Published in J Comp Physiol B on July 18, 2014
Differential gene expression in the liver of the African lungfish, Protopterus annectens, after 6 months of aestivation in air or 1 day of arousal from 6 months of aestivation. PLoS One (2015) 0.78
Molecular Characterization of Aquaporin 1 and Aquaporin 3 from the Gills of the African Lungfish, Protopterus annectens, and Changes in Their Branchial mRNA Expression Levels and Protein Abundance during Three Phases of Aestivation. Front Physiol (2016) 0.76
Aestivation Induces Changes in the mRNA Expression Levels and Protein Abundance of Two Isoforms of Urea Transporters in the Gills of the African Lungfish, Protopterus annectens. Front Physiol (2017) 0.75
Molecular characterization of myostatin from the skeletal muscle of the African lungfish, Protopterus annectens, and changes in its mRNA and protein expression levels during three phases of aestivation. J Comp Physiol B (2017) 0.75
Nitric oxide synthases: structure, function and inhibition. Biochem J (2001) 9.73
Arginine metabolism: nitric oxide and beyond. Biochem J (1998) 6.44
Transcriptional regulation of metabolism. Physiol Rev (2006) 3.68
Free radicals, antioxidants, and nutrition. Nutrition (2002) 3.66
Nitrite and nitrate determinations in plasma: a critical evaluation. Clin Chem (1995) 3.33
The African coelacanth genome provides insights into tetrapod evolution. Nature (2013) 2.78
Regulation of enzymes of the urea cycle and arginine metabolism. Annu Rev Nutr (2002) 2.70
The crystal structure of GMP synthetase reveals a novel catalytic triad and is a structural paradigm for two enzyme families. Nat Struct Biol (1996) 2.11
The physiology and pathophysiology of nitric oxide in the brain. Prog Neurobiol (2005) 1.81
Methods to detect nitric oxide and its metabolites in biological samples. Free Radic Biol Med (2007) 1.81
Argininosuccinate synthetase from the urea cycle to the citrulline-NO cycle. Eur J Biochem (2003) 1.69
Functional and structural adaptations of skeletal muscle to microgravity. J Exp Biol (2001) 1.65
Requirement of argininosuccinate lyase for systemic nitric oxide production. Nat Med (2011) 1.54
Regulation of enzymes of urea and arginine synthesis. Annu Rev Nutr (1992) 1.49
Animal response to drastic changes in oxygen availability and physiological oxidative stress. Comp Biochem Physiol C Toxicol Pharmacol (2002) 1.48
Muscle wasting and dedifferentiation induced by oxidative stress in a murine model of cachexia is prevented by inhibitors of nitric oxide synthesis and antioxidants. EMBO J (1996) 1.43
Arginine metabolism and the synthesis of nitric oxide in the nervous system. Prog Neurobiol (2001) 1.40
Involvement of oxidative stress and caspase 2-mediated intrinsic pathway signaling in age-related increase in muscle cell apoptosis in mice. Apoptosis (2008) 1.36
Arginine metabolic enzymes, nitric oxide and infection. J Nutr (2004) 1.24
Protein metabolism and beta-myosin heavy-chain mRNA in unweighted soleus muscle. Am J Physiol (1989) 1.23
Regulation of mRNA levels for five urea cycle enzymes in rat liver by diet, cyclic AMP, and glucocorticoids. Arch Biochem Biophys (1987) 1.16
Argininosuccinate synthase: at the center of arginine metabolism. Int J Biochem Mol Biol (2011) 1.16
Early change in skeletal muscle protein synthesis after limb immobilization of rats. J Appl Physiol Respir Environ Exerc Physiol (1979) 1.13
Argininosuccinate synthetase is reversibly inactivated by S-nitrosylation in vitro and in vivo. J Biol Chem (2004) 1.13
Gene transcript changes in individual rainbow trout livers following an inflammatory stimulus. Fish Shellfish Immunol (2006) 1.11
Argininosuccinate lyase: purification and characterization from human liver. Biochemistry (1981) 1.09
Real-time measurement of nitric oxide in single mature mouse skeletal muscle fibres during contractions. J Physiol (2007) 1.09
Emerging roles of ROS/RNS in muscle function and fatigue. Antioxid Redox Signal (2011) 1.06
Ammonia production, excretion, toxicity, and defense in fish: a review. Front Physiol (2010) 1.05
Role of nitric oxide in the regulation of neuronal proliferation, survival and differentiation. Neurochem Int (2004) 1.04
Nitrogen metabolism in the African lungfish (Protopterus dolloi) aestivating in a mucus cocoon on land. J Exp Biol (2004) 1.03
High levels of ascorbic acid, not glutathione, in the CNS of anoxia-tolerant reptiles contrasted with levels in anoxia-intolerant species. J Neurochem (1995) 0.99
Isolation and characterization of argininosuccinate synthetase from human liver. Biochemistry (1979) 0.99
Aestivation of the African lungfish Protopterus aethiopicus: cardiovascular and respiratory functions. J Exp Biol (1974) 0.98
Nitric oxide in myogenesis and therapeutic muscle repair. Mol Neurobiol (2012) 0.95
The nitric oxide pathway--evidence and mechanisms for protection against liver ischaemia reperfusion injury. Liver Int (2012) 0.93
Structure determination and refinement at 2.44 A resolution of argininosuccinate lyase from Escherichia coli. Acta Crystallogr D Biol Crystallogr (2004) 0.90
Ornithine-urea cycle and urea synthesis in African lungfishes, Protopterus aethiopicus and Protopterus annectens, exposed to terrestrial conditions for six days. J Exp Zool A Comp Exp Biol (2005) 0.89
Three-dimensional structure of the argininosuccinate lyase frequently complementing allele Q286R. Biochemistry (2001) 0.88
Decreased Jun-D and myogenin expression in muscle wasting of human cachexia. Am J Physiol Endocrinol Metab (2009) 0.88
Expression and function of arginine-producing and consuming-enzymes in the kidney. Amino Acids (2011) 0.88
Excretory nitrogen metabolism and defence against ammonia toxicity in air-breathing fishes. J Fish Biol (2014) 0.87
THE METABOLISM OF THE AESTIVATING AFRICAN LUNGFISH. Comp Biochem Physiol (1964) 0.86
Nitric oxide: biologic effects on muscle and role in muscle diseases. Neuromuscul Disord (2001) 0.86
Differential gene expression in the brain of the African lungfish, Protopterus annectens, after six days or six months of aestivation in air. PLoS One (2013) 0.86
L-arginine and nitric oxide in CNS function and neurodegenerative diseases. Crit Rev Food Sci Nutr (2013) 0.85
Antioxidant defenses and metabolic depression in a pulmonate land snail. Am J Physiol (1995) 0.85
Intragenic complementation and the structure and function of argininosuccinate lyase. Cell Mol Life Sci (2000) 0.84
Role of nitric oxide in liver regeneration. Ann Hepatol (2012) 0.83
Regulation of urea and citrulline synthesis under physiological conditions. Biochem J (1993) 0.83
Nutritional and hormonal regulation of mRNA abundance for arginine biosynthetic enzymes in kidney. Arch Biochem Biophys (1989) 0.83
Phosphorylation of argininosuccinate synthase by protein kinase A. Biochem Biophys Res Commun (2008) 0.82
Nitric oxide synthase-dependent "on/off" switch and apoptosis in freshwater and aestivating lungfish, Protopterus annectens: skeletal muscle versus cardiac muscle. Nitric Oxide (2013) 0.81
Structure of human argininosuccinate synthetase. Acta Crystallogr D Biol Crystallogr (2008) 0.81
Differential gene expression in the liver of the African lungfish, Protopterus annectens, after 6 days of estivation in air. J Comp Physiol B (2011) 0.81
Urea synthesis in the African lungfish Protopterus dolloi--hepatic carbamoyl phosphate synthetase III and glutamine synthetase are upregulated by 6 days of aerial exposure. J Exp Biol (2003) 0.81
Increased urea synthesis and/or suppressed ammonia production in the African lungfish, Protopterus annectens, during aestivation in air or mud. J Comp Physiol B (2007) 0.81
Effects of intra-peritoneal injection with NH4Cl, urea, or NH4Cl+urea on nitrogen excretion and metabolism in the African lungfish Protopterus dolloi. J Exp Zool A Comp Exp Biol (2005) 0.80
Transient ischemia increases neuronal nitric oxide synthase, argininosuccinate synthetase and argininosuccinate lyase co-expression in rat striatal neurons. Exp Neurol (2007) 0.80
The 1.6 A crystal structure of E. coli argininosuccinate synthetase suggests a conformational change during catalysis. Structure (2001) 0.80
The interplay of increased urea synthesis and reduced ammonia production in the African lungfish Protopterus aethiopicus during 46 days of aestivation in a mucus cocoon. J Exp Zool A Comp Exp Biol (2005) 0.80
The ammonotelic African lungfish, Protopterus dolloi, increases the rate of urea synthesis and becomes ureotelic after feeding. J Comp Physiol B (2004) 0.79
Activated microglia cells express argininosuccinate synthetase and argininosuccinate lyase in the rat brain after transient ischemia. Exp Neurol (2007) 0.79
Protein kinase Cα phosphorylates a novel argininosuccinate synthase site at serine 328 during calcium-dependent stimulation of endothelial nitric-oxide synthase in vascular endothelial cells. J Biol Chem (2012) 0.79
Interactions between reactive oxygen species generated by contractile activity and aging in skeletal muscle? Antioxid Redox Signal (2013) 0.78
Molecular characterization and mRNA expression of carbamoyl phosphate synthetase III in the liver of the African lungfish, Protopterus annectens, during aestivation or exposure to ammonia. J Comp Physiol B (2011) 0.78
Brain Na+/K+-ATPase α-subunit isoforms and aestivation in the African lungfish, Protopterus annectens. J Comp Physiol B (2014) 0.78
Effects of hypoxia on the energy status and nitrogen metabolism of African lungfish during aestivation in a mucus cocoon. J Comp Physiol B (2008) 0.77
Lungfish aestivating activities are locked in distinct encephalic γ-aminobutyric acid type A receptor α subunits. J Neurosci Res (2011) 0.77
The alimentary canal of the African lungfish Protopterus annectens during aestivation and after arousal. Anat Rec (Hoboken) (2011) 0.77
L-gulono-γ-lactone oxidase expression and vitamin C synthesis in the brain and kidney of the African lungfish, Protopterus annectens. FASEB J (2014) 0.77
Renal corpuscle of the african lungfish Protopterus dolloi: structural and histochemical modifications during aestivation. Anat Rec (Hoboken) (2008) 0.77
The connection between oxidative stress and estivation in gastropods and anurans. Prog Mol Subcell Biol (2010) 0.76
Aestivation and hypoxia-related events share common silent neuron trafficking processes. BMC Neurosci (2012) 0.76
Potential respiratory and circulatory adjustments to hypoxia in the African lungfish. Fed Proc (1970) 0.76
Phylogenetic aspects of carbamoyl phosphate synthetase in lungfish: a transitional enzyme in transitional fishes. Comp Biochem Physiol Part D Genomics Proteomics (2011) 0.76
The interaction of Glu294 at the subunit interface is important for the activity and stability of goose delta-crystallin. Mol Vis (2009) 0.75
Formation of arginine and guanidinoacetic acid in the kidney in vivo. Their relations with the liver and their regulation. J Biochem (1981) 0.75
Ammonia production, excretion, toxicity, and defense in fish: a review. Front Physiol (2010) 1.05
Nitrogen metabolism in the African lungfish (Protopterus dolloi) aestivating in a mucus cocoon on land. J Exp Biol (2004) 1.03
The accumulation of methylamine counteracting solutes in elasmobranchs with differing levels of urea: a comparison of marine and freshwater species. J Exp Biol (2006) 0.89
Active ammonia transport and excretory nitrogen metabolism in the climbing perch, Anabas testudineus, during 4 days of emersion or 10 minutes of forced exercise on land. J Exp Biol (2006) 0.88
Both seawater acclimation and environmental ammonia exposure lead to increases in mRNA expression and protein abundance of Na⁺:K⁺:2Cl⁻ cotransporter in the gills of the climbing perch, Anabas testudineus. J Comp Physiol B (2011) 0.88
Environmental ammonia exposure induces oxidative stress in gills and brain of Boleophthalmus boddarti (mudskipper). Aquat Toxicol (2009) 0.87
Roles of three branchial Na(+)-K(+)-ATPase α-subunit isoforms in freshwater adaptation, seawater acclimation, and active ammonia excretion in Anabas testudineus. Am J Physiol Regul Integr Comp Physiol (2012) 0.86
Differential gene expression in the brain of the African lungfish, Protopterus annectens, after six days or six months of aestivation in air. PLoS One (2013) 0.86
Ventricle and outflow tract of the African lungfish Protopterus dolloi. J Morphol (2005) 0.86
The swamp eel Monopterus albus reduces endogenous ammonia production and detoxifies ammonia to glutamine during 144 h of aerial exposure. J Exp Biol (2003) 0.84
The osmotic response of the Asian freshwater stingray (Himantura signifer) to increased salinity: a comparison with marine (Taeniura lymma) and Amazonian freshwater (Potamotrygon motoro) stingrays. J Exp Biol (2003) 0.84
Postprandial increases in nitrogenous excretion and urea synthesis in the Chinese soft-shelled turtle, Pelodiscus sinensis. J Comp Physiol B (2006) 0.84
Strategies for surviving high concentrations of environmental ammonia in the swamp eel Monopterus albus. Physiol Biochem Zool (2004) 0.83
The influence of feeding and fasting on plasma metabolites in the dogfish shark (Squalus acanthias). Comp Biochem Physiol A Mol Integr Physiol (2009) 0.82
The African lungfish (Protopterus dolloi): ionoregulation and osmoregulation in a fish out of water. Physiol Biochem Zool (2006) 0.82
Chronic and acute ammonia toxicity in mudskippers, Periophthalmodon schlosseri and Boleophthalmus boddaerti: brain ammonia and glutamine contents, and effects of methionine sulfoximine and MK801. J Exp Biol (2005) 0.82
Cystic fibrosis transmembrane conductance regulator in the gills of the climbing perch, Anabas testudineus, is involved in both hypoosmotic regulation during seawater acclimation and active ammonia excretion during ammonia exposure. J Comp Physiol B (2012) 0.82
Heart inflow tract of the African lungfish Protopterus dolloi. J Morphol (2005) 0.82
Branchial Na(+):K(+):2Cl(-) cotransporter 1 and Na(+)/K(+)-ATPase α-subunit in a brackish water-type ionocyte of the euryhaline freshwater white-rimmed stingray, Himantura signifer. Front Physiol (2013) 0.82
Urea synthesis in the African lungfish Protopterus dolloi--hepatic carbamoyl phosphate synthetase III and glutamine synthetase are upregulated by 6 days of aerial exposure. J Exp Biol (2003) 0.81
Increased urea synthesis and/or suppressed ammonia production in the African lungfish, Protopterus annectens, during aestivation in air or mud. J Comp Physiol B (2007) 0.81
Effects of intra-peritoneal injection with NH4Cl, urea, or NH4Cl+urea on nitrogen excretion and metabolism in the African lungfish Protopterus dolloi. J Exp Zool A Comp Exp Biol (2005) 0.80
Active ammonia excretion in the giant mudskipper, Periophthalmodon schlosseri (Pallas), during emersion. J Exp Zool A Ecol Genet Physiol (2007) 0.80
Ammonia toxicity and tolerance in the brain of the African sharptooth catfish, Clarias gariepinus. Aquat Toxicol (2007) 0.80
Ascorbic Acid Biosynthesis and Brackish Water Acclimation in the Euryhaline Freshwater White-Rimmed Stingray, Himantura signifer. PLoS One (2013) 0.80
Exposure to brackish water, upon feeding, leads to enhanced conservation of nitrogen and increased urea synthesis and retention in the Asian freshwater stingray Himantura signifer. J Exp Biol (2006) 0.80
The giant mudskipper Periophthalmodon schlosseri facilitates active NH(4)(+) excretion by increasing acid excretion and decreasing NH(3) permeability in the skin. J Exp Biol (2004) 0.79
Acute ammonia toxicity and the protective effects of methionine sulfoximine on the swamp eel, Monopterus albus. J Exp Zool A Ecol Genet Physiol (2009) 0.79
Strategies adopted by the mudskipper Boleophthalmus boddaerti to survive sulfide exposure in normoxia or hypoxia. Physiol Biochem Zool (2004) 0.78
Nitrogen metabolism and branchial osmoregulatory acclimation in the juvenile marble goby, Oxyeleotris marmorata, exposed to seawater. Comp Biochem Physiol A Mol Integr Physiol (2009) 0.78
Light induces an increase in the pH of and a decrease in the ammonia concentration in the extrapallial fluid of the giant clam Tridacna squamosa. Physiol Biochem Zool (2006) 0.78
The structural characteristics of the heart ventricle of the African lungfish Protopterus dolloi: freshwater and aestivation. J Anat (2008) 0.78
Glutamine accumulation and up-regulation of glutamine synthetase activity in the swamp eel, Monopterus albus (Zuiew), exposed to brackish water. J Exp Biol (2009) 0.78
Greatly elevated urea excretion after air exposure appears to be carrier mediated in the slender lungfish (Protopterus dolloi). Physiol Biochem Zool (2005) 0.78
Brain Na+/K+-ATPase α-subunit isoforms and aestivation in the African lungfish, Protopterus annectens. J Comp Physiol B (2014) 0.78
The gut of the juvenile African lungfish Protopterus annectens: a light and scanning electron microscope study. J Morphol (2011) 0.78
A comparison of the effects of environmental ammonia exposure on the Asian freshwater stingray Himantura signifer and the Amazonian freshwater stingray Potamotrygon motoro. J Exp Biol (2003) 0.77
Postprandial increases in nitrogenous excretion and urea synthesis in the giant mudskipper Periophthalmodon schlosseri. J Exp Biol (2004) 0.77
African sharptooth catfish Clarias gariepinus does not detoxify ammonia to urea or amino acids but actively excretes ammonia during exposure to environmental ammonia. Physiol Biochem Zool (2004) 0.77
Exposure to air, but not seawater, increases the glutamine content and the glutamine synthetase activity in the marsh clam Polymesoda expansa. J Exp Biol (2004) 0.77
Renal corpuscle of the african lungfish Protopterus dolloi: structural and histochemical modifications during aestivation. Anat Rec (Hoboken) (2008) 0.77