Published in Br J Pharmacol on September 05, 2014
Amyloid-clearing proteins and their epigenetic regulation as a therapeutic target in Alzheimer's disease. Front Aging Neurosci (2014) 0.94
Opioid receptor desensitization: mechanisms and its link to tolerance. Front Pharmacol (2014) 0.91
Identification of GPR83 as the receptor for the neuroendocrine peptide PEN. Sci Signal (2016) 0.78
Protein Kinase D and Gβγ Subunits Mediate Agonist-evoked Translocation of Protease-activated Receptor-2 from the Golgi Apparatus to the Plasma Membrane. J Biol Chem (2016) 0.76
Collybolide is a novel biased agonist of κ-opioid receptors with potent antipruritic activity. Proc Natl Acad Sci U S A (2016) 0.75
Animal research: reporting in vivo experiments: the ARRIVE guidelines. Br J Pharmacol (2010) 17.30
Guidelines for reporting experiments involving animals: the ARRIVE guidelines. Br J Pharmacol (2010) 13.76
Acidification of the endocytic and exocytic pathways. Annu Rev Biochem (1986) 10.90
The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands. Nucleic Acids Res (2013) 9.61
The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors. Br J Pharmacol (2013) 5.74
The Concise Guide to PHARMACOLOGY 2013/14: enzymes. Br J Pharmacol (2013) 5.57
A novel class of clathrin-coated vesicles budding from endosomes. J Cell Biol (1996) 4.05
Regulation of GPCRs by endocytic membrane trafficking and its potential implications. Annu Rev Pharmacol Toxicol (2008) 4.04
A role for heterodimerization of mu and delta opiate receptors in enhancing morphine analgesia. Proc Natl Acad Sci U S A (2004) 3.00
Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance. Pharmacol Rev (2013) 2.42
Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases. J Biol Chem (2001) 1.82
Endothelin-converting enzyme-2 is a membrane-bound, phosphoramidon-sensitive metalloprotease with acidic pH optimum. J Biol Chem (1995) 1.73
The preendosomal compartment comprises distinct coated and noncoated endocytic vesicle populations. J Cell Biol (1991) 1.48
Endocytosis of a glycosylphosphatidylinositol-anchored protein via clathrin-coated vesicles, sorting by default in endosomes, and exocytosis via RAB11-positive carriers. Mol Biol Cell (2003) 1.46
Regulation of CB1 cannabinoid receptor trafficking by the adaptor protein AP-3. FASEB J (2008) 1.40
Molecular pharmacology of endothelin converting enzymes. Biochem Pharmacol (1996) 1.39
Conformation state-sensitive antibodies to G-protein-coupled receptors. J Biol Chem (2006) 1.37
Disruption of ECE-1 and ECE-2 reveals a role for endothelin-converting enzyme-2 in murine cardiac development. J Clin Invest (2000) 1.36
Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity. Proc Natl Acad Sci U S A (2013) 1.34
Sequestration of the delta opioid receptor. Role of the C terminus in agonist-mediated internalization. J Biol Chem (1996) 1.31
Opioid receptor oligomerization. Detection and functional characterization of interacting receptors. Methods Mol Med (2003) 1.28
Endosomal endothelin-converting enzyme-1: a regulator of beta-arrestin-dependent ERK signaling. J Biol Chem (2009) 1.27
The cloned mu, delta and kappa receptors and their endogenous ligands: evidence for two opioid peptide recognition cores. Brain Res (1995) 1.24
Thr353, located within the COOH-terminal tail of the delta opiate receptor, is involved in receptor down-regulation. J Biol Chem (1996) 1.23
Endothelin-converting enzyme 1 degrades neuropeptides in endosomes to control receptor recycling. Proc Natl Acad Sci U S A (2007) 1.21
Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins. J Cell Biol (2007) 1.20
Stimulation of guanosine-5'-O-(3-[35S]thio)triphosphate binding by endogenous opioids acting at a cloned mu receptor. J Pharmacol Exp Ther (1998) 1.19
A new family of endogenous "big" Met-enkephalins from bovine adrenal medulla: purification and structure of docosa- (BAM-22P) and eicosapeptide (BAM-20P) with very potent opiate activity. Biochem Biophys Res Commun (1980) 1.14
Modulating neuromodulation by receptor membrane traffic in the endocytic pathway. Neuron (2012) 1.07
A new endogenous opioid peptide from bovine adrenal medulla: isolation and amino acid sequence of a dodecapeptide (BAM-12P). Biochem Biophys Res Commun (1980) 1.06
Receptor-induced internalization of selective peptidic mu and delta opioid ligands. J Biol Chem (1997) 1.03
Endothelin-converting enzyme 1 promotes re-sensitization of neurokinin 1 receptor-dependent neurogenic inflammation. Br J Pharmacol (2009) 1.02
Optimisation and validation of an angiotensin-converting enzyme inhibition assay for the screening of bioactive peptides. J Biochem Biophys Methods (2002) 1.02
Challenges for opioid receptor nomenclature: IUPHAR Review 9. Br J Pharmacol (2014) 0.99
Peptidases prevent mu-opioid receptor internalization in dorsal horn neurons by endogenously released opioids. J Neurosci (2003) 0.97
Fast modulation of μ-opioid receptor (MOR) recycling is mediated by receptor agonists. J Biol Chem (2012) 0.94
Characterization of endothelin-converting enzyme-2. Implication for a role in the nonclassical processing of regulatory peptides. J Biol Chem (2003) 0.94
Endothelin-converting enzymes degrade intracellular β-amyloid produced within the endosomal/lysosomal pathway and autophagosomes. J Biol Chem (2013) 0.93
Recycling and resensitization of delta opioid receptors. DNA Cell Biol (2000) 0.93
F11 neuroblastoma x DRG neuron hybrid cells express inhibitory mu- and delta-opioid receptors which increase voltage-dependent K+ currents upon activation. Brain Res (1992) 0.93
Spatially restricted G protein-coupled receptor activity via divergent endocytic compartments. J Biol Chem (2013) 0.92
Neurotensin-induced proinflammatory signaling in human colonocytes is regulated by β-arrestins and endothelin-converting enzyme-1-dependent endocytosis and resensitization of neurotensin receptor 1. J Biol Chem (2012) 0.90
Homology modeling and site-directed mutagenesis to identify selective inhibitors of endothelin-converting enzyme-2. J Med Chem (2008) 0.90
Kinetics of G-protein-coupled receptor endosomal trafficking pathways revealed by single quantum dots. Proc Natl Acad Sci U S A (2010) 0.90
GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding. Proc Natl Acad Sci U S A (2013) 0.87
Post-activation-mediated changes in opioid receptors detected by N-terminal antibodies. J Biol Chem (2008) 0.86
Selective inactivation of opioid receptors in rat hippocampus demonstrates that dynorphin-A and -B may act on mu-receptors in the CA1 region. Brain Res (1985) 0.86
Analgesia produced by immobilization stress and an enkephalinase inhibitor in amphibians. Pharmacol Biochem Behav (1995) 0.86
Opioid receptor function is regulated by post-endocytic peptide processing. J Biol Chem (2014) 0.85
Endothelin-converting enzyme-1 actions determine differential trafficking and signaling of corticotropin-releasing factor receptor 1 at high agonist concentrations. Mol Endocrinol (2012) 0.84
Differential structure-activity relationships of phosphoramidon analogues for inhibition of three metalloproteases: endothelin-converting enzyme, neutral endopeptidase, and angiotensin-converting enzyme. J Cardiovasc Pharmacol (1995) 0.84
Agonist-biased trafficking of somatostatin receptor 2A in enteric neurons. J Biol Chem (2013) 0.81
Proenkephalin A-derived peptide E and its fragments alter opioid contractility in the small intestine. Eur J Pharmacol (1990) 0.80
G-protein-coupled heteromers: regulation in disease. Methods Enzymol (2013) 0.80
Select G-protein-coupled receptors modulate agonist-induced signaling via a ROCK, LIMK, and β-arrestin 1 pathway. Cell Rep (2013) 0.80
Dynorphins: similar relative potencies on mu, delta- and kappa-opiate receptors. Eur J Pharmacol (1981) 0.80
Validation of DRG-like F11 cells for evaluation of KCNQ/M-channel modulators. Assay Drug Dev Technol (2006) 0.79
Mice deficient in endothelin-converting enzyme-2 exhibit abnormal responses to morphine and altered peptide levels in the spinal cord. J Neurochem (2011) 0.79
Characterisation of neutral endopeptidase 3.4.24.11 (NEP) in the kidney: comparison between normotensive, genetically hypertensive and experimentally hypertensive rats. J Enzyme Inhib (1991) 0.79
Potentiation of [D-ala2]enkephalinamide analgesia in rats by thiorphan. Eur J Pharmacol (1982) 0.79
The effect of monensin and chloroquine on the endocytosis and toxicity of chimeric toxins. Cell Mol Life Sci (1998) 0.79
Receptor preference of dynorphin A fragments in the mouse vas deferens determined by different techniques. J Pharmacol Exp Ther (1984) 0.78
Identification of an endothelin-converting enzyme-2-specific fluorigenic substrate and development of an in vitro and ex vivo enzymatic assay. J Biol Chem (2010) 0.77
Dynorphin B-29: chemical synthesis and pharmacological properties in opioid systems in vitro. Neuropeptides (1984) 0.75
G-protein-coupled receptor heterodimerization modulates receptor function. Nature (1999) 4.73
Heterodimerization of mu and delta opioid receptors: A role in opiate synergy. J Neurosci (2000) 2.90
Dimerization of the delta opioid receptor: implication for a role in receptor internalization. J Biol Chem (1997) 2.51
G-protein-coupled receptor dimerization: modulation of receptor function. Pharmacol Ther (2002) 2.18
Rapid selection of genetic and antigenic variants of foot-and-mouth disease virus during persistence in cattle. J Virol (1988) 1.92
Oligomerization of opioid receptors with beta 2-adrenergic receptors: a role in trafficking and mitogen-activated protein kinase activation. Proc Natl Acad Sci U S A (2001) 1.82
Bax cleavage is mediated by calpain during drug-induced apoptosis. Oncogene (1998) 1.79
Functional interactions between mu opioid and alpha 2A-adrenergic receptors. Mol Pharmacol (2003) 1.49
Mutation rates at Y chromosome specific microsatellites. Hum Mutat (2005) 1.48
Identification and characterization of proSAAS, a granin-like neuroendocrine peptide precursor that inhibits prohormone processing. J Neurosci (2000) 1.43
Sequestration of the delta opioid receptor. Role of the C terminus in agonist-mediated internalization. J Biol Chem (1996) 1.31
G protein coupled receptor dimerization: implications in modulating receptor function. J Mol Med (Berl) (2001) 1.28
Dynamic changes of the endogenous cannabinoid and opioid mesocorticolimbic systems during adolescence: THC effects. Eur Neuropsychopharmacol (2008) 1.28
Expression of rat cathepsin S in phagocytic cells. J Biol Chem (1996) 1.27
A novel nuclear protein, 5qNCA (LOC51780) is a candidate for the myeloid leukemia tumor suppressor gene on chromosome 5 band q31. Oncogene (2001) 1.25
Thr353, located within the COOH-terminal tail of the delta opiate receptor, is involved in receptor down-regulation. J Biol Chem (1996) 1.23
Opioid receptor endocytosis and activation of MAP kinase pathway. Brain Res Mol Brain Res (2000) 1.19
Identification of peptides from brain and pituitary of Cpe(fat)/Cpe(fat) mice. Proc Natl Acad Sci U S A (2001) 1.18
Animals lacking endothelin-converting enzyme-2 are deficient in learning and memory. Genes Brain Behav (2008) 1.09
Molecular mechanisms of opioid receptor signal transduction. Br J Anaesth (1998) 1.09
The C-terminal region of proSAAS is a potent inhibitor of prohormone convertase 1. J Biol Chem (2000) 1.09
Inflammatory mediators regulate cathepsin S in macrophages and microglia: A role in attenuating heparan sulfate interactions. Mol Med (1999) 1.08
Opioids and their complicated receptor complexes. Neuropsychopharmacology (2000) 1.07
Defective prodynorphin processing in mice lacking prohormone convertase PC2. J Neurochem (2000) 1.06
Cannabidiol causes activated hepatic stellate cell death through a mechanism of endoplasmic reticulum stress-induced apoptosis. Cell Death Dis (2011) 1.03
Expression of the aphthovirus RNA polymerase gene in Escherichia coli and its use together with other bioengineered nonstructural antigens in detection of late persistent infections. Virology (1991) 1.03
Neurotrophic factors regulate cathepsin S in macrophages and microglia: A role in the degradation of myelin basic protein and amyloid beta peptide. Mol Med (1999) 1.00
Carboxypeptidase E activity is deficient in mice with the fat mutation. Effect on peptide processing. J Biol Chem (1996) 1.00
ProSAAS processing in mouse brain and pituitary. J Biol Chem (2000) 0.99
Studies on a wild strain of Schizophyllum commune: Cellulase and xylanase production and formation of the extracellular polysaccharide Schizophyllan. Biotechnol Bioeng (1987) 0.99
Inhibitory specificity and potency of proSAAS-derived peptides toward proprotein convertase 1. J Biol Chem (2001) 0.97
Kappa opioid receptor endocytosis by dynorphin peptides. DNA Cell Biol (2000) 0.97
Impaired prohormone convertases in Cpe(fat)/Cpe(fat) mice. J Biol Chem (2001) 0.97
Morphine priming in rats with chronic inflammation reveals a dichotomy between antihyperalgesic and antinociceptive properties of deltorphin. Neuroscience (2006) 0.96
Cloning, expression, and characterization of human metalloprotease 1: a novel member of the pitrilysin family of metalloendoproteases. DNA Cell Biol (1999) 0.96
Raf and fibroblast growth factor phosphorylate Elk1 and activate the serum response element of the immediate early gene pip92 by mitogen-activated protein kinase-independent as well as -dependent signaling pathways. Mol Cell Biol (1998) 0.95
Diagnosis of persistent aphthovirus infection and its differentiation from vaccination response in cattle by use of enzyme-linked immunoelectrotransfer blot analysis with bioengineered nonstructural viral antigens. Am J Vet Res (1993) 0.95
Genetic data of 10 X-STRs in a Spanish population sample. Forensic Sci Int (2007) 0.93
Recycling and resensitization of delta opioid receptors. DNA Cell Biol (2000) 0.93
Heterogeneity of the polyribocytidilic acid tract in aphthovirus: changes in the size of the poly(C) of viruses recovered from persistently infected cattle. Virology (1988) 0.91
Effect of green tea (Camellia sinensis) consumption on the components of metabolic syndrome in elderly. J Nutr Health Aging (2012) 0.91
Identification of G protein-coupled receptor kinase 2 phosphorylation sites responsible for agonist-stimulated delta-opioid receptor phosphorylation. Mol Pharmacol (2000) 0.88
Stereoselective interaction of ketamine with recombinant mu, kappa, and delta opioid receptors expressed in Chinese hamster ovary cells. Anesthesiology (1999) 0.88
Nontuberculous mycobacteria in non-AIDS patients. Rev Port Pneumol (2008) 0.88
Acute ethanol treatment modulates delta opioid receptors in N18TG2 cells. Anesthesiology (2000) 0.87
Src tyrosine kinase mediates stimulation of Raf-1 and mitogen-activated protein kinase by the tumor promoter thapsigargin. Cancer Res (1997) 0.87
Expression of immediate early gene pip92 during anisomycin-induced cell death is mediated by the JNK- and p38-dependent activation of Elk1. Eur J Biochem (2000) 0.87
RNA/DNA co-analysis from human saliva and semen stains--results of a third collaborative EDNAP exercise. Forensic Sci Int Genet (2012) 0.87
Linkage analysis of the 5q31-33 candidate region for asthma in 240 UK families. Genes Immun (2001) 0.86
[Prognosis factors in cryptococcal meningoencephalitis]. Arq Neuropsiquiatr (1999) 0.86
The effects of endomorphin-1 and endomorphin-2 in CHO cells expressing recombinant mu-opioid receptors and SH-SY5Y cells. Br J Pharmacol (1999) 0.85
RNA/DNA co-analysis from human menstrual blood and vaginal secretion stains: results of a fourth and fifth collaborative EDNAP exercise. Forensic Sci Int Genet (2013) 0.84
Improvement of sympathetic skin responses under enzyme replacement therapy in Fabry disease. J Inherit Metab Dis (2006) 0.84
Histamine antagonizes serotonin and growth factor-induced mitogen-activated protein kinase activation in bovine tracheal smooth muscle cells. J Biol Chem (1995) 0.84
Effects of C-terminal truncation of the recombinant delta-opioid receptor on phospholipase C and adenylyl cyclase coupling. J Neurochem (1998) 0.83
Genetic variation of foot-and-mouth disease virus during persistent infection in cattle. Virus Res (1994) 0.83
Further studies on markers of foot-and-mouth disease virus. Bull Off Int Epizoot (1972) 0.82
Marker studies of foot-and-mouth disease virus. Bull Off Int Epizoot (1971) 0.81
[Autonomic neuropathy in patients with impaired glucose tolerance]. Arq Neuropsiquiatr (1997) 0.80
Role for C-tail residues in delta opioid receptor downregulation. DNA Cell Biol (2000) 0.80
Further information on the survival of modified foot-and-mouth disease virus in cattle. Bull Off Int Epizoot (1972) 0.80
[Acute appendicitis: a study on 118 patients]. Nihon Geka Gakkai Zasshi (1985) 0.79
[The clinical laboratory characteristics of 104 cases of cryptococcal meningoencephalitis]. Rev Soc Bras Med Trop (2000) 0.79
Thermolabile xylanase of the Antarctic yeast Cryptococcus adeliae: production and properties. Extremophiles (2000) 0.78
[Prognostic factors of tuberculous meningoencephalitis lethality]. Arq Neuropsiquiatr (1998) 0.78
[Cystic fibrosis: review]. Rev Port Pneumol (2008) 0.77
Plaque morphology of some South American strains of foot-and-mouth disease virus and the effects of polyionic compounds on plaque formation. Arch Gesamte Virusforsch (1970) 0.77
[HTLV-1 associated myelopathies in the city of Salvador, Bahia]. Arq Neuropsiquiatr (1994) 0.77
Specificity of the dynorphin-processing endoprotease: comparison with prohormone convertases. J Neurochem (1999) 0.77
Smoking habits in secondary school students. Rev Port Pneumol (2009) 0.77
Potency control of foot-and-mouth disease vaccine in cattle. Comparison of the 50% protective dose and the protection against generalization. Vaccine (1993) 0.77
Studies on a Rabbit-Adapted Foot-and-Mouth Disease Virus of Type C. Waldmann: I. Adaptation and Immunogenicity. Can J Comp Med Vet Sci (1964) 0.75
Behavior of intertypic recombinants between virulent and attenuated aphthovirus strains in tissue culture and cattle. J Virol (1988) 0.75
The effect of C-terminal truncation of the recombinant delta-opioid receptor on Ca2+i signaling. Eur J Pharmacol (1999) 0.75
Ferromagnetic coordination polymer composed of heterocyclic thiazyl radical, 1,3,5-trithia-2,4,6-triazapentalenyl (TTTA), and Bis(hexafluoroacetylacetonato)copper(II) (Cu(hfac)(2)). J Am Chem Soc (2001) 0.75
Adult T-cell leukemia-lymphoma in a patient with HTLV-I/II associated myelopathy. Arq Neuropsiquiatr (1997) 0.75
Potentiation of FMD vaccines with polycationic-nucleic acid complexes. Arch Virol (1977) 0.75
Quasi-one-dimensional molecular magnets based on derivatives of (fluorobenzyl)pyridinium with the [M(mnt)2] monoanion (M = Ni, Pd or Pt; mnt2- = maleonitriledithiolate): syntheses, crystal structures and magnetic properties. Dalton Trans (2006) 0.75
Susceptibility of various FMDV strains to urea. Arch Virol (1978) 0.75
[Laboratory and clinical variables in the differential diagnosis of aseptic and pyogenic meningitis in children]. Arq Neuropsiquiatr (1997) 0.75
Purification and characterization of a dynorphin-processing endopeptidase. J Biol Chem (1995) 0.75
Structural phase transition driven by spin-lattice interaction in a quasi-one-dimensional spin system of [1-(4'-iodobenzyl)pyridinium][Ni(mnt)2]. J Phys Chem B (2005) 0.75
[Tubercular meningoencephalitis: evaluation of 231 cases]. Rev Soc Bras Med Trop (1998) 0.75
[HTLV-I-associated myelopathy: a systemic disease]. Arq Neuropsiquiatr (1994) 0.75
[Clinical and laboratory characteristics of 62 tuberculous meningoencephalitis cases]. Arq Neuropsiquiatr (1996) 0.75
[Clinical and laboratory characteristics of bacterial meningitis in children]. Arq Neuropsiquiatr (1996) 0.75
Pulmonary involvement in patients with HTLV-I associated myelopathy. Arq Neuropsiquiatr (1995) 0.75
[Survival analysis of acute pyogenic meningitis in children]. Arq Neuropsiquiatr (1998) 0.75
Dynorphin A processing enzyme: tissue distribution, isolation, and characterization. J Biochem (1999) 0.75
One-dimensional antiferromagnetic chain in [Ni(dmit)2]- salts of [K+ or Rb+(4,13-diaza-18-crown-6)] supramolecular cation. Inorg Chem (2000) 0.75
Modifications of the sympathetic skin response in workers chronically exposed to lead. Braz J Med Biol Res (2007) 0.75
Detection of foot-and-mouth disease viral sequences in various fluids and tissues during persistence of the virus in cattle. Am J Vet Res (1996) 0.75
[Cystic fibrosis in adults]. Rev Port Pneumol (2007) 0.75
Photoinduced phase transition in an organic radical crystal with room-temperature optical and magnetic bistability. Phys Rev Lett (2003) 0.75
Heterologous desensitization of the human endothelin A and neurokinin A receptors in Xenopus laevis oocytes. Recept Signal Transduct (1996) 0.75