Published in Physiology (Bethesda) on October 01, 2007
Cadherins and cancer: how does cadherin dysfunction promote tumor progression? Oncogene (2008) 3.63
Interplay of cadherin-mediated cell adhesion and canonical Wnt signaling. Cold Spring Harb Perspect Biol (2010) 3.02
Exosome release of β-catenin: a novel mechanism that antagonizes Wnt signaling. J Cell Biol (2010) 2.85
Platelets, petechiae, and preservation of the vascular wall. N Engl J Med (2008) 2.25
Wilms' tumours: about tumour suppressor genes, an oncogene and a chameleon gene. Nat Rev Cancer (2011) 2.02
Wnt-related molecules and signaling pathway equilibrium in hematopoiesis. Cell Stem Cell (2009) 2.00
Frequent long-range epigenetic silencing of protocadherin gene clusters on chromosome 5q31 in Wilms' tumor. PLoS Genet (2009) 1.77
Vinculin regulates cell-surface E-cadherin expression by binding to beta-catenin. J Cell Sci (2010) 1.60
Adhesive and signaling functions of cadherins and catenins in vertebrate development. Cold Spring Harb Perspect Biol (2009) 1.52
Regulation of Wnt/beta-catenin signaling by protein kinases. Dev Dyn (2010) 1.45
Wnt/beta-catenin signaling and small molecule inhibitors. Curr Pharm Des (2013) 1.44
Epithelial phenotype and the RPE: is the answer blowing in the Wnt? Prog Retin Eye Res (2008) 1.32
Overexpression of fatty acid synthase is associated with palmitoylation of Wnt1 and cytoplasmic stabilization of beta-catenin in prostate cancer. Lab Invest (2008) 1.30
β-Catenin signaling increases during melanoma progression and promotes tumor cell survival and chemoresistance. PLoS One (2011) 1.25
Wnt-5a-CKI{alpha} signaling promotes {beta}-catenin/E-cadherin complex formation and intercellular adhesion in human breast epithelial cells. J Biol Chem (2009) 1.18
Identification of beta-catenin as a target of the intracellular tyrosine kinase PTK6. J Cell Sci (2009) 1.10
Dissociation of E-cadherin and beta-catenin in a mouse model of total parenteral nutrition: a mechanism for the loss of epithelial cell proliferation and villus atrophy. J Physiol (2008) 1.08
Identification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the 'PTP-ome'. Genes Dev (2011) 1.06
Integrin regulation of beta-catenin signaling in ovarian carcinoma. J Biol Chem (2011) 1.06
Oncogenic KRAS signalling promotes the Wnt/β-catenin pathway through LRP6 in colorectal cancer. Oncogene (2014) 1.03
Reversal of gene dysregulation in cultured cytotrophoblasts reveals possible causes of preeclampsia. J Clin Invest (2013) 1.03
Activation of glycogen synthase kinase-3 beta is required for hyperdopamine and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex. J Neurosci (2009) 1.03
p120ctn and P-cadherin but not E-cadherin regulate cell motility and invasion of DU145 prostate cancer cells. PLoS One (2010) 1.02
Quantitative phosphoproteomics in nuclei of vasopressin-sensitive renal collecting duct cells. Am J Physiol Cell Physiol (2012) 0.98
Molecular targets for anti-oxidative protection of green tea polyphenols against myocardial ischemic injury. Biomedicine (Taipei) (2014) 0.98
Conformational epitopes at cadherin calcium-binding sites and p120-catenin phosphorylation regulate cell adhesion. Mol Biol Cell (2012) 0.98
Cadmium induces Wnt signaling to upregulate proliferation and survival genes in sub-confluent kidney proximal tubule cells. Mol Cancer (2010) 0.97
β-Catenin signaling initiates the activation of astrocytes and its dysregulation contributes to the pathogenesis of astrocytomas. Proc Natl Acad Sci U S A (2012) 0.96
The Wnt/β-catenin pathway in human fibrotic-like diseases and its eligibility as a therapeutic target. Mol Cell Ther (2015) 0.94
Mechanism of β-catenin-mediated transcriptional regulation of epidermal growth factor receptor expression in glycogen synthase kinase 3 β-inactivated prostate cancer cells. J Biol Chem (2012) 0.94
The γ-secretase cleavage product of polycystin-1 regulates TCF and CHOP-mediated transcriptional activation through a p300-dependent mechanism. Dev Cell (2011) 0.92
Above genetics: lessons from cerebral development in autism. Transl Neurosci (2011) 0.90
Nuclear signaling from cadherin adhesion complexes. Curr Top Dev Biol (2015) 0.90
Intercellular adhesion: mechanisms for growth and metastasis of epithelial cancers. Wiley Interdiscip Rev Syst Biol Med (2011) 0.90
Epigallocatechin-3-gallate-mediated cardioprotection by Akt/GSK-3β/caveolin signalling in H9c2 rat cardiomyoblasts. J Biomed Sci (2013) 0.90
A dual array-based approach to assess the abundance and posttranslational modification state of signaling proteins. Sci Signal (2012) 0.90
Threonine 393 of beta-catenin regulates interaction with Axin. J Cell Biochem (2009) 0.89
Signaling from the adherens junction. Subcell Biochem (2012) 0.89
Nemo kinase phosphorylates β-catenin to promote ommatidial rotation and connects core PCP factors to E-cadherin-β-catenin. Nat Struct Mol Biol (2011) 0.88
Vasopressin and the regulation of aquaporin-2. Clin Exp Nephrol (2013) 0.87
Non-muscle Mlck is required for β-catenin- and FoxO1-dependent downregulation of Cldn5 in IL-1β-mediated barrier dysfunction in brain endothelial cells. J Cell Sci (2014) 0.87
PIPKIγ regulates β-catenin transcriptional activity downstream of growth factor receptor signaling. Cancer Res (2011) 0.85
Ca2+/calmodulin-stimulated PDE1 regulates the beta-catenin/TCF signaling through PP2A B56 gamma subunit in proliferating vascular smooth muscle cells. FEBS J (2010) 0.85
The postsynaptic adenomatous polyposis coli (APC) multiprotein complex is required for localizing neuroligin and neurexin to neuronal nicotinic synapses in vivo. J Neurosci (2010) 0.84
CD82 inhibits canonical Wnt signalling by controlling the cellular distribution of β-catenin in carcinoma cells. Int J Oncol (2012) 0.84
The terminal region of beta-catenin promotes stability by shielding the Armadillo repeats from the axin-scaffold destruction complex. J Biol Chem (2009) 0.83
Snapshots of protein dynamics and post-translational modifications in one experiment--beta-catenin and its functions. Mol Cell Proteomics (2011) 0.83
Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium. EMBO J (2016) 0.82
Intersection of AHR and Wnt signaling in development, health, and disease. Int J Mol Sci (2014) 0.82
TNF-induced activation of pulmonary microvessel endothelial cells: a role for GSK3beta. Am J Physiol Lung Cell Mol Physiol (2009) 0.82
Beta-catenin phosphorylated at threonine 120 antagonizes generation of active beta-catenin by spatial localization in trans-Golgi network. PLoS One (2012) 0.82
Cadherin-mediated cell-cell adhesion and signaling in the skeleton. Calcif Tissue Int (2013) 0.82
Modulation of the ligand-independent traffic of Notch by Axin and Apc contributes to the activation of Armadillo in Drosophila. Development (2011) 0.82
Different modes of endothelial-smooth muscle cell interaction elicit differential β-catenin phosphorylations and endothelial functions. Proc Natl Acad Sci U S A (2014) 0.81
Beta-catenin signaling involves HGF-enhanced HepG2 scattering through activating MMP-7 transcription. Histochem Cell Biol (2010) 0.80
Changes in the distribution of type II transmembrane serine protease, TMPRSS2 and in paracellular permeability in IPEC-J2 cells exposed to oxidative stress. Inflammation (2015) 0.80
Inhibition of melanogenesis by the pyridinyl imidazole class of compounds: possible involvement of the Wnt/β-catenin signaling pathway. PLoS One (2012) 0.80
Computational modeling of the interplay between cadherin-mediated cell adhesion and Wnt signaling pathway. PLoS One (2014) 0.79
β catenin in health: A review. J Oral Maxillofac Pathol (2015) 0.79
TNFα-mediated loss of β-catenin/E-cadherin association and subsequent increase in cell migration is partially restored by NKX3.1 expression in prostate cells. PLoS One (2014) 0.79
Lack of Matrilin-2 favors liver tumor development via Erk1/2 and GSK-3β pathways in vivo. PLoS One (2014) 0.79
General aspects of colorectal cancer. ISRN Oncol (2012) 0.79
Expression and redistribution of β-catenin in the cardiac myocytes of left ventricle of spontaneously hypertensive rat. J Mol Histol (2013) 0.79
Activation of PPARγ2 by PPARγ1 through a functional PPRE in transdifferentiation of myoblasts to adipocytes induced by EPA. Cell Cycle (2015) 0.79
Altered {beta}-catenin accumulation in hepatocellular carcinomas of diethylnitrosamine-exposed rhesus macaques. Toxicol Pathol (2008) 0.78
Polycystin-1 cleavage and the regulation of transcriptional pathways. Pediatr Nephrol (2013) 0.78
Tumor necrosis factor-α induces increased lung vascular permeability: a role for GSK3α/β. Eur J Pharmacol (2011) 0.78
The effect of differentiation induction on FAK and Src activity in live HMSCs visualized by FRET. PLoS One (2013) 0.78
Src transformation of colonic epithelial cells: enhanced anchorage-independent growth in an Apc(+/min) background. Mol Carcinog (2009) 0.77
Adherens junction proteins in the hamster uterus: their contributions to the success of implantation. Biol Reprod (2011) 0.77
SIRT1 in B[a]P-induced lung tumorigenesis. Oncotarget (2015) 0.76
Sex-specific expression of CTNNB1 in the gonadal morphogenesis of the chicken. Reprod Biol Endocrinol (2013) 0.76
CCR6 expression in colon cancer is associated with advanced disease and supports epithelial-to-mesenchymal transition. Br J Cancer (2016) 0.75
The Role of E-Cadherin in Maintaining the Barrier Function of Corneal Epithelium after Treatment with Cultured Autologous Oral Mucosa Epithelial Cell Sheet Grafts for Limbal Stem Deficiency. J Ophthalmol (2016) 0.75
Synchronization by Daytime Restricted Food Access Modulates the Presence and Subcellular Distribution of β-Catenin and Its Phosphorylated Forms in the Rat Liver. Front Endocrinol (Lausanne) (2017) 0.75
The immunological effect of hyaluronan in tumor angiogenesis. Clin Transl Immunology (2015) 0.75
Cadherins and Wnt signalling: a functional link controlling bone formation. Bonekey Rep (2013) 0.75
Helicobacter pylori CagA and IL-1β Promote the Epithelial-to-Mesenchymal Transition in a Nontransformed Epithelial Cell Model. Gastroenterol Res Pract (2016) 0.75
Active GSK3β and an intact β-catenin TCF complex are essential for the differentiation of human myogenic progenitor cells. Sci Rep (2017) 0.75
Structural and functional characterization of the α-catenin·β-catenin binding interface in Caenorhabditis elegans reveals conserved requirements for cell-cell adhesion in metazoans. J Biol Chem (2017) 0.75
Wnt/beta-catenin signaling in development and disease. Cell (2006) 30.09
Wnt signaling and cancer. Genes Dev (2000) 18.53
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The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell (2002) 13.92
Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell (2002) 10.34
Regulation of cadherin-mediated adhesion in morphogenesis. Nat Rev Mol Cell Biol (2005) 9.27
Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly. Science (1996) 9.12
Deconstructing the cadherin-catenin-actin complex. Cell (2005) 8.39
The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3. Genes Dev (1996) 7.78
Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly. Cell (2005) 7.62
Three-dimensional structure of the armadillo repeat region of beta-catenin. Cell (1997) 7.35
Cell-adhesion molecule uvomorulin is localized in the intermediate junctions of adult intestinal epithelial cells. J Cell Biol (1985) 6.09
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A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation. Nature (2005) 5.50
Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction. Nature (2005) 4.88
A core function for p120-catenin in cadherin turnover. J Cell Biol (2003) 4.85
Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity. J Biol Chem (2007) 4.60
Wnt signaling controls the phosphorylation status of beta-catenin. J Biol Chem (2002) 4.40
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p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho. Cell (2006) 4.24
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The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell. Curr Biol (1999) 4.06
The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes. Genes Dev (2006) 3.85
The p300/CBP acetyltransferases function as transcriptional coactivators of beta-catenin in vertebrates. EMBO J (2000) 3.77
Regulation of E-cadherin/Catenin association by tyrosine phosphorylation. J Biol Chem (1999) 3.53
Cellular levels of p120 catenin function as a set point for cadherin expression levels in microvascular endothelial cells. J Cell Biol (2003) 3.39
Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1. EMBO J (1999) 3.18
Wnt signaling: complexity at the surface. J Cell Sci (2006) 3.11
Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase. J Biol Chem (2006) 3.10
P68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing Axin from beta-catenin. Cell (2006) 3.04
Wnt signals are transmitted through N-terminally dephosphorylated beta-catenin. EMBO Rep (2001) 3.02
Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions. Genes Dev (2004) 2.99
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The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation. EMBO J (2001) 2.87
Binding to cadherins antagonizes the signaling activity of beta-catenin during axis formation in Xenopus. J Cell Biol (1996) 2.86
shotgun encodes Drosophila E-cadherin and is preferentially required during cell rearrangement in the neurectoderm and other morphogenetically active epithelia. Genes Dev (1996) 2.83
Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex. Genes Dev (1999) 2.78
Coupling assembly of the E-cadherin/beta-catenin complex to efficient endoplasmic reticulum exit and basal-lateral membrane targeting of E-cadherin in polarized MDCK cells. J Cell Biol (1999) 2.62
Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase stabilizes beta-catenin through inhibition of its ubiquitination. Mol Cell Biol (2005) 2.62
Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo. Cell (2006) 2.47
Apc tumor suppressor gene is the "zonation-keeper" of mouse liver. Dev Cell (2006) 2.45
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Depolarization drives beta-Catenin into neuronal spines promoting changes in synaptic structure and function. Neuron (2002) 2.26
The cadherin cytoplasmic domain is unstructured in the absence of beta-catenin. A possible mechanism for regulating cadherin turnover. J Biol Chem (2000) 2.23
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Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency. Proc Natl Acad Sci U S A (2007) 2.15
Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activity. EMBO J (2000) 2.15
Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation. Mol Cell (2004) 2.13
Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin. Genes Dev (2006) 2.10
Thermodynamics of beta-catenin-ligand interactions: the roles of the N- and C-terminal tails in modulating binding affinity. J Biol Chem (2005) 2.04
Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex. Proc Natl Acad Sci U S A (2002) 2.04
Functional characterization of multiple transactivating elements in beta-catenin, some of which interact with the TATA-binding protein in vitro. J Biol Chem (1999) 1.98
Casein kinase II phosphorylation of E-cadherin increases E-cadherin/beta-catenin interaction and strengthens cell-cell adhesion. J Biol Chem (2000) 1.90
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Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex. Genes Dev (2003) 1.78
Nucleo-cytoplasmic distribution of beta-catenin is regulated by retention. J Cell Sci (2006) 1.78
Notch modulates Wnt signalling by associating with Armadillo/beta-catenin and regulating its transcriptional activity. Development (2005) 1.62
A mode of regulation of beta-catenin signaling activity in Xenopus embryos independent of its levels. Dev Biol (2000) 1.55
Armadillo repeat proteins: beyond the animal kingdom. Trends Cell Biol (2003) 1.55
Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex. EMBO J (2007) 1.55
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Pygopus and legless provide essential transcriptional coactivator functions to armadillo/beta-catenin. Curr Biol (2005) 1.50
Structure-function analysis of Frizzleds. Cell Signal (2006) 1.45
Axin: a master scaffold for multiple signaling pathways. Neurosignals (2004) 1.45
A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression. Biochem Biophys Res Commun (1999) 1.44
Armadillo nuclear import is regulated by cytoplasmic anchor Axin and nuclear anchor dTCF/Pan. Development (2001) 1.44
Wingless-independent association of Pygopus with dTCF target genes. Curr Biol (2007) 1.40
Axin-dependent phosphorylation of the adenomatous polyposis coli protein mediated by casein kinase 1epsilon. J Biol Chem (2001) 1.39
CK2 controls the recruitment of Wnt regulators to target genes in vivo. Curr Biol (2006) 1.30
Casein kinase 1 is a novel negative regulator of E-cadherin-based cell-cell contacts. Mol Cell Biol (2007) 1.30
RanBP3 enhances nuclear export of active (beta)-catenin independently of CRM1. J Cell Biol (2005) 1.29
Involvement of Src family kinases in N-cadherin phosphorylation and beta-catenin dissociation during transendothelial migration of melanoma cells. Mol Biol Cell (2005) 1.24
The tuberin-hamartin complex negatively regulates beta-catenin signaling activity. J Biol Chem (2003) 1.20
Mechanism of homophilic cadherin adhesion. Curr Opin Cell Biol (2000) 1.18
Retracted Beta-catenin N- and C-terminal tails modulate the coordinated binding of adherens junction proteins to beta-catenin. J Biol Chem (2002) 1.16
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Translocation of beta-catenin into the nucleus independent of interactions with FG-rich nucleoporins. Exp Cell Res (2003) 0.92
In situ phosphorylation of immobilized receptors on biosensor surfaces: application to E-cadherin/beta-catenin interactions. Anal Biochem (2006) 0.87
Functional correlates of mutations in beta-catenin exon 3 phosphorylation sites. J Biol Chem (2003) 0.86
Cell adhesion: separation of p120's powers? Curr Biol (2007) 0.79
Cyclin-dependent kinase 2 regulates the interaction of Axin with beta-catenin. Biochem Biophys Res Commun (2004) 0.79
Modulation of beta-catenin by cyclin-dependent kinase 6 in Wnt-stimulated cells. Eur J Cell Biol (2007) 0.78
Mitochondrial reactive oxygen species promote epidermal differentiation and hair follicle development. Sci Signal (2013) 2.78
Molecular components of the adherens junction. Biochim Biophys Acta (2008) 1.78
Polycystin-1 C-terminal tail associates with beta-catenin and inhibits canonical Wnt signaling. Hum Mol Genet (2008) 1.62
Wnt coreceptor Lrp5 is a driver of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med (2014) 1.61
Activity of the beta-catenin phosphodestruction complex at cell-cell contacts is enhanced by cadherin-based adhesion. J Cell Biol (2009) 1.57
Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: a novel mouse model for scleroderma? Arthritis Rheum (2011) 1.51
Regulation of Wnt/beta-catenin signaling by protein kinases. Dev Dyn (2010) 1.45
Nuclear β-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation. Am J Respir Cell Mol Biol (2011) 1.44
β-catenin signaling: a novel mediator of fibrosis and potential therapeutic target. Curr Opin Rheumatol (2011) 1.41
Beta-catenin/T-cell factor signaling is activated during lung injury and promotes the survival and migration of alveolar epithelial cells. J Biol Chem (2009) 1.35
Wnt/β-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells. Arthritis Rheum (2012) 1.22
α-catenin cytomechanics--role in cadherin-dependent adhesion and mechanotransduction. J Cell Sci (2014) 1.17
Beta-catenin phosphorylated at serine 45 is spatially uncoupled from beta-catenin phosphorylated in the GSK3 domain: implications for signaling. PLoS One (2010) 1.14
VE-cadherin and beta-catenin binding dynamics during histamine-induced endothelial hyperpermeability. Am J Physiol Cell Physiol (2008) 1.09
Integrin regulation of beta-catenin signaling in ovarian carcinoma. J Biol Chem (2011) 1.06
Nesprin-2 interacts with {alpha}-catenin and regulates Wnt signaling at the nuclear envelope. J Biol Chem (2010) 1.04
Paracrine activation of WNT/β-catenin pathway in uterine leiomyoma stem cells promotes tumor growth. Proc Natl Acad Sci U S A (2013) 0.98
Signaling from the adherens junction. Subcell Biochem (2012) 0.89
Role of von Hippel-Lindau protein in fibroblast proliferation and fibrosis. FASEB J (2011) 0.89
Nemo kinase phosphorylates β-catenin to promote ommatidial rotation and connects core PCP factors to E-cadherin-β-catenin. Nat Struct Mol Biol (2011) 0.88
UVB radiation-induced β-catenin signaling is enhanced by COX-2 expression in keratinocytes. Mol Carcinog (2011) 0.87
α-Catenin is an inhibitor of transcription. Proc Natl Acad Sci U S A (2014) 0.86
Issues associated with assessing nuclear localization of N-terminally unphosphorylated beta-catenin with monoclonal antibody 8E7. Biol Direct (2009) 0.86
Considerations for targeting β-catenin signaling in fibrosis. Am J Respir Crit Care Med (2013) 0.86
The terminal region of beta-catenin promotes stability by shielding the Armadillo repeats from the axin-scaffold destruction complex. J Biol Chem (2009) 0.83
When domestiques rebel: kinesins, cadherins and neuronal proliferation. Nat Cell Biol (2005) 0.79
Terminal regions of beta-catenin come into view. Structure (2008) 0.78
Regenerative pathways and emphysema: a new paradigm? Am J Respir Crit Care Med (2011) 0.77
ICAT is a novel Ptf1a interactor that regulates pancreatic acinar differentiation and displays altered expression in tumours. Biochem J (2013) 0.76
Tissue-specific knockout/knockdown of type 2 TGF-β receptor and protection against bleomycin injury/fibrosis. Am J Respir Crit Care Med (2011) 0.75
Fat in fibrosis. Am J Respir Crit Care Med (2013) 0.75
Terminating Wnt signals: a novel nuclear export mechanism targets activated (beta)-catenin. J Cell Biol (2005) 0.75
The increase in maternal expression of axin1 and axin2 contribute to the zebrafish mutant ichabod ventralized phenotype. J Cell Biochem (2015) 0.75