Published in Proteomics on October 28, 2014
Proteomics Research in Cardiovascular Medicine and Biomarker Discovery. J Am Coll Cardiol (2016) 0.76
Targeting the SUMO pathway for neuroprotection in brain ischaemia. Stroke Vasc Neurol (2016) 0.75
A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2. Cell (1997) 9.01
A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex. J Cell Biol (1996) 7.64
Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell (2011) 7.30
SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation. Mol Cell (1998) 6.62
RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation. Nat Cell Biol (2008) 5.90
Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9. J Biol Chem (2001) 5.04
A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation. Science (2006) 4.42
A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Mol Cell Proteomics (2011) 4.40
Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks. Nature (2009) 4.30
Identification of a SUMO-binding motif that recognizes SUMO-modified proteins. Proc Natl Acad Sci U S A (2004) 4.19
Principles of ubiquitin and SUMO modifications in DNA repair. Nature (2009) 4.10
The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice. Dev Cell (2005) 3.96
SUMO modification of Huntingtin and Huntington's disease pathology. Science (2004) 3.85
Specification of SUMO1- and SUMO2-interacting motifs. J Biol Chem (2006) 3.59
Defining the SUMO-modified proteome by multiple approaches in Saccharomyces cerevisiae. J Biol Chem (2004) 3.53
System-wide changes to SUMO modifications in response to heat shock. Sci Signal (2009) 3.50
A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis. Science (2011) 3.49
Targeting the ubiquitin system in cancer therapy. Nature (2009) 3.27
Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling. Nat Biotechnol (2010) 3.16
SUMO-targeted ubiquitin ligases in genome stability. EMBO J (2007) 2.77
Isolation of a polypeptide that has lymphocyte-differentiating properties and is probably represented universally in living cells. Proc Natl Acad Sci U S A (1975) 2.77
Distinct and overlapping sets of SUMO-1 and SUMO-2 target proteins revealed by quantitative proteomics. Mol Cell Proteomics (2006) 2.64
Conserved function of RNF4 family proteins in eukaryotes: targeting a ubiquitin ligase to SUMOylated proteins. EMBO J (2007) 2.59
A proteomic strategy for gaining insights into protein sumoylation in yeast. Mol Cell Proteomics (2004) 2.58
The complete amino acid sequence of ubiquitin, an adenylate cyclase stimulating polypeptide probably universal in living cells. Biochemistry (1975) 2.51
Protein group modification and synergy in the SUMO pathway as exemplified in DNA repair. Cell (2012) 2.36
A proteome-wide approach identifies sumoylated substrate proteins in yeast. J Biol Chem (2004) 2.31
In vivo identification of human small ubiquitin-like modifier polymerization sites by high accuracy mass spectrometry and an in vitro to in vivo strategy. Mol Cell Proteomics (2007) 2.30
A universal strategy for proteomic studies of SUMO and other ubiquitin-like modifiers. Mol Cell Proteomics (2004) 2.21
RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair. Genes Dev (2012) 2.16
Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif. Mol Cell (2010) 2.10
A proteomic study of SUMO-2 target proteins. J Biol Chem (2004) 1.92
SUMO-targeted ubiquitin E3 ligase RNF4 is required for the response of human cells to DNA damage. Genes Dev (2012) 1.90
SUMO1-dependent modulation of SERCA2a in heart failure. Nature (2011) 1.89
Ubiquitin and ubiquitin-like proteins in protein regulation. Circ Res (2007) 1.87
Sumoylation of heterogeneous nuclear ribonucleoproteins, zinc finger proteins, and nuclear pore complex proteins: a proteomic analysis. Proc Natl Acad Sci U S A (2004) 1.85
The ubiquitin-proteasome system is a key component of the SUMO-2/3 cycle. Mol Cell Proteomics (2008) 1.81
Protein SUMOylation is massively increased in hibernation torpor and is critical for the cytoprotection provided by ischemic preconditioning and hypothermia in SHSY5Y cells. J Cereb Blood Flow Metab (2006) 1.75
Transient global cerebral ischemia induces a massive increase in protein sumoylation. J Cereb Blood Flow Metab (2007) 1.74
Purification and identification of endogenous polySUMO conjugates. EMBO Rep (2011) 1.72
Comparative proteomic analysis identifies a role for SUMO in protein quality control. Sci Signal (2011) 1.54
Proteomic analyses identify a diverse array of nuclear processes affected by small ubiquitin-like modifier conjugation in Arabidopsis. Proc Natl Acad Sci U S A (2010) 1.53
Small ubiquitin-like modifier (SUMO) modification of natively unfolded proteins tau and alpha-synuclein. J Biol Chem (2006) 1.48
Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Mol Cell Proteomics (2012) 1.48
Genetic and proteomic evidence for roles of Drosophila SUMO in cell cycle control, Ras signaling, and early pattern formation. PLoS One (2009) 1.48
Transient focal cerebral ischemia induces a dramatic activation of small ubiquitin-like modifier conjugation. J Cereb Blood Flow Metab (2008) 1.45
Detecting endogenous SUMO targets in mammalian cells and tissues. Nat Struct Mol Biol (2013) 1.44
Loss of SUMO1 in mice affects RanGAP1 localization and formation of PML nuclear bodies, but is not lethal as it can be compensated by SUMO2 or SUMO3. J Cell Sci (2008) 1.44
Proteome-wide identification of SUMO2 modification sites. Sci Signal (2014) 1.44
SUMO regulates the assembly and function of a cytoplasmic intermediate filament protein in C. elegans. Dev Cell (2009) 1.43
SUMO Losing Balance: SUMO Proteases Disrupt SUMO Homeostasis to Facilitate Cancer Development and Progression. Genes Cancer (2010) 1.42
SUMOylation participates in induction of ischemic tolerance. J Neurochem (2009) 1.38
Inflammation and the neurovascular unit in the setting of focal cerebral ischemia. Neuroscience (2008) 1.37
Sumo-1 function is dispensable in normal mouse development. Mol Cell Biol (2008) 1.37
SUMO on the road to neurodegeneration. Biochim Biophys Acta (2007) 1.35
SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter and defines a novel gene family. Genomics (1997) 1.34
Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities. Cell Death Differ (2006) 1.34
A novel proteomics approach to identify SUMOylated proteins and their modification sites in human cells. Mol Cell Proteomics (2010) 1.34
Stabilization of PML nuclear localization by conjugation and oligomerization of SUMO-3. Oncogene (2005) 1.33
Emerging roles of desumoylating enzymes. Biochim Biophys Acta (2009) 1.33
SUMO2/3 conjugation is an endogenous neuroprotective mechanism. J Cereb Blood Flow Metab (2011) 1.32
SUMOylation in carcinogenesis. Cancer Lett (2011) 1.29
Sumoylation and human disease pathogenesis. Trends Biochem Sci (2009) 1.29
SENP1 induces prostatic intraepithelial neoplasia through multiple mechanisms. J Biol Chem (2010) 1.29
Characterization of a second member of the sentrin family of ubiquitin-like proteins. J Biol Chem (1998) 1.28
Elevated global SUMOylation in Ubc9 transgenic mice protects their brains against focal cerebral ischemic damage. PLoS One (2011) 1.28
Uncovering SUMOylation dynamics during cell-cycle progression reveals FoxM1 as a key mitotic SUMO target protein. Mol Cell (2014) 1.26
Novel proteomics strategy brings insight into the prevalence of SUMO-2 target sites. Mol Cell Proteomics (2009) 1.26
Control of nuclear activities by substrate-selective and protein-group SUMOylation. Annu Rev Genet (2013) 1.25
Sumoylation regulates lamin A function and is lost in lamin A mutants associated with familial cardiomyopathies. J Cell Biol (2008) 1.20
DeSUMOylating isopeptidase: a second class of SUMO protease. EMBO Rep (2012) 1.18
Expression analysis of Ubc9, the single small ubiquitin-like modifier (SUMO) E2 conjugating enzyme, in normal and malignant tissues. Hum Pathol (2010) 1.16
SUMO-specific protease 1 promotes prostate cancer progression and metastasis. Oncogene (2012) 1.16
SUMOylation of the polyglutamine repeat protein, ataxin-1, is dependent on a functional nuclear localization signal. J Biol Chem (2005) 1.15
Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functions. EMBO Rep (2012) 1.15
Sumoylation inhibits alpha-synuclein aggregation and toxicity. J Cell Biol (2011) 1.13
"ChopNSpice," a mass spectrometric approach that allows identification of endogenous small ubiquitin-like modifier-conjugated peptides. Mol Cell Proteomics (2009) 1.13
Cross talk of signaling pathways in the regulation of the glucocorticoid receptor function. Mol Endocrinol (2008) 1.13
Deep hypothermia markedly activates the small ubiquitin-like modifier conjugation pathway; implications for the fate of cells exposed to transient deep hypothermic cardiopulmonary bypass. J Cereb Blood Flow Metab (2009) 1.10
SUMO-specific protease 1 regulates the in vitro and in vivo growth of colon cancer cells with the upregulated expression of CDK inhibitors. Cancer Lett (2011) 1.10
SUMO, the three Rs and cancer. Curr Top Microbiol Immunol (2007) 1.08
Sumoylation in neurodegenerative diseases. Cell Mol Life Sci (2012) 1.08
In vivo and in vitro examination of the functional significances of novel lamin gene mutations in heart failure patients. J Med Genet (2005) 1.07
Differential expression of SUMO-specific protease 7 variants regulates epithelial-mesenchymal transition. Proc Natl Acad Sci U S A (2012) 1.05
Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition. Mol Cell Proteomics (2009) 1.05
Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. J Proteome Res (2012) 1.05
In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification. J Biol Chem (2010) 1.04
SUMO and its role in human diseases. Int Rev Cell Mol Biol (2011) 1.03
PIAS1 is increased in human prostate cancer and enhances proliferation through inhibition of p21. Am J Pathol (2012) 1.02
The small ubiquitin-like modifier (SUMO)-conjugating system of Toxoplasma gondii. Int J Parasitol (2008) 1.01
Characterizing ubiquitination sites by peptide-based immunoaffinity enrichment. Mol Cell Proteomics (2012) 1.00
SUMO boosts the DNA damage response barrier against cancer. Cancer Cell (2010) 0.99
Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics. J Proteome Res (2011) 0.98
A proteomic screen for nucleolar SUMO targets shows SUMOylation modulates the function of Nop5/Nop58. Mol Cell (2010) 0.97
SUMO-1 modification increases human SOD1 stability and aggregation. Biochem Biophys Res Commun (2006) 0.96
In vivo localization and identification of SUMOylated proteins in the brain of His6-HA-SUMO1 knock-in mice. Proc Natl Acad Sci U S A (2012) 0.95
SUMO2 is essential while SUMO3 is dispensable for mouse embryonic development. EMBO Rep (2014) 0.95
The ROS/SUMO axis contributes to the response of acute myeloid leukemia cells to chemotherapeutic drugs. Cell Rep (2014) 0.94
Transient global cerebral ischemia induces a massive increase in protein sumoylation. J Cereb Blood Flow Metab (2007) 1.74
Transient focal cerebral ischemia induces a dramatic activation of small ubiquitin-like modifier conjugation. J Cereb Blood Flow Metab (2008) 1.45
SUMO2/3 conjugation is an endogenous neuroprotective mechanism. J Cereb Blood Flow Metab (2011) 1.32
Endoplasmic reticulum stress. Ann N Y Acad Sci (2007) 1.18
Long-term neuroprotection from a potent redox-modulating metalloporphyrin in the rat. Free Radic Biol Med (2009) 1.10
Deep hypothermia markedly activates the small ubiquitin-like modifier conjugation pathway; implications for the fate of cells exposed to transient deep hypothermic cardiopulmonary bypass. J Cereb Blood Flow Metab (2009) 1.10
Cerebral ischemia/stroke and small ubiquitin-like modifier (SUMO) conjugation--a new target for therapeutic intervention? J Neurochem (2008) 1.00
Down-regulation of parkin protein in transient focal cerebral ischemia: A link between stroke and degenerative disease? Proc Natl Acad Sci U S A (2002) 0.98
Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics. J Proteome Res (2011) 0.98
Mechanisms underlying suppression of protein synthesis induced by transient focal cerebral ischemia in mouse brain. Exp Neurol (2002) 0.97
Moderate hypothermia induces marked increase in levels and nuclear accumulation of SUMO2/3-conjugated proteins in neurons. J Neurochem (2012) 0.94
Conditional gene silencing in mammalian cells mediated by a stress-inducible promoter. Biochem Biophys Res Commun (2007) 0.93
Gene expression and cell growth are modified by silencing SUMO2 and SUMO3 expression. Biochem Biophys Res Commun (2009) 0.91
Small ubiquitin-like modifier 1-3 conjugation [corrected] is activated in human astrocytic brain tumors and is required for glioblastoma cell survival. Cancer Sci (2012) 0.86
The endoplasmic reticulum and neurological diseases. Exp Neurol (2009) 0.85
Spinal cord trauma activates processing of xbp1 mRNA indicative of endoplasmic reticulum dysfunction. J Neurotrauma (2005) 0.84
Analysis of changes in SUMO-2/3 modification during breast cancer progression and metastasis. J Proteome Res (2014) 0.82
Genes associated with pro-apoptotic and protective mechanisms are affected differently on exposure of neuronal cell cultures to arsenite. No indication for endoplasmic reticulum stress despite activation of grp78 and gadd153 expression. Brain Res Mol Brain Res (2002) 0.81
Phosphorylation state, solubility, and activity of calcium/calmodulin-dependent protein kinase II alpha in transient focal ischemia in mouse brain. Neurochem Res (2002) 0.81
Spreading depression activates unfolded protein response. Neurosci Lett (2004) 0.77
Development of a high-throughput screening assay for inhibitors of small ubiquitin-like modifier proteases. J Biomol Screen (2013) 0.77