Published in J Biol Chem on May 25, 1989
Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions. Biochem J (1999) 9.00
The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets. Mol Cell (2010) 5.06
Genome-wide reprogramming in the mouse germ line entails the base excision repair pathway. Science (2010) 4.32
Transcriptional control by PARP-1: chromatin modulation, enhancer-binding, coregulation, and insulation. Curr Opin Cell Biol (2008) 3.18
Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler. Proc Natl Acad Sci U S A (2009) 3.02
Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B. Proc Natl Acad Sci U S A (1996) 1.90
Dual roles of PARP-1 promote cancer growth and progression. Cancer Discov (2012) 1.63
PARP inhibition versus PARP-1 silencing: different outcomes in terms of single-strand break repair and radiation susceptibility. Nucleic Acids Res (2008) 1.61
The Zn3 domain of human poly(ADP-ribose) polymerase-1 (PARP-1) functions in both DNA-dependent poly(ADP-ribose) synthesis activity and chromatin compaction. J Biol Chem (2010) 1.47
PARP1 promotes gene expression at the post-transcriptiona level by modulating the RNA-binding protein HuR. Nat Commun (2017) 1.38
PARP-1 and PARP-2: New players in tumour development. Am J Cancer Res (2011) 1.23
Poly (ADP-ribose) polymerase 1 is required for protein localization to Cajal body. PLoS Genet (2009) 1.15
Disruption of poly(ADP-ribosyl)ation mechanisms alters responses of Arabidopsis to biotic stress. Plant Physiol (2009) 1.12
Regulation of poly(ADP-ribose) polymerase-1 (PARP-1) gene expression through the post-translational modification of Sp1: a nuclear target protein of PARP-1. BMC Mol Biol (2007) 1.10
Post-translational modifications of histones that influence nucleosome dynamics. Chem Rev (2014) 0.99
Targeting poly(ADP-ribose) polymerase activity for cancer therapy. Cell Mol Life Sci (2010) 0.96
CHFR is important for the first wave of ubiquitination at DNA damage sites. Nucleic Acids Res (2012) 0.93
PARP-1: Friend or Foe of DNA Damage and Repair in Tumorigenesis? Cancers (Basel) (2013) 0.92
Transcriptional roles of PARP1 in cancer. Mol Cancer Res (2014) 0.91
Immunodetection of histone epitopes correlates with early stages of apoptosis in activated human peripheral T lymphocytes. Am J Pathol (1996) 0.90
PARP is involved in replicative aging in Neurospora crassa. Fungal Genet Biol (2010) 0.90
RANKL up-regulates brain-type creatine kinase via poly(ADP-ribose) polymerase-1 during osteoclastogenesis. J Biol Chem (2010) 0.87
PARP-1 enhances the mismatch-dependence of 5'-directed excision in human mismatch repair in vitro. DNA Repair (Amst) (2011) 0.87
Chromatin-modifying enzymes as therapeutic targets--Part 2. Expert Opin Ther Targets (2008) 0.85
ADP-ribosyltransferases Parp1 and Parp7 safeguard pluripotency of ES cells. Nucleic Acids Res (2014) 0.84
New Zealand white rabbits immunized with RNA-complexed total histones develop an autoimmune-like response. Clin Exp Immunol (1991) 0.84
Crosstalk between SET7/9-dependent methylation and ARTD1-mediated ADP-ribosylation of histone H1.4. Epigenetics Chromatin (2013) 0.83
Binding kinetics and activity of human poly(ADP-ribose) polymerase-1 on oligo-deoxyribonucleotide substrates. J Mol Recognit (2009) 0.83
Global Transcriptome Analysis Reveals That Poly(ADP-Ribose) Polymerase 1 Regulates Gene Expression through EZH2. Mol Cell Biol (2015) 0.79
PARP1 enhances lung adenocarcinoma metastasis by novel mechanisms independent of DNA repair. Oncogene (2016) 0.78
Poly(ADP-ribosyl)ation is recognized by ECT2 during mitosis. Cell Cycle (2014) 0.78
A comprehensive view of the epigenetic landscape. Part II: Histone post-translational modification, nucleosome level, and chromatin regulation by ncRNAs. Neurotox Res (2014) 0.77
Epstein-Barr Virus Oncoprotein LMP1 Mediates Epigenetic Changes in Host Gene Expression through PARP1. J Virol (2016) 0.76
Novel insights into the neuroendocrine control of inflammation: the role of GR and PARP1. Endocr Connect (2013) 0.76
Small interfering RNA mediated Poly (ADP-ribose) Polymerase-1 inhibition upregulates the heat shock response in a murine fibroblast cell line. J Inflamm (Lond) (2011) 0.75
The poly(ADP-ribose)-dependent chromatin remodeler Alc1 induces local chromatin relaxation upon DNA damage. Mol Biol Cell (2016) 0.75
Poly(ADP-ribose) polymerase-1 modulates Nrf2-dependent transcription. Free Radic Biol Med (2013) 0.75
Understanding specific functions of PARP-2: new lessons for cancer therapy. Am J Cancer Res (2016) 0.75
Co-operative interactions of oligonucleosomal DNA with the H1e histone variant and its poly(ADP-ribosyl)ated isoform. Biochem J (1996) 0.75
Is there an epigenetic component underlying the resistance of triple-negative breast cancers to parp inhibitors? Front Pharmacol (2012) 0.75
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Differ (2008) 10.45
Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature (1994) 10.22
Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell (1995) 9.22
Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions. Biochem J (1999) 9.00
Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis. Cancer Res (1993) 6.31
Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells. Proc Natl Acad Sci U S A (1997) 5.24
XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage. Mol Cell Biol (1998) 4.51
Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization. Science (1996) 4.38
Importance of poly(ADP-ribose) polymerase and its cleavage in apoptosis. Lesson from an uncleavable mutant. J Biol Chem (1998) 3.97
Molecular ordering of the cell death pathway. Bcl-2 and Bcl-xL function upstream of the CED-3-like apoptotic proteases. J Biol Chem (1996) 3.97
Immunolocalization of CENP-A suggests a distinct nucleosome structure at the inner kinetochore plate of active centromeres. Curr Biol (1997) 3.62
Second locus involved in human immunodeficiency virus type 1 resistance to protease inhibitors. J Virol (1996) 3.39
Impaired fitness of human immunodeficiency virus type 1 variants with high-level resistance to protease inhibitors. J Virol (1997) 3.29
PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase. J Biol Chem (1999) 2.92
Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution. Proc Natl Acad Sci U S A (1995) 2.89
Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks. Trends Biochem Sci (1995) 2.85
Base excision repair is impaired in mammalian cells lacking Poly(ADP-ribose) polymerase-1. Biochemistry (2000) 2.84
Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model? Mutat Res (2000) 2.81
Resistance to endotoxic shock as a consequence of defective NF-kappaB activation in poly (ADP-ribose) polymerase-1 deficient mice. EMBO J (1999) 2.75
High susceptibility to collagen-induced arthritis in mice lacking IFN-gamma receptors. J Immunol (1997) 2.59
A convenient method for the ATPase assay. Anal Biochem (1978) 2.56
The cytopathic effect of HIV is associated with apoptosis. Virology (1991) 2.43
Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells. EMBO J (1993) 2.38
Poly(ADP-ribosyl)ation of polynucleosomes causes relaxation of chromatin structure. Proc Natl Acad Sci U S A (1982) 2.37
Dynamin and beta-arrestin reveal distinct mechanisms for G protein-coupled receptor internalization. J Biol Chem (1996) 2.32
The second zinc-finger domain of poly(ADP-ribose) polymerase determines specificity for single-stranded breaks in DNA. Proc Natl Acad Sci U S A (1990) 2.32
Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis. Proc Natl Acad Sci U S A (1996) 2.31
Mutations in the alpha1 subunit of an L-type voltage-activated Ca2+ channel cause myotonia in Caenorhabditis elegans. EMBO J (1997) 2.27
Why peptides? Their possible role in the evolution of MHC-restricted T-cell recognition. Immunol Today (1989) 2.23
DNA repair defect in poly(ADP-ribose) polymerase-deficient cell lines. Nucleic Acids Res (1998) 2.21
Involvement of poly(ADP-ribose) polymerase in base excision repair. Biochimie (1999) 2.13
ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B. J Biol Chem (1996) 2.12
Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7. J Biol Chem (1999) 2.09
Characterization of the necrotic cleavage of poly(ADP-ribose) polymerase (PARP-1): implication of lysosomal proteases. Cell Death Differ (2001) 1.91
Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B. Proc Natl Acad Sci U S A (1996) 1.90
Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis. J Biol Chem (1997) 1.88
Importance of poly(ADP-ribose) glycohydrolase in the control of poly(ADP-ribose) metabolism. Exp Cell Res (2001) 1.85
Evaluation of surgical gamma probes for radioguided sentinel node localisation. Eur J Nucl Med (1998) 1.82
No death without life: vital functions of apoptotic effectors. Cell Death Differ (2008) 1.80
Synthetic peptides as antigens: pitfalls of conjugation methods. J Immunol Methods (1985) 1.76
Congenital anomalies and anthropometry of 42 individuals with deletions of chromosome 18q. Am J Med Genet (1999) 1.76
Structure of the catalytic fragment of poly(AD-ribose) polymerase from chicken. Proc Natl Acad Sci U S A (1996) 1.75
Poly(ADP-ribose)polymerase: a novel finger protein. Nucleic Acids Res (1989) 1.72
Identification by immunoprecipitation of cauliflower mosaic virus in vitro major translation product with a specific serum against viroplasm protein. EMBO J (1982) 1.69
Membrane expression of HIV envelope glycoproteins triggers apoptosis in CD4 cells. AIDS Res Hum Retroviruses (1993) 1.67
DNA ligase III is recruited to DNA strand breaks by a zinc finger motif homologous to that of poly(ADP-ribose) polymerase. Identification of two functionally distinct DNA binding regions within DNA ligase III. J Biol Chem (1999) 1.66
In vivo competition between self peptides and foreign antigens in T-cell activation. Nature (1988) 1.66
Bcl-2 and adenovirus E1B 19 kDA protein prevent E1A-induced processing of CPP32 and cleavage of poly(ADP-ribose) polymerase. Oncogene (1996) 1.64
Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice. J Exp Med (1998) 1.63
Sequence requirements for plasmid nuclear import. Exp Cell Res (1999) 1.63
NMDA but not non-NMDA excitotoxicity is mediated by Poly(ADP-ribose) polymerase. J Neurosci (2000) 1.61
Detection of papillomavirus DNA in human semen. Science (1986) 1.59
The human poly(ADP-ribose) polymerase nuclear localization signal is a bipartite element functionally separate from DNA binding and catalytic activity. EMBO J (1992) 1.57
Inhibitor and NAD+ binding to poly(ADP-ribose) polymerase as derived from crystal structures and homology modeling. Biochemistry (1998) 1.56
Both stimulatory and inhibitory GDP/GTP exchange proteins, smg GDS and rho GDI, are active on multiple small GTP-binding proteins. Biochem Biophys Res Commun (1992) 1.55
Mutational analysis of the interaction between CD4 and class II MHC: class II antigens contact CD4 on a surface opposite the gp120-binding site. Cell (1991) 1.53
Molecular and biochemical features of poly (ADP-ribose) metabolism. Mol Cell Biochem (1993) 1.52
Structure and binding properties of monoclonal antibodies to core histones from autoimmune mice. Mol Immunol (1993) 1.51
NAD(+)-dependent repair of damaged DNA by human cell extracts. J Biol Chem (1993) 1.50
A rapid screening procedure to identify mini-Tn10 insertion mutants of Escherichia coli K-12 with altered adhesion properties. FEMS Microbiol Lett (1996) 1.49
Zinc-binding domain of poly(ADP-ribose)polymerase participates in the recognition of single strand breaks on DNA. J Mol Biol (1989) 1.49
The conserved seven-transmembrane sequence NP(X)2,3Y of the G-protein-coupled receptor superfamily regulates multiple properties of the beta 2-adrenergic receptor. Biochemistry (1995) 1.49
Bacteremia due to Stenotrophomonas (Xanthomonas) maltophilia: a prospective, multicenter study of 91 episodes. Clin Infect Dis (1996) 1.46
Palliative surgical debulking in malignant mesothelioma. Predictors of survival and symptom control. Eur J Cardiothorac Surg (2001) 1.45
Gain-of-function of poly(ADP-ribose) polymerase-1 upon cleavage by apoptotic proteases: implications for apoptosis. J Cell Sci (2001) 1.43
Trials in primary care: statistical issues in the design, conduct and evaluation of complex interventions. Stat Methods Med Res (2010) 1.42
Structural and functional analysis of poly(ADP ribose) polymerase: an immunological study. Biochim Biophys Acta (1988) 1.42
Use of self-retaining barbed suture for rectal wall closure in transanal endoscopic microsurgery. Tech Coloproctol (2014) 1.40
Tocolytic drugs for use in veterinary obstetrics. Can Vet J (1984) 1.38
Conformational analysis of a 139 base-pair DNA fragment containing a single-stranded break and its interaction with human poly(ADP-ribose) polymerase. J Mol Biol (1994) 1.37
Dual function for poly(ADP-ribose) synthesis in response to DNA strand breakage. Biochemistry (1994) 1.35
Fibroblast growth factor-2 inhibits endothelial cell apoptosis by Bcl-2-dependent and independent mechanisms. Am J Pathol (1997) 1.35
Involvement of caspase-dependent activation of cytosolic phospholipase A2 in tumor necrosis factor-induced apoptosis. Proc Natl Acad Sci U S A (1997) 1.32
Proteasomes play an essential role in thymocyte apoptosis. EMBO J (1996) 1.30
Modulation of chromatin superstructure induced by poly(ADP-ribose) synthesis and degradation. J Biol Chem (1986) 1.30
Detection of poly(ADP ribose) polymerase in crude extracts by activity-blot. Anal Biochem (1991) 1.30
Persistence and determinants of statin therapy among middle-aged patients for primary and secondary prevention. Br J Clin Pharmacol (2005) 1.29
The mechanism of the elongation and branching reaction of poly(ADP-ribose) polymerase as derived from crystal structures and mutagenesis. J Mol Biol (1998) 1.28
PARP-3 associates with polycomb group bodies and with components of the DNA damage repair machinery. J Cell Biochem (2007) 1.28
Methods for biochemical study of poly(ADP-ribose) metabolism in vitro and in vivo. Anal Biochem (1995) 1.28
Relative affinities of poly(ADP-ribose) polymerase and DNA-dependent protein kinase for DNA strand interruptions. Biochim Biophys Acta (1999) 1.27
The potential impact of CT-MRI matching on tumor volume delineation in advanced head and neck cancer. Int J Radiat Oncol Biol Phys (1997) 1.26
Functional association of poly(ADP-ribose) polymerase with DNA polymerase alpha-primase complex: a link between DNA strand break detection and DNA replication. Nucleic Acids Res (1998) 1.26
Regulation of poly(ADP-ribose) metabolism by poly(ADP-ribose) glycohydrolase: where and when? Cell Mol Life Sci (2005) 1.26
Different cleavage pattern for poly(ADP-ribose) polymerase during necrosis and apoptosis in HL-60 cells. Biochem Biophys Res Commun (1996) 1.26
Electron microscopic studies of the different topological forms of the cauliflower mosaic virus DNA: knotted encapsidated DNA and nuclear minichromosome. EMBO J (1983) 1.26
Early embryonic lethality in PARP-1 Atm double-mutant mice suggests a functional synergy in cell proliferation during development. Mol Cell Biol (2001) 1.25
Electron microscopic visualization of N-acetoxy-N-2-acetylaminofluorene binding sites in ColE1 DNA by means of specific antibodies. Proc Natl Acad Sci U S A (1979) 1.24
Role of phosphorylation in agonist-promoted beta 2-adrenergic receptor sequestration. Rescue of a sequestration-defective mutant receptor by beta ARK1. J Biol Chem (1995) 1.24
A bidirectional promoter connects the poly(ADP-ribose) polymerase 2 (PARP-2) gene to the gene for RNase P RNA. structure and expression of the mouse PARP-2 gene. J Biol Chem (2000) 1.24