Published in Proc Natl Acad Sci U S A on September 16, 2013
Ghrelin: ghrelin as a regulatory Peptide in growth hormone secretion. J Clin Diagn Res (2014) 0.86
Opioid receptor function is regulated by post-endocytic peptide processing. J Biol Chem (2014) 0.85
Carboxypeptidases in disease: insights from peptidomic studies. Proteomics Clin Appl (2014) 0.83
Endothelin-converting enzyme 2 differentially regulates opioid receptor activity. Br J Pharmacol (2014) 0.81
A d-Amino Acid-Containing Neuropeptide Discovery Funnel. Anal Chem (2016) 0.78
Identification of GPR83 as the receptor for the neuroendocrine peptide PEN. Sci Signal (2016) 0.78
Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake. Sci Signal (2016) 0.78
The neural chaperone proSAAS blocks α-synuclein fibrillation and neurotoxicity. Proc Natl Acad Sci U S A (2016) 0.76
GPR171 expression enhances proliferation and metastasis of lung cancer cells. Oncotarget (2016) 0.75
Prohormone convertase 2 activity is increased in the hippocampus of Wfs1 knockout mice. Front Mol Neurosci (2015) 0.75
The BigLEN-GPR171 Peptide Receptor System within the Basolateral Amygdala Regulates Anxiety-Like Behavior and Contextual Fear Conditioning. Neuropsychopharmacology (2017) 0.75
Neuro-psychopharmacological perspective of Orphan receptors of Rhodopsin (class A) family of G protein-coupled receptors. Psychopharmacology (Berl) (2017) 0.75
Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res (2002) 28.38
Genome-wide atlas of gene expression in the adult mouse brain. Nature (2006) 28.02
NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates. Science (2005) 6.55
Rapid, reversible activation of AgRP neurons drives feeding behavior in mice. J Clin Invest (2011) 5.12
Gene expression nervous system atlas (GENSAT). Nat Neurosci (2004) 4.74
Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice. Mol Cell Biol (2002) 3.14
Anatomical profiling of G protein-coupled receptor expression. Cell (2008) 2.88
Circadian rhythms and metabolic syndrome: from experimental genetics to human disease. Circ Res (2010) 2.49
Estimation of energy expenditure, net carbohydrate utilization, and net fat oxidation and synthesis by indirect calorimetry: evaluation of errors with special reference to the detailed composition of fuels. Am J Clin Nutr (1988) 1.99
mu opioid and CB1 cannabinoid receptor interactions: reciprocal inhibition of receptor signaling and neuritogenesis. Br J Pharmacol (2006) 1.93
Increased abundance of opioid receptor heteromers after chronic morphine administration. Sci Signal (2010) 1.90
Design logic of a cannabinoid receptor signaling network that triggers neurite outgrowth. Science (2008) 1.82
C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. Proc Natl Acad Sci U S A (2002) 1.82
Hemopressin is an inverse agonist of CB1 cannabinoid receptors. Proc Natl Acad Sci U S A (2007) 1.70
Role of neuropeptides in appetite regulation and obesity--a review. Neuropeptides (2006) 1.67
NIH experiment in centralized mouse phenotyping: the Vanderbilt experience and recommendations for evaluating glucose homeostasis in the mouse. Am J Physiol Endocrinol Metab (2009) 1.62
AgRP in energy balance: Will the real AgRP please stand up? Cell Metab (2006) 1.55
Identification and characterization of proSAAS, a granin-like neuroendocrine peptide precursor that inhibits prohormone processing. J Neurosci (2000) 1.43
Conformation state-sensitive antibodies to G-protein-coupled receptors. J Biol Chem (2006) 1.37
An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors. J Mol Biol (2001) 1.36
The carboxypeptidase E knockout mouse exhibits endocrinological and behavioral deficits. Endocrinology (2004) 1.33
Neuropeptides, food intake and body weight regulation: a hypothalamic focus. Peptides (2002) 1.33
Cannabinoid receptor-induced neurite outgrowth is mediated by Rap1 activation through G(alpha)o/i-triggered proteasomal degradation of Rap1GAPII. J Biol Chem (2005) 1.32
Opioid receptor oligomerization. Detection and functional characterization of interacting receptors. Methods Mol Med (2003) 1.28
Mass spectrometry-based discovery of circadian peptides. Proc Natl Acad Sci U S A (2008) 1.27
G protein-coupled receptor heteromerization: a role in allosteric modulation of ligand binding. Mol Pharmacol (2011) 1.27
AgRP neurons regulate development of dopamine neuronal plasticity and nonfood-associated behaviors. Nat Neurosci (2012) 1.26
Novel endogenous peptide agonists of cannabinoid receptors. FASEB J (2009) 1.25
The G alpha(o/i)-coupled cannabinoid receptor-mediated neurite outgrowth involves Rap regulation of Src and Stat3. J Biol Chem (2005) 1.25
Opioid receptor endocytosis and activation of MAP kinase pathway. Brain Res Mol Brain Res (2000) 1.19
AT1R-CB₁R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II. EMBO J (2011) 1.18
Serotonin receptor activation leads to neurite outgrowth and neuronal survival. Brain Res Mol Brain Res (2005) 1.14
Obesity and diabetes in transgenic mice expressing proSAAS. J Endocrinol (2004) 1.04
ProSAAS processing in mouse brain and pituitary. J Biol Chem (2000) 0.99
The propeptide precursor proSAAS is involved in fetal neuropeptide processing and body weight regulation. J Neurochem (2010) 0.96
Region selective up-regulation of micro-, delta- and kappa-opioid receptors but not opioid receptor-like 1 receptors in the brains of enkephalin and dynorphin knockout mice. Neuroscience (2003) 0.93
ProSAAS-derived peptides are colocalized with neuropeptide Y and function as neuropeptides in the regulation of food intake. PLoS One (2011) 0.89
Gpr171, a putative P2Y-like receptor, negatively regulates myeloid differentiation in murine hematopoietic progenitors. Exp Hematol (2012) 0.82
The fate of P2Y-related orphan receptors: GPR80/99 and GPR91 are receptors of dicarboxylic acids. Purinergic Signal (2004) 0.79
Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice. Nature (2007) 4.59
Automated design of ligands to polypharmacological profiles. Nature (2012) 3.54
A role for heterodimerization of mu and delta opiate receptors in enhancing morphine analgesia. Proc Natl Acad Sci U S A (2004) 3.00
A beta-arrestin 2 signaling complex mediates lithium action on behavior. Cell (2008) 2.76
Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function. Neuron (2011) 2.71
Building a new conceptual framework for receptor heteromers. Nat Chem Biol (2009) 2.41
Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3. Hum Mol Genet (2011) 2.38
D2 receptors regulate dopamine transporter function via an extracellular signal-regulated kinases 1 and 2-dependent and phosphoinositide 3 kinase-independent mechanism. Mol Pharmacol (2007) 2.28
Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiency. Proc Natl Acad Sci U S A (2008) 2.23
MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants. Nat Neurosci (2010) 2.19
Mice deficient for the vesicular acetylcholine transporter are myasthenic and have deficits in object and social recognition. Neuron (2006) 1.98
Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy. Proc Natl Acad Sci U S A (2011) 1.98
mu opioid and CB1 cannabinoid receptor interactions: reciprocal inhibition of receptor signaling and neuritogenesis. Br J Pharmacol (2006) 1.93
Increased abundance of opioid receptor heteromers after chronic morphine administration. Sci Signal (2010) 1.90
Receptor heterodimerization leads to a switch in signaling: beta-arrestin2-mediated ERK activation by mu-delta opioid receptor heterodimers. FASEB J (2007) 1.89
IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth. Proc Natl Acad Sci U S A (2007) 1.88
Cocaine increases dopamine release by mobilization of a synapsin-dependent reserve pool. J Neurosci (2006) 1.88
N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT1A agonist, as a putative mediator of quetiapine's antidepressant activity. Neuropsychopharmacology (2007) 1.83
G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives. Pharmacol Rev (2014) 1.82
Prior activation of kappa opioid receptors by U50,488 mimics repeated forced swim stress to potentiate cocaine place preference conditioning. Neuropsychopharmacology (2006) 1.81
Different presynaptic roles of synapsins at excitatory and inhibitory synapses. J Neurosci (2004) 1.72
Hemopressin is an inverse agonist of CB1 cannabinoid receptors. Proc Natl Acad Sci U S A (2007) 1.70
ABI2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memory. Mol Cell Biol (2004) 1.70
The emerging functions of endocannabinoid signaling during CNS development. Trends Pharmacol Sci (2007) 1.68
Visual snapshots of intracellular kinase activity at the onset of mitosis. Chem Biol (2007) 1.63
Quantitative neuropeptidomics of microwave-irradiated mouse brain and pituitary. Mol Cell Proteomics (2005) 1.62
Systems approach to explore components and interactions in the presynapse. Proteomics (2009) 1.61
Activation of the murine interleukin-12 p40 promoter by functional interactions between NFAT and ICSBP. J Biol Chem (2003) 1.56
Molecular factors and biochemical pathways induced by febrile temperature in intraerythrocytic Plasmodium falciparum parasites. Infect Immun (2007) 1.55
HDP-a novel heme detoxification protein from the malaria parasite. PLoS Pathog (2008) 1.55
Aberrant responses in social interaction of dopamine transporter knockout mice. Behav Brain Res (2004) 1.52
Multiple isotopic labels for quantitative mass spectrometry. Anal Chem (2008) 1.49
Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice. Arthritis Res Ther (2010) 1.48
Vmat2 heterozygous mutant mice display a depressive-like phenotype. J Neurosci (2007) 1.45
Prolonged kappa opioid receptor phosphorylation mediated by G-protein receptor kinase underlies sustained analgesic tolerance. J Biol Chem (2003) 1.45
Morphine administration alters the profile of hippocampal postsynaptic density-associated proteins: a proteomics study focusing on endocytic proteins. Mol Cell Proteomics (2006) 1.43
Cell surface targeting of mu-delta opioid receptor heterodimers by RTP4. Proc Natl Acad Sci U S A (2008) 1.42
A novel subfamily of mouse cytosolic carboxypeptidases. FASEB J (2007) 1.41
Nna1-like proteins are active metallocarboxypeptidases of a new and diverse M14 subfamily. FASEB J (2007) 1.41
Quantitative peptidomics of mouse pituitary: comparison of different stable isotopic tags. J Mass Spectrom (2005) 1.41
Regulation of CB1 cannabinoid receptor trafficking by the adaptor protein AP-3. FASEB J (2008) 1.40
Novelty seeking and stereotypic activation of behavior in mice with disruption of the Dat1 gene. Neuropsychopharmacology (2005) 1.39
Receptor heteromerization and drug discovery. Trends Pharmacol Sci (2010) 1.37
Genetic dissociation of opiate tolerance and physical dependence in delta-opioid receptor-1 and preproenkephalin knock-out mice. J Neurosci (2002) 1.37
Conformation state-sensitive antibodies to G-protein-coupled receptors. J Biol Chem (2006) 1.37
Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity. Proc Natl Acad Sci U S A (2013) 1.34
The carboxypeptidase E knockout mouse exhibits endocrinological and behavioral deficits. Endocrinology (2004) 1.33
Cannabinoid receptor-induced neurite outgrowth is mediated by Rap1 activation through G(alpha)o/i-triggered proteasomal degradation of Rap1GAPII. J Biol Chem (2005) 1.32
Epidermal stem cells are retained in vivo throughout skin aging. Aging Cell (2008) 1.31
Exploring a role for heteromerization in GPCR signalling specificity. Biochem J (2011) 1.31
Dopamine-independent locomotor actions of amphetamines in a novel acute mouse model of Parkinson disease. PLoS Biol (2005) 1.31
Downregulation of NR3A-containing NMDARs is required for synapse maturation and memory consolidation. Neuron (2009) 1.31
Transfusion-transmitted babesiosis in the United States: summary of a workshop. Transfusion (2009) 1.30
Multiple actions of spinophilin regulate mu opioid receptor function. Neuron (2008) 1.30
Metallocarboxypeptidases: emerging drug targets in biomedicine. Curr Pharm Des (2007) 1.30
Deletion of peptide amidation enzymatic activity leads to edema and embryonic lethality in the mouse. Dev Biol (2005) 1.29
Diminished growth and enhanced glucose metabolism in triple knockout mice containing mutations of insulin-like growth factor binding protein-3, -4, and -5. Mol Endocrinol (2006) 1.29
WRP/srGAP3 facilitates the initiation of spine development by an inverse F-BAR domain, and its loss impairs long-term memory. J Neurosci (2011) 1.29
Opioid receptor oligomerization. Detection and functional characterization of interacting receptors. Methods Mol Med (2003) 1.28
G protein-coupled receptor heteromerization: a role in allosteric modulation of ligand binding. Mol Pharmacol (2011) 1.27
Neuroanatomical phenotypes in the reeler mouse. Neuroimage (2006) 1.26
Neuropathic pain activates the endogenous kappa opioid system in mouse spinal cord and induces opioid receptor tolerance. J Neurosci (2004) 1.26
A novel chimeric Plasmodium vivax circumsporozoite protein induces biologically functional antibodies that recognize both VK210 and VK247 sporozoites. Infect Immun (2006) 1.25
Novel endogenous peptide agonists of cannabinoid receptors. FASEB J (2009) 1.25
The G alpha(o/i)-coupled cannabinoid receptor-mediated neurite outgrowth involves Rap regulation of Src and Stat3. J Biol Chem (2005) 1.25
Neural cell adhesion molecule-secreting transgenic mice display abnormalities in GABAergic interneurons and alterations in behavior. J Neurosci (2005) 1.24
New roles of carboxypeptidase E in endocrine and neural function and cancer. Endocr Rev (2012) 1.23
Relative quantitation of peptides in wild-type and Cpe(fat/fat) mouse pituitary using stable isotopic tags and mass spectrometry. J Mass Spectrom (2005) 1.21
Safety, tolerability, and lack of antibody responses after administration of a PfCSP DNA malaria vaccine via needle or needle-free jet injection, and comparison of intramuscular and combination intramuscular/intradermal routes. Hum Gene Ther (2002) 1.21
Peptidomics of Cpe(fat/fat) mouse brain regions: implications for neuropeptide processing. J Neurochem (2008) 1.21
Hydrolysis of third-generation cephalosporins by class C beta-lactamases. Structures of a transition state analog of cefotoxamine in wild-type and extended spectrum enzymes. J Biol Chem (2003) 1.19
Disruption of Arp2/3 results in asymmetric structural plasticity of dendritic spines and progressive synaptic and behavioral abnormalities. J Neurosci (2013) 1.19
Structure-functional selectivity relationship studies of β-arrestin-biased dopamine D₂ receptor agonists. J Med Chem (2012) 1.19
The role of prohormone convertase-2 in hypothalamic neuropeptide processing: a quantitative neuropeptidomic study. J Neurochem (2006) 1.19
Optimization of neuropeptide extraction from the mouse hypothalamus. J Proteome Res (2007) 1.18
AT1R-CB₁R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II. EMBO J (2011) 1.18