Published in Commun Integr Biol on May 16, 2014
Baicalin Inhibits Lipopolysaccharide-Induced Inflammation Through Signaling NF-κB Pathway in HBE16 Airway Epithelial Cells. Inflammation (2015) 0.82
Role of Sphingolipids in the Pathobiology of Lung Inflammation. Mediators Inflamm (2015) 0.77
Improved Chemotherapeutic Activity by Morus alba Fruits through Immune Response of Toll-Like Receptor 4. Int J Mol Sci (2015) 0.76
Andrographolide sulfonate ameliorates lipopolysaccharide-induced acute lung injury in mice by down-regulating MAPK and NF-κB pathways. Acta Pharm Sin B (2016) 0.75
Protective Role of Proton-Sensing TDAG8 in Lipopolysaccharide-Induced Acute Lung Injury. Int J Mol Sci (2015) 0.75
Prior infection with Type A Francisella tularensis antagonizes the pulmonary transcriptional response to an aerosolized Toll-like receptor 4 agonist. BMC Genomics (2015) 0.75
FXYD5 Is an Essential Mediator of the Inflammatory Response during Lung Injury. Front Immunol (2017) 0.75
Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science (1998) 37.15
Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol (1999) 16.86
Rab GTPases as coordinators of vesicle traffic. Nat Rev Mol Cell Biol (2009) 13.01
TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet (2000) 8.79
TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol (2008) 7.87
Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell (2008) 6.37
Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell (2006) 6.01
Harnessing actin dynamics for clathrin-mediated endocytosis. Nat Rev Mol Cell Biol (2006) 5.59
Essential role of MD-2 in LPS responsiveness and TLR4 distribution. Nat Immunol (2002) 5.41
Immunoregulatory functions of surfactant proteins. Nat Rev Immunol (2005) 4.55
A cell biological view of Toll-like receptor function: regulation through compartmentalization. Nat Rev Immunol (2009) 4.19
Soluble CD14 participates in the response of cells to lipopolysaccharide. J Exp Med (1992) 4.02
Distinct molecular mechanism for initiating TRAF6 signalling. Nature (2002) 3.82
Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction. J Biol Chem (2002) 3.58
Mediators of innate immune recognition of bacteria concentrate in lipid rafts and facilitate lipopolysaccharide-induced cell activation. J Cell Sci (2002) 3.29
Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity. EMBO J (2006) 3.07
CD14 controls the LPS-induced endocytosis of Toll-like receptor 4. Cell (2011) 3.00
Pulmonary surfactant: functions and molecular composition. Biochim Biophys Acta (1998) 2.47
Modulation of the TLR-mediated inflammatory response by the endogenous human host defense peptide LL-37. J Immunol (2006) 2.32
Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M. J Clin Invest (2006) 2.29
The Rab11a GTPase controls Toll-like receptor 4-induced activation of interferon regulatory factor-3 on phagosomes. Immunity (2010) 2.29
TLR4 polymorphisms, infectious diseases, and evolutionary pressure during migration of modern humans. Proc Natl Acad Sci U S A (2007) 2.28
Cutting edge: myeloid differentiation factor 88 is essential for pulmonary host defense against Pseudomonas aeruginosa but not Staphylococcus aureus. J Immunol (2004) 2.26
Response of human pulmonary epithelial cells to lipopolysaccharide involves Toll-like receptor 4 (TLR4)-dependent signaling pathways: evidence for an intracellular compartmentalization of TLR4. J Biol Chem (2003) 2.20
Localisation and trafficking of Toll-like receptors: an important mode of regulation. Curr Opin Immunol (2010) 2.08
Oxidative stress generated by hemorrhagic shock recruits Toll-like receptor 4 to the plasma membrane in macrophages. J Exp Med (2006) 2.07
Structure of pulmonary surfactant membranes and films: the role of proteins and lipid-protein interactions. Biochim Biophys Acta (2008) 2.01
The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock. Nat Immunol (2012) 1.94
CD14-dependent lipopolysaccharide-induced beta-defensin-2 expression in human tracheobronchial epithelium. J Biol Chem (2000) 1.89
Toll-like receptor 4 mediates innate immune responses to Haemophilus influenzae infection in mouse lung. J Immunol (2002) 1.88
Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling. Biochem Biophys Res Commun (2008) 1.76
Role of Toll-like receptor 4 in gram-positive and gram-negative pneumonia in mice. Infect Immun (2004) 1.73
Expression of functional toll-like receptor-2 and -4 on alveolar epithelial cells. Am J Respir Cell Mol Biol (2004) 1.71
The MyD88-dependent, but not the MyD88-independent, pathway of TLR4 signaling is important in clearing nontypeable haemophilus influenzae from the mouse lung. J Immunol (2005) 1.65
The development of early host response to Pseudomonas aeruginosa lung infection is critically dependent on myeloid differentiation factor 88 in mice. J Biol Chem (2004) 1.58
TLR4-dependent GM-CSF protects against lung injury in Gram-negative bacterial pneumonia. Am J Physiol Lung Cell Mol Physiol (2011) 1.57
Central role of toll-like receptor 4 signaling and host defense in experimental pneumonia caused by Gram-negative bacteria. Infect Immun (2005) 1.53
TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway. Nat Immunol (2009) 1.52
Pulmonary surfactant protein A regulates TLR expression and activity in human macrophages. J Immunol (2008) 1.49
Both TRIF- and MyD88-dependent signaling contribute to host defense against pulmonary Klebsiella infection. J Immunol (2009) 1.48
The critical role of hematopoietic cells in lipopolysaccharide-induced airway inflammation. Am J Respir Crit Care Med (2004) 1.48
Transport of bacterial lipopolysaccharide to the golgi apparatus. J Exp Med (1999) 1.45
Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Blood (2007) 1.45
Toll-like receptor 2 expression is decreased on alveolar macrophages in cigarette smokers and COPD patients. Respir Res (2005) 1.44
Lateral diffusion of Toll-like receptors reveals that they are transiently confined within lipid rafts on the plasma membrane. J Cell Sci (2004) 1.41
Toll/IL-1R domain-containing adaptor protein (TIRAP) is a critical mediator of antibacterial defense in the lung against Klebsiella pneumoniae but not Pseudomonas aeruginosa. J Immunol (2006) 1.40
Pulmonary collectins and innate host defense of the lung. Microbes Infect (2001) 1.39
Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis. J Immunol (2011) 1.31
The Asp299Gly polymorphism alters TLR4 signaling by interfering with recruitment of MyD88 and TRIF. J Immunol (2012) 1.31
Toll-IL-1 receptor domain-containing adaptor protein is critical for early lung immune responses against Escherichia coli lipopolysaccharide and viable Escherichia coli. J Immunol (2005) 1.24
Ras-related protein Rab10 facilitates TLR4 signaling by promoting replenishment of TLR4 onto the plasma membrane. Proc Natl Acad Sci U S A (2010) 1.22
Differential expression of Toll-like receptors on human alveolar macrophages and autologous peripheral monocytes. Respir Res (2010) 1.22
Airway epithelial control of Pseudomonas aeruginosa infection in cystic fibrosis. Trends Mol Med (2008) 1.21
Rab7b controls trafficking from endosomes to the TGN. J Cell Sci (2010) 1.20
Differences in LPS-induced activation of bronchial epithelial cells (BEAS-2B) and type II-like pneumocytes (A-549). Scand J Immunol (2002) 1.19
The inflammatory versus constitutive trafficking of mononuclear phagocytes into the alveolar space of mice is associated with drastic changes in their gene expression profiles. J Immunol (2005) 1.19
Innate immune recognition of bacterial lipopolysaccharide: dependence on interactions with membrane lipids and endocytic movement. Immunity (1998) 1.17
Glia maturation factor-gamma is preferentially expressed in microvascular endothelial and inflammatory cells and modulates actin cytoskeleton reorganization. Circ Res (2006) 1.16
Ventilator-associated pneumonia in patients undergoing major heart surgery: an incidence study in Europe. Crit Care (2009) 1.16
A role of Toll-IL-1 receptor domain-containing adaptor-inducing IFN-beta in the host response to Pseudomonas aeruginosa lung infection in mice. J Immunol (2007) 1.13
Potential role of membrane internalization and vesicle fusion in adhesion of neutrophils in response to lipopolysaccharide and TNF. J Immunol (1996) 1.11
Structural analyses of human Toll-like receptor 4 polymorphisms D299G and T399I. J Biol Chem (2012) 1.11
Regulation of Toll-like receptor 4 expression in the lung following hemorrhagic shock and lipopolysaccharide. J Immunol (2002) 1.10
Gene expression of Toll-like receptors and associated molecules induced by inflammatory stimuli in the primary alveolar macrophage. Biochem Biophys Res Commun (2003) 1.09
The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation. Nat Commun (2012) 1.09
Innate immune responses to bacterial ligands in the peripheral human lung--role of alveolar epithelial TLR expression and signalling. PLoS One (2011) 1.09
Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts. Crit Care (2010) 1.08
Expression of toll-like receptor 2 and 4 in lipopolysaccharide-induced lung injury in mouse. Cell Tissue Res (2005) 1.06
Toll-like receptor mRNA levels in alveolar macrophages after inhalation of endotoxin. Eur Respir J (2006) 1.04
Surfactant lipids regulate LPS-induced interleukin-8 production in A549 lung epithelial cells by inhibiting translocation of TLR4 into lipid raft domains. J Lipid Res (2009) 1.03
Specific engagement of TLR4 or TLR3 does not lead to IFN-beta-mediated innate signal amplification and STAT1 phosphorylation in resident murine alveolar macrophages. J Immunol (2004) 1.02
Surfactant protein D increases fusion of Mycobacterium tuberculosis-containing phagosomes with lysosomes in human macrophages. Infect Immun (2006) 1.01
Gram-negative bacterial pneumonia: aetiology and management. Curr Opin Pulm Med (2006) 0.98
Mice genetically hyporesponsive to lipopolysaccharide (LPS) exhibit a defect in endocytic uptake of LPS and ceramide. J Exp Med (1997) 0.96
Persistence of LPS-induced lung inflammation in surfactant protein-C-deficient mice. Am J Respir Cell Mol Biol (2013) 0.93
Host defence during Klebsiella pneumonia relies on haematopoietic-expressed Toll-like receptors 4 and 2. Eur Respir J (2010) 0.91
Pulmonary surfactant protein A and surfactant lipids upregulate IRAK-M, a negative regulator of TLR-mediated inflammation in human macrophages. Am J Physiol Lung Cell Mol Physiol (2012) 0.91
Pulmonary collectins protect macrophages against pore-forming activity of Legionella pneumophila and suppress its intracellular growth. J Biol Chem (2010) 0.90
Neutrophils activate alveolar macrophages by producing caspase-6-mediated cleavage of IL-1 receptor-associated kinase-M. J Immunol (2010) 0.89
Differential response of primary alveolar type I and type II cells to LPS stimulation. PLoS One (2013) 0.88
Priming of alveolar macrophages upon instillation of lipopolysaccharide in the human lung. Am J Respir Cell Mol Biol (2009) 0.85
Severe pneumonia mortality in elderly patients is associated with downregulation of Toll-like receptors 2 and 4 on monocytes. Am J Med Sci (2014) 0.84
Toll-like receptor 4 is not targeted to the lysosome in cystic fibrosis airway epithelial cells. Am J Physiol Lung Cell Mol Physiol (2013) 0.84
Tetraspanin CD9 negatively regulates lipopolysaccharide-induced macrophage activation and lung inflammation. J Immunol (2009) 0.83
Review: The intersection of surfactant homeostasis and innate host defense of the lung: lessons from newborn infants. Innate Immun (2010) 0.83
Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung. Pharmaceuticals (Basel) (2012) 0.82
Pulmonary surfactant protein A enhances endolysosomal trafficking in alveolar macrophages through regulation of Rab7. J Immunol (2011) 0.81
LPS-stimulated cytokine production in type I cells is modulated by the renin-angiotensin system. Am J Respir Cell Mol Biol (2011) 0.80
Glia maturation factor-γ negatively modulates TLR4 signaling by facilitating TLR4 endocytic trafficking in macrophages. J Immunol (2013) 0.80
Surfactant protein-A modulates LPS-induced TLR4 localization and signaling via β-arrestin 2. PLoS One (2013) 0.79
The antimicrobial peptide cathelicidin enhances activation of lung epithelial cells by LPS. FASEB J (2010) 0.79
Adenylyl cyclase 6 activation negatively regulates TLR4 signaling through lipid raft-mediated endocytosis. J Immunol (2013) 0.78
Dysfunction of alveolar macrophages after cardiac surgery and postoperative pneumonia?--An observational study. Crit Care (2013) 0.78
Looped host defense peptide CLP-19 binds to microtubules and inhibits surface expression of TLR4 on mouse macrophages. J Immunol (2013) 0.77
Impaired phospholipases A₂production by stimulated macrophages from patients with acute respiratory distress syndrome. Biochim Biophys Acta (2010) 0.76