Post-translational structural modifications of immunoglobulin G and their effect on biological activity.

PubWeight™: 0.85‹?›

🔗 View Article (PMID 25200070)

Published in Anal Bioanal Chem on September 10, 2014

Authors

Laura K Hmiel1, Kurt A Brorson, Michael T Boyne

Author Affiliations

1: Center for Drug Evaluation and Research, Office of Testing and Research, Division of Pharmaceutical Analysis, United States Food and Drug Administration, Saint Louis, MO, 63110, USA.

Articles by these authors

Precise and parallel characterization of coding polymorphisms, alternative splicing, and modifications in human proteins by mass spectrometry. Mol Cell Proteomics (2005) 1.86

Top-down proteomics on a chromatographic time scale using linear ion trap fourier transform hybrid mass spectrometers. Anal Chem (2007) 1.60

Hydroxymalonyl-acyl carrier protein (ACP) and aminomalonyl-ACP are two additional type I polyketide synthase extender units. Proc Natl Acad Sci U S A (2006) 1.56

Abacavir induces loading of novel self-peptides into HLA-B*57: 01: an autoimmune model for HLA-associated drug hypersensitivity. AIDS (2012) 1.54

"Proteotyping": population proteomics of human leukocytes using top down mass spectrometry. Anal Chem (2008) 1.46

Biosynthesis of pipecolic acid by RapL, a lysine cyclodeaminase encoded in the rapamycin gene cluster. J Am Chem Soc (2006) 1.20

Mycoplasma testing of cell substrates and biologics: Review of alternative non-microbiological techniques. Mol Cell Probes (2011) 1.20

Quality assessment of U.S. marketplace vancomycin for injection products using high-resolution liquid chromatography-mass spectrometry and potency assays. Antimicrob Agents Chemother (2012) 1.17

Characterization of the aminocarboxycyclopropane-forming enzyme CmaC. Biochemistry (2007) 1.13

Versatile online-offline engine for automated acquisition of high-resolution tandem mass spectra. Anal Chem (2008) 1.09

Comparisons of optically monitored small-scale stirred tank vessels to optically controlled disposable bag bioreactors. Microb Cell Fact (2009) 1.06

Validation of an optical sensor-based high-throughput bioreactor system for mammalian cell culture. J Biotechnol (2006) 1.05

Comparisons of optical pH and dissolved oxygen sensors with traditional electrochemical probes during mammalian cell culture. Biotechnol Bioeng (2007) 1.03

Fermentanomics informed amino acid supplementation of an antibody producing mammalian cell culture. Biotechnol Prog (2013) 1.02

Industry and regulatory experience of the glycosylation of monoclonal antibodies. Biotechnol Appl Biochem (2011) 0.95

Structural comparison of two anti-CD20 monoclonal antibody drug products using middle-down mass spectrometry. Analyst (2013) 0.91

Quality by design: impact of formulation variables and their interactions on quality attributes of a lyophilized monoclonal antibody. Int J Pharm (2012) 0.91

Direct approach for qualitative and quantitative characterization of glycoproteins using tandem mass tags and an LTQ Orbitrap XL electron transfer dissociation hybrid mass spectrometer. Anal Chem (2013) 0.87

Advances in clone selection using high-throughput bioreactors. Biotechnol Prog (2010) 0.84

Dissolved oxygen and pH profile evolution after cryovial thaw and repeated cell passaging in a T-75 flask. Biotechnol Bioeng (2010) 0.84

Particle concentration measurement of virus samples using electrospray differential mobility analysis and quantitative amino acid analysis. J Chromatogr A (2009) 0.83

Physical characterization of icosahedral virus ultra structure, stability, and integrity using electrospray differential mobility analysis. Anal Chem (2011) 0.81

Impact of controlled ice nucleation on process performance and quality attributes of a lyophilized monoclonal antibody. Int J Pharm (2013) 0.80

Identification of site-specific heterogeneity in peptide drugs using intact mass spectrometry with electron transfer dissociation. Rapid Commun Mass Spectrom (2014) 0.80

Integrating a 250 mL-spinner flask with other stirred bench-scale cell culture devices: a mass transfer perspective. Biotechnol Prog (2011) 0.80

Evaluation of intact mass spectrometry for the quantitative analysis of protein therapeutics. Anal Chem (2012) 0.80

Evaluation of electrospray differential mobility analysis for virus particle analysis: Potential applications for biomanufacturing. J Virol Methods (2011) 0.78

Genomic analysis of a hybridoma batch cell culture metabolic status in a standard laboratory 5 L bioreactor. Biotechnol Prog (2012) 0.78

A case study in converting disposable process scouting devices into disposable bioreactors as a future bioprocessing tool. Biotechnol Bioeng (2012) 0.78

Optical sensor enabled rocking T-flasks as novel upstream bioprocessing tools. Biotechnol Bioeng (2012) 0.77

Liquid Chromatography-High Resolution Mass Spectrometry for Peptide Drug Quality Control. AAPS J (2015) 0.77

Direct site-specific glycoform identification and quantitative comparison of glycoprotein therapeutics: imiglucerase and velaglucerase alfa. AAPS J (2014) 0.75

Quality by design approach for viral clearance by protein a chromatography. Biotechnol Bioeng (2013) 0.75

Analytical techniques and bioactivity assays to compare the structure and function of filgrastim (granulocyte-colony stimulating factor) therapeutics from different manufacturers. Anal Bioanal Chem (2013) 0.75

Adapting viral safety assurance strategies to continuous processing of biological products. Biotechnol Bioeng (2017) 0.75

Analyses of marketplace tacrolimus drug product quality: bioactivity, NMR and LC-MS. J Pharm Biomed Anal (2013) 0.75

Modern analytics for naturally derived complex drug substances: NMR and MS tests for protamine sulfate from chum salmon. Anal Bioanal Chem (2014) 0.75

Bioreactor environment-sensitive sentinel genes as novel metrics for cell culture scale-down comparability. Biotechnol Prog (2012) 0.75