Bioengineering paradigms for cell migration in confined microenvironments.

PubWeight™: 0.82‹?›

🔗 View Article (PMC 4354884)

Published in Curr Opin Cell Biol on June 26, 2014

Authors

Kimberly M Stroka1, Zhizhan Gu1, Sean X Sun2, Konstantinos Konstantopoulos3

Author Affiliations

1: Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA; Johns Hopkins Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore, MD 21218, USA; Johns Hopkins Physical Sciences - Oncology Center, The Johns Hopkins University, Baltimore, MD 21218, USA.
2: Johns Hopkins Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore, MD 21218, USA; Johns Hopkins Physical Sciences - Oncology Center, The Johns Hopkins University, Baltimore, MD 21218, USA; Department of Mechanical Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA.
3: Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA; Johns Hopkins Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore, MD 21218, USA; Johns Hopkins Physical Sciences - Oncology Center, The Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address: konstant@jhu.edu.

Articles cited by this

Cellular motility driven by assembly and disassembly of actin filaments. Cell (2003) 26.05

Tissue cells feel and respond to the stiffness of their substrate. Science (2005) 23.42

Microenvironmental regulation of metastasis. Nat Rev Cancer (2008) 15.76

Taking cell-matrix adhesions to the third dimension. Science (2001) 15.21

Cell movement is guided by the rigidity of the substrate. Biophys J (2000) 13.84

Matrix metalloproteinase inhibitors and cancer: trials and tribulations. Science (2002) 12.29

Cell motility driven by actin polymerization. Biophys J (1996) 7.29

Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells. Nat Cell Biol (2007) 7.20

Cancer invasion and the microenvironment: plasticity and reciprocity. Cell (2011) 6.36

Intravital imaging of cell movement in tumours. Nat Rev Cancer (2003) 6.35

Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion. Nat Cell Biol (2007) 6.15

Spatiotemporal feedback between actomyosin and focal-adhesion systems optimizes rapid cell migration. Cell (2006) 6.02

Cellular motions and thermal fluctuations: the Brownian ratchet. Biophys J (1993) 5.99

One-dimensional topography underlies three-dimensional fibrillar cell migration. J Cell Biol (2009) 5.07

Chemotaxis: signalling the way forward. Nat Rev Mol Cell Biol (2004) 4.96

Cell interactions with three-dimensional matrices. Curr Opin Cell Biol (2002) 4.34

Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues. Nat Mater (2012) 4.10

Non-equilibration of hydrostatic pressure in blebbing cells. Nature (2005) 4.08

A distinctive role for focal adhesion proteins in three-dimensional cell motility. Nat Cell Biol (2010) 3.84

The physics of cancer: the role of physical interactions and mechanical forces in metastasis. Nat Rev Cancer (2011) 3.42

Mechanical modes of 'amoeboid' cell migration. Curr Opin Cell Biol (2009) 2.99

Collagen-based cell migration models in vitro and in vivo. Semin Cell Dev Biol (2009) 2.84

Stretchy proteins on stretchy substrates: the important elements of integrin-mediated rigidity sensing. Dev Cell (2010) 2.65

Dynamic imaging of cancer growth and invasion: a modified skin-fold chamber model. Histochem Cell Biol (2008) 2.39

Integrins and extracellular matrix in mechanotransduction. Cold Spring Harb Perspect Biol (2010) 2.36

Emergence of patterned stem cell differentiation within multicellular structures. Stem Cells (2008) 2.34

Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function. Proc Natl Acad Sci U S A (2012) 2.29

Physical and biochemical regulation of integrin release during rear detachment of migrating cells. J Cell Sci (1998) 2.23

Cell stiffness is a biomarker of the metastatic potential of ovarian cancer cells. PLoS One (2012) 2.23

The physics of cell motility. J Cell Sci Suppl (1987) 2.13

Intravital microscopy through an abdominal imaging window reveals a pre-micrometastasis stage during liver metastasis. Sci Transl Med (2012) 2.02

Aquaporins and cell migration. Pflugers Arch (2007) 2.02

Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival. J Cell Biol (2014) 2.01

Crossing the endothelial barrier during metastasis. Nat Rev Cancer (2013) 2.00

Making all the right moves: chemotaxis in neutrophils and Dictyostelium. Curr Opin Cell Biol (2004) 1.95

Independent regulation of tumor cell migration by matrix stiffness and confinement. Proc Natl Acad Sci U S A (2012) 1.89

Matrix geometry determines optimal cancer cell migration strategy and modulates response to interventions. Nat Cell Biol (2013) 1.84

Physical confinement alters tumor cell adhesion and migration phenotypes. FASEB J (2012) 1.74

Characterizing deformability and surface friction of cancer cells. Proc Natl Acad Sci U S A (2013) 1.72

Water permeation drives tumor cell migration in confined microenvironments. Cell (2014) 1.69

Intracellular fluid flow in rapidly moving cells. Nat Cell Biol (2009) 1.65

Implications of a poroelastic cytoplasm for the dynamics of animal cell shape. Semin Cell Dev Biol (2008) 1.64

Pushing off the walls: a mechanism of cell motility in confinement. Phys Rev Lett (2009) 1.56

Role of ion channels and transporters in cell migration. Physiol Rev (2012) 1.52

Cells move when ions and water flow. Pflugers Arch (2006) 1.52

p160ROCK mediates RhoA activation of Na-H exchange. EMBO J (1998) 1.45

Selective gene-expression profiling of migratory tumor cells in vivo predicts clinical outcome in breast cancer patients. Breast Cancer Res (2012) 1.43

Microfilament actin remodeling as a potential target for cancer drug development. Curr Cancer Drug Targets (2004) 1.41

Cortactin phosphorylation regulates cell invasion through a pH-dependent pathway. J Cell Biol (2011) 1.38

Correlation between cell deformability and metastatic potential in B16-F1 melanoma cell variants. Cancer Res (1988) 1.37

Distinct signaling mechanisms regulate migration in unconfined versus confined spaces. J Cell Biol (2013) 1.34

Endothelial cell substrate stiffness influences neutrophil transmigration via myosin light chain kinase-dependent cell contraction. Blood (2011) 1.31

Three-dimensional cell migration does not follow a random walk. Proc Natl Acad Sci U S A (2014) 1.30

Dimensional and temporal controls of three-dimensional cell migration by zyxin and binding partners. Nat Commun (2012) 1.30

Chemotaxis of cell populations through confined spaces at single-cell resolution. PLoS One (2012) 1.22

Focal localization of the NHE-1 isoform of the Na+/H+ antiport: assessment of effects on intracellular pH. EMBO J (1993) 1.22

Aquaporin-5: a marker protein for proliferation and migration of human breast cancer cells. PLoS One (2011) 1.19

Geometric control of vascular networks to enhance engineered tissue integration and function. Proc Natl Acad Sci U S A (2013) 1.19

Animal cell hydraulics. J Cell Sci (2009) 1.19

Polarization of Na(+)/H(+) and Cl(-)/HCO (3)(-) exchangers in migrating renal epithelial cells. J Gen Physiol (2000) 1.18

Shear-induced interleukin-6 synthesis in chondrocytes: roles of E prostanoid (EP) 2 and EP3 in cAMP/protein kinase A- and PI3-K/Akt-dependent NF-kappaB activation. J Biol Chem (2010) 1.18

Expression of aquaporin 5 (AQP5) promotes tumor invasion in human non small cell lung cancer. PLoS One (2008) 1.17

Neutrophils display biphasic relationship between migration and substrate stiffness. Cell Motil Cytoskeleton (2009) 1.17

Guidance of cell migration by substrate dimension. Biophys J (2013) 1.15

Preclinical intravital microscopy of the tumour-stroma interface: invasion, metastasis, and therapy response. Curr Opin Cell Biol (2013) 1.12

Cellular pressure and volume regulation and implications for cell mechanics. Biophys J (2013) 1.12

Microfabricated collagen tracks facilitate single cell metastatic invasion in 3D. Integr Biol (Camb) (2013) 1.09

Effect of inhibitors of Na+/H+-exchange and gastric H+/K+ ATPase on cell volume, intracellular pH and migration of human polymorphonuclear leucocytes. Br J Pharmacol (1998) 1.09

The carboxyl terminus of the alpha-subunit of the amiloride-sensitive epithelial sodium channel binds to F-actin. J Biol Chem (2005) 1.07

ATP dependence of NHE-1, the ubiquitous isoform of the Na+/H+ antiporter. Analysis of phosphorylation and subcellular localization. J Biol Chem (1994) 1.07

Aquaporin 2 promotes cell migration and epithelial morphogenesis. J Am Soc Nephrol (2012) 1.05

Mechanotransduction of fluid stresses governs 3D cell migration. Proc Natl Acad Sci U S A (2014) 1.02

Microfabricated physical spatial gradients for investigating cell migration and invasion dynamics. PLoS One (2011) 1.00

Physical biology in cancer. 4. Physical cues guide tumor cell adhesion and migration. Am J Physiol Cell Physiol (2013) 0.99

Mechanisms of leading edge protrusion in interstitial migration. Nat Commun (2013) 0.97

Integrin signaling modulates AQP2 trafficking via Arg-Gly-Asp (RGD) motif. Cell Physiol Biochem (2011) 0.96

Transforming potential and matrix stiffness co-regulate confinement sensitivity of tumor cell migration. Integr Biol (Camb) (2013) 0.96

HIV-1 Nef interferes with T-lymphocyte circulation through confined environments in vivo. Proc Natl Acad Sci U S A (2012) 0.95

Adhesion regulates MAP kinase/ternary complex factor exchange to control a proliferative transcriptional switch. Curr Biol (2012) 0.93

Microtubule depolymerization induces traction force increase through two distinct pathways. J Cell Sci (2011) 0.93

Biased migration of confined neutrophil-like cells in asymmetric hydraulic environments. Proc Natl Acad Sci U S A (2013) 0.92

The antagonistic actions of endogenous interleukin-1β and 15-deoxy-Δ12,14-prostaglandin J2 regulate the temporal synthesis of matrix metalloproteinase-9 in sheared chondrocytes. J Biol Chem (2012) 0.91

Microfluidic cell trap array for controlled positioning of single cells on adhesive micropatterns. Lab Chip (2013) 0.90

Cytoplasmic force gradient in migrating adhesive cells. Biophys J (2008) 0.90

Geometric friction directs cell migration. Phys Rev Lett (2013) 0.87

Cellular F-actin levels as a marker for cellular transformation: correlation with bladder cancer risk. Cancer Res (1991) 0.87

Relationship of aquaporin 1, 3, and 5 expression in lung cancer cells to cellular differentiation, invasive growth, and metastasis potential. Hum Pathol (2011) 0.86

The osmotic migration of cells in a solute gradient. Biophys J (1999) 0.86

A novel role for aquaporin-5 in enhancing microtubule organization and stability. PLoS One (2012) 0.85

A POROELASTIC MODEL FOR CELL CRAWLING INCLUDING MECHANICAL COUPLING BETWEEN CYTOSKELETAL CONTRACTION AND ACTIN POLYMERIZATION. J Mech Mater Struct (2011) 0.85

Regulation of Kir4.1 and AQP4 expression and stability at the basolateral domain of epithelial MDCK cells by the extracellular matrix. Am J Physiol Renal Physiol (2011) 0.85

Probing cell traction forces in confined microenvironments. Lab Chip (2013) 0.85

Micropatterning cell adhesion on polyacrylamide hydrogels. Methods Mol Biol (2013) 0.79

Master equation-based analysis of a motor-clutch model for cell traction force. Cell Mol Bioeng (2013) 0.79