Published in Front Pharmacol on August 28, 2014
Flux balance analysis predicts essential genes in clear cell renal cell carcinoma metabolism. Sci Rep (2015) 0.82
Editorial: the changing faces of glutathione, a cellular protagonist. Front Pharmacol (2015) 0.77
Role of hemoglobin and transferrin in multi-wall carbon nanotube-induced mesothelial injury and carcinogenesis. Cancer Sci (2016) 0.76
Transferrin: Endocytosis and Cell Signaling in Parasitic Protozoa. Biomed Res Int (2015) 0.76
Peroxiredoxin I is important for cancer-cell survival in Ras-induced hepatic tumorigenesis. Oncotarget (2016) 0.75
Ovarian endometriosis-associated stromal cells reveal persistently high affinity for iron. Redox Biol (2015) 0.75
α-((4-Cyanobenzoyl)oxy)-ω-methyl poly(ethylene glycol): a new stabilizer for silver nanoparticles. Beilstein J Nanotechnol (2017) 0.75
Chemical conversion of human fibroblasts into neuronal cells: dawn of future clinical trials. J Clin Biochem Nutr (2015) 0.75
Plasma total antioxidant capacity and peroxidation biomarkers in psoriasis. J Biomed Sci (2016) 0.75
The hallmarks of cancer. Cell (2000) 113.05
A comprehensive catalogue of somatic mutations from a human cancer genome. Nature (2009) 24.27
The cancer genome. Nature (2009) 23.13
The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev (2007) 21.13
An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem Biophys Res Commun (1997) 14.09
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev (1999) 13.43
Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA (2007) 11.87
The epigenetic progenitor origin of human cancer. Nat Rev Genet (2006) 9.65
Diabetes and atherosclerosis: epidemiology, pathophysiology, and management. JAMA (2002) 8.81
H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase. Science (2008) 7.89
Cancer epigenetics: from mechanism to therapy. Cell (2012) 7.74
Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling. Science (2003) 6.96
Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis. Lancet (2004) 6.35
Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell (2012) 6.31
Mitochondrial free radical generation, oxidative stress, and aging. Free Radic Biol Med (2000) 6.25
Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling. Free Radic Biol Med (2005) 5.83
Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies. Lancet Oncol (2012) 5.70
Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress. Proc Natl Acad Sci U S A (1996) 5.53
Two to tango: regulation of Mammalian iron metabolism. Cell (2010) 5.45
Antibody therapy of cancer. Nat Rev Cancer (2012) 5.17
Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood (2003) 5.11
A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab (2005) 4.79
A mutator phenotype in cancer. Cancer Res (2001) 4.41
Persistent oxidative stress in cancer. FEBS Lett (1995) 3.85
Hydrogen peroxide: a metabolic by-product or a common mediator of ageing signals? Nat Rev Mol Cell Biol (2007) 3.62
Induction of sarcoma in the rat by iron-dextran complex. Br Med J (1959) 3.56
Specific aquaporins facilitate the diffusion of hydrogen peroxide across membranes. J Biol Chem (2006) 3.54
Reduction of iron stores and cardiovascular outcomes in patients with peripheral arterial disease: a randomized controlled trial. JAMA (2007) 3.44
CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth. Cancer Cell (2011) 3.41
Glutathione and its role in cellular functions. Free Radic Biol Med (1999) 3.33
Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours. J Pathol (2002) 3.00
Mitoferrin is essential for erythroid iron assimilation. Nature (2006) 2.99
Alpha-Tocopherol and beta-carotene supplements and lung cancer incidence in the alpha-tocopherol, beta-carotene cancer prevention study: effects of base-line characteristics and study compliance. J Natl Cancer Inst (1996) 2.98
Premature termination of reprogramming in vivo leads to cancer development through altered epigenetic regulation. Cell (2014) 2.82
Membrane transport of hydrogen peroxide. Biochim Biophys Acta (2006) 2.81
Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-kappa B and AP-1. Proc Natl Acad Sci U S A (1994) 2.62
Glutathione peroxidases. Biochim Biophys Acta (2012) 2.53
NADPH oxidase-mediated redox signaling: roles in cellular stress response, stress tolerance, and tissue repair. Pharmacol Rev (2011) 2.53
The magic bullets and tuberculosis drug targets. Annu Rev Pharmacol Toxicol (2005) 2.52
The thioredoxin antioxidant system. Free Radic Biol Med (2013) 2.39
Wnt signaling in stem and cancer stem cells. Curr Opin Cell Biol (2013) 2.35
Toward clinical application of the Keap1-Nrf2 pathway. Trends Pharmacol Sci (2013) 2.26
Quantitative immunohistochemical determination of 8-hydroxy-2'-deoxyguanosine by a monoclonal antibody N45.1: its application to ferric nitrilotriacetate-induced renal carcinogenesis model. Lab Invest (1997) 2.25
Iron and chronic viral hepatitis. Hepatology (1997) 2.18
Estimation of H2O2 gradients across biomembranes. FEBS Lett (2000) 2.10
Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis. Proc Natl Acad Sci U S A (2011) 2.01
Chemical determination of free radical-induced damage to DNA. Free Radic Biol Med (1991) 1.89
Long-term phlebotomy with low-iron diet therapy lowers risk of development of hepatocellular carcinoma from chronic hepatitis C. J Gastroenterol (2007) 1.85
A mammalian siderophore synthesized by an enzyme with a bacterial homolog involved in enterobactin production. Cell (2010) 1.85
Role of iron in carcinogenesis: cancer as a ferrotoxic disease. Cancer Sci (2008) 1.81
Role of metabolic H2O2 generation: redox signaling and oxidative stress. J Biol Chem (2014) 1.70
Cytosolic and nuclear protein targets of thiol-reactive electrophiles. Chem Res Toxicol (2006) 1.69
Role of glutathione in cancer progression and chemoresistance. Oxid Med Cell Longev (2013) 1.68
The Keap1-Nrf2 system in cancers: stress response and anabolic metabolism. Front Oncol (2012) 1.64
Iron and cancer risk--a systematic review and meta-analysis of the epidemiological evidence. Cancer Epidemiol Biomarkers Prev (2013) 1.57
Contents of endometriotic cysts, especially the high concentration of free iron, are a possible cause of carcinogenesis in the cysts through the iron-induced persistent oxidative stress. Clin Cancer Res (2008) 1.57
Molecular pathways: reactive oxygen species homeostasis in cancer cells and implications for cancer therapy. Clin Cancer Res (2013) 1.56
Mammalian frataxin: an essential function for cellular viability through an interaction with a preformed ISCU/NFS1/ISD11 iron-sulfur assembly complex. PLoS One (2011) 1.56
Iron-induced carcinogenesis: the role of redox regulation. Free Radic Biol Med (1996) 1.56
Transition metals as catalysts of "autoxidation" reactions. Free Radic Biol Med (1990) 1.50
Iron deficiency accelerates Helicobacter pylori-induced carcinogenesis in rodents and humans. J Clin Invest (2012) 1.45
On the cytotoxicity of vitamin C and metal ions. A site-specific Fenton mechanism. Eur J Biochem (1983) 1.41
Formation of 4-hydroxy-2-nonenal-modified proteins in the renal proximal tubules of rats treated with a renal carcinogen, ferric nitrilotriacetate. Proc Natl Acad Sci U S A (1994) 1.38
Cysteine metabolism and metal toxicity. Altern Med Rev (1998) 1.38
Pharmacological ascorbate with gemcitabine for the control of metastatic and node-positive pancreatic cancer (PACMAN): results from a phase I clinical trial. Cancer Chemother Pharmacol (2013) 1.33
Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration. Nat Chem Biol (2012) 1.32
Targeting cancer with small-molecular-weight kinase inhibitors. Methods Mol Biol (2012) 1.29
Induction of diabetes in animals by parenteral administration of ferric nitrilotriacetate. A model of experimental hemochromatosis. Am J Pathol (1979) 1.24
Nephrotoxicity and renal cell carcinoma after use of iron- and aluminum-nitrilotriacetate complexes in rats. J Natl Cancer Inst (1986) 1.23
Increased cancer risk in a cohort of 230 patients with hereditary hemochromatosis in comparison to matched control patients with non-iron-related chronic liver disease. Hepatology (2001) 1.21
DNA base modifications in renal chromatin of Wistar rats treated with a renal carcinogen, ferric nitrilotriacetate. Int J Cancer (1994) 1.15
Aetiology, genetics and prevention of secondary neoplasms in adult cancer survivors. Nat Rev Clin Oncol (2013) 1.13
Induction and nuclear translocation of thioredoxin by oxidative damage in the mouse kidney: independence of tubular necrosis and sulfhydryl depletion. Lab Invest (1997) 1.13
Homozygous deletion of CDKN2A/2B is a hallmark of iron-induced high-grade rat mesothelioma. Lab Invest (2010) 1.12
Role of sulfiredoxin as a regulator of peroxiredoxin function and regulation of its expression. Free Radic Biol Med (2012) 1.11
Two distinct mechanisms for loss of thioredoxin-binding protein-2 in oxidative stress-induced renal carcinogenesis. Lab Invest (2005) 1.10
Specific allelic loss of p16 (INK4A) tumor suppressor gene after weeks of iron-mediated oxidative damage during rat renal carcinogenesis. Am J Pathol (2002) 1.09
Iron overload signature in chrysotile-induced malignant mesothelioma. J Pathol (2012) 1.08
Redox regulation of annexin 2 and its implications for oxidative stress-induced renal carcinogenesis and metastasis. Oncogene (2004) 1.07
The biological chemistry of hydrogen peroxide. Methods Enzymol (2013) 1.07
Toxicity of thiols and disulphides: involvement of free-radical species. Free Radic Biol Med (1989) 1.06
Subacute nephrotoxicity and induction of renal cell carcinoma in mice treated with ferric nitrilotriacetate. Cancer Res (1987) 1.05
Iron-mediated DNA damage: sensitive detection of DNA strand breakage catalyzed by iron. J Inorg Biochem (1992) 1.04
Novel roles of peroxiredoxins in inflammation, cancer and innate immunity. J Clin Biochem Nutr (2012) 1.04
Iron and carcinogenesis: from Fenton reaction to target genes. Redox Rep (2002) 1.02
High incidence of allelic loss on chromosome 5 and inactivation of p15INK4B and p16INK4A tumor suppressor genes in oxystress-induced renal cell carcinoma of rats. Oncogene (1999) 1.01
Fenton reaction induced cancer in wild type rats recapitulates genomic alterations observed in human cancer. PLoS One (2012) 1.00
Expression of stress-response and cell proliferation genes in renal cell carcinoma induced by oxidative stress. Am J Pathol (2000) 0.99
The LDL-HDL profile determines the risk of atherosclerosis: a mathematical model. PLoS One (2014) 0.98
Iron-induced tissue damage and cancer: the role of reactive oxygen species-free radicals. Pathol Int (1996) 0.94
Genotoxicity and carcinogenicity risk of carbon nanotubes. Adv Drug Deliv Rev (2013) 0.94
Iron as a target of chemoprevention for longevity in humans. Free Radic Res (2011) 0.93
Combined histochemical and biochemical analysis of sex hormone dependence of ferric nitrilotriacetate-induced renal lipid peroxidation in ddY mice. Cancer Res (1990) 0.93
Met is the most frequently amplified gene in endometriosis-associated ovarian clear cell adenocarcinoma and correlates with worsened prognosis. PLoS One (2013) 0.91
Role of transferrin in determining internal iron distribution. Blood (1977) 0.91
DNA single- and double-strand breaks produced by ferric nitrilotriacetate in relation to renal tubular carcinogenesis. Carcinogenesis (1993) 0.91
Low incidence of point mutations in H-, K- and N-ras oncogenes and p53 tumor suppressor gene in renal cell carcinoma and peritoneal mesothelioma of Wistar rats induced by ferric nitrilotriacetate. Jpn J Cancer Res (1995) 0.91
DNA double-strand breaks cooperate with loss of Ink4 and Arf tumor suppressors to generate glioblastomas with frequent Met amplification. Oncogene (2014) 0.90
Association between 8-hydroxy-2'-deoxyguanosine formation and DNA strand breaks mediated by copper and iron. Free Radic Biol Med (1996) 0.89