Published in PLoS One on September 30, 2014
Smoothened is a poor prognosis factor and a potential therapeutic target in glioma. Sci Rep (2017) 0.77
Non-essential role for cilia in coordinating precise alignment of lens fibres. Mech Dev (2016) 0.75
Genetic dissection of anterior segment dysgenesis caused by a Col4a1 mutation in mouse. Dis Model Mech (2017) 0.75
Hedgehog signaling in animal development: paradigms and principles. Genes Dev (2001) 14.75
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature (1996) 11.46
Mutations in the human Sonic Hedgehog gene cause holoprosencephaly. Nat Genet (1996) 5.70
Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development (2001) 4.89
Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith-Wiedemann syndrome. Nature (1997) 4.82
Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye. Genes Dev (2000) 3.85
Complications of the naevoid basal cell carcinoma syndrome: results of a population based study. J Med Genet (1993) 3.84
Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly. Nat Genet (1996) 3.50
The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice. Dev Cell (2006) 2.62
Patterning activities of vertebrate hedgehog proteins in the developing eye and brain. Curr Biol (1995) 2.54
Orchestrating ontogenesis: variations on a theme by sonic hedgehog. Nat Rev Genet (2006) 2.26
Zebrafish smoothened functions in ventral neural tube specification and axon tract formation. Development (2001) 2.26
Fate maps of neural crest and mesoderm in the mammalian eye. Invest Ophthalmol Vis Sci (2005) 1.98
Mutations in BMP4 cause eye, brain, and digit developmental anomalies: overlap between the BMP4 and hedgehog signaling pathways. Am J Hum Genet (2008) 1.86
Comparative synteny cloning of zebrafish you-too: mutations in the Hedgehog target gli2 affect ventral forebrain patterning. Genes Dev (1999) 1.77
Expression of zebrafish nk2.2 is influenced by sonic hedgehog/vertebrate hedgehog-1 and demarcates a zone of neuronal differentiation in the embryonic forebrain. Development (1995) 1.66
A forkhead gene, FoxE3, is essential for lens epithelial proliferation and closure of the lens vesicle. Genes Dev (2000) 1.65
Eye morphogenesis and patterning of the optic vesicle. Curr Top Dev Biol (2010) 1.60
The lens organizes the anterior segment: specification of neural crest cell differentiation in the avian eye. Dev Biol (2000) 1.56
Patched1 functions as a gatekeeper by promoting cell cycle progression. Cancer Res (2006) 1.56
Patched1 inhibits epidermal progenitor cell expansion and basal cell carcinoma formation by limiting Igfbp2 activity. Cancer Prev Res (Phila) (2010) 1.55
Retinal ganglion cell-derived sonic hedgehog locally controls proliferation and the timing of RGC development in the embryonic mouse retina. Development (2005) 1.53
Patched1 interacts with cyclin B1 to regulate cell cycle progression. EMBO J (2001) 1.52
Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity. J Cell Biol (2009) 1.48
The Talpid3 gene (KIAA0586) encodes a centrosomal protein that is essential for primary cilia formation. Development (2009) 1.45
Neuropilin 2/semaphorin 3F signaling is essential for cranial neural crest migration and trigeminal ganglion condensation. Dev Neurobiol (2007) 1.43
The chicken talpid3 gene encodes a novel protein essential for Hedgehog signaling. Genes Dev (2006) 1.42
Compound developmental eye disorders following inactivation of TGFbeta signaling in neural-crest stem cells. J Biol (2005) 1.40
Insertion of a Pax6 consensus binding site into the alphaA-crystallin promoter acts as a lens epithelial cell enhancer in transgenic mice. Invest Ophthalmol Vis Sci (2004) 1.40
TGFbeta2 in corneal morphogenesis during mouse embryonic development. Dev Biol (2001) 1.39
A single morphogenetic field gives rise to two retina primordia under the influence of the prechordal plate. Development (1997) 1.32
Expression of keratin 12 and maturation of corneal epithelium during development and postnatal growth. Invest Ophthalmol Vis Sci (2006) 1.31
Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling. Dev Cell (2007) 1.31
Notch signaling regulates growth and differentiation in the mammalian lens. Dev Biol (2008) 1.29
Temporal and spatial effects of Sonic hedgehog signaling in chick eye morphogenesis. Dev Biol (2001) 1.26
Shh controls epithelial proliferation via independent pathways that converge on N-Myc. Dev Cell (2005) 1.24
Hedgehog secretion and signal transduction in vertebrates. J Biol Chem (2012) 1.24
Differential requirement for beta-catenin in epithelial and fiber cells during lens development. Dev Biol (2008) 1.21
Neural crest derivatives in ocular and periocular structures. Int J Dev Biol (2005) 1.20
Understanding the role of growth factors in embryonic development: insights from the lens. Philos Trans R Soc Lond B Biol Sci (2011) 1.20
Expression of keratins K12, K4 and K14 during development of ocular surface epithelium. Curr Eye Res (1994) 1.17
pitx3 defines an equivalence domain for lens and anterior pituitary placode. Development (2005) 1.16
Noncanonical Hedgehog signaling. Vitam Horm (2012) 1.14
A novel role of the hedgehog pathway in lens regeneration. Dev Biol (2004) 1.12
The lens epithelium in ocular health and disease. Int J Biochem Cell Biol (2010) 1.11
Context-dependent signal integration by the GLI code: the oncogenic load, pathways, modifiers and implications for cancer therapy. Semin Cell Dev Biol (2014) 1.08
Axes establishment during eye morphogenesis in Xenopus by coordinate and antagonistic actions of BMP4, Shh, and RA. Genesis (2002) 1.07
The lens: a classical model of embryonic induction providing new insights into cell determination in early development. Philos Trans R Soc Lond B Biol Sci (2011) 1.07
Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation. Invest Ophthalmol Vis Sci (2009) 1.04
Corneal keratocytes retain neural crest progenitor cell properties. Dev Biol (2005) 1.04
Foxe3 is required for morphogenesis and differentiation of the anterior segment of the eye and is sensitive to Pax6 gene dosage. Dev Biol (2006) 1.00
Focal adhesion kinase (FAK) expression and activation during lens development. Mol Vis (2007) 1.00
Zebrafish mutations in Gli-mediated hedgehog signaling lead to lens transdifferentiation from the adenohypophysis anlage. Mech Dev (2000) 0.98
Abnormalities of the vitreoretinal interface caused by dysregulated Hedgehog signaling during retinal development. Hum Mol Genet (2003) 0.97
Semaphorin3A/neuropilin-1 signaling acts as a molecular switch regulating neural crest migration during cornea development. Dev Biol (2009) 0.96
Tgfbeta receptor expression in lens: implications for differentiation and cataractogenesis. Exp Eye Res (2001) 0.95
Gorlin syndrome: the PTCH gene links ocular developmental defects and tumour formation. Br J Ophthalmol (2005) 0.94
Craniofacial development in the talpid3 chicken mutant. Differentiation (2004) 0.93
BMP and activin receptor expression in lens development. Mol Vis (2004) 0.90
Identification of an unexpected link between the Shh pathway and a G2/M regulator, the phosphatase CDC25B. Dev Biol (2006) 0.90
Requirements for Jag1-Rbpj mediated Notch signaling during early mouse lens development. Dev Dyn (2012) 0.88
Role of sonic hedgehog in maintaining a pool of proliferating stem cells in the human fetal epidermis. Hum Reprod (2006) 0.87
Olfactory and lens placode formation is controlled by the hedgehog-interacting protein (Xhip) in Xenopus. Dev Biol (2005) 0.85
Review of patients with basal cell nevus syndrome. Ophthal Plast Reconstr Surg (2006) 0.82
Ocular abnormalities in mice lacking the immunoglobulin superfamily member Cdo. FEBS J (2009) 0.81
Activation of the hedgehog signaling pathway in the developing lens stimulates ectopic FoxE3 expression and disruption in fiber cell differentiation. Invest Ophthalmol Vis Sci (2012) 0.76