Published in PLoS One on June 26, 2014
Interlocked positive and negative feedback network motifs regulate β-catenin activity in the adherens junction pathway. Mol Biol Cell (2015) 0.80
Newly Constructed Network Models of Different WNT Signaling Cascades Applied to Breast Cancer Expression Data. PLoS One (2015) 0.77
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Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer (2002) 34.99
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Wnt/β-catenin signaling and disease. Cell (2012) 16.05
Convergence of Wnt, beta-catenin, and cadherin pathways. Science (2004) 13.13
The Hedgehog and Wnt signalling pathways in cancer. Nature (2001) 9.19
Wnt signalling and its impact on development and cancer. Nat Rev Cancer (2008) 8.37
Caught up in a Wnt storm: Wnt signaling in cancer. Biochim Biophys Acta (2003) 7.85
Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly. Cell (2005) 7.62
Cell adhesion and signalling by cadherins and Ig-CAMs in cancer. Nat Rev Cancer (2004) 6.73
Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation. Science (2007) 5.45
Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly. J Cell Biol (1994) 5.03
The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway. PLoS Biol (2003) 4.89
Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice. Genes Dev (2008) 4.38
Epithelial-mesenchymal transition in cancer: parallels between normal development and tumor progression. J Mammary Gland Biol Neoplasia (2010) 3.93
Beta-catenin hits chromatin: regulation of Wnt target gene activation. Nat Rev Mol Cell Biol (2009) 3.67
Diffusion, crowding & protein stability in a dynamic molecular model of the bacterial cytoplasm. PLoS Comput Biol (2010) 3.65
Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions. Development (2007) 3.28
Wnt3a plays a major role in the segmentation clock controlling somitogenesis. Dev Cell (2003) 3.15
The Wnt signaling pathway and its role in tumor development. J Cancer Res Clin Oncol (2003) 3.06
Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex. Cell (2012) 3.03
Wnt signals are transmitted through N-terminally dephosphorylated beta-catenin. EMBO Rep (2001) 3.02
Interplay of cadherin-mediated cell adhesion and canonical Wnt signaling. Cold Spring Harb Perspect Biol (2010) 3.02
Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions. Genes Dev (2004) 2.99
Dynamic and static interactions between p120 catenin and E-cadherin regulate the stability of cell-cell adhesion. Cell (2010) 2.83
Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex. Genes Dev (1999) 2.78
Structure and biochemistry of cadherins and catenins. Cold Spring Harb Perspect Biol (2009) 2.37
The β-catenin destruction complex. Cold Spring Harb Perspect Biol (2013) 2.22
The extracellular architecture of adherens junctions revealed by crystal structures of type I cadherins. Structure (2011) 2.19
Wnt/Notch signalling and information processing during development. Development (2008) 2.18
Evidence that fold-change, and not absolute level, of beta-catenin dictates Wnt signaling. Mol Cell (2009) 2.11
beta-Catenin: a pivot between cell adhesion and Wnt signalling. Curr Biol (2005) 2.06
Thermodynamics of beta-catenin-ligand interactions: the roles of the N- and C-terminal tails in modulating binding affinity. J Biol Chem (2005) 2.04
Biochemical interactions in the wnt pathway. Biochim Biophys Acta (2000) 1.96
Cadherin-mediated cell-cell adhesion: sticking together as a family. Curr Opin Struct Biol (2003) 1.94
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Principles of E-cadherin supramolecular organization in vivo. Curr Biol (2013) 1.79
Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex. Genes Dev (2003) 1.78
A hidden oncogenic positive feedback loop caused by crosstalk between Wnt and ERK pathways. Oncogene (2007) 1.76
Convergence between Wnt-β-catenin and EGFR signaling in cancer. Mol Cancer (2010) 1.74
Transforming binding affinities from three dimensions to two with application to cadherin clustering. Nature (2011) 1.73
Spontaneous assembly and active disassembly balance adherens junction homeostasis. Proc Natl Acad Sci U S A (2010) 1.59
Modeling the influence of the E-cadherin-beta-catenin pathway in cancer cell invasion: a multiscale approach. Biophys J (2008) 1.57
Activity of the beta-catenin phosphodestruction complex at cell-cell contacts is enhanced by cadherin-based adhesion. J Cell Biol (2009) 1.57
A comprehensive model of the spatio-temporal stem cell and tissue organisation in the intestinal crypt. PLoS Comput Biol (2011) 1.55
p120-catenin binding masks an endocytic signal conserved in classical cadherins. J Cell Biol (2012) 1.48
Cooperativity between trans and cis interactions in cadherin-mediated junction formation. Proc Natl Acad Sci U S A (2010) 1.46
Wnt stabilization of β-catenin reveals principles for morphogen receptor-scaffold assemblies. Science (2013) 1.43
Frizzled and LRP5/6 receptors for Wnt/β-catenin signaling. Cold Spring Harb Perspect Biol (2012) 1.43
A positive role of cadherin in Wnt/β-catenin signalling during epithelial-mesenchymal transition. PLoS One (2011) 1.40
Signaling clusters in the cell membrane. Curr Opin Cell Biol (2011) 1.39
An integrative computational model for intestinal tissue renewal. Cell Prolif (2009) 1.36
Emerging links between CDK cell cycle regulators and Wnt signaling. Trends Cell Biol (2010) 1.27
Cadherin-bound beta-catenin feeds into the Wnt pathway upon adherens junctions dissociation: evidence for an intersection between beta-catenin pools. PLoS One (2009) 1.24
Kinetic responses of β-catenin specify the sites of Wnt control. Science (2012) 1.23
Signalling complexes and clusters: functional advantages and methodological hurdles. J Cell Sci (2010) 1.21
Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling. Mol Biol Cell (2011) 1.21
Wnt signalling pathway parameters for mammalian cells. PLoS One (2012) 1.20
Toward realistic modeling of dynamic processes in cell signaling: quantification of macromolecular crowding effects. J Chem Phys (2007) 1.20
The effects of macromolecular crowding on the mechanical stability of protein molecules. Protein Sci (2008) 1.12
A theoretical investigation of the effect of proliferation and adhesion on monoclonal conversion in the colonic crypt. J Theor Biol (2012) 1.07
Looking beyond the Wnt pathway for the deep nature of β-catenin. EMBO Rep (2013) 1.06
Elucidating the interactions between the adhesive and transcriptional functions of beta-catenin in normal and cancerous cells. J Theor Biol (2007) 1.01
Wnt pathway mutations selected by optimal beta-catenin signaling for tumorigenesis. FEBS Lett (2006) 1.01
Brownian dynamics simulation of nucleocytoplasmic transport: a coarse-grained model for the functional state of the nuclear pore complex. PLoS Comput Biol (2011) 0.99
Extended analyses of the Wnt/beta-catenin pathway: robustness and oscillatory behaviour. FEBS Lett (2007) 0.97
Toward a quantitative understanding of the Wnt/β-catenin pathway through simulation and experiment. Wiley Interdiscip Rev Syst Biol Med (2013) 0.96
Model reduction and analysis of robustness for the Wnt/beta-catenin signal transduction pathway. Genome Inform (2004) 0.95
A new validated mathematical model of the Wnt signalling pathway predicts effective combinational therapy by sFRP and Dkk. Biochem J (2012) 0.92
E-cadherin/catenin complexes are formed cotranslationally in the endoplasmic reticulum/Golgi compartments. Cell Commun Adhes (2008) 0.91
A multiple timescale analysis of a mathematical model of the Wnt/beta-catenin signalling pathway. J Math Biol (2009) 0.89
The three-dimensional structure of the cadherin-catenin complex. Subcell Biochem (2012) 0.84
Nucleo-cytoplasmic shuttling of APC can maximize β-catenin/TCF concentration. J Theor Biol (2011) 0.79
A coarse-grained model for the simulations of biomolecular interactions in cellular environments. J Chem Phys (2014) 0.77
Wnt signaling: the many interfaces of β-catenin. Curr Biol (2012) 0.76