TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta.

PubWeight™: 7.87‹?› | Rank: Top 0.1%

🔗 View Article (PMC 4112825)

Published in Nat Immunol on February 24, 2008

Authors

Jonathan C Kagan1, Tian Su, Tiffany Horng, Amy Chow, Shizuo Akira, Ruslan Medzhitov

Author Affiliations

1: Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA. jonathan.kagan@childrens.harvard.edu

Articles citing this

(truncated to the top 100)

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol (2010) 24.08

Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses. Science (2009) 6.07

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Nat Immunol (2009) 5.87

Endocytosis and signalling: intertwining molecular networks. Nat Rev Mol Cell Biol (2009) 5.83

The roles of TLRs, RLRs and NLRs in pathogen recognition. Int Immunol (2009) 5.21

Pathogen recognition and inflammatory signaling in innate immune defenses. Clin Microbiol Rev (2009) 4.55

TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria. Cell (2012) 4.44

A cell biological view of Toll-like receptor function: regulation through compartmentalization. Nat Rev Immunol (2009) 4.19

Bifurcation of Toll-like receptor 9 signaling by adaptor protein 3. Science (2010) 3.37

Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands. Nat Immunol (2009) 3.17

CD14 controls the LPS-induced endocytosis of Toll-like receptor 4. Cell (2011) 3.00

Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines. Nat Immunol (2009) 2.52

Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation. J Biol Chem (2009) 2.47

Putting endotoxin to work for us: monophosphoryl lipid A as a safe and effective vaccine adjuvant. Cell Mol Life Sci (2008) 2.39

Endosomes: a legitimate platform for the signaling train. Proc Natl Acad Sci U S A (2009) 2.33

A Stringent Systems Approach Uncovers Gene-Specific Mechanisms Regulating Inflammation. Cell (2016) 2.30

Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer. Pharmacol Rev (2009) 2.30

Hepatocyte death: a clear and present danger. Physiol Rev (2010) 2.18

CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation. Nature (2009) 2.13

Innate immunity in the respiratory epithelium. Am J Respir Cell Mol Biol (2011) 2.04

Cystic fibrosis: a mucosal immunodeficiency syndrome. Nat Med (2012) 2.03

A promiscuous lipid-binding protein diversifies the subcellular sites of toll-like receptor signal transduction. Cell (2014) 1.99

Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity. Cell Metab (2014) 1.96

The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock. Nat Immunol (2012) 1.94

Pattern recognition: recent insights from Dectin-1. Curr Opin Immunol (2009) 1.93

Nonconventional initiation complex assembly by STAT and NF-kappaB transcription factors regulates nitric oxide synthase expression. Immunity (2010) 1.90

Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells. Nat Immunol (2009) 1.90

Pathogen Cell-to-Cell Variability Drives Heterogeneity in Host Immune Responses. Cell (2015) 1.87

Information processing during phagocytosis. Nat Rev Immunol (2012) 1.84

High-density lipoprotein suppresses the type I interferon response, a family of potent antiviral immunoregulators, in macrophages challenged with lipopolysaccharide. Circulation (2010) 1.80

The role of ubiquitylation in immune defence and pathogen evasion. Nat Rev Immunol (2011) 1.76

Toll-like receptor signaling in endogenous neuroprotection and stroke. Neuroscience (2008) 1.73

Induction of type I interferons by bacteria. Cell Microbiol (2010) 1.70

Toll-like receptor 4 in CNS pathologies. J Neurochem (2010) 1.68

pH-dependent internalization of muramyl peptides from early endosomes enables Nod1 and Nod2 signaling. J Biol Chem (2009) 1.68

Phosphoinositide binding by the Toll adaptor dMyD88 controls antibacterial responses in Drosophila. Immunity (2012) 1.67

Innate immune pattern recognition: a cell biological perspective. Annu Rev Immunol (2015) 1.66

Helminth-derived immunomodulators: can understanding the worm produce the pill? Nat Rev Immunol (2010) 1.66

Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling. Proc Natl Acad Sci U S A (2009) 1.65

Adaptor protein-3 in dendritic cells facilitates phagosomal toll-like receptor signaling and antigen presentation to CD4(+) T cells. Immunity (2012) 1.59

TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway. Nat Immunol (2009) 1.52

Autophagy and pattern recognition receptors in innate immunity. Immunol Rev (2009) 1.51

Both TRIF- and MyD88-dependent signaling contribute to host defense against pulmonary Klebsiella infection. J Immunol (2009) 1.48

Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice. J Clin Invest (2009) 1.48

TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity. J Virol (2012) 1.47

Endocytosed BCRs sequentially regulate MAPK and Akt signaling pathways from intracellular compartments. Nat Immunol (2011) 1.46

Adipose tissue exosome-like vesicles mediate activation of macrophage-induced insulin resistance. Diabetes (2009) 1.42

The TRAF-associated protein TANK facilitates cross-talk within the IkappaB kinase family during Toll-like receptor signaling. Proc Natl Acad Sci U S A (2011) 1.41

Heme Oxygenase 2 Binds Myristate to Regulate Retrovirus Assembly and TLR4 Signaling. Cell Host Microbe (2017) 1.40

A role for TLR4 in Clostridium difficile infection and the recognition of surface layer proteins. PLoS Pathog (2011) 1.39

Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection. Proc Natl Acad Sci U S A (2011) 1.38

Analysis of proteinase-activated receptor 2 and TLR4 signal transduction: a novel paradigm for receptor cooperativity. J Biol Chem (2008) 1.38

Innate immune signalling at the intestinal epithelium in homeostasis and disease. EMBO Rep (2012) 1.37

Type I interferon production induced by Streptococcus pyogenes-derived nucleic acids is required for host protection. PLoS Pathog (2011) 1.36

The role of TLRs, NLRs, and RLRs in mucosal innate immunity and homeostasis. Mucosal Immunol (2009) 1.35

Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosis. PLoS Pathog (2008) 1.34

MyD88 adapter-like (Mal)/TIRAP interaction with TRAF6 is critical for TLR2- and TLR4-mediated NF-kappaB proinflammatory responses. J Biol Chem (2009) 1.34

Sensors of the innate immune system: their mode of action. Nat Rev Rheumatol (2009) 1.31

TRIF mediates Toll-like receptor 5-induced signaling in intestinal epithelial cells. J Biol Chem (2010) 1.31

The Asp299Gly polymorphism alters TLR4 signaling by interfering with recruitment of MyD88 and TRIF. J Immunol (2012) 1.31

Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis. J Immunol (2011) 1.31

Autophagy in immunity against mycobacterium tuberculosis: a model system to dissect immunological roles of autophagy. Curr Top Microbiol Immunol (2009) 1.30

Innate immune sensing of DNA viruses. Virology (2011) 1.30

Murine toll-like receptor 2 activation induces type I interferon responses from endolysosomal compartments. PLoS One (2010) 1.28

Current views of toll-like receptor signaling pathways. Gastroenterol Res Pract (2010) 1.27

Human β-defensin 3 affects the activity of pro-inflammatory pathways associated with MyD88 and TRIF. Eur J Immunol (2011) 1.27

Toll-like receptors in control of immunological autophagy. Cell Death Differ (2009) 1.26

Selective activation of the p38 MAPK pathway by synthetic monophosphoryl lipid A. J Biol Chem (2009) 1.25

Intracellular pathogen detection by RIG-I-like receptors. Adv Immunol (2013) 1.25

UNC93B1 is essential for TLR11 activation and IL-12-dependent host resistance to Toxoplasma gondii. J Biol Chem (2010) 1.25

Toll-like receptors: key players in antiviral immunity. Curr Opin Virol (2011) 1.24

Synthesis and immunological characterization of toll-like receptor 7 agonistic conjugates. Bioconjug Chem (2009) 1.20

Induction of endotoxin tolerance in vivo inhibits activation of IRAK4 and increases negative regulators IRAK-M, SHIP-1, and A20. J Leukoc Biol (2011) 1.20

Assembly of oligomeric death domain complexes during Toll receptor signaling. J Biol Chem (2008) 1.19

Endocytic pathway is required for Drosophila Toll innate immune signaling. Proc Natl Acad Sci U S A (2010) 1.18

Co-operation of TLR4 and raft proteins in LPS-induced pro-inflammatory signaling. Cell Mol Life Sci (2014) 1.18

Synergistic interactions of TLR2/6 and TLR9 induce a high level of resistance to lung infection in mice. J Immunol (2011) 1.16

How location governs toll-like receptor signaling. Traffic (2009) 1.16

Salmonella synthesizing 1-dephosphorylated [corrected] lipopolysaccharide exhibits low endotoxic activity while retaining its immunogenicity. J Immunol (2011) 1.15

Signaling organelles of the innate immune system. Cell (2012) 1.15

Induction of nuclear factor-κB responses by the S100A9 protein is Toll-like receptor-4-dependent. Immunology (2012) 1.14

Endotoxin tolerance impairs IL-1 receptor-associated kinase (IRAK) 4 and TGF-beta-activated kinase 1 activation, K63-linked polyubiquitination and assembly of IRAK1, TNF receptor-associated factor 6, and IkappaB kinase gamma and increases A20 expression. J Biol Chem (2011) 1.14

Selective TRIF-dependent signaling by a synthetic toll-like receptor 4 agonist. Sci Signal (2012) 1.13

Molecular control of steady-state dendritic cell maturation and immune homeostasis. Annu Rev Immunol (2013) 1.13

Signaling flux redistribution at toll-like receptor pathway junctions. PLoS One (2008) 1.12

The immunobiology of toll-like receptor 4 agonists: from endotoxin tolerance to immunoadjuvants. Shock (2013) 1.12

Soluble CD36 ectodomain binds negatively charged diacylglycerol ligands and acts as a co-receptor for TLR2. PLoS One (2009) 1.12

TLR signaling in mast cells: common and unique features. Front Immunol (2012) 1.12

Toll-Like Receptors and Cancer: MYD88 Mutation and Inflammation. Front Immunol (2014) 1.10

Targeting TLR/IL-1R signalling in human diseases. Mediators Inflamm (2010) 1.09

TLR2-mediated expansion of MDSCs is dependent on the source of tumor exosomes. Am J Pathol (2010) 1.09

Cell signalling in macrophages, the principal innate immune effector cells of rheumatoid arthritis. Arthritis Res Ther (2008) 1.09

Innate immune responses to bacterial ligands in the peripheral human lung--role of alveolar epithelial TLR expression and signalling. PLoS One (2011) 1.09

The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation. Nat Commun (2012) 1.09

Role of CD14 in host protection against infections and in metabolism regulation. Front Cell Infect Microbiol (2013) 1.08

Genome-wide expression profiling and mutagenesis studies reveal that lipopolysaccharide responsiveness appears to be absolutely dependent on TLR4 and MD-2 expression and is dependent upon intermolecular ionic interactions. J Immunol (2011) 1.08

MyD88: a central player in innate immune signaling. F1000Prime Rep (2014) 1.08

Internalization of Dectin-1 terminates induction of inflammatory responses. Eur J Immunol (2009) 1.08

Overview of the biology of type I interferons. Arthritis Res Ther (2010) 1.07

Microbial sensing by Toll-like receptors and intracellular nucleic acid sensors. Cold Spring Harb Perspect Biol (2014) 1.07

Articles cited by this

Pathogen recognition and innate immunity. Cell (2006) 44.14

Innate immune recognition. Annu Rev Immunol (2001) 26.65

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature (2001) 25.15

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature (2006) 22.65

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science (2003) 17.57

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science (2004) 16.26

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature (2001) 14.24

DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature (2007) 13.56

IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature (2005) 13.23

Dynasore, a cell-permeable inhibitor of dynamin. Dev Cell (2006) 13.15

The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat Rev Immunol (2007) 12.00

Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc Natl Acad Sci U S A (2004) 9.00

The dynamin superfamily: universal membrane tubulation and fission molecules? Nat Rev Mol Cell Biol (2004) 8.58

TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nat Immunol (2004) 8.06

TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction. Nat Immunol (2003) 7.06

IRF3 mediates a TLR3/TLR4-specific antiviral gene program. Immunity (2002) 6.85

TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40. Science (1995) 6.41

Control of EGF receptor signaling by clathrin-mediated endocytosis. Science (1996) 6.01

Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell (2006) 6.01

Toll-like receptor signaling pathways. Science (2003) 5.86

Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature (2005) 5.72

Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat Immunol (2004) 5.71

Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response. Nature (2005) 5.56

TIRAP: an adapter molecule in the Toll signaling pathway. Nat Immunol (2001) 5.49

Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3. Science (2000) 5.20

TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat Immunol (2003) 4.94

Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature (2002) 4.81

ADP-ribosylation factor 6 regulates a novel plasma membrane recycling pathway. J Cell Biol (1997) 4.76

TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages. Nat Immunol (2002) 4.63

Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nat Immunol (2005) 4.30

The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature (2002) 4.15

Legionella phagosomes intercept vesicular traffic from endoplasmic reticulum exit sites. Nat Cell Biol (2002) 3.98

Clathrin-independent pinocytosis is induced in cells overexpressing a temperature-sensitive mutant of dynamin. J Cell Biol (1995) 3.92

Antiviral signaling through pattern recognition receptors. J Biochem (2006) 3.84

Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis. J Cell Biol (2000) 3.63

Compartmentalization of TNF receptor 1 signaling: internalized TNF receptosomes as death signaling vesicles. Immunity (2004) 3.26

A role for clathrin in the sorting of vacuolar proteins in the Golgi complex of yeast. EMBO J (1992) 3.10

Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity. EMBO J (2006) 3.07

Phosphoinositide lipids as signaling molecules: common themes for signal transduction, cytoskeletal regulation, and membrane trafficking. Annu Rev Cell Dev Biol (1998) 3.01

Macropinosome maturation and fusion with tubular lysosomes in macrophages. J Cell Biol (1993) 2.86

Targeted disruption of TRAF3 leads to postnatal lethality and defective T-dependent immune responses. Immunity (1996) 2.70

TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta. J Biol Chem (2003) 2.61

Lipopolysaccharide interaction with cell surface Toll-like receptor 4-MD-2: higher affinity than that with MD-2 or CD14. J Exp Med (2003) 2.39

The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction. Proc Natl Acad Sci U S A (2006) 2.13

A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins. PLoS One (2007) 1.73

Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-beta. Biochem Biophys Res Commun (2005) 1.72

Recruitment of CD40 and tumor necrosis factor receptor-associated factors 2 and 3 to membrane microdomains during CD40 signaling. J Biol Chem (2000) 1.70

The membrane targeting and spatial activation of Src, Yes and Fyn is influenced by palmitoylation and distinct RhoB/RhoD endosome requirements. J Cell Sci (2007) 1.57

MAPPIT analysis of TLR adaptor complexes. FEBS Lett (2007) 1.16

Effects of dynamin inactivation on pathways of anthrax toxin uptake. Eur J Cell Biol (2004) 1.06

Articles by these authors

Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell (2004) 29.32

Innate immune recognition. Annu Rev Immunol (2001) 26.65

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol (2004) 26.12

Toll-like receptors. Annu Rev Immunol (2001) 26.06

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol (2010) 24.08

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature (2006) 22.65

Pattern recognition receptors and inflammation. Cell (2010) 21.05

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

Toll-like receptor control of the adaptive immune responses. Nat Immunol (2004) 19.15

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol (2005) 18.32

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science (2003) 17.57

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science (2004) 16.26

5'-Triphosphate RNA is the ligand for RIG-I. Science (2006) 15.78

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science (2004) 14.80

Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science (2003) 14.04

Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol (2002) 13.10

Toll-like receptors in innate immunity. Int Immunol (2005) 12.24

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature (2008) 11.39

Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity (2011) 11.15

Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity (2006) 10.61

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature (2006) 9.77

Innate immune recognition of viral infection. Nat Immunol (2006) 9.59

Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell (2008) 9.59

Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature (2004) 9.40

Cell type-specific involvement of RIG-I in antiviral response. Immunity (2005) 9.37

Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J Immunol (2005) 9.17

TLR signaling pathways. Semin Immunol (2004) 9.08

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5. J Exp Med (2008) 9.00

TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Nature (2007) 8.87

Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat Med (2005) 8.49

TLR signaling. Semin Immunol (2007) 8.16

Regulation of adaptive immunity by the innate immune system. Science (2010) 8.00

A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nat Immunol (2005) 7.94

ER stress triggers apoptosis by activating BH3-only protein Bim. Cell (2007) 7.50

Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. J Exp Med (2003) 7.38

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. Nat Cell Biol (2009) 7.35

Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature (2007) 7.34

Type I interferons in host defense. Immunity (2006) 7.32

Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med (2003) 7.26

Identification of a key pathway required for the sterile inflammatory response triggered by dying cells. Nat Med (2007) 7.25

Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity. J Virol (2007) 7.18

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat Med (2005) 7.18

Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling. J Immunol (2002) 7.07

Innate immunity to virus infection. Immunol Rev (2009) 7.04

IRAK-M is a negative regulator of Toll-like receptor signaling. Cell (2002) 6.79

Regulation of phagosome maturation by signals from toll-like receptors. Science (2004) 6.79

A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol (2008) 6.78

Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation. Nat Cell Biol (2009) 6.62

Control of inducible gene expression by signal-dependent transcriptional elongation. Cell (2009) 6.57

Signaling to NF-kappaB by Toll-like receptors. Trends Mol Med (2007) 6.52

Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. J Clin Invest (2002) 6.48

Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis. Gastroenterology (2004) 6.47

Control of B-cell responses by Toll-like receptors. Nature (2005) 6.44

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines. Nature (2008) 6.40

Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell (2008) 6.37

Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat Immunol (2005) 6.13

Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell (2006) 6.01

Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment. Immunity (2006) 5.98

Toll-like receptor and RIG-I-like receptor signaling. Ann N Y Acad Sci (2008) 5.95

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature (2002) 5.95

Toll-like receptor signaling pathways. Science (2003) 5.86

Pathogen recognition by the innate immune system. Int Rev Immunol (2011) 5.76

Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat Immunol (2004) 5.71

Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2. Proc Natl Acad Sci U S A (2006) 5.70

Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus. Immunity (2009) 5.70

Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J Exp Med (2006) 5.63

Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E. Proc Natl Acad Sci U S A (2004) 5.58

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev (2005) 5.56

Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science (2007) 5.54

Toll-dependent selection of microbial antigens for presentation by dendritic cells. Nature (2006) 5.54

Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J Immunol (2002) 5.48

Essential role of MD-2 in LPS responsiveness and TLR4 distribution. Nat Immunol (2002) 5.41

The roles of TLRs, RLRs and NLRs in pathogen recognition. Int Immunol (2009) 5.21

Transcriptional control of the inflammatory response. Nat Rev Immunol (2009) 5.20

Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf. J Biol Chem (2006) 5.11

Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5. Nat Immunol (2008) 5.10

Essential role of IPS-1 in innate immune responses against RNA viruses. J Exp Med (2006) 5.01

TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat Immunol (2003) 4.94

Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus. J Exp Med (2005) 4.92

Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway. Nat Immunol (2005) 4.91

RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J Exp Med (2005) 4.85

The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I. J Immunol (2005) 4.83

Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature (2002) 4.81

Toll-like receptor 2 controls expansion and function of regulatory T cells. J Clin Invest (2006) 4.72

The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection. Nat Immunol (2010) 4.66

TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function. Immunity (2004) 4.50

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response. Proc Natl Acad Sci U S A (2009) 4.48

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure. Nature (2012) 4.46

Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans. Nat Immunol (2006) 4.37

Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nat Immunol (2005) 4.30

Toll-like receptors and cancer. Nat Rev Cancer (2008) 4.29

Toll-like receptors and innate immunity. Biochem Biophys Res Commun (2009) 4.26

IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nat Immunol (2003) 4.25

Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity. J Exp Med (2006) 4.23

Deletion of TLR5 results in spontaneous colitis in mice. J Clin Invest (2007) 4.18

Autophagy in infection, inflammation and immunity. Nat Rev Immunol (2013) 4.16

Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells. Nat Immunol (2006) 4.15

The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature (2002) 4.15