Published in Cell Mol Immunol on February 20, 2012
The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing. Nat Rev Immunol (2014) 2.82
Optineurin regulates the interferon response in a cell cycle-dependent manner. PLoS Pathog (2015) 1.42
Regulation of A20 and other OTU deubiquitinases by reversible oxidation. Nat Commun (2013) 1.17
The deubiquitinase A20 mediates feedback inhibition of interleukin-17 receptor signaling. Sci Signal (2013) 1.16
A20 restricts ubiquitination of pro-interleukin-1β protein complexes and suppresses NLRP3 inflammasome activity. Immunity (2015) 1.11
Regulation of nuclear factor-κB in autoimmunity. Trends Immunol (2013) 1.05
A new look at T cell receptor signaling to nuclear factor-κB. Trends Immunol (2013) 0.97
Autophagy enhances NFκB activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity. Nat Commun (2015) 0.97
UBE2O negatively regulates TRAF6-mediated NF-κB activation by inhibiting TRAF6 polyubiquitination. Cell Res (2013) 0.95
Cooperative signaling via transcription factors NF-κB and AP1/c-Fos mediates endothelial cell STIM1 expression and hyperpermeability in response to endotoxin. J Biol Chem (2014) 0.93
Tumor necrosis factor receptor- associated factor 6 (TRAF6) regulation of development, function, and homeostasis of the immune system. Immunol Rev (2015) 0.92
The role of A20 in the pathogenesis of lymphocytic malignancy. Cancer Cell Int (2012) 0.87
Context-Dependent Regulation of Autophagy by IKK-NF-κB Signaling: Impact on the Aging Process. Int J Cell Biol (2012) 0.87
Bromodomain and extraterminal (BET) protein inhibition suppresses human T cell leukemia virus 1 (HTLV-1) Tax protein-mediated tumorigenesis by inhibiting nuclear factor κB (NF-κB) signaling. J Biol Chem (2013) 0.87
The anaphase-promoting complex protein 5 (AnapC5) associates with A20 and inhibits IL-17-mediated signal transduction. PLoS One (2013) 0.86
Interleukin-17 (IL-17)-induced microRNA 873 (miR-873) contributes to the pathogenesis of experimental autoimmune encephalomyelitis by targeting A20 ubiquitin-editing enzyme. J Biol Chem (2014) 0.85
Acquired deficiency of A20 results in rapid apoptosis, systemic inflammation, and abnormal hematopoietic stem cell function. PLoS One (2014) 0.84
Imiquimod induces apoptosis of squamous cell carcinoma (SCC) cells via regulation of A20. PLoS One (2014) 0.82
Molecular and genomic aberrations in Chlamydophila psittaci negative ocular adnexal marginal zone lymphomas. Am J Hematol (2013) 0.82
Commensal microbiota contributes to chronic endocarditis in TAX1BP1 deficient mice. PLoS One (2013) 0.82
RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway. Nat Commun (2015) 0.82
The opioid antagonist, β-funaltrexamine, inhibits NF-κB signaling and chemokine expression in human astrocytes and in mice. Eur J Pharmacol (2015) 0.80
IL-17 signaling and A20: a balancing act. Cell Cycle (2013) 0.79
Open reading frame 3 of genotype 1 hepatitis E virus inhibits nuclear factor-κappa B signaling induced by tumor necrosis factor-α in human A549 lung epithelial cells. PLoS One (2014) 0.79
The RING ubiquitin E3 RNF114 interacts with A20 and modulates NF-κB activity and T-cell activation. Cell Death Dis (2014) 0.78
NF-κB in inflammation and renal diseases. Cell Biosci (2015) 0.77
Small molecule deubiquitinase inhibitors promote macrophage anti-infective capacity. PLoS One (2014) 0.76
A20 regulates atherogenic interferon (IFN)-γ signaling in vascular cells by modulating basal IFNβ levels. J Biol Chem (2014) 0.76
Ubiquitin-specific Protease 20 Regulates the Reciprocal Functions of β-Arrestin2 in Toll-like Receptor 4-promoted Nuclear Factor κB (NFκB) Activation. J Biol Chem (2016) 0.76
Correlation of Biomarker Expression in Colonic Mucosa with Disease Phenotype in Crohn's Disease and Ulcerative Colitis. Dig Dis Sci (2015) 0.75
An IκB Kinase-Regulated Feedforward Circuit Prolongs Inflammation. Cell Rep (2015) 0.75
A20 Haploinsufficiency Aggravates Transplant Arteriosclerosis in Mouse Vascular Allografts: Implications for Clinical Transplantation. Transplantation (2016) 0.75
Nemo-like kinase as a negative regulator of nuclear receptor Nurr1 gene transcription in prostate cancer. BMC Cancer (2016) 0.75
Ubiquitin ligase A20 regulates p53 protein in human colon epithelial cells. J Biomed Sci (2013) 0.75
Rice Stress Associated Protein 1 (OsSAP1) Interacts with Aminotransferase (OsAMTR1) and Pathogenesis-Related 1a Protein (OsSCP) and Regulates Abiotic Stress Responses. Front Plant Sci (2016) 0.75
Candidate genes of Waldenström's macroglobulinemia: current evidence and research. Appl Clin Genet (2013) 0.75
miR-125b regulates differentiation and metabolic reprogramming of T cell acute lymphoblastic leukemia by directly targeting A20. Oncotarget (2016) 0.75
S-adenosylhomocysteine inhibits NF-κB-mediated gene expression in hepatocytes and confers sensitivity to TNF cytotoxicity. Alcohol Clin Exp Res (2013) 0.75
Oocyte exposure to ZnO nanoparticles inhibits early embryonic development through the γ-H2AX and NF-κB signaling pathways. Oncotarget (2017) 0.75
Therapeutic Effect of Exogenous Truncated IK Protein in Inflammatory Arthritis. Int J Mol Sci (2017) 0.75
Inflammation-Related Gene Polymorphisms Associated With Primary Immune Thrombocytopenia. Front Immunol (2017) 0.75
The ubiquitin system. Annu Rev Biochem (1998) 43.36
Shared principles in NF-kappaB signaling. Cell (2008) 20.96
Signaling to NF-kappaB. Genes Dev (2004) 19.78
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling. Nature (2004) 12.41
TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature (2001) 11.84
Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice. Science (2000) 10.98
Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell (2000) 10.90
The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses. Nat Immunol (2004) 9.42
A genomic and functional inventory of deubiquitinating enzymes. Cell (2005) 9.36
NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway. Science (1993) 9.03
Regulation and function of IKK and IKK-related kinases. Sci STKE (2006) 8.98
Breaking the chains: structure and function of the deubiquitinases. Nat Rev Mol Cell Biol (2009) 8.85
Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma. Nature (2009) 7.37
Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Mol Cell (2006) 7.32
Common variants at CD40 and other loci confer risk of rheumatoid arthritis. Nat Genet (2008) 7.07
Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation. Nat Cell Biol (2009) 6.62
Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes. Annu Rev Biochem (2009) 6.23
Atypical ubiquitin chains: new molecular signals. 'Protein Modifications: Beyond the Usual Suspects' review series. EMBO Rep (2008) 6.21
TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains. Mol Cell (2004) 6.00
Linear ubiquitination prevents inflammation and regulates immune signalling. Nature (2011) 4.85
IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation. Nature (2005) 4.31
Frequent inactivation of A20 in B-cell lymphomas. Nature (2009) 4.22
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis. Nature (2011) 4.14
The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation. Proc Natl Acad Sci U S A (1996) 4.03
Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes. Science (2010) 4.03
Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains. EMBO Rep (2009) 3.94
Deubiquitylation and regulation of the immune response. Nat Rev Immunol (2008) 3.59
The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20. Nat Immunol (2008) 3.55
T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20. Nat Immunol (2008) 3.45
The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein. J Biol Chem (1990) 3.41
Transcriptional activation of the tumor necrosis factor alpha-inducible zinc finger protein, A20, is mediated by kappa B elements. J Biol Chem (1992) 3.36
The HECT family of E3 ubiquitin ligases: multiple players in cancer development. Cancer Cell (2008) 3.35
Toll-like receptor signaling. J Biol Chem (2003) 3.24
The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals. Immunity (2008) 3.19
Characterization of a novel protein-binding module--the WW domain. FEBS Lett (1995) 3.11
Functional proteomics mapping of a human signaling pathway. Genome Res (2004) 3.04
The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity. J Biol Chem (1992) 2.90
Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20. J Exp Med (2008) 2.80
TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma. J Exp Med (2009) 2.80
A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation. EMBO J (2007) 2.72
Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins. Oncogene (2008) 2.71
JAMM: a metalloprotease-like zinc site in the proteasome and signalosome. PLoS Biol (2003) 2.56
K11-linked polyubiquitination in cell cycle control revealed by a K11 linkage-specific antibody. Mol Cell (2010) 2.52
Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol. Mol Cell Biol (2002) 2.47
A20 zinc finger protein inhibits TNF and IL-1 signaling. J Immunol (1996) 2.44
c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling. EMBO J (2010) 2.33
Direct, noncatalytic mechanism of IKK inhibition by A20. Mol Cell (2011) 2.32
IkappaB kinase beta phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-kappaB pathway. Mol Cell Biol (2007) 2.31
Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity. Biochem J (2004) 2.23
B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice. Blood (2010) 2.17
The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling. EMBO J (2009) 2.17
Linear polyubiquitination: a new regulator of NF-kappaB activation. EMBO Rep (2009) 2.15
Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor-induced toxicity and experimental colitis. J Exp Med (2010) 2.15
Ubiquitination of RIP1 regulates an NF-kappaB-independent cell-death switch in TNF signaling. Curr Biol (2007) 2.15
CYLD: a tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processes. Cell Death Differ (2010) 2.14
The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6. FEBS Lett (1999) 2.12
Deubiquitinases in the regulation of NF-κB signaling. Cell Res (2010) 2.00
TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas. Blood (2009) 1.99
The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity. Immunity (2010) 1.97
Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling. EMBO J (2007) 1.95
ABIN-1 binds to NEMO/IKKgamma and co-operates with A20 in inhibiting NF-kappaB. J Biol Chem (2006) 1.91
Lymphoid expression and regulation of A20, an inhibitor of programmed cell death. J Immunol (1995) 1.91
Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation. EMBO J (2008) 1.87
A20 negatively regulates T cell receptor signaling to NF-kappaB by cleaving Malt1 ubiquitin chains. J Immunol (2009) 1.84
Inhibition of MALT1 protease activity is selectively toxic for activated B cell-like diffuse large B cell lymphoma cells. J Exp Med (2009) 1.80
A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis. Nat Genet (2011) 1.78
Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis. Nat Immunol (2011) 1.77
ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development. Nature (2008) 1.72
A20 is an antigen presentation attenuator, and its inhibition overcomes regulatory T cell-mediated suppression. Nat Med (2008) 1.65
The ubiquitin-editing protein A20 prevents dendritic cell activation, recognition of apoptotic cells, and systemic autoimmunity. Immunity (2011) 1.63
The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases. Oncogene (1999) 1.59
NF-κB signaling pathways regulated by CARMA family of scaffold proteins. Cell Res (2010) 1.58
14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules. J Biol Chem (1996) 1.53
Structure-function analysis of the A20-binding inhibitor of NF-kappa B activation, ABIN-1. FEBS Lett (2003) 1.51
Polyubiquitin binding to ABIN1 is required to prevent autoimmunity. J Exp Med (2011) 1.42
Enhanced NF-kappaB activation and cellular function in macrophages lacking IkappaB kinase 1 (IKK1). Proc Natl Acad Sci U S A (2005) 1.41
Ubiquitin binding to A20 ZnF4 is required for modulation of NF-κB signaling. Mol Cell (2010) 1.41
A20 is targeted by promoter methylation, deletion and inactivating mutation in MALT lymphoma. Leukemia (2009) 1.38
Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions. FEBS Lett (2001) 1.37
AIP4/Itch regulates Notch receptor degradation in the absence of ligand. PLoS One (2008) 1.35
Targeting A20 decreases glioma stem cell survival and tumor growth. PLoS Biol (2010) 1.27
Ubiquitin-mediated regulation of TNFR1 signaling. Cytokine Growth Factor Rev (2008) 1.24
CREB-2, a cellular CRE-dependent transcription repressor, functions in association with Tax as an activator of the human T-cell leukemia virus type 1 promoter. J Virol (1998) 1.23
The zinc finger protein A20 targets TRAF2 to the lysosomes for degradation. Biochim Biophys Acta (2008) 1.18
Human T cell leukemia virus type I Tax and phorbol 12-myristate 13-acetate induce expression of the A20 zinc finger protein by distinct mechanisms involving nuclear factor kappa B. J Biol Chem (1993) 1.16
A20/TNFAIP3, a new estrogen-regulated gene that confers tamoxifen resistance in breast cancer cells. Oncogene (2007) 1.15
Signature biomarkers in Crohn's disease: toward a molecular classification. Mucosal Immunol (2008) 1.15
The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation. Nat Immunol (2011) 1.14
The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase. Br J Cancer (2003) 1.14
A20 deficiency in B cells enhances B-cell proliferation and results in the development of autoantibodies. Eur J Immunol (2011) 1.13
Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis. Cell Death Differ (2011) 1.13
T6BP, a TRAF6-interacting protein involved in IL-1 signaling. Proc Natl Acad Sci U S A (2000) 1.11
RNF11 is a multifunctional modulator of growth factor receptor signalling and transcriptional regulation. Eur J Cancer (2005) 1.10
A20-binding inhibitor of NF-κB (ABIN1) controls Toll-like receptor-mediated CCAAT/enhancer-binding protein β activation and protects from inflammatory disease. Proc Natl Acad Sci U S A (2011) 1.08
The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1. Nat Immunol (2011) 1.05
Tumor suppressor TNFAIP3 (A20) is frequently deleted in Sézary syndrome. Leukemia (2011) 0.99
TNFAIP3 maintains intestinal barrier function and supports epithelial cell tight junctions. PLoS One (2011) 0.98
The RING-H2 protein RNF11 is differentially expressed in breast tumours and interacts with HECT-type E3 ligases. Biochim Biophys Acta (2003) 0.97
Itchy mice: the identification of a new pathway for the development of autoimmunity. Curr Top Microbiol Immunol (2008) 0.95
Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes. Science (2010) 4.03
The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20. Nat Immunol (2008) 3.55
Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation. J Biol Chem (2004) 3.35
The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling. EMBO J (2009) 2.17
Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling. EMBO J (2007) 1.95
The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation. J Virol (2007) 1.66
ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways. Curr Biol (2009) 1.34
TAX1BP1 and A20 inhibit antiviral signaling by targeting TBK1-IKKi kinases. J Biol Chem (2010) 1.29
Activation of NF-kappa B by the human T cell leukemia virus type I Tax oncoprotein is associated with ubiquitin-dependent relocalization of I kappa B kinase. J Biol Chem (2006) 1.23
Characterization of a nuclear export signal within the human T cell leukemia virus type I transactivator protein Tax. J Biol Chem (2003) 1.20
IRF-4 and c-Rel expression in antiviral-resistant adult T-cell leukemia/lymphoma. Blood (2007) 1.06
The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1. Nat Immunol (2011) 1.05
Human T cell leukemia virus type 1 Tax inhibits innate antiviral signaling via NF-kappaB-dependent induction of SOCS1. J Virol (2011) 1.05
Myocyte enhancer factor (MEF)-2 plays essential roles in T-cell transformation associated with HTLV-1 infection by stabilizing complex between Tax and CREB. Retrovirology (2015) 0.97
ABIN1 protein cooperates with TAX1BP1 and A20 proteins to inhibit antiviral signaling. J Biol Chem (2011) 0.95
An RNA interference screen identifies the Deubiquitinase STAMBPL1 as a critical regulator of human T-cell leukemia virus type 1 tax nuclear export and NF-κB activation. J Virol (2012) 0.94
Regulation of inflammatory and antiviral signaling by A20. Microbes Infect (2010) 0.92
RING finger protein 11 targets TBK1/IKKi kinases to inhibit antiviral signaling. PLoS One (2013) 0.89
Deregulated expression of CD40 ligand in HTLV-I infection: distinct mechanisms of downregulation in HTLV-I-transformed cell lines and ATL patients. Virology (2007) 0.88
Role of post-translational modifications of HTLV-1 Tax in NF-κB activation. World J Biol Chem (2010) 0.84
EBV LMP1: New and shared pathways to NF-κB activation. Proc Natl Acad Sci U S A (2012) 0.82
Mediators of central nervous system damage during the progression of human T-cell leukemia type I-associated myelopathy/tropical spastic paraparesis. J Neurovirol (2003) 0.80
Cell signaling. Anchors away for ubiquitin chains. Science (2010) 0.78
Outfoxing FoxO transcription factors: HTLV-1 Tax oncoprotein inactivates FoxO4 via the ubiquitin-proteasome pathway. Future Virol (2011) 0.76
Elucidating dynamic protein-protein interactions and ubiquitination in NF-κB signaling pathways. Methods Mol Biol (2015) 0.76
IKKi: a novel regulator of Act1, IL-17 signaling and pulmonary inflammation. Cell Mol Immunol (2011) 0.76
Is there a role for ubiquitin or SUMO in human T-cell leukemia virus type 2 Tax-induced NF-κB activation? Future Virol (2013) 0.75
The NLRP4-DTX4 axis: a key suppressor of TBK1 and innate antiviral signaling. Cell Mol Immunol (2012) 0.75
Role of the proteasome in the downregulation of transcription factors NFkappaB and C/EBP in macrophages from tumor hosts. Oncol Rep (2010) 0.75