Published in Seikagaku on August 01, 2014
Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev Cell (2002) 9.10
Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts. Cell (2007) 4.71
Autoamplification of NFATc1 expression determines its essential role in bone homeostasis. J Exp Med (2005) 3.70
Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice. Hepatology (2004) 3.43
GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease. Biochemistry (2007) 2.71
A novel role of the mammalian GSPT/eRF3 associating with poly(A)-binding protein in Cap/Poly(A)-dependent translation. J Biol Chem (2002) 2.43
Novel role of the small GTPase Rheb: its implication in endocytic pathway independent of the activation of mammalian target of rapamycin. J Biochem (2005) 2.28
A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Cell (2010) 2.27
Structure, activation, and biology of calpain. Diabetes (2004) 2.16
A cell-based assay to screen stimulators of the Hippo pathway reveals the inhibitory effect of dobutamine on the YAP-dependent gene transcription. J Biochem (2011) 2.00
Translation termination factor eRF3 mediates mRNA decay through the regulation of deadenylation. J Biol Chem (2003) 1.85
An in vivo model for monitoring trans-differentiation of bone marrow cells into functional hepatocytes. J Biochem (2003) 1.81
Genetically encoded calcium indicator illuminates calcium dynamics in primary cilia. Nat Methods (2013) 1.76
An Arf-like small G protein, ARL-8, promotes the axonal transport of presynaptic cargoes by suppressing vesicle aggregation. Neuron (2010) 1.70
Mechanism of mRNA deadenylation: evidence for a molecular interplay between translation termination factor eRF3 and mRNA deadenylases. Genes Dev (2007) 1.68
A systematic genome-wide screen for mutations affecting organogenesis in Medaka, Oryzias latipes. Mech Dev (2004) 1.65
Joubert syndrome Arl13b functions at ciliary membranes and stabilizes protein transport in Caenorhabditis elegans. J Cell Biol (2010) 1.60
Identification of a human cytoplasmic poly(A) nuclease complex stimulated by poly(A)-binding protein. J Biol Chem (2003) 1.58
Blockage by SP600125 of Fcepsilon receptor-induced degranulation and cytokine gene expression in mast cells is mediated through inhibition of phosphatidylinositol 3-kinase signalling pathway. J Biochem (2008) 1.52
MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence. Nat Cell Biol (2004) 1.51
Interaction between Ski7p and Upf1p is required for nonsense-mediated 3'-to-5' mRNA decay in yeast. EMBO J (2003) 1.47
RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway. J Cell Sci (2003) 1.47
Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis. J Mol Biol (2007) 1.41
cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites. Mol Biol Cell (2011) 1.39
RalA functions as an indispensable signal mediator for the nutrient-sensing system. J Biol Chem (2008) 1.28
Activation of extracellular signal-regulated kinase by ultraviolet is mediated through Src-dependent epidermal growth factor receptor phosphorylation. Its implication in an anti-apoptotic function. J Biol Chem (2001) 1.21
A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5. J Biol Chem (2001) 1.21
Calpain chronicle--an enzyme family under multidisciplinary characterization. Proc Jpn Acad Ser B Phys Biol Sci (2011) 1.21
The GTP-binding release factor eRF3 as a key mediator coupling translation termination to mRNA decay. J Biol Chem (2004) 1.20
Activation of the c-Jun N-terminal kinase pathway by MST1 is essential and sufficient for the induction of chromatin condensation during apoptosis. Mol Cell Biol (2007) 1.19
Decapping reaction of mRNA requires Dcp1 in fission yeast: its characterization in different species from yeast to human. J Biochem (2004) 1.16
Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice. J Clin Invest (2012) 1.16
Control of the hippo pathway by Set7-dependent methylation of Yap. Dev Cell (2013) 1.11
Different properties of SEK1 and MKK7 in dual phosphorylation of stress-induced activated protein kinase SAPK/JNK in embryonic stem cells. J Biol Chem (2003) 1.11
Physiological roles of SAPK/JNK signaling pathway. J Biochem (2004) 1.10
Novel small GTPase subfamily capable of associating with tubulin is required for chromosome segregation. J Cell Sci (2004) 1.09
Autotaxin regulates vascular development via multiple lysophosphatidic acid (LPA) receptors in zebrafish. J Biol Chem (2011) 1.08
Transforming mutations of RAC guanosine triphosphatases in human cancers. Proc Natl Acad Sci U S A (2013) 1.07
Upf1 potentially serves as a RING-related E3 ubiquitin ligase via its association with Upf3 in yeast. RNA (2008) 1.06
Mice lacking Dok-1, Dok-2, and Dok-3 succumb to aggressive histiocytic sarcoma. Lab Invest (2010) 1.06
The arf-like GTPase Arl8 mediates delivery of endocytosed macromolecules to lysosomes in Caenorhabditis elegans. Mol Biol Cell (2010) 1.05
Role of activation of PIP5Kgamma661 by AP-2 complex in synaptic vesicle endocytosis. EMBO J (2007) 1.05
Non-proteolytic functions of calpain-3 in sarcoplasmic reticulum in skeletal muscles. J Mol Biol (2011) 1.05
Expanding members and roles of the calpain superfamily and their genetically modified animals. Exp Anim (2010) 1.03
Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation. EMBO J (2006) 1.02
C. elegans AMPKs promote survival and arrest germline development during nutrient stress. Biol Open (2012) 1.02
Biochemical characterization of missense mutations in the Arf/Arl-family small GTPase Arl6 causing Bardet-Biedl syndrome. Biochem Biophys Res Commun (2009) 1.02
Development of cell therapy using autologous bone marrow cells for liver cirrhosis. Med Mol Morphol (2005) 1.02
A novel acetylation cycle of transcription co-activator Yes-associated protein that is downstream of Hippo pathway is triggered in response to SN2 alkylating agents. J Biol Chem (2012) 1.02
Liver development and regeneration: from laboratory study to clinical therapy. Dev Growth Differ (2007) 1.01
Impact of genetic insights into calpain biology. J Biochem (2011) 1.00
Active transport and diffusion barriers restrict Joubert Syndrome-associated ARL13B/ARL-13 to an Inv-like ciliary membrane subdomain. PLoS Genet (2013) 1.00
Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy. J Clin Invest (2010) 0.99
Stress-activated protein kinase MKK7 regulates axon elongation in the developing cerebral cortex. J Neurosci (2011) 0.97
SEK1/MKK4-mediated SAPK/JNK signaling participates in embryonic hepatoblast proliferation via a pathway different from NF-kappaB-induced anti-apoptosis. Dev Biol (2002) 0.96
Possible involvement of IkappaB kinase 2 and MKK7 in osteoclastogenesis induced by receptor activator of nuclear factor kappaB ligand. J Bone Miner Res (2002) 0.96
Di-Ras, a distinct subgroup of ras family GTPases with unique biochemical properties. J Biol Chem (2002) 0.95
Human homologue of maid is a useful marker protein in hepatocarcinogenesis. Gastroenterology (2005) 0.95
Neoculin as a new taste-modifying protein occurring in the fruit of Curculigo latifolia. Biosci Biotechnol Biochem (2004) 0.94
Medaka as a model for human nonalcoholic steatohepatitis. Dis Model Mech (2010) 0.94
Domain architecture of the atypical Arf-family GTPase Arl13b involved in cilia formation. Biochem Biophys Res Commun (2008) 0.94
Novel antibody to human BASP1 labels apoptotic cells post-caspase activation. Biochem Biophys Res Commun (2008) 0.93
A common origin: signaling similarities in the regulation of the circadian clock and DNA damage responses. Biol Pharm Bull (2010) 0.92
Lesson from the GFP/CCl4 model--translational research project: the development of cell therapy using autologous bone marrow cells in patients with liver cirrhosis. J Hepatobiliary Pancreat Surg (2005) 0.91
Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine. Proc Natl Acad Sci U S A (2013) 0.91
The LIM protein Ajuba is required for ciliogenesis and left-right axis determination in medaka. Biochem Biophys Res Commun (2010) 0.91
Common light signaling pathways controlling DNA repair and circadian clock entrainment in zebrafish. Cell Cycle (2009) 0.91
Quantitative characterization of Tob interactions provides the thermodynamic basis for translation termination-coupled deadenylase regulation. J Biol Chem (2010) 0.91
Caf1 regulates translocation of ribonucleotide reductase by releasing nucleoplasmic Spd1-Suc22 assembly. Nucleic Acids Res (2007) 0.91
Activation mechanism of Gi and Go by reactive oxygen species. J Biol Chem (2002) 0.91
Characterization of Rab45/RASEF containing EF-hand domain and a coiled-coil motif as a self-associating GTPase. Biochem Biophys Res Commun (2007) 0.90
Possible functions of p94 in connectin-mediated signaling pathways in skeletal muscle cells. J Muscle Res Cell Motil (2005) 0.89
Negative regulation of wnt11 expression by Jnk signaling during zebrafish gastrulation. J Cell Biochem (2010) 0.89
Arl8/ARL-8 functions in apoptotic cell removal by mediating phagolysosome formation in Caenorhabditis elegans. Mol Biol Cell (2013) 0.88
Diverse physiological functions of MKK4 and MKK7 during early embryogenesis. J Biochem (2010) 0.88
The expanding role of fish models in understanding non-alcoholic fatty liver disease. Dis Model Mech (2013) 0.88
Skeletal muscle-specific calpain is an intracellular Na+-dependent protease. J Biol Chem (2010) 0.88
p38 Mitogen-activated protein kinase controls a switch between cardiomyocyte and neuronal commitment of murine embryonic stem cells by activating myocyte enhancer factor 2C-dependent bone morphogenetic protein 2 transcription. Stem Cells Dev (2010) 0.88
Characterization of RIN3 as a guanine nucleotide exchange factor for the Rab5 subfamily GTPase Rab31. J Biol Chem (2011) 0.87
Telmisartan improves nonalcoholic steatohepatitis in medaka (Oryzias latipes) by reducing macrophage infiltration and fat accumulation. Cell Tissue Res (2011) 0.86
Prospective isolation and characterization of bipotent progenitor cells in early mouse liver development. Stem Cells Dev (2011) 0.86