Sterile immunity to malaria after DNA prime/adenovirus boost immunization is associated with effector memory CD8+T cells targeting AMA1 class I epitopes.

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Published in PLoS One on September 11, 2014

Authors

Martha Sedegah1, Michael R Hollingdale1, Fouzia Farooq1, Harini Ganeshan1, Maria Belmonte1, Yohan Kim2, Bjoern Peters2, Alessandro Sette2, Jun Huang1, Shannon McGrath1, Esteban Abot1, Keith Limbach1, Meng Shi3, Lorraine Soisson4, Carter Diggs4, Ilin Chuang1, Cindy Tamminga1, Judith E Epstein1, Eileen Villasante1, Thomas L Richie1

Author Affiliations

1: US Military Malaria Vaccine Program, Naval Medical Research Center, Silver Spring, Maryland, United States of America.
2: La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America.
3: Division of Medical, Audio, Visual, Library and Statistical Services, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.
4: USAID, Washington, DC, United States of America.

Associated clinical trials:

Clinical Trial for Malaria Vaccines to Test for Safety, Immune Response and Protection Against Malaria (DNA-Ad) | NCT00870987

NMRC-M3V-Ad-PfCA Vaccine - Clinical Trial 1 | NCT00392015

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