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Novel mutations target distinct subgroups of medulloblastoma. Nature (2012) 4.82

The many faces and functions of β-catenin. EMBO J (2012) 3.85

The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway. Nat Immunol (2010) 2.95

Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration. Cell (2011) 2.53

Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom). Genes Dev (2010) 2.53

beta-Catenin primes organizer gene expression by recruiting a histone H3 arginine 8 methyltransferase, Prmt2. Dev Cell (2010) 2.44

Lentiviral vectors to probe and manipulate the Wnt signaling pathway. PLoS One (2010) 2.28

The TCF-1 and LEF-1 transcription factors have cooperative and opposing roles in T cell development and malignancy. Immunity (2012) 2.15

A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription. Cancer Res (2010) 2.05

Wnt/β-catenin signaling regulates Yes-associated protein (YAP) gene expression in colorectal carcinoma cells. J Biol Chem (2012) 1.89

The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasis. PLoS Biol (2010) 1.81

Identification of {beta}-catenin binding regions in colon cancer cells using ChIP-Seq. Nucleic Acids Res (2010) 1.81

TCF/LEFs and Wnt signaling in the nucleus. Cold Spring Harb Perspect Biol (2012) 1.78

Licensed to elongate: a molecular mechanism for MLL-based leukaemogenesis. Nat Rev Cancer (2010) 1.77

Drug discovery approaches to target Wnt signaling in cancer stem cells. Oncotarget (2010) 1.71

Drugging Wnt signalling in cancer. EMBO J (2012) 1.63

Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. Nat Genet (2011) 1.60

When pathways collide: collaboration and connivance among signalling proteins in development. Nat Rev Mol Cell Biol (2010) 1.57

Somatic mutation as a mechanism of Wnt/β-catenin pathway activation in CLL. Blood (2014) 1.55

Regulation of Wnt/beta-catenin signaling by protein kinases. Dev Dyn (2010) 1.45

Targeting metabolic remodeling in glioblastoma multiforme. Oncotarget (2010) 1.42

A Role for MYC in Lithium-Stimulated Repair of the Colonic Epithelium After DSS-Induced Damage in Mice. Dig Dis Sci (2015) 1.40

Wnt/beta-catenin signaling in T-cell immunity and cancer immunotherapy. Clin Cancer Res (2010) 1.40

A beta-catenin/TCF-coordinated chromatin loop at MYC integrates 5' and 3' Wnt responsive enhancers. Proc Natl Acad Sci U S A (2009) 1.37

The way Wnt works: components and mechanism. Growth Factors (2012) 1.37

Wnt some lose some: transcriptional governance of stem cells by Wnt/β-catenin signaling. Genes Dev (2014) 1.33

The kinase TNIK is an essential activator of Wnt target genes. EMBO J (2009) 1.26

Epigenetics, hippocampal neurogenesis, and neuropsychiatric disorders: unraveling the genome to understand the mind. Neurobiol Dis (2010) 1.26

Probing transcription-specific outputs of β-catenin in vivo. Genes Dev (2011) 1.18

An intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acid. Nat Commun (2012) 1.11

Junctional music that the nucleus hears: cell-cell contact signaling and the modulation of gene activity. Cold Spring Harb Perspect Biol (2009) 1.09

Lithium rescues synaptic plasticity and memory in Down syndrome mice. J Clin Invest (2012) 1.07

Multiple Wnt/ß-catenin responsive enhancers align with the MYC promoter through long-range chromatin loops. PLoS One (2011) 1.05

Wnt-induced transcriptional activation is exclusively mediated by TCF/LEF. EMBO J (2014) 1.05

Nesprin-2 interacts with {alpha}-catenin and regulates Wnt signaling at the nuclear envelope. J Biol Chem (2010) 1.04

Modulation of Wnt/β-catenin signaling and proliferation by a ferrous iron chelator with therapeutic efficacy in genetically engineered mouse models of cancer. Oncogene (2011) 1.04

A coactivator role of CARM1 in the dysregulation of β-catenin activity in colorectal cancer cell growth and gene expression. Mol Cancer Res (2011) 1.02

Endogenous retinoic acid regulates cardiac progenitor differentiation. Proc Natl Acad Sci U S A (2010) 1.02

The oligomeric state of CtBP determines its role as a transcriptional co-activator and co-repressor of Wingless targets. EMBO J (2011) 1.02

Wnt/β-catenin signalling induces MLL to create epigenetic changes in salivary gland tumours. EMBO J (2013) 1.02

Pygo2 associates with MLL2 histone methyltransferase and GCN5 histone acetyltransferase complexes to augment Wnt target gene expression and breast cancer stem-like cell expansion. Mol Cell Biol (2010) 1.01

Nanowire-mediated delivery enables functional interrogation of primary immune cells: application to the analysis of chronic lymphocytic leukemia. Nano Lett (2012) 1.01

Inhibition of androgen receptor and β-catenin activity in prostate cancer. Proc Natl Acad Sci U S A (2013) 1.01

Shared molecular mechanisms regulate multiple catenin proteins: canonical Wnt signals and components modulate p120-catenin isoform-1 and additional p120 subfamily members. J Cell Sci (2010) 0.99

mrhl RNA, a long noncoding RNA, negatively regulates Wnt signaling through its protein partner Ddx5/p68 in mouse spermatogonial cells. Mol Cell Biol (2012) 0.99

Colon cancer stem cells. Gastrointest Cancer Res (2010) 0.98

Paracrine activation of WNT/β-catenin pathway in uterine leiomyoma stem cells promotes tumor growth. Proc Natl Acad Sci U S A (2013) 0.98

β-Catenin promotes colitis and colon cancer through imprinting of proinflammatory properties in T cells. Sci Transl Med (2014) 0.96

Requirement of TCF7L2 for TGF-beta-dependent transcriptional activation of the TMEPAI gene. J Biol Chem (2010) 0.96

Ca2+-mediated mitochondrial reactive oxygen species metabolism augments Wnt/β-catenin pathway activation to facilitate cell differentiation. J Biol Chem (2014) 0.96

SRSF1 and SRSF9 RNA binding proteins promote Wnt signalling-mediated tumorigenesis by enhancing β-catenin biosynthesis. EMBO Mol Med (2013) 0.95

Global gene expression profiling of somatic motor neuron populations with different vulnerability identify molecules and pathways of degeneration and protection. Brain (2010) 0.95

Wnt/β-catenin Signaling in Normal and Cancer Stem Cells. Cancers (Basel) (2011) 0.94

Dissecting Major Signaling Pathways throughout the Development of Prostate Cancer. Prostate Cancer (2013) 0.94

A Comprehensive Overview of Skeletal Phenotypes Associated with Alterations in Wnt/β-catenin Signaling in Humans and Mice. Bone Res (2013) 0.94

Regulation of ubiquitination-mediated protein degradation by survival kinases in cancer. Front Oncol (2012) 0.93

Chemical Enhancement of In Vitro and In Vivo Direct Cardiac Reprogramming. Circulation (2016) 0.93

En1 and Wnt signaling in midbrain dopaminergic neuronal development. Neural Dev (2011) 0.92

Jerky/Earthbound facilitates cell-specific Wnt/Wingless signalling by modulating β-catenin-TCF activity. EMBO J (2011) 0.92

c-Cbl, a ubiquitin E3 ligase that targets active β-catenin: a novel layer of Wnt signaling regulation. J Biol Chem (2013) 0.92

β-Catenin-independent activation of TCF1/LEF1 in human hematopoietic tumor cells through interaction with ATF2 transcription factors. PLoS Genet (2013) 0.91

Targeting self-renewal pathways in cancer stem cells: clinical implications for cancer therapy. Oncogenesis (2015) 0.90

Integrative ChIP-seq/microarray analysis identifies a CTNNB1 target signature enriched in intestinal stem cells and colon cancer. PLoS One (2014) 0.90

Epithelial stem cells: an epigenetic and Wnt-centric perspective. J Cell Biochem (2010) 0.89

Reversible modification of adenomatous polyposis coli (APC) with K63-linked polyubiquitin regulates the assembly and activity of the β-catenin destruction complex. J Biol Chem (2012) 0.89

Pre-clinical efficacy of combined therapy with novel β-catenin antagonist BC2059 and histone deacetylase inhibitor against AML cells. Leukemia (2014) 0.88

Combined inhibition of EGFR and c-ABL suppresses the growth of triple-negative breast cancer growth through inhibition of HOTAIR. Oncotarget (2015) 0.88

Down's-syndrome-related kinase Dyrk1A modulates the p120-catenin-Kaiso trajectory of the Wnt signaling pathway. J Cell Sci (2012) 0.88

In vitro effects of a small-molecule antagonist of the Tcf/ß-catenin complex on endometrial and endometriotic cells of patients with endometriosis. PLoS One (2013) 0.88

Repression of Wnt signaling by a Fer-type nonreceptor tyrosine kinase. Proc Natl Acad Sci U S A (2010) 0.87

A dynamic exchange of TCF3 and TCF4 transcription factors controls MYC expression in colorectal cancer cells. Cell Cycle (2015) 0.87

Winning WNT: race to Wnt signaling inhibitors. Proc Natl Acad Sci U S A (2011) 0.87

Wnt signaling through T-cell factor phosphorylation. Cell Res (2011) 0.87

Updating the Wnt pathways. Biosci Rep (2014) 0.86

Allosteric remodelling of the histone H3 binding pocket in the Pygo2 PHD finger triggered by its binding to the B9L/BCL9 co-factor. J Mol Biol (2010) 0.86

Identification of two Wnt-responsive elements in the intron of RING finger protein 43 (RNF43) gene. PLoS One (2014) 0.85

Wnt gene expression in human trabecular meshwork cells. Mol Vis (2010) 0.85

BCL9/9L-β-catenin Signaling is Associated With Poor Outcome in Colorectal Cancer. EBioMedicine (2015) 0.85

Ring Finger Protein 14 is a new regulator of TCF/β-catenin-mediated transcription and colon cancer cell survival. EMBO Rep (2013) 0.85

A Protein Interaction between β-Catenin and Dnmt1 Regulates Wnt Signaling and DNA Methylation in Colorectal Cancer Cells. Mol Cancer Res (2015) 0.84

Endothelial progenitor cell dysfunction in myelodysplastic syndromes: possible contribution of a defective vascular niche to myelodysplasia. Neoplasia (2015) 0.84

Monitoring interactions and dynamics of endogenous beta-catenin with intracellular nanobodies in living cells. Mol Cell Proteomics (2015) 0.84

Pro-growth role of the JMJD2C histone demethylase in HCT-116 colon cancer cells and identification of curcuminoids as JMJD2 inhibitors. Am J Transl Res (2014) 0.84

Fas signal promotes the immunosuppressive function of regulatory dendritic cells via the ERK/β-catenin pathway. J Biol Chem (2013) 0.84

Mechanism of Wnt signaling induced down regulation of mrhl long non-coding RNA in mouse spermatogonial cells. Nucleic Acids Res (2015) 0.84

Serotonin: a novel bone mass controller may have implications for alveolar bone. J Negat Results Biomed (2013) 0.84

Epigenome-guided analysis of the transcriptome of plaque macrophages during atherosclerosis regression reveals activation of the Wnt signaling pathway. PLoS Genet (2014) 0.84

DEAD-box protein p68 is regulated by β-catenin/transcription factor 4 to maintain a positive feedback loop in control of breast cancer progression. Breast Cancer Res (2014) 0.84

The TCF C-clamp DNA binding domain expands the Wnt transcriptome via alternative target recognition. Nucleic Acids Res (2014) 0.84

Intrinsic properties of Tcf1 and Tcf4 splice variants determine cell-type-specific Wnt/β-catenin target gene expression. Nucleic Acids Res (2012) 0.83

A strong promoter activity of pre-B cell stage-specific Crlz1 gene is caused by one distal LEF-1 and multiple proximal Ets sites. Mol Cells (2011) 0.83

The Myc 3' Wnt-responsive element regulates homeostasis and regeneration in the mouse intestinal tract. Mol Cell Biol (2012) 0.83

Construction and Experimental Validation of a Petri Net Model of Wnt/β-Catenin Signaling. PLoS One (2016) 0.82

Epigenetic regulation of WNT signaling in chronic lymphocytic leukemia. Epigenomics (2010) 0.82

Regulation of MYC gene expression by aberrant Wnt/β-catenin signaling in colorectal cancer. World J Biol Chem (2015) 0.82

Phosphosulindac (OXT-328) selectively targets breast cancer stem cells in vitro and in human breast cancer xenografts. Stem Cells (2012) 0.82

Wnt ligands regulate Tkv expression to constrain Dpp activity in the Drosophila ovarian stem cell niche. J Cell Biol (2015) 0.81

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Pax6-dependent, but β-catenin-independent, function of Bcl9 proteins in mouse lens development. Genes Dev (2014) 0.81

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Wnt/β-catenin signaling regulates sequential fate decisions of murine cortical precursor cells. Stem Cells (2015) 0.83

Wnt lipid modifications: not as saturated as we thought. Dev Cell (2006) 0.81

Sphingolipid depletion impairs endocytic traffic and inhibits Wingless signaling. Mech Dev (2013) 0.81

Coop functions as a corepressor of Pangolin and antagonizes Wingless signaling. Genes Dev (2010) 0.80

A reverse genetic screen in Drosophila using a deletion-inducing mutagen. Genome Biol (2004) 0.80

The Pygo2-H3K4me2/3 interaction is dispensable for mouse development and Wnt signaling-dependent transcription. Development (2013) 0.79

Morphogen gradients: expand and repress. Curr Biol (2011) 0.79

Manipulating the sensitivity of signal-induced repression: quantification and consequences of altered brinker gradients. PLoS One (2013) 0.78

Quantitative proteomics: a central technology for systems biology. J Proteomics (2009) 0.77

Multiorder correction algorithms to remove image distortions from mass spectrometry imaging data sets. Anal Chem (2013) 0.77

Powerful Drosophila screens that paved the wingless pathway. Fly (Austin) (2015) 0.76

A RING finger to wed TCF and β-catenin. EMBO Rep (2013) 0.75

Confronting morphogen gradients: how important are they for growth? Sci Signal (2009) 0.75

Correction for Zhang et al., The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proc Natl Acad Sci U S A (2015) 0.75

DIGESTIF: a universal quality standard for the control of bottom-up proteomics experiments. J Proteome Res (2014) 0.75