Streptococcus pneumoniae translocates into the myocardium and forms unique microlesions that disrupt cardiac function.

PubWeight™: 1.01‹?› | Rank: Top 15%

🔗 View Article (PMC 4169480)

Published in PLoS Pathog on September 18, 2014

Authors

Armand O Brown1, Beth Mann2, Geli Gao2, Jane S Hankins3, Jessica Humann2, Jonathan Giardina2, Paola Faverio4, Marcos I Restrepo5, Ganesh V Halade6, Eric M Mortensen7, Merry L Lindsey8, Martha Hanes9, Kyle I Happel10, Steve Nelson10, Gregory J Bagby10, Jose A Lorent11, Pablo Cardinal11, Rosario Granados11, Andres Esteban11, Claude J LeSaux12, Elaine I Tuomanen2, Carlos J Orihuela1

Author Affiliations

1: Dept. of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America.
2: Dept. of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
3: Dept. of Hematology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
4: University of Milan Bicocca and Dept. of Respiratory Medicine, San Gerardo Hospital, Monza, Italy.
5: Dept. of Medicine, South Texas Veterans Health Care System and University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America.
6: Division of Cardiovascular Disease, Dept. of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, United States of America.
7: Medical Service, Veterans Affairs North Texas Health Care System and Dept. of Internal Medicine and Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America.
8: Dept. of Physiology and Biophysics University of Mississippi Medical Center, Jackson, Mississippi, United States of America.
9: Dept. of Laboratory Animal Resources. University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America.
10: Dept. of Physiology and Section of Pulmonary/Critical Care Medicine. Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America.
11: CIBER de Enfermedades Respiratorias, Hospital Universitario de Getafe, Madrid, Spain.
12: Division of Cardiology, Dept. of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America.

Associated clinical trials:

Myocardial Injury and Severe Pneumococcal Pneumonia (NEUMOCAR) | NCT03058211

Articles citing this

Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia. PLoS Pathog (2015) 0.98

Circulating Pneumolysin Is a Potent Inducer of Cardiac Injury during Pneumococcal Infection. PLoS Pathog (2015) 0.92

Cardiotoxicity during invasive pneumococcal disease. Am J Respir Crit Care Med (2015) 0.86

Cigarette Smoke Attenuates the Nasal Host Response to Streptococcus pneumoniae and Predisposes to Invasive Pneumococcal Disease in Mice. Infect Immun (2016) 0.83

Infiltrated Macrophages Die of Pneumolysin-Mediated Necroptosis following Pneumococcal Myocardial Invasion. Infect Immun (2016) 0.82

Pneumolysin activates neutrophil extracellular trap formation. Clin Exp Immunol (2016) 0.79

Statin-Conferred Enhanced Cellular Resistance against Bacterial Pore-Forming Toxins in Airway Epithelial Cells. Am J Respir Cell Mol Biol (2015) 0.79

Intermediate and long-term risk of new-onset heart failure after hospitalization for pneumonia in elderly adults. Am Heart J (2015) 0.79

Individuality, phenotypic differentiation, dormancy and 'persistence' in culturable bacterial systems: commonalities shared by environmental, laboratory, and clinical microbiology. F1000Res (2015) 0.79

Anatomical site-specific contributions of pneumococcal virulence determinants. Pneumonia (Nathan) (2016) 0.79

Bacterial exploitation of phosphorylcholine mimicry suppresses inflammation to promote airway infection. J Clin Invest (2015) 0.78

Pneumolysin Mediates Platelet Activation In Vitro. Lung (2016) 0.78

Visualization of Streptococcus pneumoniae within Cardiac Microlesions and Subsequent Cardiac Remodeling. J Vis Exp (2015) 0.77

Disentangling competence for genetic transformation and virulence in Streptococcus pneumoniae. Curr Genet (2015) 0.77

Severe Pneumococcal Pneumonia Causes Acute Cardiac Toxicity and Subsequent Cardiac Remodeling. Am J Respir Crit Care Med (2017) 0.76

Streptococcus pneumoniae Cell-Wall-Localized Phosphoenolpyruvate Protein Phosphotransferase Can Function as an Adhesin: Identification of Its Host Target Molecules and Evaluation of Its Potential as a Vaccine. PLoS One (2016) 0.76

A Non-Human Primate Model of Severe Pneumococcal Pneumonia. PLoS One (2016) 0.75

Increased Zinc Availability Enhances Initial Aggregation and Biofilm Formation of Streptococcus pneumoniae. Front Cell Infect Microbiol (2017) 0.75

Invasive Pneumococcal Disease: Still Lots to Learn and a Need for Standardized Data Collection Instruments. Can Respir J (2017) 0.75

Pore-forming toxin-mediated ion dysregulation leads to death receptor-independent necroptosis of lung epithelial cells during bacterial pneumonia. Cell Death Differ (2017) 0.75

Epidemiology, virulence factors and management of the pneumococcus. F1000Res (2016) 0.75

Cardiac Electrical and Structural Changes During Bacterial Infection: An Instructive Model to Study Cardiac Dysfunction in Sepsis. J Am Heart Assoc (2016) 0.75

Acute myocardial infarction versus other cardiovascular events in community-acquired pneumonia. ERJ Open Res (2015) 0.75

Streptococcus pneumoniae in the heart subvert the host response through biofilm-mediated resident macrophage killing. PLoS Pathog (2017) 0.75

Prevalence, pathogenesis, therapy, and prevention of cardiovascular events in patients with community-acquired pneumonia. Pneumonia (Nathan) (2016) 0.75

Articles cited by this

Complete genome sequence of a virulent isolate of Streptococcus pneumoniae. Science (2001) 21.99

Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2. J Immunol (1999) 6.60

Streptococcus pneumoniae anchor to activated human cells by the receptor for platelet-activating factor. Nature (1995) 5.15

Effect of pneumococcal conjugate vaccine on pneumococcal meningitis. N Engl J Med (2009) 4.38

Genome sequence of Avery's virulent serotype 2 strain D39 of Streptococcus pneumoniae and comparison with that of unencapsulated laboratory strain R6. J Bacteriol (2006) 3.40

Necroptosis: the release of damage-associated molecular patterns and its physiological relevance. Immunity (2013) 3.22

Pneumonia: still the old man's friend? Arch Intern Med (2003) 3.12

The 37/67-kilodalton laminin receptor is a receptor for adeno-associated virus serotypes 8, 2, 3, and 9. J Virol (2006) 2.94

Reentry as a cause of ventricular tachycardia in patients with chronic ischemic heart disease: electrophysiologic and anatomic correlation. Circulation (1988) 2.86

Genetic requirements for Staphylococcus aureus abscess formation and persistence in host tissues. FASEB J (2009) 2.82

Laminin receptor initiates bacterial contact with the blood brain barrier in experimental meningitis models. J Clin Invest (2009) 2.51

Necrostatin: a potentially novel cardioprotective agent? Cardiovasc Drugs Ther (2007) 2.50

Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4. PLoS Pathog (2010) 2.33

Relationship between successful ablation sites and the scar border zone defined by substrate mapping for ventricular tachycardia post-myocardial infarction. J Cardiovasc Electrophysiol (2005) 2.12

Is statin use associated with reduced mortality after pneumonia? A systematic review and meta-analysis. Am J Med (2012) 2.09

Toll-like receptor stimulation in cardiomyoctes decreases contractility and initiates an NF-kappaB dependent inflammatory response. Cardiovasc Res (2006) 1.96

Neuroprotection by a caspase inhibitor in acute bacterial meningitis. Nat Med (1999) 1.71

Only two amino acids are essential for cytolytic toxin recognition of cholesterol at the membrane surface. Proc Natl Acad Sci U S A (2010) 1.66

beta-Arrestin 1 participates in platelet-activating factor receptor-mediated endocytosis of Streptococcus pneumoniae. Infect Immun (2005) 1.60

Cardiac complications in patients with community-acquired pneumonia: incidence, timing, risk factors, and association with short-term mortality. Circulation (2012) 1.52

The association between pneumococcal pneumonia and acute cardiac events. Clin Infect Dis (2007) 1.52

Detection of 11 common viral and bacterial pathogens causing community-acquired pneumonia or sepsis in asymptomatic patients by using a multiplex reverse transcription-PCR assay with manual (enzyme hybridization) or automated (electronic microarray) detection. J Clin Microbiol (2008) 1.51

Solution structure of choline binding protein A, the major adhesin of Streptococcus pneumoniae. EMBO J (2004) 1.47

Statins protect against fulminant pneumococcal infection and cytolysin toxicity in a mouse model of sickle cell disease. J Clin Invest (2010) 1.44

Cardiac complications in patients with community-acquired pneumonia: a systematic review and meta-analysis of observational studies. PLoS Med (2011) 1.42

Platelet-activating factor receptor and innate immunity: uptake of gram-positive bacterial cell wall into host cells and cell-specific pathophysiology. J Immunol (2006) 1.37

Streptococcus pneumoniae recruits complement factor H through the amino terminus of CbpA. J Biol Chem (2006) 1.36

Critical roles of ASC inflammasomes in caspase-1 activation and host innate resistance to Streptococcus pneumoniae infection. J Immunol (2011) 1.33

Human histopathology of electroanatomic mapping after cooled-tip radiofrequency ablation to treat ventricular tachycardia in remote myocardial infarction. J Cardiovasc Electrophysiol (2005) 1.29

Acute pneumonia and the cardiovascular system. Lancet (2013) 1.25

The NLRP3 inflammasome contributes to brain injury in pneumococcal meningitis and is activated through ATP-dependent lysosomal cathepsin B release. J Immunol (2011) 1.21

Acute bacterial pneumonia is associated with the occurrence of acute coronary syndromes. Medicine (Baltimore) (2009) 1.14

Biological properties of pneumolysin. Microb Drug Resist (1997) 1.12

Early biofilm formation on microtiter plates is not correlated with the invasive disease potential of Streptococcus pneumoniae. Microb Pathog (2010) 1.11

Programmed cellular necrosis mediated by the pore-forming alpha-toxin from Clostridium septicum. PLoS Pathog (2009) 1.09

Age-related defects in TLR2 signaling diminish the cytokine response by alveolar macrophages during murine pneumococcal pneumonia. Exp Gerontol (2012) 1.07

The human polymeric immunoglobulin receptor binds to Streptococcus pneumoniae via domains 3 and 4. J Biol Chem (2003) 0.97

Clostridium perfringens beta-toxin induces necrostatin-inhibitable, calpain-dependent necrosis in primary porcine endothelial cells. PLoS One (2013) 0.97

Broadly protective protein-based pneumococcal vaccine composed of pneumolysin toxoid-CbpA peptide recombinant fusion protein. J Infect Dis (2013) 0.94

Do the spatial characteristics of myocardial scar tissue determine the risk of ventricular arrhythmias? Cardiovasc Res (2012) 0.89

Bacterial flagellin triggers cardiac innate immune responses and acute contractile dysfunction. PLoS One (2010) 0.88

Effect of bacterial pneumonia on lung simian immunodeficiency virus (SIV) replication in alcohol consuming SIV-infected rhesus macaques. Alcohol Clin Exp Res (2013) 0.86

Physical characterization and formulation development of a recombinant pneumolysoid protein-based pneumococcal vaccine. J Pharm Sci (2012) 0.86

Assessing risk for ventricular tachyarrhythmias and sudden cardiac death: is there a role for cardiac MRI? Circ Cardiovasc Imaging (2012) 0.81