Published in Exp Gerontol on April 23, 2012
Age-dependent dysregulation of innate immunity. Nat Rev Immunol (2013) 2.44
Host Factors and Biomarkers Associated with Poor Outcomes in Adults with Invasive Pneumococcal Disease. PLoS One (2016) 1.39
Protective immunity and defects in the neonatal and elderly immune response to sepsis. J Immunol (2014) 1.01
Streptococcus pneumoniae translocates into the myocardium and forms unique microlesions that disrupt cardiac function. PLoS Pathog (2014) 1.01
Toll like receptor signaling in "inflammaging": microRNA as new players. Immun Ageing (2013) 0.99
Impaired innate mucosal immunity in aged mice permits prolonged Streptococcus pneumoniae colonization. Infect Immun (2013) 0.89
Aged mice are unable to mount an effective myeloid response to sepsis. J Immunol (2013) 0.89
Cardiotoxicity during invasive pneumococcal disease. Am J Respir Crit Care Med (2015) 0.86
Requirement for Serratia marcescens cytolysin in a murine model of hemorrhagic pneumonia. Infect Immun (2014) 0.84
Influence of age, past smoking, and disease severity on TLR2, neutrophilic inflammation, and MMP-9 levels in COPD. Mediators Inflamm (2013) 0.83
Innate immune responses in the ageing lung. Clin Exp Immunol (2016) 0.82
Infiltrated Macrophages Die of Pneumolysin-Mediated Necroptosis following Pneumococcal Myocardial Invasion. Infect Immun (2016) 0.82
Elevated A20 contributes to age-dependent macrophage dysfunction in the lungs. Exp Gerontol (2014) 0.81
The α-tocopherol form of vitamin E reverses age-associated susceptibility to streptococcus pneumoniae lung infection by modulating pulmonary neutrophil recruitment. J Immunol (2014) 0.80
Enhanced inflammation in aged mice following infection with Streptococcus pneumoniae is associated with decreased IL-10 and augmented chemokine production. Am J Physiol Lung Cell Mol Physiol (2015) 0.79
Flagellin-dependent TLR5/caveolin-1 as a promising immune activator in immunosenescence. Aging Cell (2015) 0.79
Immunosenescence in monocytes, macrophages, and dendritic cells: lessons learned from the lung and heart. Immunol Lett (2014) 0.79
Extracellular Adenosine Protects against Streptococcus pneumoniae Lung Infection by Regulating Pulmonary Neutrophil Recruitment. PLoS Pathog (2015) 0.78
Donor age and early graft failure after lung transplantation: a cohort study. Am J Transplant (2013) 0.77
Advanced Age Alters Monocyte and Macrophage Responses. Antioxid Redox Signal (2016) 0.75
Peritoneal exudate cells from long-lived rats exhibit increased IL-10/IL-1β expression ratio and preserved NO/urea ratio following LPS-stimulation in vitro. Age (Dordr) (2014) 0.75
Inflammaging and the Lung. Clin Geriatr Med (2017) 0.75
Aging Impairs Alveolar Macrophage Phagocytosis and Increases Influenza-Induced Mortality in Mice. J Immunol (2017) 0.75
Toll-like receptors. Annu Rev Immunol (2001) 26.06
Complete genome sequence of a virulent isolate of Streptococcus pneumoniae. Science (2001) 21.99
Decline in invasive pneumococcal disease after the introduction of protein-polysaccharide conjugate vaccine. N Engl J Med (2003) 15.48
Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2. J Immunol (1999) 6.60
Effectiveness of pneumococcal polysaccharide vaccine in older adults. N Engl J Med (2003) 5.60
Mechanisms and functions of p38 MAPK signalling. Biochem J (2010) 4.59
Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection. Proc Natl Acad Sci U S A (2003) 4.56
Aging of the immune system: how much can the adaptive immune system adapt? Immunity (2006) 4.30
23-valent pneumococcal polysaccharide vaccine in HIV-1-infected Ugandan adults: double-blind, randomised and placebo controlled trial. Lancet (2000) 4.23
Cutting edge: impaired Toll-like receptor expression and function in aging. J Immunol (2002) 3.04
Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. J Exp Med (2007) 2.85
Cytoplasmic DNA innate immune pathways. Immunol Rev (2011) 2.84
Sustained desensitization to bacterial Toll-like receptor ligands after resolution of respiratory influenza infection. J Exp Med (2008) 2.77
Inflammasome activation and IL-1β and IL-18 processing during infection. Trends Immunol (2011) 2.75
Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response. J Immunol (2010) 2.63
IL-10 is an important mediator of the enhanced susceptibility to pneumococcal pneumonia after influenza infection. J Immunol (2004) 2.59
Pneumococcal pneumolysin and H(2)O(2) mediate brain cell apoptosis during meningitis. J Clin Invest (2002) 2.50
The scavenger receptor MARCO is required for lung defense against pneumococcal pneumonia and inhaled particles. J Exp Med (2004) 2.46
Interleukin-6 gene-deficient mice show impaired defense against pneumococcal pneumonia. J Infect Dis (1997) 2.39
Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4. PLoS Pathog (2010) 2.33
Age-associated defect in human TLR-1/2 function. J Immunol (2007) 2.20
Toll-like receptor 2-deficient mice are highly susceptible to Streptococcus pneumoniae meningitis because of reduced bacterial clearing and enhanced inflammation. J Infect Dis (2002) 2.16
Toll-like receptors and their signaling mechanisms. Scand J Infect Dis (2003) 2.08
Toll-like receptor 2 plays a role in the early inflammatory response to murine pneumococcal pneumonia but does not contribute to antibacterial defense. J Immunol (2004) 1.91
The apoptotic response to pneumolysin is Toll-like receptor 4 dependent and protects against pneumococcal disease. Infect Immun (2005) 1.86
Role of Toll-like receptor 4 in gram-positive and gram-negative pneumonia in mice. Infect Immun (2004) 1.73
Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression. J Leukoc Biol (2003) 1.67
Toll-like receptor 9 acts at an early stage in host defence against pneumococcal infection. Cell Microbiol (2006) 1.62
Molecular basis of age-associated cytokine dysregulation in LPS-stimulated macrophages. J Leukoc Biol (2006) 1.59
The role of pneumolysin in pneumococcal pneumonia and meningitis. Clin Exp Immunol (2004) 1.57
The hemolytic and complement-activating properties of pneumolysin do not contribute individually to virulence in a pneumococcal bacteremia model. Microb Pathog (1997) 1.55
Age-associated inflammation and toll-like receptor dysfunction prime the lungs for pneumococcal pneumonia. J Infect Dis (2009) 1.49
Mast cell IL-6 improves survival from Klebsiella pneumonia and sepsis by enhancing neutrophil killing. J Immunol (2008) 1.48
The effect of age on the B-cell repertoire. J Clin Immunol (2000) 1.47
Tumor necrosis factor induces GSK3 kinase-mediated cross-tolerance to endotoxin in macrophages. Nat Immunol (2011) 1.46
Aging negatively skews macrophage TLR2- and TLR4-mediated pro-inflammatory responses without affecting the IL-2-stimulated pathway. Mech Ageing Dev (2005) 1.46
Aging impairs IFN regulatory factor 7 up-regulation in plasmacytoid dendritic cells during TLR9 activation. J Immunol (2008) 1.45
Glycogen synthase kinase 3: a point of convergence for the host inflammatory response. Cytokine (2010) 1.36
Alveolar macrophages transport pathogens to lung draining lymph nodes. J Immunol (2009) 1.33
Impaired functions of peripheral blood monocyte subpopulations in aged humans. J Clin Immunol (2010) 1.32
Immune dysregulation in the aging human lung. Am J Respir Crit Care Med (1996) 1.29
miR-365, a novel negative regulator of interleukin-6 gene expression, is cooperatively regulated by Sp1 and NF-kappaB. J Biol Chem (2011) 1.29
Innate immunity to pneumococcal infection of the central nervous system depends on toll-like receptor (TLR) 2 and TLR4. J Infect Dis (2008) 1.28
Neutrophils and low-grade inflammation in the seemingly normal aging human lung. Mech Ageing Dev (1998) 1.23
Lipoteichoic acid-induced lung inflammation depends on TLR2 and the concerted action of TLR4 and the platelet-activating factor receptor. J Immunol (2008) 1.22
Signaling crosstalk during sequential TLR4 and TLR9 activation amplifies the inflammatory response of mouse macrophages. J Immunol (2009) 1.20
MAPKAP kinases MK2 and MK3 in inflammation: complex regulation of TNF biosynthesis via expression and phosphorylation of tristetraprolin. Biochem Pharmacol (2010) 1.19
Streptococcus pneumoniae and Pseudomonas aeruginosa pneumonia induce distinct host responses. Crit Care Med (2010) 1.14
Rapid transit in the immune cells: the role of mRNA turnover regulation. J Leukoc Biol (2007) 1.14
IL-6 cytoprotection in hyperoxic acute lung injury occurs via suppressor of cytokine signaling-1-induced apoptosis signal-regulating kinase-1 degradation. Am J Respir Cell Mol Biol (2008) 1.08
Aging of the Innate Immune System: An Update. Curr Immunol Rev (2011) 1.06
Multiple causes of death in old age. Aging Trends (2008) 1.05
Advanced age impairs macrophage polarization. J Interferon Cytokine Res (2011) 1.04
Inflammation and mesenchymal stem cell aging. Curr Opin Immunol (2011) 1.03
Induction of meningeal inflammation by diverse bacterial cell walls. Eur J Clin Microbiol (1986) 1.01
IL-12 enhances efficacy and shortens enrichment time in cytokine-induced killer cell immunotherapy. Cancer Immunol Immunother (2010) 0.98
Modulation of the inflammatory response to Streptococcus pneumoniae in a model of acute lung tissue infection. Am J Respir Cell Mol Biol (2008) 0.98
Tumor necrosis factor-alpha from macrophages enhances LPS-induced clara cell expression of keratinocyte-derived chemokine. Am J Respir Cell Mol Biol (2007) 0.95
Dysregulated inflammation as a risk factor for pneumonia in the elderly. Aging Dis (2011) 0.93
Pneumonia in the elderly. Curr Opin Infect Dis (2004) 0.91
Enhancement of humoral immunity by interleukin-12. Ann N Y Acad Sci (1996) 0.91
Molecular mechanisms underlying anti-inflammatory phenotype of neonatal splenic macrophages. J Leukoc Biol (2007) 0.88
Nonspecific presentation of pneumonia in hospitalized older people: age effect or dementia? J Am Geriatr Soc (2000) 0.87
Role of phosphoinositide 3-kinase-Akt signaling pathway in the age-related cytokine dysregulation in splenic macrophages stimulated via TLR-2 or TLR-4 receptors. Mech Ageing Dev (2011) 0.87
EstA protein, a novel virulence factor of Streptococcus pneumoniae, induces nitric oxide and pro-inflammatory cytokine production in RAW 264.7 macrophages through NF-kappaB/MAPK. Microb Pathog (2009) 0.84
TLR-2 independent recognition of Mycobacterium tuberculosis by CD11c+ pulmonary cells from old mice. Mech Ageing Dev (2010) 0.83
Molecular mechanisms of the secretion of cytokines and chemokines from human monocytes activated by pneumococcal surface protein A (PspA): Roles of mitogen-activated protein kinases and NF-kappaB. Microb Pathog (2010) 0.76
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci (2010) 5.54
Identification of a Candidate Streptococcus pneumoniae core genome and regions of diversity correlated with invasive pneumococcal disease. Infect Immun (2006) 2.33
Induction of pro- and anti-inflammatory molecules in a mouse model of pneumococcal pneumonia after influenza. Comp Med (2007) 1.99
Caspase-1 contributes to Chlamydia trachomatis-induced upper urogenital tract inflammatory pathologies without affecting the course of infection. Infect Immun (2007) 1.85
Antibodies against PsrP, a novel Streptococcus pneumoniae adhesin, block adhesion and protect mice against pneumococcal challenge. J Infect Dis (2008) 1.67
The Streptococcus pneumoniae adhesin PsrP binds to Keratin 10 on lung cells. Mol Microbiol (2009) 1.62
beta-Arrestin 1 participates in platelet-activating factor receptor-mediated endocytosis of Streptococcus pneumoniae. Infect Immun (2005) 1.60
The pneumococcal serine-rich repeat protein is an intra-species bacterial adhesin that promotes bacterial aggregation in vivo and in biofilms. PLoS Pathog (2010) 1.57
Virulence in mice of pneumococcal clonal types with known invasive disease potential in humans. J Infect Dis (2005) 1.51
Age-associated inflammation and toll-like receptor dysfunction prime the lungs for pneumococcal pneumonia. J Infect Dis (2009) 1.49
TLR2/MyD88/NF-κB pathway, reactive oxygen species, potassium efflux activates NLRP3/ASC inflammasome during respiratory syncytial virus infection. PLoS One (2012) 1.48
Statins protect against fulminant pneumococcal infection and cytolysin toxicity in a mouse model of sickle cell disease. J Clin Invest (2010) 1.44
A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum. J Immunol (2009) 1.39
Intracellular interleukin-1alpha mediates interleukin-8 production induced by Chlamydia trachomatis infection via a mechanism independent of type I interleukin-1 receptor. Infect Immun (2007) 1.37
Platelet-activating factor receptor and innate immunity: uptake of gram-positive bacterial cell wall into host cells and cell-specific pathophysiology. J Immunol (2006) 1.37
TLR-dependent control of Francisella tularensis infection and host inflammatory responses. PLoS One (2009) 1.33
Mast cells inhibit intramacrophage Francisella tularensis replication via contact and secreted products including IL-4. Proc Natl Acad Sci U S A (2008) 1.21
Streptococcus pneumoniae in biofilms are unable to cause invasive disease due to altered virulence determinant production. PLoS One (2011) 1.16
Phosphatidylinositol 3-kinase activation attenuates the TLR2-mediated macrophage proinflammatory cytokine response to Francisella tularensis live vaccine strain. J Immunol (2010) 1.14
Early biofilm formation on microtiter plates is not correlated with the invasive disease potential of Streptococcus pneumoniae. Microb Pathog (2010) 1.11
Regions of Diversity 8, 9 and 13 contribute to Streptococcus pneumoniae virulence. BMC Microbiol (2007) 1.11
Incidence of cardiovascular events after hospital admission for pneumonia. Am J Med (2011) 1.10
Optimized transfection of mRNA transcribed from a d(A/T)100 tail-containing vector. Biochem Biophys Res Commun (2005) 1.08
Cellular senescence increases expression of bacterial ligands in the lungs and is positively correlated with increased susceptibility to pneumococcal pneumonia. Aging Cell (2011) 1.08
Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence. Exp Gerontol (2012) 1.07
Vaccination with a defined Francisella tularensis subsp. novicida pathogenicity island mutant (DeltaiglB) induces protective immunity against homotypic and heterotypic challenge. Vaccine (2009) 1.03
Aurora kinase-A inactivates DNA damage-induced apoptosis and spindle assembly checkpoint response functions of p73. Cancer Cell (2012) 1.02
Changes in capsular serotype alter the surface exposure of pneumococcal adhesins and impact virulence. PLoS One (2011) 0.97
Pneumococci: immunology of the innate host response. Respirology (2010) 0.95
Dysregulated inflammation as a risk factor for pneumonia in the elderly. Aging Dis (2011) 0.93
Prevalence and clonal distribution of pcpA, psrP and Pilus-1 among pediatric isolates of Streptococcus pneumoniae. PLoS One (2012) 0.93
Structural studies of two mutants of amicyanin from Paracoccus denitrificans that stabilize the reduced state of the copper. Biochemistry (2004) 0.93
Pneumococcal gene complex involved in resistance to extracellular oxidative stress. Infect Immun (2012) 0.92
Impact of oral simvastatin therapy on acute lung injury in mice during pneumococcal pneumonia. BMC Microbiol (2012) 0.90
Pneumococcal microbial surface components recognizing adhesive matrix molecules targeting of the extracellular matrix. Mol Microbiol (2010) 0.90
Distinct roles of CD28- and CD40 ligand-mediated costimulation in the development of protective immunity and pathology during Chlamydia muridarum urogenital infection in mice. Infect Immun (2009) 0.89
Interactions between blood-borne Streptococcus pneumoniae and the blood-brain barrier preceding meningitis. PLoS One (2013) 0.88
Biofilm and planktonic pneumococci demonstrate disparate immunoreactivity to human convalescent sera. BMC Microbiol (2011) 0.88
CD4+ T cells are required during priming but not the effector phase of antibody-mediated IFN-gamma-dependent protective immunity against pulmonary Francisella novicida infection. Immunol Cell Biol (2008) 0.87
Expression of RUNX2 isoforms: involvement of cap-dependent and cap-independent mechanisms of translation. J Cell Biochem (2006) 0.87
Cardiotoxicity during invasive pneumococcal disease. Am J Respir Crit Care Med (2015) 0.86
PsrP, a protective pneumococcal antigen, is highly prevalent in children with pneumonia and is strongly associated with clonal type. Clin Vaccine Immunol (2010) 0.86
Characterization of the hypothetical protein Cpn1027, a newly identified inclusion membrane protein unique to Chlamydia pneumoniae. Microbiology (2007) 0.86
Future perspective on host-pathogen interactions during bacterial biofilm formation within the nasopharynx. Future Microbiol (2012) 0.85
A novel telomerase activator suppresses lung damage in a murine model of idiopathic pulmonary fibrosis. PLoS One (2013) 0.85
Role played by psrP-secY2A2 (accessory region 34) in the invasive disease potential of Streptococcus pneumoniae. J Infect Dis (2009) 0.84
Mast cell TLR2 signaling is crucial for effective killing of Francisella tularensis. J Immunol (2012) 0.82
Anatomical site-specific contributions of pneumococcal virulence determinants. Pneumonia (Nathan) (2016) 0.79
Assessment of molecular typing methods to determine invasiveness and to differentiate clones of Streptococcus pneumoniae. Infect Genet Evol (2007) 0.77
Chromogranin A levels and mortality in patients with severe sepsis. Biomarkers (2015) 0.77
Cyanogen bromide-activated coupling: DNA catalytic chromatography purification of EcoRI endonuclease. Nat Protoc (2006) 0.76