Production of an attenuated phenol-soluble modulin variant unique to the MRSA clonal complex 30 increases severity of bloodstream infection.

PubWeight™: 0.92‹?›

🔗 View Article (PMC 4140855)

Published in PLoS Pathog on August 21, 2014

Authors

Gordon Y C Cheung1, Dorothee Kretschmer2, Anthony C Duong1, Anthony J Yeh1, Trung V Ho1, Yan Chen1, Hwang-Soo Joo1, Barry N Kreiswirth3, Andreas Peschel2, Michael Otto1

Author Affiliations

1: Pathogen Molecular Genetics Section, Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, Maryland, United States of America.
2: Cellular and Molecular Microbiology Division, Interfaculty Institute of Microbiology and Infection Medicine, University of Tübingen, Tübingen, Germany.
3: Public Health Research Institute Tuberculosis Center, New Jersey Medical School, Rutgers University, Newark, New Jersey, United States of America.

Articles citing this

Evolutionary Trade-Offs Underlie the Multi-faceted Virulence of Staphylococcus aureus. PLoS Biol (2015) 1.55

Staphylococcal manipulation of host immune responses. Nat Rev Microbiol (2015) 1.42

Neutrophil recruitment to lymph nodes limits local humoral response to Staphylococcus aureus. PLoS Pathog (2015) 0.85

Pathogenesis of Staphylococcus aureus Bloodstream Infections. Annu Rev Pathol (2016) 0.83

Dendritic cells during Staphylococcus aureus infection: subsets and roles. J Transl Med (2014) 0.83

Clinical MRSA isolates from skin and soft tissue infections show increased in vitro production of phenol soluble modulins. J Infect (2015) 0.82

Quorum-sensing regulation in staphylococci-an overview. Front Microbiol (2015) 0.81

Potential Influence of Staphylococcus aureus Clonal Complex 30 Genotype and Transcriptome on Hematogenous Infections. Open Forum Infect Dis (2015) 0.81

Increased in vitro phenol-soluble modulin production is associated with soft tissue infection source in clinical isolates of methicillin-susceptible Staphylococcus aureus. J Infect (2016) 0.80

Impact of Bacterial and Human Genetic Variation on Staphylococcus aureus Infections. PLoS Pathog (2016) 0.78

Molecular Characterization of a Prevalent Ribocluster of Methicillin-Sensitive Staphylococcus aureus from Orthopedic Implant Infections. Correspondence with MLST CC30. Front Cell Infect Microbiol (2016) 0.77

Functional characteristics of the Staphylococcus aureus δ-toxin allelic variant G10S. Sci Rep (2015) 0.77

Bacterial Toxins as Pathogen Weapons Against Phagocytes. Front Microbiol (2016) 0.77

Staphylococcus aureus bacteremic pneumonia. Eur J Clin Microbiol Infect Dis (2016) 0.76

Pathogenic Characteristics of Staphylococcus aureus Endovascular Infection Isolates from Different Clonal Complexes. Front Microbiol (2017) 0.75

Articles cited by this

Staphylococcus aureus infections. N Engl J Med (1998) 36.39

Synthesis of staphylococcal virulence factors is controlled by a regulatory RNA molecule. EMBO J (1993) 11.30

Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance. Proc Natl Acad Sci U S A (2004) 8.95

Is Panton-Valentine leukocidin the major virulence determinant in community-associated methicillin-resistant Staphylococcus aureus disease? J Infect Dis (2006) 8.17

Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA. Nat Med (2007) 7.75

Immune evasion by staphylococci. Nat Rev Microbiol (2005) 7.22

Allelic replacement in Staphylococcus aureus with inducible counter-selection. Plasmid (2005) 6.11

A major outbreak of methicillin-resistant Staphylococcus aureus caused by a new phage-type (EMRSA-16) J Hosp Infect (1995) 4.10

Dominance of EMRSA-15 and -16 among MRSA causing nosocomial bacteraemia in the UK: analysis of isolates from the European Antimicrobial Resistance Surveillance System (EARSS). J Antimicrob Chemother (2001) 3.51

RNAIII-independent target gene control by the agr quorum-sensing system: insight into the evolution of virulence regulation in Staphylococcus aureus. Mol Cell (2008) 3.44

Chemotaxis inhibitory protein of Staphylococcus aureus, a bacterial antiinflammatory agent. J Exp Med (2004) 2.96

Persistent bacteremia due to methicillin-resistant Staphylococcus aureus infection is associated with agr dysfunction and low-level in vitro resistance to thrombin-induced platelet microbicidal protein. J Infect Dis (2004) 2.83

Human formyl peptide receptor 2 senses highly pathogenic Staphylococcus aureus. Cell Host Microbe (2010) 2.64

Essential Staphylococcus aureus toxin export system. Nat Med (2013) 2.50

agr function in clinical Staphylococcus aureus isolates. Microbiology (2008) 2.33

Comparative analysis of USA300 virulence determinants in a rabbit model of skin and soft tissue infection. J Infect Dis (2011) 2.19

Potential associations between hematogenous complications and bacterial genotype in Staphylococcus aureus infection. J Infect Dis (2007) 2.00

High levels of antibody to panton-valentine leukocidin are not associated with resistance to Staphylococcus aureus-associated skin and soft-tissue infection. Clin Infect Dis (2010) 1.84

Molecular tracing of the emergence, adaptation, and transmission of hospital-associated methicillin-resistant Staphylococcus aureus. Proc Natl Acad Sci U S A (2012) 1.83

Inducible production and cellular location of the epidermin biosynthetic enzyme EpiB using an improved staphylococcal expression system. FEMS Microbiol Lett (1996) 1.81

MRSA virulence and spread. Cell Microbiol (2012) 1.79

Neutrophils versus Staphylococcus aureus: a biological tug of war. Annu Rev Microbiol (2013) 1.74

Molecular differentiation of historic phage-type 80/81 and contemporary epidemic Staphylococcus aureus. Proc Natl Acad Sci U S A (2011) 1.70

Immune-activating properties of Panton-Valentine leukocidin improve the outcome in a model of methicillin-resistant Staphylococcus aureus pneumonia. Infect Immun (2012) 1.70

Phenol-soluble modulins and staphylococcal infection. Nat Rev Microbiol (2013) 1.56

Antimicrobial activity of community-associated methicillin-resistant Staphylococcus aureus is caused by phenol-soluble modulin derivatives. J Biol Chem (2011) 1.51

Antibody-mediated enhancement of community-acquired methicillin-resistant Staphylococcus aureus infection. Proc Natl Acad Sci U S A (2010) 1.49

A new staphylococcal anti-inflammatory protein that antagonizes the formyl peptide receptor-like 1. J Immunol (2006) 1.40

Direct and synergistic hemolysis caused by Staphylococcus phenol-soluble modulins: implications for diagnosis and pathogenesis. Microbes Infect (2011) 1.37

PSMs of hypervirulent Staphylococcus aureus act as intracellular toxins that kill infected osteoblasts. PLoS One (2013) 1.26

Community-associated MRSA: what makes them special? Int J Med Microbiol (2013) 1.25

Phenol-soluble modulins--critical determinants of staphylococcal virulence. FEMS Microbiol Rev (2014) 1.21

Staphylococcal alpha-phenol soluble modulins contribute to neutrophil lysis after phagocytosis. Cell Microbiol (2013) 1.19

Staphylococcus aureus Panton-Valentine leukocidin induces an inflammatory response in human phagocytes via the NLRP3 inflammasome. J Leukoc Biol (2012) 1.11

Sublytic concentrations of Staphylococcus aureus Panton-Valentine leukocidin alter human PMN gene expression and enhance bactericidal capacity. J Leukoc Biol (2012) 1.08

Antibiotic-mediated selection of quorum-sensing-negative Staphylococcus aureus. MBio (2013) 1.03

The isolation and analysis of phenol-soluble modulins of Staphylococcus epidermidis. Methods Mol Biol (2014) 0.96

Insight into structure-function relationship in phenol-soluble modulins using an alanine screen of the phenol-soluble modulin (PSM) α3 peptide. FASEB J (2013) 0.86

Interaction of phenol-soluble modulins with phosphatidylcholine vesicles. Pathogens (2012) 0.84