Published in Nat Cell Biol on July 08, 2007
Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell (2009) 14.40
Matrix metalloproteinases: regulators of the tumor microenvironment. Cell (2010) 12.90
Collective cell migration in morphogenesis, regeneration and cancer. Nat Rev Mol Cell Biol (2009) 9.87
Plasticity of cell migration: a multiscale tuning model. J Cell Biol (2009) 5.82
Mechanics, malignancy, and metastasis: the force journey of a tumor cell. Cancer Metastasis Rev (2009) 4.36
The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function. Nat Rev Mol Cell Biol (2011) 4.24
Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited. J Cell Biol (2009) 4.04
Mechanotransduction gone awry. Nat Rev Mol Cell Biol (2009) 4.00
A distinctive role for focal adhesion proteins in three-dimensional cell motility. Nat Cell Biol (2010) 3.84
Physical limits of cell migration: control by ECM space and nuclear deformation and tuning by proteolysis and traction force. J Cell Biol (2013) 3.77
Chemotaxis in cancer. Nat Rev Cancer (2011) 3.68
Contact guidance mediated three-dimensional cell migration is regulated by Rho/ROCK-dependent matrix reorganization. Biophys J (2008) 3.49
The mechanical rigidity of the extracellular matrix regulates the structure, motility, and proliferation of glioma cells. Cancer Res (2009) 3.42
Nuclear shape, mechanics, and mechanotransduction. Circ Res (2008) 3.12
Migratory neighbors and distant invaders: tumor-associated niche cells. Genes Dev (2008) 2.95
Integrins in cell migration--the actin connection. J Cell Sci (2009) 2.88
A mechanoresponsive cadherin-keratin complex directs polarized protrusive behavior and collective cell migration. Dev Cell (2011) 2.87
Collagen-based cell migration models in vitro and in vivo. Semin Cell Dev Biol (2009) 2.84
Classifying collective cancer cell invasion. Nat Cell Biol (2012) 2.83
The actin cytoskeleton in cancer cell motility. Clin Exp Metastasis (2008) 2.82
Dynamic interplay between the collagen scaffold and tumor evolution. Curr Opin Cell Biol (2010) 2.79
Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6. Nat Cell Biol (2010) 2.58
Rac and Rho GTPases in cancer cell motility control. Cell Commun Signal (2010) 2.56
Mammary gland ECM remodeling, stiffness, and mechanosignaling in normal development and tumor progression. Cold Spring Harb Perspect Biol (2011) 2.48
Dynamic imaging of cancer growth and invasion: a modified skin-fold chamber model. Histochem Cell Biol (2008) 2.39
Nuclear mechanics during cell migration. Curr Opin Cell Biol (2010) 2.32
The actin-bundling protein fascin stabilizes actin in invadopodia and potentiates protrusive invasion. Curr Biol (2010) 2.23
ECM microenvironment regulates collective migration and local dissemination in normal and malignant mammary epithelium. Proc Natl Acad Sci U S A (2012) 2.20
Directed cell invasion and migration during metastasis. Curr Opin Cell Biol (2011) 2.12
The calpain system and cancer. Nat Rev Cancer (2011) 2.10
Endothelial cell lumen and vascular guidance tunnel formation requires MT1-MMP-dependent proteolysis in 3-dimensional collagen matrices. Blood (2009) 2.04
Significantly improved precision of cell migration analysis in time-lapse video microscopy through use of a fully automated tracking system. BMC Cell Biol (2010) 2.04
Mapping local matrix remodeling induced by a migrating tumor cell using three-dimensional multiple-particle tracking. Biophys J (2008) 1.99
Contractility of the cell rear drives invasion of breast tumor cells in 3D Matrigel. Proc Natl Acad Sci U S A (2011) 1.98
Synthesis of photodegradable hydrogels as dynamically tunable cell culture platforms. Nat Protoc (2010) 1.92
Velocity fields in a collectively migrating epithelium. Biophys J (2010) 1.90
Heterogeneous tumor subpopulations cooperate to drive invasion. Cell Rep (2014) 1.88
N-WASP-mediated invadopodium formation is involved in intravasation and lung metastasis of mammary tumors. J Cell Sci (2012) 1.84
Mapping proteolytic cancer cell-extracellular matrix interfaces. Clin Exp Metastasis (2008) 1.83
Preformed portals facilitate dendritic cell entry into afferent lymphatic vessels. J Exp Med (2009) 1.83
LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells. J Cell Biol (2010) 1.79
RAC1 activation mediates Twist1-induced cancer cell migration. Nat Cell Biol (2012) 1.69
Matrix metalloproteinases stimulate epithelial-mesenchymal transition during tumor development. Clin Exp Metastasis (2008) 1.69
Initial steps of metastasis: cell invasion and endothelial transmigration. Mutat Res (2011) 1.67
Elastic moduli of collagen gels can be predicted from two-dimensional confocal microscopy. Biophys J (2009) 1.66
Mechanical properties of cellularly responsive hydrogels and their experimental determination. Adv Mater (2010) 1.60
High-affinity peptide against MT1-MMP for in vivo tumor imaging. J Control Release (2011) 1.59
Extracellular matrix control of mammary gland morphogenesis and tumorigenesis: insights from imaging. Histochem Cell Biol (2008) 1.55
Collagen fibril flow and tissue translocation coupled to fibroblast migration in 3D collagen matrices. Mol Biol Cell (2008) 1.54
Distinct roles for paxillin and Hic-5 in regulating breast cancer cell morphology, invasion, and metastasis. Mol Biol Cell (2011) 1.54
Molecular dissection of the structural machinery underlying the tissue-invasive activity of membrane type-1 matrix metalloproteinase. Mol Biol Cell (2008) 1.54
Complement fragment C3a controls mutual cell attraction during collective cell migration. Dev Cell (2011) 1.54
Advances in tenascin-C biology. Cell Mol Life Sci (2011) 1.50
Comparative mechanisms of cancer cell migration through 3D matrix and physiological microtracks. Am J Physiol Cell Physiol (2014) 1.50
Cellular traction stresses increase with increasing metastatic potential. PLoS One (2012) 1.50
Discoidin domain receptor 2 regulates neutrophil chemotaxis in 3D collagen matrices. Blood (2012) 1.49
Integrin function in T-cell homing to lymphoid and nonlymphoid sites: getting there and staying there. Crit Rev Immunol (2009) 1.49
New dimensions in cell migration. Nat Rev Mol Cell Biol (2012) 1.46
Individual versus collective fibroblast spreading and migration: regulation by matrix composition in 3D culture. Exp Eye Res (2012) 1.46
Pleiotropic roles of matrix metalloproteinases in tumor angiogenesis: contrasting, overlapping and compensatory functions. Biochim Biophys Acta (2009) 1.46
FMN2 Makes Perinuclear Actin to Protect Nuclei during Confined Migration and Promote Metastasis. Cell (2016) 1.46
N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods. J Cell Biol (2012) 1.45
Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53. Cancer Res (2011) 1.44
Impact of tumor cell cytoskeleton organization on invasiveness and migration: a microchannel-based approach. PLoS One (2010) 1.43
Direct visualization of protease activity on cells migrating in three-dimensions. Matrix Biol (2008) 1.42
Fellow travellers: emergent properties of collective cell migration. EMBO Rep (2012) 1.41
The distinct roles of the nucleus and nucleus-cytoskeleton connections in three-dimensional cell migration. Sci Rep (2012) 1.36
Dimensions in cell migration. Curr Opin Cell Biol (2013) 1.36
MT4-(MMP17) and MT6-MMP (MMP25), A unique set of membrane-anchored matrix metalloproteinases: properties and expression in cancer. Cancer Metastasis Rev (2008) 1.34
Isoform-specific contributions of alpha-actinin to glioma cell mechanobiology. PLoS One (2009) 1.34
MT1-MMP- and Cdc42-dependent signaling co-regulate cell invasion and tunnel formation in 3D collagen matrices. J Cell Sci (2009) 1.33
Breast cancer progression: insights into multifaceted matrix metalloproteinases. Clin Exp Metastasis (2007) 1.32
Targeting tumor cell motility to prevent metastasis. Adv Drug Deliv Rev (2011) 1.32
Fibronectin in aging extracellular matrix fibrils is progressively unfolded by cells and elicits an enhanced rigidity response. Faraday Discuss (2008) 1.30
Endosomal WASH and exocyst complexes control exocytosis of MT1-MMP at invadopodia. J Cell Biol (2013) 1.28
Epidermal growth factor-induced enhancement of glioblastoma cell migration in 3D arises from an intrinsic increase in speed but an extrinsic matrix- and proteolysis-dependent increase in persistence. Mol Biol Cell (2008) 1.27
The role of the tissue microenvironment in the regulation of cancer cell motility and invasion. Cell Commun Signal (2010) 1.27
Investigating endothelial invasion and sprouting behavior in three-dimensional collagen matrices. Nat Protoc (2009) 1.26
2D protrusion but not motility predicts growth factor-induced cancer cell migration in 3D collagen. J Cell Biol (2012) 1.26
Rheology and confocal reflectance microscopy as probes of mechanical properties and structure during collagen and collagen/hyaluronan self-assembly. Biophys J (2009) 1.25
Biophysical control of invasive tumor cell behavior by extracellular matrix microarchitecture. Biomaterials (2012) 1.24
Adhesion rings surround invadopodia and promote maturation. Biol Open (2012) 1.23
Keratins significantly contribute to cell stiffness and impact invasive behavior. Proc Natl Acad Sci U S A (2013) 1.23
Multiparametric classification links tumor microenvironments with tumor cell phenotype. PLoS Biol (2014) 1.22
Orientation and polarity in collectively migrating cell structures: statics and dynamics. Biophys J (2011) 1.22
Physico-mechanical aspects of extracellular matrix influences on tumorigenic behaviors. Semin Cancer Biol (2010) 1.21
Mechanisms of force generation and force transmission during interstitial leukocyte migration. EMBO Rep (2010) 1.21
Microfluidics-based devices: New tools for studying cancer and cancer stem cell migration. Biomicrofluidics (2011) 1.21
Basement membrane sliding and targeted adhesion remodels tissue boundaries during uterine-vulval attachment in Caenorhabditis elegans. Nat Cell Biol (2011) 1.20
Targeting tumor cell motility as a strategy against invasion and metastasis. Trends Pharmacol Sci (2013) 1.19
3D collagen alignment limits protrusions to enhance breast cancer cell persistence. Biophys J (2014) 1.19
Signaling inputs to invadopodia and podosomes. J Cell Sci (2013) 1.18
Leading malignant cells initiate collective epithelial cell invasion in a three-dimensional heterotypic tumor spheroid model. Clin Exp Metastasis (2013) 1.18
The Wnt/planar cell polarity protein-tyrosine kinase-7 (PTK7) is a highly efficient proteolytic target of membrane type-1 matrix metalloproteinase: implications in cancer and embryogenesis. J Biol Chem (2010) 1.17
Interstitial cell migration: integrin-dependent and alternative adhesion mechanisms. Cell Tissue Res (2009) 1.16
Tumor cell migration in complex microenvironments. Cell Mol Life Sci (2012) 1.16
Implications of the Hybrid Epithelial/Mesenchymal Phenotype in Metastasis. Front Oncol (2015) 1.15
Interplay between β1-integrin and Rho signaling regulates differential scattering and motility of pancreatic cancer cells by snail and Slug proteins. J Biol Chem (2012) 1.12
Epithelial and mesenchymal phenotypic switchings modulate cell motility in metastasis. Front Biosci (Landmark Ed) (2011) 1.12
The front and rear of collective cell migration. Nat Rev Mol Cell Biol (2016) 1.12
Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis. J Cell Biol (2003) 7.89
Physical limits of cell migration: control by ECM space and nuclear deformation and tuning by proteolysis and traction force. J Cell Biol (2013) 3.77
Differential regulation of protrusion and polarity by PI3K during neutrophil motility in live zebrafish. Dev Cell (2010) 3.19
Collagen-based cell migration models in vitro and in vivo. Semin Cell Dev Biol (2009) 2.84
Collective cell movement in primary melanoma explants: plasticity of cell-cell interaction, beta1-integrin function, and migration strategies. Cancer Res (2002) 2.55
The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways. Blood (2012) 2.47
Light-mediated activation reveals a key role for Rac in collective guidance of cell movement in vivo. Nat Cell Biol (2010) 2.45
Amoeboid shape change and contact guidance: T-lymphocyte crawling through fibrillar collagen is independent of matrix remodeling by MMPs and other proteases. Blood (2003) 2.40
Dynamic imaging of cancer growth and invasion: a modified skin-fold chamber model. Histochem Cell Biol (2008) 2.39
Readily accessible bicyclononynes for bioorthogonal labeling and three-dimensional imaging of living cells. Angew Chem Int Ed Engl (2010) 2.36
Mechanisms of collective cell migration at a glance. J Cell Sci (2009) 2.15
Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition. Circ Res (2007) 2.05
A woman who gained weight and became schizophrenic. Lancet (2002) 2.04
Membrane protease proteomics: Isotope-coded affinity tag MS identification of undescribed MT1-matrix metalloproteinase substrates. Proc Natl Acad Sci U S A (2004) 1.91
Engagement of collagen-binding integrins promotes matrix metalloproteinase-9-dependent E-cadherin ectodomain shedding in ovarian carcinoma cells. Cancer Res (2007) 1.90
Infrared multiphoton microscopy: subcellular-resolved deep tissue imaging. Curr Opin Biotechnol (2009) 1.86
Mapping proteolytic cancer cell-extracellular matrix interfaces. Clin Exp Metastasis (2008) 1.83
Extracellular matrix determinants of proteolytic and non-proteolytic cell migration. Trends Cell Biol (2011) 1.82
Proinvasive properties of ovarian cancer ascites-derived membrane vesicles. Cancer Res (2004) 1.69
The fibrin-derived peptide Bbeta15-42 protects the myocardium against ischemia-reperfusion injury. Nat Med (2005) 1.66
Phenotypic plasticity of neoplastic ovarian epithelium: unique cadherin profiles in tumor progression. Clin Exp Metastasis (2008) 1.65
Stathmin activity influences sarcoma cell shape, motility, and metastatic potential. Mol Biol Cell (2008) 1.62
Vimentin organization modulates the formation of lamellipodia. Mol Biol Cell (2011) 1.60
Human retinal pigment epithelium cells as functional models for the RPE in vivo. Invest Ophthalmol Vis Sci (2011) 1.55
A spectrum of biophysical interaction modes between T cells and different antigen-presenting cells during priming in 3-D collagen and in vivo. Blood (2004) 1.54
Ablation of matrix metalloproteinase-9 increases severity of viral myocarditis in mice. Circulation (2008) 1.54
Proteases, extracellular matrix, and cancer: a workshop of the path B study section. Am J Pathol (2004) 1.52
Matrix metalloproteinase 9 is a mediator of epidermal growth factor-dependent e-cadherin loss in ovarian carcinoma cells. Cancer Res (2008) 1.51
Molecular mechanisms of cancer cell invasion and plasticity. Br J Dermatol (2006) 1.50
Membrane type 1-matrix metalloproteinase: substrate diversity in pericellular proteolysis. Semin Cell Dev Biol (2007) 1.50
Cancer invasion and resistance: interconnected processes of disease progression and therapy failure. Trends Mol Med (2011) 1.49
p53 family members in myogenic differentiation and rhabdomyosarcoma development. Cancer Cell (2006) 1.47
The tumor suppressor functions of p27(kip1) include control of the mesenchymal/amoeboid transition. Mol Cell Biol (2009) 1.43
Genomic instability of micronucleated cells revealed by single-cell comparative genomic hybridization. Cytometry A (2009) 1.43
Interstitial guidance of cancer invasion. J Pathol (2012) 1.42
Cyclooxygenase-2 functions as a downstream mediator of lysophosphatidic acid to promote aggressive behavior in ovarian carcinoma cells. Cancer Res (2005) 1.39
Epidermal growth factor receptor inhibition promotes desmosome assembly and strengthens intercellular adhesion in squamous cell carcinoma cells. J Biol Chem (2004) 1.37
Determinants of leader cells in collective cell migration. Integr Biol (Camb) (2010) 1.37
Two-photon laser-generated microtracks in 3D collagen lattices: principles of MMP-dependent and -independent collective cancer cell invasion. Phys Biol (2011) 1.30
Microenvironmental regulation of membrane type 1 matrix metalloproteinase activity in ovarian carcinoma cells via collagen-induced EGR1 expression. J Biol Chem (2006) 1.24
Invasion of porcine brain microvascular endothelial cells by Streptococcus suis serotype 2. Infect Immun (2004) 1.22
Critical role of lysophospholipids in the pathophysiology, diagnosis, and management of ovarian cancer. Cancer Treat Res (2002) 1.22
Selective hydrolysis of triple-helical substrates by matrix metalloproteinase-2 and -9. J Biol Chem (2003) 1.22
Interstitial cell migration: integrin-dependent and alternative adhesion mechanisms. Cell Tissue Res (2009) 1.16
Cell surface chondroitin sulfate glycosaminoglycan in melanoma: role in the activation of pro-MMP-2 (pro-gelatinase A). Biochem J (2007) 1.16
Platelet NAD(P)H-oxidase-generated ROS production regulates alphaIIbbeta3-integrin activation independent of the NO/cGMP pathway. Blood (2005) 1.15
Glycosylation broadens the substrate profile of membrane type 1 matrix metalloproteinase. J Biol Chem (2003) 1.14
The RacGEF Tiam1 inhibits migration and invasion of metastatic melanoma via a novel adhesive mechanism. J Cell Sci (2004) 1.14
Preclinical intravital microscopy of the tumour-stroma interface: invasion, metastasis, and therapy response. Curr Opin Cell Biol (2013) 1.12
Ovarian cancer cell detachment and multicellular aggregate formation are regulated by membrane type 1 matrix metalloproteinase: a potential role in I.p. metastatic dissemination. Cancer Res (2009) 1.10
Influence of corneal collagen crosslinking with riboflavin and ultraviolet-a irradiation on excimer laser surgery. Invest Ophthalmol Vis Sci (2010) 1.09
Down-regulation of integrin alpha2 surface expression by mutant epidermal growth factor receptor (EGFRvIII) induces aberrant cell spreading and focal adhesion formation. Cancer Res (2005) 1.09
p27kip1 controls cell morphology and motility by regulating microtubule-dependent lipid raft recycling. Mol Cell Biol (2010) 1.08
Modulation of the membrane type 1 matrix metalloproteinase cytoplasmic tail enhances tumor cell invasion and proliferation in three-dimensional collagen matrices. J Biol Chem (2009) 1.08
Calcium regulation of matrix metalloproteinase-mediated migration in oral squamous cell carcinoma cells. J Biol Chem (2002) 1.07
Polypyrimidine tract-binding protein (PTB) differentially affects malignancy in a cell line-dependent manner. J Biol Chem (2008) 1.07
Integrin regulation of beta-catenin signaling in ovarian carcinoma. J Biol Chem (2011) 1.06
Expressing a gene encoding wheat oxalate oxidase enhances resistance to Sclerotinia sclerotiorum in oilseed rape (Brassica napus). Planta (2008) 1.06
Diverse mechanisms for activation of Wnt signalling in the ovarian tumour microenvironment. Biochem J (2011) 1.05
Functional relevance of urinary-type plasminogen activator receptor-alpha3beta1 integrin association in proteinase regulatory pathways. J Biol Chem (2006) 1.04
Proteinase suppression by E-cadherin-mediated cell-cell attachment in premalignant oral keratinocytes. J Biol Chem (2002) 1.02
Peptide Bbeta(15-42) preserves endothelial barrier function in shock. PLoS One (2009) 1.02
Functional imaging of pericellular proteolysis in cancer cell invasion. Biochimie (2005) 1.02
Release of cell fragments by invading melanoma cells. Eur J Cell Biol (2004) 1.01
Motility-related actinin alpha-4 is associated with advanced and metastatic ovarian carcinoma. Lab Invest (2008) 1.01
MMP13 mediates cell cycle progression in melanocytes and melanoma cells: in vitro studies of migration and proliferation. Mol Cancer (2010) 1.01
Human endothelial cells selectively express large amounts of pancreatic-type ribonuclease (RNase 1). J Cell Biochem (2002) 1.01
External push and internal pull forces recruit curvature-sensing N-BAR domain proteins to the plasma membrane. Nat Cell Biol (2012) 1.00
Haemophilus parasuis invades porcine brain microvascular endothelial cells. Microbiology (2006) 1.00
Microenvironmental regulation of ovarian cancer metastasis. Cancer Treat Res (2009) 0.99
Lysophosphatidic acid down-regulates stress fibers and up-regulates pro-matrix metalloproteinase-2 activation in ovarian cancer cells. Mol Cancer Res (2007) 0.99
Bisphosphonate effects on the behaviour of oral epithelial cells and oral fibroblasts. Arch Oral Biol (2010) 0.99
Mesenchymal transformation in epithelial ovarian tumor cells expressing epidermal growth factor receptor variant III. Mol Carcinog (2006) 0.98
Microarray and proteomic analysis of breast cancer cell and osteoblast co-cultures: role of osteoblast matrix metalloproteinase (MMP)-13 in bone metastasis. J Biol Chem (2011) 0.97
Microenvironmental regulation of chemokine (C-X-C-motif) receptor 4 in ovarian carcinoma. Mol Cancer Res (2010) 0.97
Targeting the EGF receptor for ovarian cancer therapy. J Oncol (2009) 0.96
Potent inhibition of human platelets by cGMP analogs independent of cGMP-dependent protein kinase. Blood (2003) 0.96
Confocal reflection imaging of 3D fibrin polymers. Blood Cells Mol Dis (2006) 0.96
Pushing the limit: masticatory stress and adaptive plasticity in mammalian craniomandibular joints. J Exp Biol (2007) 0.95
Downregulation of connective tissue growth factor by three-dimensional matrix enhances ovarian carcinoma cell invasion. Int J Cancer (2009) 0.95
Synthesis and anticancer activities of 6-amino amonafide derivatives. Anticancer Drugs (2008) 0.94
Urinary-type plasminogen activator (uPA) and its receptor (uPAR) in squamous cell carcinoma of the oral cavity. Biochem J (2007) 0.94
Mannose-binding lectin (MBL) mutants are susceptible to matrix metalloproteinase proteolysis: potential role in human MBL deficiency. J Biol Chem (2002) 0.93
Thrombin stimulation of p38 MAP kinase in human platelets is mediated by ADP and thromboxane A2 and inhibited by cGMP/cGMP-dependent protein kinase. Blood (2006) 0.93