Published in Mol Cell Biol on July 07, 2014
The atypical MAPK ERK3 controls positive selection of thymocytes. Immunology (2015) 0.80
A regulatory BMI1/let-7i/ERK3 pathway controls the motility of head and neck cancer cells. Mol Oncol (2016) 0.75
Deubiquitinating Enzyme USP20 Regulates Extracellular Signal-Regulated Kinase 3 Stability and Biological Activity. Mol Cell Biol (2017) 0.75
Regulation of atypical MAP kinases ERK3 and ERK4 by the phosphatase DUSP2. Sci Rep (2017) 0.75
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem (1998) 28.13
Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol (1999) 16.81
Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev (2001) 14.02
ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell (1991) 9.54
Positive and negative selection of T cells. Annu Rev Immunol (2002) 8.32
Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro. Immunity (2002) 8.17
V(D)J recombination: RAG proteins, repair factors, and regulation. Annu Rev Biochem (2001) 5.44
Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139. J Biol Chem (2000) 4.36
The role of erk1 and erk2 in multiple stages of T cell development. Immunity (2005) 2.96
MAPKAP kinases - MKs - two's company, three's a crowd. Nat Rev Mol Cell Biol (2006) 2.80
The cellular response to general and programmed DNA double strand breaks. DNA Repair (Amst) (2004) 2.72
Commitment and developmental potential of extrathymic and intrathymic T cell precursors: plenty to choose from. Immunity (2007) 2.51
Productive T-cell receptor beta-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo. Genes Dev (1996) 2.47
Regulation of the TCRalpha repertoire by the survival window of CD4(+)CD8(+) thymocytes. Nat Immunol (2002) 2.46
The role of the non-homologous end-joining pathway in lymphocyte development. Immunol Rev (2004) 2.44
Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTbetaR. J Exp Med (2003) 2.12
Bclx regulates the survival of double-positive thymocytes. Proc Natl Acad Sci U S A (1995) 2.00
Cell cycle regulation of V(D)J recombination-activating protein RAG-2. Proc Natl Acad Sci U S A (1994) 1.74
IL-7 receptor expression levels do not identify CD8+ memory T lymphocyte precursors following peptide immunization. J Immunol (2005) 1.72
Bcl-XL displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic mice. J Exp Med (1995) 1.59
Crosstalk in the mouse thymus. Immunol Today (1994) 1.59
An essential role for the transcription factor HEB in thymocyte survival, Tcra rearrangement and the development of natural killer T cells. Nat Immunol (2010) 1.57
Atypical mitogen-activated protein kinases: structure, regulation and functions. Biochim Biophys Acta (2006) 1.56
Disorganization and restoration of thymic medullary epithelial cells in T cell receptor-negative scid mice: evidence that receptor-bearing lymphocytes influence maturation of the thymic microenvironment. Eur J Immunol (1991) 1.53
The anti-apoptotic Bcl-2 family member Mcl-1 promotes T lymphocyte survival at multiple stages. J Immunol (2008) 1.49
Regulation of T-cell progenitor survival and cell-cycle entry by the pre-T-cell receptor. Immunol Rev (2006) 1.45
Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway. EMBO J (2004) 1.43
Scaffolding by ERK3 regulates MK5 in development. EMBO J (2004) 1.36
Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation. Mol Cell Biol (2003) 1.35
Characterization of the atypical MAPK ERK4 and its activation of the MAPK-activated protein kinase MK5. J Biol Chem (2006) 1.27
The transcription factor c-Myb primes CD4+CD8+ immature thymocytes for selection into the iNKT lineage. Nat Immunol (2010) 1.25
Activation loop phosphorylation of the atypical MAP kinases ERK3 and ERK4 is required for binding, activation and cytoplasmic relocalization of MK5. J Cell Physiol (2008) 1.20
PARP-2 deficiency affects the survival of CD4+CD8+ double-positive thymocytes. EMBO J (2006) 1.18
The gamma-H2A.X: is it just a surrogate marker of double-strand breaks or much more? Environ Mol Mutagen (2008) 1.18
Regulation of MAPK-activated protein kinase 5 activity and subcellular localization by the atypical MAPK ERK4/MAPK4. J Biol Chem (2006) 1.16
Enhancer control of local accessibility to V(D)J recombinase. Mol Cell Biol (1997) 1.12
Loss of Erk3 function in mice leads to intrauterine growth restriction, pulmonary immaturity, and neonatal lethality. Proc Natl Acad Sci U S A (2009) 1.12
Identification of the atypical MAPK Erk3 as a novel substrate for p21-activated kinase (Pak) activity. J Biol Chem (2011) 1.06
c-Myb promotes the survival of CD4+CD8+ double-positive thymocytes through upregulation of Bcl-xL. J Immunol (2010) 1.05
Activation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathway. J Biol Chem (2010) 1.01
T cell factor 1 regulates thymocyte survival via a RORγt-dependent pathway. J Immunol (2011) 1.00
The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology. Mol Cell Biol (2012) 0.96
Molecular and genetic parameters defining T-cell clonal selection. Immunol Cell Biol (2010) 0.91
Does MK5 reconcile classical and atypical MAP kinases? Front Biosci (2008) 0.89
Visualization of CD4/CD8 T cell commitment. J Exp Med (1998) 0.87
Targeted inactivation of Mapk4 in mice reveals specific nonredundant functions of Erk3/Erk4 subfamily mitogen-activated protein kinases. Mol Cell Biol (2010) 0.87
MK5 activates Rag transcription via Foxo1 in developing B cells. J Exp Med (2013) 0.86
CD40-activated B cells can efficiently prime antigen-specific naïve CD8+ T cells to generate effector but not memory T cells. PLoS One (2012) 0.84
The non-classical MAP kinase ERK3 controls T cell activation. PLoS One (2014) 0.86