Published in Vitam Horm on January 01, 2012
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The Hedgehog signal transduction network. Sci Signal (2012) 1.80
Roles for Hedgehog signaling in adult organ homeostasis and repair. Development (2014) 1.17
Meckel-Gruber syndrome and the role of primary cilia in kidney, skeleton, and central nervous system development. Organogenesis (2013) 0.98
Smoothened is a fully competent activator of the heterotrimeric G protein G(i). Mol Pharmacol (2013) 0.91
The transcriptional activator Gli2 modulates T-cell receptor signalling through attenuation of AP-1 and NFκB activity. J Cell Sci (2015) 0.90
Canonical and non-canonical Hedgehog signalling and the control of metabolism. Semin Cell Dev Biol (2014) 0.89
Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened. Oncotarget (2015) 0.89
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Hedgehog/GLI and PI3K signaling in the initiation and maintenance of chronic lymphocytic leukemia. Oncogene (2015) 0.83
Characterization and Management of Hedgehog Pathway Inhibitor-Related Adverse Events in Patients With Advanced Basal Cell Carcinoma. Oncologist (2016) 0.82
Hedgehog Acyltransferase as a target in estrogen receptor positive, HER2 amplified, and tamoxifen resistant breast cancer cells. Mol Cancer (2015) 0.82
Cholesterol and its derivatives in Sonic Hedgehog signaling and cancer. Curr Opin Pharmacol (2012) 0.82
The Potential Role of Hedgehog Signaling in the Luminal/Basal Phenotype of Breast Epithelia and in Breast Cancer Invasion and Metastasis. Cancers (Basel) (2015) 0.81
Patched-1 proapoptotic activity is downregulated by modification of K1413 by the E3 ubiquitin-protein ligase Itchy homolog. Mol Cell Biol (2014) 0.81
Crosstalk between Desmoglein 2 and Patched 1 accelerates chemical-induced skin tumorigenesis. Oncotarget (2015) 0.80
The hedgehog pathway in triple-negative breast cancer. Cancer Med (2016) 0.80
A role for smoothened during murine lens and cornea development. PLoS One (2014) 0.80
Tamoxifen Resistance: Emerging Molecular Targets. Int J Mol Sci (2016) 0.80
Thiocoraline alters neuroendocrine phenotype and activates the Notch pathway in MTC-TT cell line. Cancer Med (2013) 0.80
Development of mediastinal lymphoma after radiotherapy for concurrent medulloblastoma and PNET in a patient with Gorlin syndrome. World J Surg Oncol (2016) 0.78
Gi proteins mediate activation of the canonical hedgehog pathway in the myocardium. Am J Physiol Heart Circ Physiol (2014) 0.78
The Hedgehog signalling pathway in bone formation. Int J Oral Sci (2015) 0.78
Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation. Nat Commun (2016) 0.78
Lung fibroblasts share mesenchymal stem cell features which are altered in chronic obstructive pulmonary disease via the overactivation of the Hedgehog signaling pathway. PLoS One (2015) 0.76
Sonic hedgehog stimulates neurite outgrowth in a mechanical stretch model of reactive-astrogliosis. Sci Rep (2016) 0.76
Expression analysis of Shh signaling members in early stages of chick lung development. Histochem Cell Biol (2016) 0.76
Back to the drawing board: Re-thinking the role of GLI1 in pancreatic carcinogenesis. F1000Res (2014) 0.75
Hedgehog Signaling Non-Canonical Activated by Pro-Inflammatory Cytokines in Pancreatic Ductal Adenocarcinoma. J Cancer (2016) 0.75
Hedgehog Signaling in Pancreatic Fibrosis and Cancer. Medicine (Baltimore) (2016) 0.75
Functional Genomics Identifies Tis21-Dependent Mechanisms and Putative Cancer Drug Targets Underlying Medulloblastoma Shh-Type Development. Front Pharmacol (2016) 0.75
N-docosahexaenoylethanolamine regulates Hedgehog signaling and promotes growth of cortical axons. Biol Open (2015) 0.75
Hh signaling in regeneration of the ischemic heart. Cell Mol Life Sci (2017) 0.75
New paradigms for the Hedgehog signaling network in mammary gland development and breast Cancer. Biochim Biophys Acta (2017) 0.75
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Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. Neuron (1999) 7.80
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Sonic hedgehog regulates the growth and patterning of the cerebellum. Development (1999) 4.78
Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors. Development (2003) 3.88
The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors. Nat Med (2001) 3.85
Sonic hedgehog promotes G(1) cyclin expression and sustained cell cycle progression in mammalian neuronal precursors. Mol Cell Biol (2000) 3.84
Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells. Science (2003) 3.63
Inhibition of neuroepithelial patched-induced apoptosis by sonic hedgehog. Science (2003) 3.62
Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum. Curr Biol (1999) 3.55
GABA and glutamate depolarize cortical progenitor cells and inhibit DNA synthesis. Neuron (1995) 3.51
Identification of the cell lineage at the origin of basal cell carcinoma. Nat Cell Biol (2010) 2.97
Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling. Proc Natl Acad Sci U S A (2006) 2.97
Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation. Curr Mol Med (2009) 2.95
Hedgehog proteins activate pro-angiogenic responses in endothelial cells through non-canonical signaling pathways. Cell Cycle (2010) 2.91
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Control of mitosis by changes in the subcellular location of cyclin-B1-Cdk1 and Cdc25C. Curr Opin Cell Biol (2000) 2.36
A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway. Nat Genet (2005) 2.26
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Sonic hedgehog guides axons through a noncanonical, Src-family-kinase-dependent signaling pathway. Neuron (2009) 1.99
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An absolute requirement for Cubitus interruptus in Hedgehog signaling. Development (2001) 1.63
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Pathways of signal transduction employed by vertebrate Hedgehogs. Biochem J (2007) 1.58
Application of active and kinase-deficient kinome collection for identification of kinases regulating hedgehog signaling. Cell (2008) 1.58
Patched1 functions as a gatekeeper by promoting cell cycle progression. Cancer Res (2006) 1.56
Promotion of Hras-induced squamous carcinomas by a polymorphic variant of the Patched gene in FVB mice. Nature (2007) 1.54
Patched1 interacts with cyclin B1 to regulate cell cycle progression. EMBO J (2001) 1.52
Epidermal growth factor-induced actin remodeling is regulated by 5-lipoxygenase and cyclooxygenase products. Cell (1993) 1.45
Heterotrimeric Gi proteins link Hedgehog signaling to activation of Rho small GTPases to promote fibroblast migration. J Biol Chem (2011) 1.41
Transmission of growth cone traction force through apCAM-cytoskeletal linkages is regulated by Src family tyrosine kinase activity. J Cell Biol (2001) 1.39
The Sonic hedgehog pathway independently controls the patterning, proliferation and survival of neuroepithelial cells by regulating Gli activity. Development (2006) 1.35
Signaling complexes of voltage-gated sodium and calcium channels. Neurosci Lett (2010) 1.34
The C-terminal tail of the Hedgehog receptor Patched regulates both localization and turnover. Genes Dev (2006) 1.32
Hedgehog signaling is critical for maintenance of the adult coronary vasculature in mice. J Clin Invest (2008) 1.32
Comparative biological responses to human Sonic, Indian, and Desert hedgehog. Mech Dev (2001) 1.31
Sonic hedgehog signaling is decoded by calcium spike activity in the developing spinal cord. Proc Natl Acad Sci U S A (2011) 1.29
In vivo functions of the patched protein: requirement of the C terminus for target gene inactivation but not Hedgehog sequestration. Mol Cell (2000) 1.25
Intracellular calcium release and protein kinase C activation stimulate sonic hedgehog gene expression during gastric acid secretion. Gastroenterology (2010) 1.24
Src-dependent tyrosine phosphorylation at the tips of growth cone filopodia promotes extension. J Neurosci (2005) 1.21
Sonic hedgehog induces transcription-independent cytoskeletal rearrangement and migration regulated by arachidonate metabolites. Cell Signal (2007) 1.16
Apoptosis and dependence receptors: a molecular basis for cellular addiction. Physiol Rev (2004) 1.16
p130CAS is required for netrin signaling and commissural axon guidance. J Neurosci (2007) 1.14
The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex. Nat Cell Biol (2009) 1.14
Activation of Erk by sonic hedgehog independent of canonical hedgehog signalling. Int J Biochem Cell Biol (2010) 1.07
Dependence receptors: between life and death. Cell Mol Life Sci (2004) 1.03
Transcriptional regulation of atonal required for Drosophila larval eye development by concerted action of eyes absent, sine oculis and hedgehog signaling independent of fused kinase and cubitus interruptus. Development (2000) 1.01
Kinase activity-independent regulation of cyclin pathway by GRK2 is essential for zebrafish early development. Proc Natl Acad Sci U S A (2009) 1.01
Sonic hedgehog signaling regulates actin cytoskeleton via Tiam1-Rac1 cascade during spine formation. Mol Cell Neurosci (2010) 1.00
A spontaneous mouse mutation, mesenchymal dysplasia (mes), is caused by a deletion of the most C-terminal cytoplasmic domain of patched (ptc). Dev Biol (2001) 0.99
Evidence for a role of protein kinase C in FGF signal transduction in the developing chick limb bud. Development (2001) 0.98
Epidermal hyperplasia and expansion of the interfollicular stem cell compartment in mutant mice with a C-terminal truncation of Patched1. Dev Biol (2007) 0.96
Immunohistochemical analysis of Sonic hedgehog signalling in normal human urinary tract development. J Anat (2007) 0.94
Constitutive activation of the shh-ptc1 pathway by a patched1 mutation identified in BCC. Oncogene (2005) 0.93
Mesenchymal dysplasia: a recessive mutation on chromosome 13 of the mouse. J Hered (1996) 0.90
Two patched protein subtypes and a conserved domain of group I proteins that regulates turnover. J Biol Chem (2008) 0.89
Leukotriene synthesis is required for hedgehog-dependent neurite projection in neuralized embryoid bodies but not for motor neuron differentiation. Stem Cells (2008) 0.89
Cubitus interruptus-independent transduction of the Hedgehog signal in Drosophila. Development (2000) 0.88
Arachidonic acid signaling to the cytoskeleton: the role of cyclooxygenase and cyclic AMP-dependent protein kinase in actin bundling. Cell Motil Cytoskeleton (2002) 0.84
Growth plate chondrocyte maturation is regulated by basal intracellular calcium. Exp Cell Res (2002) 0.84
A novel motif identified in dependence receptors. PLoS One (2007) 0.84
A novel signaling pathway mediated by the nuclear targeting of C-terminal fragments of mammalian Patched 1. PLoS One (2011) 0.78
A quantitative, randomized study evaluating three methods of mesenchymal stem cell delivery following myocardial infarction. Eur Heart J (2006) 3.43
Hedgehog proteins activate pro-angiogenic responses in endothelial cells through non-canonical signaling pathways. Cell Cycle (2010) 2.91
Klf2 is an essential regulator of vascular hemodynamic forces in vivo. Dev Cell (2006) 2.26
Impaired notch signaling promotes de novo squamous cell carcinoma formation. Cancer Res (2006) 2.02
High-efficiency somatic mutagenesis in smooth muscle cells and cardiac myocytes in SM22alpha-Cre transgenic mice. Genesis (2005) 1.99
The Hedgehog signal transduction network. Sci Signal (2012) 1.80
Myocardin-related transcription factor B is required in cardiac neural crest for smooth muscle differentiation and cardiovascular development. Proc Natl Acad Sci U S A (2005) 1.70
Myocardin regulates expression of contractile genes in smooth muscle cells and is required for closure of the ductus arteriosus in mice. J Clin Invest (2008) 1.63
Negative regulation of activated alpha-2 integrins during thrombopoiesis. Blood (2009) 1.59
Syk and Slp-76 mutant mice reveal a cell-autonomous hematopoietic cell contribution to vascular development. Dev Cell (2006) 1.50
GATA-6 regulates semaphorin 3C and is required in cardiac neural crest for cardiovascular morphogenesis. J Clin Invest (2006) 1.47
CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations. J Clin Invest (2010) 1.42
Evidence for the requirement of ITAM domains but not SLP-76/Gads interaction for integrin signaling in hematopoietic cells. Mol Cell Biol (2006) 1.41
Heterotrimeric Gi proteins link Hedgehog signaling to activation of Rho small GTPases to promote fibroblast migration. J Biol Chem (2011) 1.41
Myocardin is required for cardiomyocyte survival and maintenance of heart function. Proc Natl Acad Sci U S A (2009) 1.33
Mechanisms by which atrial fibrillation-associated mutations in the S1 domain of KCNQ1 slow deactivation of IKs channels. J Physiol (2008) 1.22
Wnt2 signaling is necessary and sufficient to activate the airway smooth muscle program in the lung by regulating myocardin/Mrtf-B and Fgf10 expression. Dev Biol (2011) 1.19
Cardiac tissue-restricted deletion of plakoglobin results in progressive cardiomyopathy and activation of {beta}-catenin signaling. Mol Cell Biol (2011) 1.17
Loss of αT-catenin alters the hybrid adhering junctions in the heart and leads to dilated cardiomyopathy and ventricular arrhythmia following acute ischemia. J Cell Sci (2012) 1.16
Slit/Robo signaling is necessary to confine early neural crest cells to the ventral migratory pathway in the trunk. Dev Biol (2005) 1.15
Myocardin regulates BMP10 expression and is required for heart development. J Clin Invest (2012) 1.10
Real-time mapping of a hydrogen peroxide concentration profile across a polymicrobial bacterial biofilm using scanning electrochemical microscopy. Proc Natl Acad Sci U S A (2011) 1.08
Notch signaling in vascular smooth muscle cells is required to pattern the cerebral vasculature. Proc Natl Acad Sci U S A (2007) 1.07
Early mitochondrial dysfunction in electron transfer activity and reactive oxygen species generation after cardiac arrest. Crit Care Med (2008) 1.06
Androgens regulate protein kinase Cdelta transcription and modulate its apoptotic function in prostate cancer cells. Cancer Res (2006) 1.04
Dynamic regulation of the cerebral cavernous malformation pathway controls vascular stability and growth. Dev Cell (2012) 1.04
Assessment of effects of chronic hydrogen sulfide poisoning on cytochrome P450 isoforms activity of rats by cocktail approach. Biol Pharm Bull (2013) 1.03
Loss of cadherin-binding proteins β-catenin and plakoglobin in the heart leads to gap junction remodeling and arrhythmogenesis. Mol Cell Biol (2012) 1.02
Sonic Hedgehog activates the GTPases Rac1 and RhoA in a Gli-independent manner through coupling of smoothened to Gi proteins. Sci Signal (2011) 1.02
Effects of berberine on potassium currents in acutely isolated CA1 pyramidal neurons of rat hippocampus. Brain Res (2004) 0.96
Rotational spectra of rare isotopic species of fluoroiodomethane: determination of the equilibrium structure from rotational spectroscopy and quantum-chemical calculations. J Chem Phys (2012) 0.94
Smoothened is a fully competent activator of the heterotrimeric G protein G(i). Mol Pharmacol (2013) 0.91
Evolution of ventricular myocyte electrophysiology. Physiol Genomics (2008) 0.90
Risk factors of earthquake inpatient death: a case control study. Crit Care (2009) 0.88
Role of p38 mitogen-activated protein kinase pathway in Porphyromonas gingivalis lipopolysaccharide-induced VCAM-1 expression in human aortic endothelial cells. J Periodontol (2011) 0.85
Aortic aneurysm generation in mice with targeted deletion of integrin-linked kinase in vascular smooth muscle cells. Circ Res (2011) 0.85
Purification and bioassay of hedgehog ligands for the study of cell death and survival. Methods Enzymol (2008) 0.84
The alpha subunit of the G protein G13 regulates activity of one or more Gli transcription factors independently of smoothened. J Biol Chem (2011) 0.83
Effects of palmatine on potassium and calcium currents in isolated rat hepatocytes. World J Gastroenterol (2003) 0.82
Adverse drug reactions and adverse events of 33 varieties of traditional Chinese medicine injections on National Essential medicines List (2004 edition) of China: an overview on published literatures. J Evid Based Med (2010) 0.82
Adverse events to Houttuynia injection: A systematic review. J Evid Based Med (2010) 0.81
Subsequent development of fibroatheromas with inflamed fibrous caps can be predicted by intracoronary near infrared spectroscopy. Arterioscler Thromb Vasc Biol (2013) 0.81
Ear acupuncture therapy for 37 cases of dysmenorrhea due to endometriosis. J Tradit Chin Med (2002) 0.80
Effects of tetrandrine on calcium and potassium currents in isolated rat hepatocytes. World J Gastroenterol (2003) 0.80
Role of JNK and NF-κB pathways in Porphyromonas gingivalis LPS-induced vascular cell adhesion molecule-1 expression in human aortic endothelial cells. Mol Med Rep (2013) 0.80
Inhibitory effects of berberine on ion channels of rat hepatocytes. World J Gastroenterol (2004) 0.80
Cloning and characterisation of three novel disintegrin precursors from the venoms of three Atheris species: Atheris chlorechis, Atheris nitschei and Atheris squamigera. Toxicon (2013) 0.80
Myocardin-like protein 2 regulates TGFβ signaling in embryonic stem cells and the developing vasculature. Development (2012) 0.79
Spectroscopic investigation of fluoroiodomethane, CH2FI: Fourier-transform microwave and millimeter-/submillimeter-wave spectroscopy and quantum-chemical calculations. J Chem Phys (2011) 0.78
Limnonectins: a new class of antimicrobial peptides from the skin secretion of the Fujian large-headed frog (Limnonectes fujianensis). Biochimie (2011) 0.78
Effects of prolonged kanamycin administration on cochlear anatomy and auditory brainstem response thresholds in chickens. Arch Otolaryngol Head Neck Surg (2008) 0.78
Adverse drug reactions of Shuanghuanglian injection: a systematic review of public literatures. J Evid Based Med (2010) 0.78
[Prevention of platelet transfusion refractoriness and HLA alloimmunization by leukocyte filtered platelet transfusion: a meta analysis]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao (2011) 0.78
Porphyromonas gingivalis lipopolysaccharide activates canonical Wnt/β-catenin and p38 MAPK signalling in stem cells from the apical papilla. Inflammation (2013) 0.77
PEGylated VRB plus quinacrine cationic liposomes for treating non-small cell lung cancer. J Drug Target (2014) 0.76
Electrophysiological effects of anthopleurin-Q on rat hepatocytes. World J Gastroenterol (2004) 0.75
Publisher's Note: "Four-component relativistic theory for NMR parameters: unified formulation and numerical assessment of different approaches" [J. Chem. Phys. 130, 144102 (2009)]. J Chem Phys (2009) 0.75
[The effect of periodontal initial therapy on chronic periodontitis and subgingival periodontal pathogen]. Shanghai Kou Qiang Yi Xue (2010) 0.75
Posttranslational Modifications and Secretion of the Hedgehog (Hh) Proteins. Preface. Methods Mol Biol (2015) 0.75
[Efficacy and safety of natalizumab for multiple sclerosis and Crohn's disease: a meta analysis]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao (2010) 0.75
The pure rotational spectrum of ruthenium monocarbide, RuC, and relativistic ab initio predictions. J Chem Phys (2013) 0.75
A spin-adapted size-extensive state-specific multi-reference perturbation theory with various partitioning schemes. II. Molecular applications. J Chem Phys (2012) 0.75
[Clinical characteristic and therapeutic strategy of eosinophilic chronic rhinosinusitis]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi (2016) 0.75
[Analysis of FcgammaRIIIb genotype of periodontal disease in the Han nationality in China]. Shanghai Kou Qiang Yi Xue (2005) 0.75
[Effect of ouabain on the aortic rings of guinea pig and its interactions with Ca2+, norepinephrine]. Yao Xue Xue Bao (2003) 0.75
[A temporal bone CT study of the infants with hearing loss referred from universal newborn hearing screening]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi (2007) 0.75
A spin-adapted size-extensive state-specific multi-reference perturbation theory. I. Formal developments. J Chem Phys (2012) 0.75
Direct perturbation theory in terms of energy derivatives: scalar-relativistic treatment up to sixth order. J Chem Phys (2011) 0.75
[Construction of luxS gene knockout mutant of Enterococcus faecalis]. Shanghai Kou Qiang Yi Xue (2015) 0.75
[The effect of rhAm and EMPs on promoting differentiation of hBMSCs into osteoblasts]. Shanghai Kou Qiang Yi Xue (2015) 0.75
Erratum: Trop-2 is up-regulated in invasive prostate cancer and displaces FAK from focal contacts. Oncotarget (2015) 0.75
[Amelogenin expression in cultured human dental pulp and periodontium related cells]. Shanghai Kou Qiang Yi Xue (2009) 0.75
[Experimental study on human periodontal ligament cells transfected with human amelogenin gene]. Shanghai Kou Qiang Yi Xue (2008) 0.75
Simultaneous determination of dextromethorphan and dextrophan in rat plasma by LC-MS/MS and its application to a pharmacokinetic study. Pharmazie (2012) 0.75
[Etiology and treatment strategy of spontaneous cerebrospinal fluid rhinorrhea]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi (2020) 0.75
[Preparation and physicochemical properties of vinorelbine liposomes]. Zhong Yao Cai (2011) 0.75
[Acoustic rhinometry in the diagnosis of children with obstructive sleep apnea-hypopnea syndrome]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi (2007) 0.75
Hyperfine interactions and electric dipole moments in the [16.0]1.5(v = 6), [16.0]3.5(v = 7), and X2Δ(5/2) states of iridium monosilicide, IrSi. J Phys Chem A (2013) 0.75
[Effects of rhAm on attachment, proliferation and immigration of human fibroblasts]. Shanghai Kou Qiang Yi Xue (2013) 0.75
Methods for Detection of Ptc1-Driven LacZ Expression in Adult Mouse Skin. Methods Mol Biol (2015) 0.75
Exact two-component relativistic theory for nuclear magnetic resonance parameters. J Chem Phys (2009) 0.75
Four-component relativistic theory for nuclear magnetic shielding constants: critical assessments of different approaches. J Chem Phys (2007) 0.75
International comparative analyses of healthcare risk management. J Evid Based Med (2011) 0.75
Making four- and two-component relativistic density functional methods fully equivalent based on the idea of "from atoms to molecule". J Chem Phys (2007) 0.75
[A study on the state of periodontal health of 400 professional adults by random sampling in Shanghai]. Shanghai Kou Qiang Yi Xue (2006) 0.75
[Analysis of adverse events caused by irrational application of Houttuynia injection]. Zhongguo Zhong Xi Yi Jie He Za Zhi (2011) 0.75
Matrix-Isolation and Quantum-Chemical Analysis of the C3v Conformer of XeF6, XeOF4 and Their Acetonitrile Adducts. J Phys Chem A (2017) 0.75
Evaluating the Activity of Smoothened Toward G Proteins Using [³⁵S]Guanosine 5'-(3-O-thio)triphosphate ([³⁵S]GTPγS). Methods Mol Biol (2015) 0.75
Communication: Extension of a universal explicit electron correlation correction to general complete active spaces. J Chem Phys (2013) 0.75