Published in J Mol Biol on February 03, 2011
Regulation and physiological roles of the calpain system in muscular disorders. Cardiovasc Res (2012) 0.97
Impaired calcium calmodulin kinase signaling and muscle adaptation response in the absence of calpain 3. Hum Mol Genet (2012) 0.90
Pathogenity of some limb girdle muscular dystrophy mutations can result from reduced anchorage to myofibrils and altered stability of calpain 3. Hum Mol Genet (2011) 0.90
Calpain-6 deficiency promotes skeletal muscle development and regeneration. PLoS Genet (2013) 0.85
Calpain 3 is important for muscle regeneration: evidence from patients with limb girdle muscular dystrophies. BMC Musculoskelet Disord (2012) 0.85
Animal models of muscular dystrophy. Prog Mol Biol Transl Sci (2012) 0.83
Redox state and mitochondrial respiratory chain function in skeletal muscle of LGMD2A patients. PLoS One (2014) 0.83
Impaired regeneration in LGMD2A supported by increased PAX7-positive satellite cell content and muscle-specific microrna dysregulation. Muscle Nerve (2013) 0.82
Calpain research for drug discovery: challenges and potential. Nat Rev Drug Discov (2016) 0.82
Failure to up-regulate transcription of genes necessary for muscle adaptation underlies limb girdle muscular dystrophy 2A (calpainopathy). Hum Mol Genet (2016) 0.79
Calpain 3 Expression Pattern during Gastrocnemius Muscle Atrophy and Regeneration Following Sciatic Nerve Injury in Rats. Int J Mol Sci (2015) 0.78
Limb-girdle muscular dystrophy subtypes: First-reported cohort from northeastern China. Neural Regen Res (2013) 0.78
The N- and C-terminal autolytic fragments of CAPN3/p94/calpain-3 restore proteolytic activity by intermolecular complementation. Proc Natl Acad Sci U S A (2014) 0.78
Limb-girdle muscular dystrophies: where next after six decades from the first proposal (Review). Mol Med Rep (2014) 0.78
The integrin-adhesome is required to maintain muscle structure, mitochondrial ATP production, and movement forces in Caenorhabditis elegans. FASEB J (2014) 0.77
Attenuated Ca(2+) release in a mouse model of limb girdle muscular dystrophy 2A. Skelet Muscle (2016) 0.77
Calpain-3 impairs cell proliferation and stimulates oxidative stress-mediated cell death in melanoma cells. PLoS One (2015) 0.76
Calpain 3 deficiency affects SERCA expression and function in the skeletal muscle. Expert Rev Mol Med (2016) 0.76
A Gastrointestinal Calpain Complex, G-calpain, is a Heterodimer of CAPN8 and CAPN9, which Play Catalytic and Regulatory Roles, Respectively. J Biol Chem (2016) 0.75
Calpain-3-mediated regulation of the Na(+)-Ca(2+) exchanger isoform 3. Pflugers Arch (2015) 0.75
Calcium dysregulation, functional calpainopathy, and endoplasmic reticulum stress in sporadic inclusion body myositis. Acta Neuropathol Commun (2017) 0.75
Intensity matters: Ryanodine receptor regulation during exercise. Proc Natl Acad Sci U S A (2015) 0.75
Emerging roles of calpain proteolytic systems in macrophage cholesterol handling. Cell Mol Life Sci (2017) 0.75
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Calpain 6 is involved in microtubule stabilization and cytoskeletal organization. Mol Cell Biol (2007) 1.14
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Suppressed disassembly of autolyzing p94/CAPN3 by N2A connectin/titin in a genetic reporter system. J Biol Chem (2006) 1.01
Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy. J Clin Invest (2010) 0.99
Mitochondrial m-calpain plays a role in the release of truncated apoptosis-inducing factor from the mitochondria. Biochim Biophys Acta (2009) 0.98
Mac-1(low) early myeloid cells in the bone marrow-derived SP fraction migrate into injured skeletal muscle and participate in muscle regeneration. Biochem Biophys Res Commun (2004) 0.96
Myogenic stage, sarcomere length, and protease activity modulate localization of muscle-specific calpain. J Biol Chem (2007) 0.94
Myopathy phenotype of transgenic mice expressing active site-mutated inactive p94 skeletal muscle-specific calpain, the gene product responsible for limb girdle muscular dystrophy type 2A. Hum Mol Genet (2000) 0.93
Mitochondrial calpain 10 activity and expression in the kidney of multiple species. Biochem Biophys Res Commun (2007) 0.89
Comprehensive survey of p94/calpain 3 substrates by comparative proteomics--possible regulation of protein synthesis by p94. Biotechnol J (2007) 0.89
Skeletal muscle-specific calpain is an intracellular Na+-dependent protease. J Biol Chem (2010) 0.88
Interaction of calcium/calmodulin-dependent protein kinase IIdeltaC with sorcin indirectly modulates ryanodine receptor function in cardiac myocytes. J Mol Cell Cardiol (2007) 0.87
Supramolecular calsequestrin complex. Eur J Biochem (2002) 0.85
Effect of preslaughter feed withdrawal period on longissimus tenderness and the expression of calpains in the ovine. J Agric Food Chem (2001) 0.85
Influences of sarcomere length and selective elimination of myosin filaments on the localization and orientation of triads in rat muscle fibres. J Muscle Res Cell Motil (1996) 0.84
Mutations of optineurin in amyotrophic lateral sclerosis. Nature (2010) 4.54
Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy. Nat Genet (2002) 2.67
Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders. Mol Brain (2008) 2.55
Changes in titin isoform expression in pacing-induced cardiac failure give rise to increased passive muscle stiffness. Circulation (2002) 2.43
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Nebulin regulates thin filament length, contractility, and Z-disk structure in vivo. EMBO J (2006) 2.17
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Calcium-dependent molecular spring elements in the giant protein titin. Proc Natl Acad Sci U S A (2003) 2.16
Determinants of poor outcome after aneurysmal subarachnoid hemorrhage when both clipping and coiling are available: Prospective Registry of Subarachnoid Aneurysms Treatment (PRESAT) in Japan. World Neurosurg (2011) 2.13
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The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules. J Mol Biol (2003) 2.12
Recessive truncating titin gene, TTN, mutations presenting as centronuclear myopathy. Neurology (2013) 2.09
Identification of a novel frameshift mutation in the giant muscle filament titin in a large Australian family with dilated cardiomyopathy. J Mol Med (Berl) (2006) 2.05
Evaluation of the hematoma consequences, neurobehavioral profiles, and histopathology in a rat model of pontine hemorrhage. J Neurosurg (2012) 2.02
A cell-based assay to screen stimulators of the Hippo pathway reveals the inhibitory effect of dobutamine on the YAP-dependent gene transcription. J Biochem (2011) 2.00
PKC phosphorylation of titin's PEVK element: a novel and conserved pathway for modulating myocardial stiffness. Circ Res (2009) 1.91
Cardiac titin: a multifunctional giant. Circulation (2010) 1.84
Titin is a target of matrix metalloproteinase-2: implications in myocardial ischemia/reperfusion injury. Circulation (2010) 1.80
Isoflurane delays the development of early brain injury after subarachnoid hemorrhage through sphingosine-related pathway activation in mice. Crit Care Med (2012) 1.78
Thin filament length dysregulation contributes to muscle weakness in nemaline myopathy patients with nebulin deficiency. Hum Mol Genet (2009) 1.73
Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy. Proc Natl Acad Sci U S A (2007) 1.70
Role of interleukin-1beta in early brain injury after subarachnoid hemorrhage in mice. Stroke (2009) 1.63
Dimerization of the cardiac ankyrin protein CARP: implications for MARP titin-based signaling. J Muscle Res Cell Motil (2005) 1.62
Molecular mechanics of cardiac titin's PEVK and N2B spring elements. J Biol Chem (2002) 1.61
Hydrogen gas ameliorates oxidative stress in early brain injury after subarachnoid hemorrhage in rats. Crit Care Med (2012) 1.60
Genetic variation in titin in arrhythmogenic right ventricular cardiomyopathy-overlap syndromes. Circulation (2011) 1.51
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Conditional expression of mutant M-line titins results in cardiomyopathy with altered sarcomere structure. J Biol Chem (2002) 1.47
Involvement of gangliosides in the process of Cbp/PAG phosphorylation by Lyn in developing cerebellar growth cones. J Neurochem (2013) 1.44
Constitutive activation of the pH-responsive Rim101 pathway in yeast mutants defective in late steps of the MVB/ESCRT pathway. Mol Cell Biol (2005) 1.43
Human platelets promote liver regeneration with Kupffer cells in SCID mice. J Surg Res (2012) 1.42
Nebulin alters cross-bridge cycling kinetics and increases thin filament activation: a novel mechanism for increasing tension and reducing tension cost. J Biol Chem (2009) 1.41
Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis. J Mol Biol (2007) 1.41
Titin isoform variance and length dependence of activation in skinned bovine cardiac muscle. J Physiol (2003) 1.39
Calpains: an elaborate proteolytic system. Biochim Biophys Acta (2011) 1.38
Reversal of hippocampal neuronal maturation by serotonergic antidepressants. Proc Natl Acad Sci U S A (2010) 1.37
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Hypothyroidism leads to increased collagen-based stiffness and re-expression of large cardiac titin isoforms with high compliance. J Mol Cell Cardiol (2006) 1.28
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Different molecular mechanics displayed by titin's constitutively and differentially expressed tandem Ig segments. J Struct Biol (2002) 1.22
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Novel role of calpain-3 in the triad-associated protein complex regulating calcium release in skeletal muscle. Hum Mol Genet (2008) 1.21
Calpain chronicle--an enzyme family under multidisciplinary characterization. Proc Jpn Acad Ser B Phys Biol Sci (2011) 1.21
Cardiac titin: structure, functions and role in disease. Clin Chim Acta (2006) 1.20
Altered myofilament function depresses force generation in patients with nebulin-based nemaline myopathy (NEM2). J Struct Biol (2009) 1.20
PDGFR-α inhibition preserves blood-brain barrier after intracerebral hemorrhage. Ann Neurol (2011) 1.19
Sarcoplasmic reticulum calcium uptake and speed of relaxation are depressed in nebulin-free skeletal muscle. FASEB J (2008) 1.17
Changes in cross-bridge cycling underlie muscle weakness in patients with tropomyosin 3-based myopathy. Hum Mol Genet (2011) 1.16
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Mouse intact cardiac myocyte mechanics: cross-bridge and titin-based stress in unactivated cells. J Gen Physiol (2011) 1.12
Possible regulation of the conventional calpain system by skeletal muscle-specific calpain, p94/calpain 3. J Biol Chem (2003) 1.11
MuRF1 is a muscle fiber-type II associated factor and together with MuRF2 regulates type-II fiber trophicity and maintenance. J Struct Biol (2010) 1.10
Multiple molecular interactions implicate the connectin/titin N2A region as a modulating scaffold for p94/calpain 3 activity in skeletal muscle. J Biol Chem (2008) 1.10
Selective diaphragm muscle weakness after contractile inactivity during thoracic surgery. Ann Surg (2011) 1.09
Titin-based modulation of active tension and interfilament lattice spacing in skinned rat cardiac muscle. Pflugers Arch (2004) 1.09
Calpain cleavage prediction using multiple kernel learning. PLoS One (2011) 1.09
Neural differentiation of adipose-derived stem cells isolated from GFP transgenic mice. Biochem Biophys Res Commun (2005) 1.08
Isoflurane attenuates blood-brain barrier disruption in ipsilateral hemisphere after subarachnoid hemorrhage in mice. Stroke (2012) 1.08
Cardiac hypertrophy and reduced contractility in hearts deficient in the titin kinase region. Circulation (2007) 1.08
Effect of diastolic pressure on MLC2v phosphorylation in the rat left ventricle. Arch Biochem Biophys (2006) 1.08
Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart. Circ Res (2011) 1.07
Prior immunization with severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) nucleocapsid protein causes severe pneumonia in mice infected with SARS-CoV. J Immunol (2008) 1.07
Low serum levels of brain-derived neurotrophic factor and epidermal growth factor in patients with chronic schizophrenia. Schizophr Res (2008) 1.07
α7 nicotinic acetylcholine receptor agonist PNU-282987 attenuates early brain injury in a perforation model of subarachnoid hemorrhage in rats. Stroke (2011) 1.07
Functional phenotype of phosphoinositide 3-kinase p85alpha-null platelets characterized by an impaired response to GP VI stimulation. Blood (2003) 1.07
Nebulin, a major player in muscle health and disease. FASEB J (2010) 1.06
Chronic fluoxetine bidirectionally modulates potentiating effects of serotonin on the hippocampal mossy fiber synaptic transmission. J Neurosci (2008) 1.05
Experimentally increasing titin compliance in a novel mouse model attenuates the Frank-Starling mechanism but has a beneficial effect on diastole. Circulation (2014) 1.05
Osteopontin reduced hypoxia-ischemia neonatal brain injury by suppression of apoptosis in a rat pup model. Stroke (2011) 1.05
Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly. Nat Med (2009) 1.04
Passive tension of rat skeletal soleus muscle fibers: effects of unloading conditions. J Appl Physiol (1985) (2002) 1.04
Expression changes of cation chloride cotransporters in the rat spinal cord following intraplantar formalin. Neurosci Res (2006) 1.04
Reduced myofibrillar connectivity and increased Z-disk width in nebulin-deficient skeletal muscle. J Cell Sci (2010) 1.03
Expanding members and roles of the calpain superfamily and their genetically modified animals. Exp Anim (2010) 1.03
Calpain 8/nCL-2 and calpain 9/nCL-4 constitute an active protease complex, G-calpain, involved in gastric mucosal defense. PLoS Genet (2010) 1.03
CaMPDB: a resource for calpain and modulatory proteolysis. Genome Inform (2010) 1.01