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Stig Linder

Author PubWeight™ 63.61‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Inhibition of proteasome deubiquitinating activity as a new cancer therapy. Nat Med 2011 4.09
2 Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling. J Biol Chem 2002 2.20
3 Differentiation between cell death modes using measurements of different soluble forms of extracellular cytokeratin 18. Cancer Res 2004 2.03
4 Acute apoptosis by cisplatin requires induction of reactive oxygen species but is not associated with damage to nuclear DNA. Int J Cancer 2007 1.67
5 Potentiation of chemotherapeutic drugs by energy metabolism inhibitors 2-deoxyglucose and etomoxir. Int J Cancer 2008 1.55
6 Calpain-mediated Bid cleavage and calpain-independent Bak modulation: two separate pathways in cisplatin-induced apoptosis. Mol Cell Biol 2002 1.54
7 A novel high-through-put assay for screening of pro-apoptotic drugs. Invest New Drugs 2002 1.49
8 Cytokeratin-18 is a useful serum biomarker for early determination of response of breast carcinomas to chemotherapy. Clin Cancer Res 2007 1.45
9 Induction of lysosomal membrane permeabilization by compounds that activate p53-independent apoptosis. Proc Natl Acad Sci U S A 2004 1.42
10 A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance. Blood 2013 1.38
11 Molecular classification of borderline ovarian tumors using hierarchical cluster analysis of protein expression profiles. Int J Cancer 2002 1.30
12 Processing of pulmonary surfactant protein B by napsin and cathepsin H. J Biol Chem 2004 1.29
13 Autophagy is a protective mechanism for human melanoma cells under acidic stress. J Biol Chem 2012 1.17
14 Large-scale proteomics analysis of human ovarian cancer for biomarkers. J Proteome Res 2007 1.12
15 The levels of caspase-cleaved cytokeratin 18 are elevated in serum from patients with lung cancer and helpful to predict the survival. Lung Cancer 2007 1.11
16 Loss of cell membrane integrity in puumala hantavirus-infected patients correlates with levels of epithelial cell apoptosis and perforin. J Virol 2006 1.09
17 Mechanisms of action of DNA-damaging anticancer drugs in treatment of carcinomas: is acute apoptosis an "off-target" effect? Mini Rev Med Chem 2007 1.09
18 Clinical cancer proteomics: promises and pitfalls. J Proteome Res 2005 1.07
19 Proteasome deubiquitinases as novel targets for cancer therapy. Int J Biochem Cell Biol 2012 1.07
20 Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells. Biochem Biophys Res Commun 2013 1.01
21 Keratin-18 and microRNA-122 complement alanine aminotransferase as novel safety biomarkers for drug-induced liver injury in two human cohorts. Liver Int 2013 1.00
22 Induction of the lysosomal apoptosis pathway by inhibitors of the ubiquitin-proteasome system. Int J Cancer 2009 0.98
23 Alterations in the cellular immune compartment of patients treated with third-party mesenchymal stromal cells following allogeneic hematopoietic stem cell transplantation. Stem Cells 2013 0.93
24 Screening for compounds that induce apoptosis of cancer cells grown as multicellular spheroids. J Biomol Screen 2007 0.92
25 Characteristics of polyomavirus BK (BKPyV) infection in primary human urothelial cells. Virology 2013 0.92
26 Cisplatin-induced nitrosylation of p53 prevents its mitochondrial translocation. Free Radic Biol Med 2009 0.91
27 Restriction of cisplatin induction of acute apoptosis to a subpopulation of cells in a three-dimensional carcinoma culture model. Int J Cancer 2009 0.91
28 The 19S Deubiquitinase inhibitor b-AP15 is enriched in cells and elicits rapid commitment to cell death. Mol Pharmacol 2014 0.90
29 Induction of tumor cell apoptosis by a proteasome deubiquitinase inhibitor is associated with oxidative stress. Antioxid Redox Signal 2013 0.90
30 Inhibition of protein translocation at the endoplasmic reticulum promotes activation of the unfolded protein response. Biochem J 2012 0.89
31 Identification of agents that induce apoptosis of multicellular tumour spheroids: enrichment for mitotic inhibitors with hydrophobic properties. Chem Biol Drug Des 2011 0.88
32 Novel activity of acriflavine against colorectal cancer tumor cells. Cancer Sci 2011 0.87
33 Diagnostic and prognostic role of plasma levels of two forms of cytokeratin 18 in patients with non-small-cell lung cancer. Eur J Cancer 2010 0.86
34 Picropodophyllotoxin or podophyllotoxin does not induce cell death via insulin-like growth factor-I receptor. Cancer Res 2007 0.86
35 Induction of endoplasmic reticulum stress by ellipticine plant alkaloids. Mol Cancer Ther 2004 0.85
36 Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters. PLoS One 2009 0.85
37 Screening of natural products for therapeutic activity against solid tumors. Indian J Exp Biol 2010 0.85
38 Targeted inhibition of the deubiquitinating enzymes, USP14 and UCHL5, induces proteotoxic stress and apoptosis in Waldenström macroglobulinaemia tumour cells. Br J Haematol 2015 0.85
39 Defective stress kinase and Bak activation in response to ionizing radiation but not cisplatin in a non-small cell lung carcinoma cell line. Exp Cell Res 2003 0.84
40 A novel inhibitor of proteasome deubiquitinating activity renders tumor cells sensitive to TRAIL-mediated apoptosis by natural killer cells and T cells. Cancer Immunol Immunother 2013 0.84
41 The aspartic protease napsin A suppresses tumor growth independent of its catalytic activity. Lab Invest 2008 0.82
42 Combining [11C]-AnxA5 PET imaging with serum biomarkers for improved detection in live mice of modest cell death in human solid tumor xenografts. PLoS One 2012 0.82
43 Phenotype-based drug screening in primary ovarian carcinoma cultures identifies intracellular iron depletion as a promising strategy for cancer treatment. Biochem Pharmacol 2011 0.82
44 Phosphorylation of BAD at Ser-128 during mitosis and paclitaxel-induced apoptosis. FEBS Lett 2005 0.82
45 Zoledronic acid induces caspase-dependent apoptosis in renal cancer cell lines. Scand J Urol Nephrol 2009 0.82
46 Target specificity and off-target effects as determinants of cancer drug efficacy. Expert Opin Drug Metab Toxicol 2008 0.81
47 A close association between alteration in growth kinetics by neoadjuvant chemotherapy and survival outcome in primary breast cancer. Int J Oncol 2004 0.81
48 Chemical biology suggests a role for calcium signaling in mediating sustained JNK activation during apoptosis. Mol Biosyst 2010 0.81
49 A natural anticancer agent thaspine targets human topoisomerase IB. Anticancer Agents Med Chem 2013 0.78
50 Expression of UPA and UPAR is associated with the clinical course of urinary bladder neoplasms. Int J Cancer 2002 0.78
51 Cell crowding induces interferon regulatory factor 9, which confers resistance to chemotherapeutic drugs. Int J Cancer 2014 0.78
52 Gambogic acid is cytotoxic to cancer cells through inhibition of the ubiquitin-proteasome system. Invest New Drugs 2012 0.78
53 Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance. BMC Cancer 2013 0.77
54 Utilization of a right-handed coiled-coil protein from archaebacterium Staphylothermus marinus as a carrier for cisplatin. Anticancer Res 2009 0.77
55 The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy. Eur J Cancer 2011 0.76
56 Two distinct steps of Bak regulation during apoptotic stress signaling: different roles of MEKK1 and JNK1. Exp Cell Res 2006 0.76
57 Site-specifically 11C-labeled Sel-tagged annexin A5 and a size-matched control for dynamic in vivo PET imaging of protein distribution in tissues prior to and after induced cell death. Biochim Biophys Acta 2013 0.76
58 Caspase-cleaved keratin 18 as a biomarker for non-alcoholic steatohepatitis (NASH) - the need for correct terminology. J Hepatol 2011 0.75
59 Conditional drug screening shows that mitotic inhibitors induce AKT/PKB-insensitive apoptosis. J Chem Biol 2009 0.75
60 Determination of cell death modes using circulating biomarkers. Liver Int 2011 0.75
61 Sense and sensibility: the use of cell death biomarker assays in high-throughput anticancer drug screening and monitoring treatment responses. Expert Opin Drug Discov 2006 0.75
62 Corrigendum: The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells. Sci Rep 2016 0.75