, 2005

Authors

Alyson A Miller1, Grant R Drummond, Harald H H W Schmidt, Christopher G Sobey

Author Affiliations

1: Department of Pharmacology, University of Melbourne, Parkville, Victoria 3010, Australia.

Articles citing this

Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets. Nat Rev Drug Discov (2011) 3.08

The pathobiology of vascular dementia. Neuron (2013) 3.07

Biochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular system. Circ Res (2012) 3.02

NADPH oxidases: functions and pathologies in the vasculature. Arterioscler Thromb Vasc Biol (2009) 2.83

Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration. PLoS Biol (2010) 2.72

Hydroethidine- and MitoSOX-derived red fluorescence is not a reliable indicator of intracellular superoxide formation: another inconvenient truth. Free Radic Biol Med (2010) 2.32

Hypertension and cerebrovascular dysfunction. Cell Metab (2008) 2.30

Threats to the mind: aging, amyloid, and hypertension. Stroke (2008) 1.68

Protecting against vascular disease in brain. Am J Physiol Heart Circ Physiol (2011) 1.66

NAD(P)H oxidase-derived reactive oxygen species contribute to age-related impairments of endothelium-dependent dilation in rat soleus feed arteries. J Appl Physiol (1985) (2011) 1.58

The role of oxidative stress and NADPH oxidase in cerebrovascular disease. Trends Mol Med (2008) 1.46

The NOX toolbox: validating the role of NADPH oxidases in physiology and disease. Cell Mol Life Sci (2012) 1.44

Mitochondrial reactive oxygen species: a double edged sword in ischemia/reperfusion vs preconditioning. Redox Biol (2014) 1.37

Reduction of cerebral infarct volume by apocynin requires pretreatment and is absent in Nox2-deficient mice. Br J Pharmacol (2009) 1.36

Hypertension: a harbinger of stroke and dementia. Hypertension (2013) 1.30

Role of vascular risk factors and vascular dysfunction in Alzheimer's disease. Mt Sinai J Med (2010) 1.28

The effects of hypertension on the cerebral circulation. Am J Physiol Heart Circ Physiol (2013) 1.25

Normobaric hyperoxia inhibits NADPH oxidase-mediated matrix metalloproteinase-9 induction in cerebral microvessels in experimental stroke. J Neurochem (2008) 1.24

The cerebrovascular dysfunction induced by slow pressor doses of angiotensin II precedes the development of hypertension. Am J Physiol Heart Circ Physiol (2010) 1.24

Impairment of both nitric oxide-mediated and EDHF-type relaxation in small mesenteric arteries from rats with streptozotocin-induced diabetes. Br J Pharmacol (2011) 1.16

Local regulation of arterial L-type calcium channels by reactive oxygen species. Circ Res (2010) 1.13

NOX1, 2, 4, 5: counting out oxidative stress. Br J Pharmacol (2011) 1.08

From form to function: the role of Nox4 in the cardiovascular system. Front Physiol (2012) 1.07

Cerebrovascular consequences of obstructive sleep apnea. J Am Heart Assoc (2012) 1.07

Neuroprotection after stroke by targeting NOX4 as a source of oxidative stress. Antioxid Redox Signal (2012) 1.03

Role of Nox isoforms in angiotensin II-induced oxidative stress and endothelial dysfunction in brain. J Appl Physiol (1985) (2012) 0.97

Localized TRPA1 channel Ca2+ signals stimulated by reactive oxygen species promote cerebral artery dilation. Sci Signal (2015) 0.97

Nox2 oxidase activity accounts for the oxidative stress and vasomotor dysfunction in mouse cerebral arteries following ischemic stroke. PLoS One (2011) 0.94

Introgression of the Brown Norway renin allele onto the Dahl salt-sensitive genetic background increases Cu/Zn SOD expression in cerebral arteries. Am J Hypertens (2011) 0.93

Sex differences in protection against angiotensin II-induced endothelial dysfunction by manganese superoxide dismutase in the cerebral circulation. Hypertension (2010) 0.93

Which NADPH oxidase isoform is relevant for ischemic stroke? The case for nox 2. Antioxid Redox Signal (2012) 0.91

Adenosine can mediate its actions through generation of reactive oxygen species. J Cereb Blood Flow Metab (2010) 0.89

Nox2-derived superoxide contributes to cerebral vascular dysfunction in diet-induced obesity. Stroke (2013) 0.88

NADPH oxidase in stroke and cerebrovascular disease. Neurol Res (2012) 0.88

Methamphetamine alters occludin expression via NADPH oxidase-induced oxidative insult and intact caveolae. J Cell Mol Med (2012) 0.88

Effects of angiotensin II on the cerebral circulation: role of oxidative stress. Front Physiol (2013) 0.88

The 1027th target candidate in stroke: Will NADPH oxidase hold up? Exp Transl Stroke Med (2012) 0.87

An investigation of the mechanisms of hydrogen sulfide-induced vasorelaxation in rat middle cerebral arteries. Naunyn Schmiedebergs Arch Pharmacol (2012) 0.87

Current status of NADPH oxidase research in cardiovascular pharmacology. Vasc Health Risk Manag (2013) 0.85

Hydrogen sulfide protects endothelial nitric oxide function under conditions of acute oxidative stress in vitro. Naunyn Schmiedebergs Arch Pharmacol (2013) 0.85

Beneficial effects of lifelong caloric restriction on endothelial function are greater in conduit arteries compared to cerebral resistance arteries. Age (Dordr) (2013) 0.83

Chronic aldosterone administration causes Nox2-mediated increases in reactive oxygen species production and endothelial dysfunction in the cerebral circulation. J Hypertens (2014) 0.82

Pregnancy enhances the effects of hypercholesterolemia on posterior cerebral arteries. Reprod Sci (2012) 0.80

Mechanisms of augmented vasoconstriction induced by 5-hydroxytryptamine in aortic rings from spontaneously hypertensive rats. Br J Pharmacol (2008) 0.80

Tracheal suctioning improves gas exchange but not hemodynamics in asphyxiated lambs with meconium aspiration. Pediatr Res (2014) 0.80

ASIC-like currents in freshly isolated cerebral artery smooth muscle cells are inhibited by endogenous oxidase activity. Cell Physiol Biochem (2011) 0.80

Ghrelin-related peptides exert protective effects in the cerebral circulation of male mice through a nonclassical ghrelin receptor(s). Endocrinology (2015) 0.79

Effect of type 1 diabetes on the production and vasoactivity of hydrogen sulfide in rat middle cerebral arteries. Physiol Rep (2013) 0.79

NADPH Oxidase as a Therapeutic Target for Neuroprotection against Ischaemic Stroke: Future Perspectives. Brain Sci (2013) 0.79

Endothelial nitric oxide synthase in the microcirculation. Cell Mol Life Sci (2015) 0.79

Functional heterogeneity of NADPH oxidase-mediated contractions to endothelin with vascular aging. Life Sci (2013) 0.78

Hypertension and Dementia: Epidemiological and Experimental Evidence Revealing a Detrimental Relationship. Int J Mol Sci (2016) 0.78

NADPH oxidase and angiogenesis following endothelin-1 induced stroke in rats: role for nox2 in brain repair. Brain Sci (2013) 0.78

Endothelial Dysfunction and Amyloid-β-Induced Neurovascular Alterations. Cell Mol Neurobiol (2015) 0.78

Targeting oxidative stress injury after ischemic stroke in conscious rats: limited benefits with apocynin highlight the need to incorporate long term recovery. Stroke Res Treat (2013) 0.78

Focal Ischemic Injury with Complex Middle Cerebral Artery in Stroke-Prone Spontaneously Hypertensive Rats with Loss-Of-Function in NADPH Oxidases. PLoS One (2015) 0.77

Cerebral Small Vessel Disease: Targeting Oxidative Stress as a Novel Therapeutic Strategy? Front Pharmacol (2016) 0.76

Tocotrienol-Rich Tocomin Attenuates Oxidative Stress and Improves Endothelium-Dependent Relaxation in Aortae from Rats Fed a High-Fat Western Diet. Front Cardiovasc Med (2016) 0.75

Microvascular NADPH oxidase in health and disease. Free Radic Biol Med (2017) 0.75

NADPH Oxidase Activity in Cerebral Arterioles Is a Key Mediator of Cerebral Small Vessel Disease-Implications for Prevention. Healthcare (Basel) (2015) 0.75

Nox4 contributes to the hypoxia-mediated regulation of actin cytoskeleton in cerebrovascular smooth muscle. Life Sci (2016) 0.75

Regulation of KCa2.3 and endothelium-dependent hyperpolarization (EDH) in the rat middle cerebral artery: the role of lipoxygenase metabolites and isoprostanes. PeerJ (2014) 0.75

Articles by these authors

Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant. Hypertension (2007) 5.80

Apoptotic mechanisms after cerebral ischemia. Stroke (2009) 3.92

Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase. J Biol Chem (2004) 3.37

Hypoxia-dependent regulation of nonphagocytic NADPH oxidase subunit NOX4 in the pulmonary vasculature. Circ Res (2007) 3.28

Nox1 overexpression potentiates angiotensin II-induced hypertension and vascular smooth muscle hypertrophy in transgenic mice. Circulation (2005) 3.12

Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets. Nat Rev Drug Discov (2011) 3.08

NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential. Nat Rev Drug Discov (2006) 2.84

Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration. PLoS Biol (2010) 2.72

Distinct roles of Nox1 and Nox4 in basal and angiotensin II-stimulated superoxide and hydrogen peroxide production. Free Radic Biol Med (2008) 2.68

Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels. J Clin Invest (2006) 2.52

Redox control of endothelial function and dysfunction: molecular mechanisms and therapeutic opportunities. Antioxid Redox Signal (2008) 2.24

Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability, and early atherosclerotic plaque formation in ApoE-/- mice. Am J Physiol Heart Circ Physiol (2009) 2.00

NADPH oxidase 1 plays a key role in diabetes mellitus-accelerated atherosclerosis. Circulation (2013) 1.78

The contribution of Nox4 to NADPH oxidase activity in mouse vascular smooth muscle. Cardiovasc Res (2005) 1.72

Inhibition of Nox2 oxidase activity ameliorates influenza A virus-induced lung inflammation. PLoS Pathog (2011) 1.62

Angiotensin II type 2 receptor stimulation initiated after stroke causes neuroprotection in conscious rats. Hypertension (2012) 1.61

Targeting Rho and Rho-kinase in the treatment of cardiovascular disease. Trends Pharmacol Sci (2005) 1.60

NADPH oxidases in the vasculature: molecular features, roles in disease and pharmacological inhibition. Pharmacol Ther (2008) 1.58

Reconstituted high-density lipoproteins inhibit the acute pro-oxidant and proinflammatory vascular changes induced by a periarterial collar in normocholesterolemic rabbits. Circulation (2005) 1.53

Pathophysiology, treatment, and animal and cellular models of human ischemic stroke. Mol Neurodegener (2011) 1.48

Role of the multidrug resistance protein-1 in hypertension and vascular dysfunction caused by angiotensin II. Arterioscler Thromb Vasc Biol (2007) 1.47

Nitric oxide suppresses NADPH oxidase-dependent superoxide production by S-nitrosylation in human endothelial cells. Cardiovasc Res (2007) 1.46

Evidence for a detrimental role of TLR8 in ischemic stroke. Exp Neurol (2013) 1.46

The NOX toolbox: validating the role of NADPH oxidases in physiology and disease. Cell Mol Life Sci (2012) 1.44

Mechanisms contributing to cerebral infarct size after stroke: gender, reperfusion, T lymphocytes, and Nox2-derived superoxide. J Cereb Blood Flow Metab (2010) 1.36

Oxidative stress and endothelial dysfunction in cerebrovascular disease. Front Biosci (Landmark Ed) (2011) 1.34

Upregulation of NAD(P)H oxidase 1 in hypoxia activates hypoxia-inducible factor 1 via increase in reactive oxygen species. Free Radic Biol Med (2004) 1.31

Novel Nox inhibitor of oxLDL-induced reactive oxygen species formation in human endothelial cells. Biochem Biophys Res Commun (2006) 1.30

Nitric oxide-independent vasodilator rescues heme-oxidized soluble guanylate cyclase from proteasomal degradation. Circ Res (2009) 1.29

Endothelium-dependent relaxation by G protein-coupled receptor 30 agonists in rat carotid arteries. Am J Physiol Heart Circ Physiol (2010) 1.29

Adiponectin receptor signalling in the brain. Br J Pharmacol (2012) 1.28

Hemodynamic and biochemical adaptations to vascular smooth muscle overexpression of p22phox in mice. Am J Physiol Heart Circ Physiol (2004) 1.26

Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice. Nat Commun (2012) 1.25

Synaptic localization of nitric oxide synthase and soluble guanylyl cyclase in the hippocampus. J Neurosci (2002) 1.24

Multiphoton imaging reveals a new leukocyte recruitment paradigm in the glomerulus. Nat Med (2012) 1.23

Good stress, bad stress--the delicate balance in the vasculature. Dtsch Arztebl Int (2009) 1.23

Oxidative stress and endothelial dysfunction in aortas of aged spontaneously hypertensive rats by NOX1/2 is reversed by NADPH oxidase inhibition. Hypertension (2010) 1.23

Importance of T lymphocytes in brain injury, immunodeficiency, and recovery after cerebral ischemia. J Cereb Blood Flow Metab (2012) 1.22

Calcium-dependent membrane association sensitizes soluble guanylyl cyclase to nitric oxide. Nat Cell Biol (2002) 1.21

NADPH oxidase isoform selective regulation of endothelial cell proliferation and survival. Naunyn Schmiedebergs Arch Pharmacol (2009) 1.15

Effect of gender on NADPH-oxidase activity, expression, and function in the cerebral circulation: role of estrogen. Stroke (2007) 1.13

Increased NADPH-oxidase activity and Nox4 expression during chronic hypertension is associated with enhanced cerebral vasodilatation to NADPH in vivo. Stroke (2004) 1.11

NADPH oxidase activity is higher in cerebral versus systemic arteries of four animal species: role of Nox2. Am J Physiol Heart Circ Physiol (2008) 1.10

Recent evidence for an involvement of rho-kinase in cerebral vascular disease. Stroke (2006) 1.08

Increased NADPH oxidase activity, gp91phox expression, and endothelium-dependent vasorelaxation during neointima formation in rabbits. Circ Res (2002) 1.07

Translating the oxidative stress hypothesis into the clinic: NOX versus NOS. J Mol Med (Berl) (2009) 1.05

Evidence that gamma-secretase-mediated Notch signaling induces neuronal cell death via the nuclear factor-kappaB-Bcl-2-interacting mediator of cell death pathway in ischemic stroke. Mol Pharmacol (2011) 1.04

Novel isoforms of NADPH oxidase in vascular physiology and pathophysiology. Clin Exp Pharmacol Physiol (2003) 1.04

Dimerization region of soluble guanylate cyclase characterized by bimolecular fluorescence complementation in vivo. Mol Pharmacol (2007) 1.04

Neuroprotection after stroke by targeting NOX4 as a source of oxidative stress. Antioxid Redox Signal (2012) 1.03

Reduced cGMP signaling associated with neointimal proliferation and vascular dysfunction in late-stage atherosclerosis. Proc Natl Acad Sci U S A (2004) 1.03

Effect of gender and sex hormones on vascular oxidative stress. Clin Exp Pharmacol Physiol (2007) 1.02

NADPH oxidases as regulators of tumor angiogenesis: current and emerging concepts. Antioxid Redox Signal (2012) 1.02

Flow-induced cerebral vasodilatation in vivo involves activation of phosphatidylinositol-3 kinase, NADPH-oxidase, and nitric oxide synthase. J Cereb Blood Flow Metab (2006) 1.02

Modulating endothelial nitric oxide synthase: a new cardiovascular therapeutic strategy. Am J Physiol Heart Circ Physiol (2011) 1.02

Evidence that nitric oxide inhibits vascular inflammation and superoxide production via a p47phox-dependent mechanism in mice. Clin Exp Pharmacol Physiol (2009) 1.01

Chemokine-related gene expression in the brain following ischemic stroke: no role for CXCR2 in outcome. Brain Res (2010) 1.00

Inwardly rectifying potassium channels in the regulation of vascular tone. Curr Drug Targets (2003) 1.00

Identification of residues crucially involved in soluble guanylate cyclase activation. FEBS Lett (2006) 1.00

Novel isoforms of NADPH-oxidase in cerebral vascular control. Pharmacol Ther (2006) 0.99

Distribution of soluble guanylyl cyclase in the rat brain. J Comp Neurol (2004) 0.99

Reactive oxygen species in the cerebral circulation: are they all bad? Antioxid Redox Signal (2006) 0.99

A constitutive NADPH oxidase-like system containing gp91phox homologs in human keratinocytes. J Invest Dermatol (2004) 0.98

There's NO binding like NOS binding: protein-protein interactions in NO/cGMP signaling. Proc Natl Acad Sci U S A (2002) 0.98

NADPH-oxidase activity is elevated in penumbral and non-ischemic cerebral arteries following stroke. Brain Res (2006) 0.98

The 'A's and 'O's of NADPH oxidase regulation: a commentary on "Subcellular localization and function of alternatively spliced Noxo1 isoforms". Free Radic Biol Med (2006) 0.98

Endothelial cell mineralocorticoid receptors regulate deoxycorticosterone/salt-mediated cardiac remodeling and vascular reactivity but not blood pressure. Hypertension (2014) 0.97

Role of Nox isoforms in angiotensin II-induced oxidative stress and endothelial dysfunction in brain. J Appl Physiol (1985) (2012) 0.97

Nox isoforms in vascular pathophysiology: insights from transgenic and knockout mouse models. Redox Rep (2010) 0.97

Importance of NOX1 for angiotensin II-induced cerebrovascular superoxide production and cortical infarct volume following ischemic stroke. Brain Res (2009) 0.97

Gender influences cerebral vascular responses to angiotensin II through Nox2-derived reactive oxygen species. Stroke (2009) 0.97

Evidence that estrogen suppresses rho-kinase function in the cerebral circulation in vivo. Stroke (2004) 0.96

Vasorelaxant and antioxidant activity of the isoflavone metabolite equol in carotid and cerebral arteries. Brain Res (2007) 0.95

Segmental differences in the roles of rho-kinase and protein kinase C in mediating vasoconstriction. J Pharmacol Exp Ther (2006) 0.95

cGMP in the vasculature. Handb Exp Pharmacol (2009) 0.94

Augmented superoxide production by Nox2-containing NADPH oxidase causes cerebral artery dysfunction during hypercholesterolemia. Stroke (2010) 0.94

Nox2 oxidase activity accounts for the oxidative stress and vasomotor dysfunction in mouse cerebral arteries following ischemic stroke. PLoS One (2011) 0.94

Pathogenesis of acute stroke and the role of inflammasomes. Ageing Res Rev (2013) 0.94