Loss of oncogenic Notch1 with resistance to a PI3K inhibitor in T-cell leukaemia.

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Published in Nature on July 20, 2014

Authors

Monique Dail1, Jason Wong1, Jessica Lawrence1, Daniel O'Connor1, Joy Nakitandwe2, Shann-Ching Chen2, Jin Xu1, Leslie B Lee3, Keiko Akagi4, Qing Li5, Jon C Aster6, Warren S Pear7, James R Downing2, Deepak Sampath3, Kevin Shannon1

Author Affiliations

1: Department of Pediatrics and Benniof Children's Hospital, University of California, San Francisco, California 94143, USA.
2: Department of Pathology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
3: Department of Translational Oncology, Genentech Inc., South San Francisco, California 94080, USA.
4: Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University, Columbus, Ohio 43210, USA.
5: Division of Haematology/Oncology, Department of Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA.
6: Department of Pathology, Brigham &Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
7: Abramson Family Cancer Research Institute and the Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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