Published in Anal Chem on October 05, 2007
Mapping intact protein isoforms in discovery mode using top-down proteomics. Nature (2011) 4.84
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Ultra high resolution linear ion trap Orbitrap mass spectrometer (Orbitrap Elite) facilitates top down LC MS/MS and versatile peptide fragmentation modes. Mol Cell Proteomics (2011) 2.13
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Characterization and quantification of intact 26S proteasome proteins by real-time measurement of intrinsic fluorescence prior to top-down mass spectrometry. PLoS One (2013) 0.86
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Top-down mass analysis of protein tyrosine nitration: comparison of electron capture dissociation with "slow-heating" tandem mass spectrometry methods. Anal Chem (2010) 0.81
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Precise characterization of human histones in the H2A gene family by top down mass spectrometry. J Proteome Res (2006) 2.09
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Orbitrap mass analyzer--overview and applications in proteomics. Proteomics (2006) 1.90
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Top down mass spectrometry of < 60-kDa proteins from Methanosarcina acetivorans using quadrupole FRMS with automated octopole collisionally activated dissociation. Mol Cell Proteomics (2006) 1.57
Whole protein dissociation in a quadrupole ion trap: identification of an a priori unknown modified protein. Anal Chem (2004) 1.57
Analysis of intact proteins on a chromatographic time scale by electron transfer dissociation tandem mass spectrometry. Int J Mass Spectrom (2007) 1.56
Gene-specific characterization of human histone H2B by electron capture dissociation. J Proteome Res (2006) 1.53
Proteomic profiling of intact proteins using WAX-RPLC 2-D separations and FTICR mass spectrometry. J Proteome Res (2007) 1.52
Proteomic analysis of the bacterial cell cycle. Proc Natl Acad Sci U S A (2001) 1.35
New and automated MSn approaches for top-down identification of modified proteins. J Am Soc Mass Spectrom (2005) 1.33
Targeted analysis and discovery of posttranslational modifications in proteins from methanogenic archaea by top-down MS. Proc Natl Acad Sci U S A (2004) 1.26
Top-down approaches for measuring expression ratios of intact yeast proteins using Fourier transform mass spectrometry. Anal Chem (2006) 1.22
Fourier-transform mass spectrometry for automated fragmentation and identification of 5-20 kDa proteins in mixtures. Electrophoresis (2002) 1.18
Integrating 'top-down" and "bottom-up" mass spectrometric approaches for proteomic analysis of Shewanella oneidensis. J Proteome Res (2003) 1.12
A new and sensitive on-line liquid chromatography/mass spectrometric approach for top-down protein analysis: the comprehensive analysis of human growth hormone in an E. coli lysate using a hybrid linear ion trap/Fourier transform ion cyclotron resonance mass spectrometer. Rapid Commun Mass Spectrom (2004) 1.02
Proteomics and its role in nutrition research. J Nutr (2006) 0.95
Mass spectrometry for high throughput quantitative proteomics in plant research: lessons from thylakoid membranes. Plant Physiol Biochem (2005) 0.89
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Proteomics in neurodegeneration--disease driven approaches. J Neural Transm (Vienna) (2006) 0.85
Proteomic analysis of cold adaptation in a Siberian permafrost bacterium--Exiguobacterium sibiricum 255-15 by two-dimensional liquid separation coupled with mass spectrometry. Proteomics (2006) 0.83
Personal omics profiling reveals dynamic molecular and medical phenotypes. Cell (2012) 12.32
Mapping intact protein isoforms in discovery mode using top-down proteomics. Nature (2011) 4.84
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A monovalent streptavidin with a single femtomolar biotin binding site. Nat Methods (2006) 3.89
Pervasive combinatorial modification of histone H3 in human cells. Nat Methods (2007) 3.54
Proteoform: a single term describing protein complexity. Nat Methods (2013) 3.48
Quantitative analysis of modified proteins and their positional isomers by tandem mass spectrometry: human histone H4. Anal Chem (2006) 3.08
Deconstruction of iterative multidomain polyketide synthase function. Science (2008) 3.02
Lacticin 481: in vitro reconstitution of lantibiotic synthetase activity. Science (2004) 2.83
The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells. Blood (2010) 2.71
Decoding protein modifications using top-down mass spectrometry. Nat Methods (2007) 2.62
A dynamic model of proteome changes reveals new roles for transcript alteration in yeast. Mol Syst Biol (2011) 2.44
Certain and progressive methylation of histone H4 at lysine 20 during the cell cycle. Mol Cell Biol (2007) 2.43
Proteomic and phosphoproteomic comparison of human ES and iPS cells. Nat Methods (2011) 2.39
Shotgun annotation of histone modifications: a new approach for streamlined characterization of proteins by top down mass spectrometry. J Am Chem Soc (2004) 2.36
Value of using multiple proteases for large-scale mass spectrometry-based proteomics. J Proteome Res (2010) 2.36
ProSight PTM 2.0: improved protein identification and characterization for top down mass spectrometry. Nucleic Acids Res (2007) 2.35
Variation and genetic control of protein abundance in humans. Nature (2013) 2.32
Mass spectrometric characterization of human histone H3: a bird's eye view. J Proteome Res (2006) 2.29
Combinatorial modification of human histone H4 quantitated by two-dimensional liquid chromatography coupled with top down mass spectrometry. J Biol Chem (2008) 2.28
Facile detection of acyl and peptidyl intermediates on thiotemplate carrier domains via phosphopantetheinyl elimination reactions during tandem mass spectrometry. Biochemistry (2006) 2.22
Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic. Proc Natl Acad Sci U S A (2006) 2.19
Precise characterization of human histones in the H2A gene family by top down mass spectrometry. J Proteome Res (2006) 2.09
Negative regulation of NF-kappaB action by Set9-mediated lysine methylation of the RelA subunit. EMBO J (2009) 2.05
Genetically encoded short peptide tag for versatile protein labeling by Sfp phosphopantetheinyl transferase. Proc Natl Acad Sci U S A (2005) 2.03
ProSight PTM: an integrated environment for protein identification and characterization by top-down mass spectrometry. Nucleic Acids Res (2004) 2.03
Genomic analyses of anaerobically induced genes in Saccharomyces cerevisiae: functional roles of Rox1 and other factors in mediating the anoxic response. J Bacteriol (2002) 1.96
Human embryonic stem cell phosphoproteome revealed by electron transfer dissociation tandem mass spectrometry. Proc Natl Acad Sci U S A (2009) 1.95
Biogeography of the Sulfolobus islandicus pan-genome. Proc Natl Acad Sci U S A (2009) 1.95
Precise and parallel characterization of coding polymorphisms, alternative splicing, and modifications in human proteins by mass spectrometry. Mol Cell Proteomics (2005) 1.86
Post-acquisition ETD spectral processing for increased peptide identifications. J Am Soc Mass Spectrom (2009) 1.86
Web and database software for identification of intact proteins using "top down" mass spectrometry. Anal Chem (2003) 1.85
Tissue-specific expression and post-translational modification of histone H3 variants. J Proteome Res (2008) 1.84
Phosphoproteomics for the masses. ACS Chem Biol (2010) 1.83
Convergence of isoprene and polyketide biosynthetic machinery: isoprenyl-S-carrier proteins in the pksX pathway of Bacillus subtilis. Proc Natl Acad Sci U S A (2006) 1.80
Lacticin 481 synthetase phosphorylates its substrate during lantibiotic production. J Am Chem Soc (2005) 1.76
Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide. Nat Chem Biol (2007) 1.72
Complete protein characterization using top-down mass spectrometry and ultraviolet photodissociation. J Am Chem Soc (2013) 1.69
A comparison of current prediction imaging programs. Am J Orthod Dentofacial Orthop (2004) 1.68
A robust two-dimensional separation for top-down tandem mass spectrometry of the low-mass proteome. J Am Soc Mass Spectrom (2009) 1.65
Statistical resynchronization and Bayesian detection of periodically expressed genes. Nucleic Acids Res (2004) 1.64
Processing complex mixtures of intact proteins for direct analysis by mass spectrometry. Anal Chem (2002) 1.63
Mass spectrometric interrogation of thioester-bound intermediates in the initial stages of epothilone biosynthesis. Chem Biol (2004) 1.61
Dichlorination of a pyrrolyl-S-carrier protein by FADH2-dependent halogenase PltA during pyoluteorin biosynthesis. Proc Natl Acad Sci U S A (2005) 1.58
Preferential dimethylation of histone H4 lysine 20 by Suv4-20. J Biol Chem (2008) 1.58
Top down mass spectrometry of < 60-kDa proteins from Methanosarcina acetivorans using quadrupole FRMS with automated octopole collisionally activated dissociation. Mol Cell Proteomics (2006) 1.57
Hydroxymalonyl-acyl carrier protein (ACP) and aminomalonyl-ACP are two additional type I polyketide synthase extender units. Proc Natl Acad Sci U S A (2006) 1.56
Metabolic-state-dependent remodeling of the transcriptome in response to anoxia and subsequent reoxygenation in Saccharomyces cerevisiae. Eukaryot Cell (2006) 1.55
Abacavir induces loading of novel self-peptides into HLA-B*57: 01: an autoimmune model for HLA-associated drug hypersensitivity. AIDS (2012) 1.54
Gene-specific characterization of human histone H2B by electron capture dissociation. J Proteome Res (2006) 1.53
Oncogene-induced cellular senescence elicits an anti-Warburg effect. Proteomics (2013) 1.50
Coevolutionary genetic variation in the legume-rhizobium transcriptome. Mol Ecol (2012) 1.49
Toward more transparent and reproducible omics studies through a common metadata checklist and data publications. OMICS (2014) 1.49
Heterologous production of fosfomycin and identification of the minimal biosynthetic gene cluster. Chem Biol (2006) 1.47
Construction of a hybrid quadrupole/Fourier transform ion cyclotron resonance mass spectrometer for versatile MS/MS above 10 kDa. J Am Soc Mass Spectrom (2004) 1.46
"Proteotyping": population proteomics of human leukocytes using top down mass spectrometry. Anal Chem (2008) 1.46
Cloning, expression, and biochemical characterization of Streptomyces rubellomurinus genes required for biosynthesis of antimalarial compound FR900098. Chem Biol (2008) 1.41
Size-sorting combined with improved nanocapillary liquid chromatography-mass spectrometry for identification of intact proteins up to 80 kDa. Anal Chem (2010) 1.40
Global assessment of combinatorial post-translational modification of core histones in yeast using contemporary mass spectrometry. LYS4 trimethylation correlates with degree of acetylation on the same H3 tail. J Biol Chem (2007) 1.40
Dissecting non-ribosomal and polyketide biosynthetic machineries using electrospray ionization Fourier-Transform mass spectrometry. Nat Prod Rep (2006) 1.39
Temporal analysis of Candida albicans gene expression during biofilm development. Microbiology (2007) 1.39
A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis. Proc Natl Acad Sci U S A (2008) 1.36
Large-scale top-down proteomics of the human proteome: membrane proteins, mitochondria, and senescence. Mol Cell Proteomics (2013) 1.33
Tandem mass spectrometry with ultrahigh mass accuracy clarifies peptide identification by database retrieval. J Proteome Res (2009) 1.33
New and automated MSn approaches for top-down identification of modified proteins. J Am Soc Mass Spectrom (2005) 1.33
On the scalability and requirements of whole protein mass spectrometry. Anal Chem (2011) 1.31
Interrogation of global active site occupancy of a fungal iterative polyketide synthase reveals strategies for maintaining biosynthetic fidelity. J Am Chem Soc (2012) 1.29
A proteomics approach to discovering natural products and their biosynthetic pathways. Nat Biotechnol (2009) 1.29
Dynamical remodeling of the transcriptome during short-term anaerobiosis in Saccharomyces cerevisiae: differential response and role of Msn2 and/or Msn4 and other factors in galactose and glucose media. Mol Cell Biol (2005) 1.28
Large-scale phosphoprotein analysis in Medicago truncatula roots provides insight into in vivo kinase activity in legumes. Plant Physiol (2009) 1.27
Mass spectrometry-based discovery of circadian peptides. Proc Natl Acad Sci U S A (2008) 1.27
Structure determination and interception of biosynthetic intermediates for the plantazolicin class of highly discriminating antibiotics. ACS Chem Biol (2011) 1.27
Kinetic and mass spectrometric analysis of p300 histone acetyltransferase domain autoacetylation. J Biol Chem (2006) 1.26
Comprehensive phosphoprotein analysis of linker histone H1 from Tetrahymena thermophila. Mol Cell Proteomics (2006) 1.26
Targeted analysis and discovery of posttranslational modifications in proteins from methanogenic archaea by top-down MS. Proc Natl Acad Sci U S A (2004) 1.26
Using ProSight PTM and related tools for targeted protein identification and characterization with high mass accuracy tandem MS data. Curr Protoc Bioinformatics (2007) 1.26
Activity screening of carrier domains within nonribosomal peptide synthetases using complex substrate mixtures and large molecule mass spectrometry. Biochemistry (2006) 1.24
Robust analysis of the yeast proteome under 50 kDa by molecular-mass-based fractionation and top-down mass spectrometry. Anal Chem (2011) 1.23