Published in J Biol Chem on September 12, 2014
A20 Haploinsufficiency Aggravates Transplant Arteriosclerosis in Mouse Vascular Allografts: Implications for Clinical Transplantation. Transplantation (2016) 0.75
Downregulation of A20 increases the cytotoxicity of IFN-γ in hepatocellular carcinoma cells. Drug Des Devel Ther (2017) 0.75
A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res (2001) 124.61
How cells respond to interferons. Annu Rev Biochem (1998) 24.27
Triggering the interferon antiviral response through an IKK-related pathway. Science (2003) 11.62
Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice. Science (2000) 10.98
Virus induction of human IFN beta gene expression requires the assembly of an enhanceosome. Cell (1995) 7.17
Interferons, interferon-like cytokines, and their receptors. Immunol Rev (2004) 6.21
Executive summary: heart disease and stroke statistics--2013 update: a report from the American Heart Association. Circulation (2013) 6.13
Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factors. Immunity (2006) 5.36
IFN-gamma potentiates atherosclerosis in ApoE knock-out mice. J Clin Invest (1997) 4.18
Positive feedback regulation of type I IFN genes by the IFN-inducible transcription factor IRF-7. FEBS Lett (1998) 3.80
Role of smooth muscle cells in the initiation and early progression of atherosclerosis. Arterioscler Thromb Vasc Biol (2008) 3.79
A weak signal for strong responses: interferon-alpha/beta revisited. Nat Rev Mol Cell Biol (2001) 3.39
An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice. Nat Med (2013) 3.15
IFN regulatory factor 3-dependent induction of type I IFNs by intracellular bacteria is mediated by a TLR- and Nod2-independent mechanism. J Immunol (2004) 2.60
Interferon-gamma elicits arteriosclerosis in the absence of leukocytes. Nature (2000) 2.55
Myeloid type I interferon signaling promotes atherosclerosis by stimulating macrophage recruitment to lesions. Cell Metab (2010) 2.33
Negative regulation of the retinoic acid-inducible gene I-induced antiviral state by the ubiquitin-editing protein A20. J Biol Chem (2005) 2.27
A20 blocks endothelial cell activation through a NF-kappaB-dependent mechanism. J Biol Chem (1996) 2.26
Synergy between interferon-gamma and tumor necrosis factor-alpha in transcriptional activation is mediated by cooperation between signal transducer and activator of transcription 1 and nuclear factor kappaB. J Biol Chem (1997) 2.05
A20 is a potent inhibitor of TLR3- and Sendai virus-induced activation of NF-kappaB and ISRE and IFN-beta promoter. FEBS Lett (2004) 1.98
SLIM is a nuclear ubiquitin E3 ligase that negatively regulates STAT signaling. Immunity (2005) 1.64
A20 is a negative regulator of IFN regulatory factor 3 signaling. J Immunol (2005) 1.63
Inhibition of endothelial cell activation by adenovirus-mediated expression of I kappa B alpha, an inhibitor of the transcription factor NF-kappa B. J Exp Med (1996) 1.49
Chemokines in the vascular inflammatory response of atherosclerosis. Cardiovasc Res (2009) 1.45
Functional crosstalk between type I and II interferon through the regulated expression of STAT1. PLoS Biol (2010) 1.40
A20, a regulator of NFkappaB, maps to an atherosclerosis locus and differs between parental sensitive C57BL/6J and resistant FVB/N strains. Proc Natl Acad Sci U S A (2003) 1.38
A20 protects endothelial cells from TNF-, Fas-, and NK-mediated cell death by inhibiting caspase 8 activation. Blood (2004) 1.37
Tag polymorphisms at the A20 (TNFAIP3) locus are associated with lower gene expression and increased risk of coronary artery disease in type 2 diabetes. Diabetes (2007) 1.35
NF-kappa B RelA subunit is crucial for early IFN-beta expression and resistance to RNA virus replication. J Immunol (2010) 1.33
Regulation of NF-κB signaling by the A20 deubiquitinase. Cell Mol Immunol (2012) 1.33
Induction of IRF-3 and IRF-7 phosphorylation following activation of the RIG-I pathway. Cell Mol Biol (Noisy-le-grand) (2006) 1.33
A20 inhibits NF-kappaB activation in endothelial cells without sensitizing to tumor necrosis factor-mediated apoptosis. Blood (1998) 1.27
IFNβ-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage. EMBO J (2013) 1.26
Interferon-gamma inhibits arterial stenosis after injury. Circulation (1991) 1.22
Distinct roles for the NF-kappa B RelA subunit during antiviral innate immune responses. J Virol (2011) 1.20
An inflammatory pathway of IFN-gamma production in coronary atherosclerosis. J Immunol (2007) 1.19
Structure and ubiquitination-dependent activation of TANK-binding kinase 1. Cell Rep (2013) 1.17
A20, a modulator of smooth muscle cell proliferation and apoptosis, prevents and induces regression of neointimal hyperplasia. FASEB J (2006) 1.09
Transcriptome analysis reveals a role of interferon-gamma in human neointima formation. Mol Cell (2001) 1.02
T cell modulation of intimal thickening after vascular injury: the bimodal role of IFN-gamma in immune deficiency. Arterioscler Thromb Vasc Biol (2005) 1.00
O-glycosylation regulates ubiquitination and degradation of the anti-inflammatory protein A20 to accelerate atherosclerosis in diabetic ApoE-null mice. PLoS One (2010) 1.00
Interferons and autoimmune disorders. Joint Bone Spine (2009) 0.99
A20 (Tnfaip3) deficiency in myeloid cells protects against influenza A virus infection. PLoS Pathog (2012) 0.96
A20 protects from CD40-CD40 ligand-mediated endothelial cell activation and apoptosis. Circulation (2003) 0.96
The A20 deubiquitinase activity negatively regulates LMP1 activation of IRF7. J Virol (2010) 0.96
Roles of IKK-beta, IRF1, and p65 in the activation of chemokine genes by interferon-gamma. J Interferon Cytokine Res (2009) 0.95
STAT1-mediated signal integration between IFNγ and LPS leads to increased EC and SMC activation and monocyte adhesion. Am J Physiol Cell Physiol (2011) 0.95
Regulation of inflammatory and antiviral signaling by A20. Microbes Infect (2010) 0.92
Activation of indoleamine 2,3-dioxygenase-induced tryptophan degradation in advanced atherosclerotic plaques: Tampere vascular study. Ann Med (2010) 0.91
A20 inhibits post-angioplasty restenosis by blocking macrophage trafficking and decreasing adventitial neovascularization. Atherosclerosis (2010) 0.91
Human T cell lymphotropic virus 1 manipulates interferon regulatory signals by controlling the TAK1-IRF3 and IRF4 pathways. J Biol Chem (2009) 0.88
Smurf1 protein negatively regulates interferon-γ signaling through promoting STAT1 protein ubiquitination and degradation. J Biol Chem (2012) 0.87
Astrocytic A20 ameliorates experimental autoimmune encephalomyelitis by inhibiting NF-κB- and STAT1-dependent chemokine production in astrocytes. Acta Neuropathol (2013) 0.87
Interferon regulator factor 1/retinoic inducible gene I (IRF1/RIG-I) axis mediates 25-hydroxycholesterol-induced interleukin-8 production in atherosclerosis. Cardiovasc Res (2011) 0.86
A20-mediated modulation of inflammatory and immune responses in aortic allografts and development of transplant arteriosclerosis. Transplantation (2012) 0.81
Inhibition of vascular smooth muscle cell proliferation and intimal hyperplasia by gene transfer of beta-interferon. Mol Med (1997) 0.79