Published in Cancer Res on February 15, 2006
Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. Cancer Cell (2008) 5.06
Basal cell carcinomas: attack of the hedgehog. Nat Rev Cancer (2008) 4.34
Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer. Trends Mol Med (2010) 1.82
Tracing the cellular origin of cancer. Nat Cell Biol (2013) 1.75
Hedgehog modulates cell cycle regulators in stem cells to control hematopoietic regeneration. Proc Natl Acad Sci U S A (2006) 1.71
Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations. J Clin Invest (2011) 1.65
Bioinformatics construction of the human cell surfaceome. Proc Natl Acad Sci U S A (2009) 1.45
DMBA/TPA treatment is necessary for BCC formation from patched deficient epidermal cells in Ptch(flox/flox)CD4Cre(+/-) mice. J Invest Dermatol (2014) 1.41
Alterations in candidate genes PHF2, FANCC, PTCH1 and XPA at chromosomal 9q22.3 region: pathological significance in early- and late-onset breast carcinoma. Mol Cancer (2008) 1.20
Noncanonical Hedgehog signaling. Vitam Horm (2012) 1.14
Plants vs. cancer: a review on natural phytochemicals in preventing and treating cancers and their druggability. Anticancer Agents Med Chem (2012) 1.14
Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma model. Proc Natl Acad Sci U S A (2012) 1.13
Basal cell carcinoma - molecular biology and potential new therapies. J Clin Invest (2012) 1.06
The hedgehog processing pathway is required for NSCLC growth and survival. Oncogene (2012) 1.05
MicroRNA-212 displays tumor-promoting properties in non-small cell lung cancer cells and targets the hedgehog pathway receptor PTCH1. Mol Biol Cell (2012) 1.04
Ptch1 is required locally for mammary gland morphogenesis and systemically for ductal elongation. Development (2009) 1.03
Ablation of Indian hedgehog in the murine uterus results in decreased cell cycle progression, aberrant epidermal growth factor signaling, and increased estrogen signaling. Biol Reprod (2010) 1.03
Kinase activity-independent regulation of cyclin pathway by GRK2 is essential for zebrafish early development. Proc Natl Acad Sci U S A (2009) 1.01
MicroRNA-203 functions as a tumor suppressor in basal cell carcinoma. Oncogenesis (2012) 1.00
Zebrafish blowout provides genetic evidence for Patched1-mediated negative regulation of Hedgehog signaling within the proximal optic vesicle of the vertebrate eye. Dev Biol (2008) 0.99
Tumor suppressor gene co-operativity in compound Patched1 and suppressor of fused heterozygous mutant mice. Mol Carcinog (2009) 0.95
Targeting sonic hedgehog-associated medulloblastoma through inhibition of Aurora and Polo-like kinases. Cancer Res (2013) 0.92
Impaired skin and hair follicle development in Runx2 deficient mice. Dev Biol (2008) 0.89
Clinical implications of hedgehog signaling pathway inhibitors. Chin J Cancer (2011) 0.88
Hedgehog pathway inhibitors - current status and future prospects. Infect Agent Cancer (2012) 0.88
Zfx facilitates tumorigenesis caused by activation of the Hedgehog pathway. Cancer Res (2014) 0.88
Hedgehog signaling in skin cancers. Cell Signal (2011) 0.87
High expression of Sonic Hedgehog signaling pathway genes indicates a risk of recurrence of breast carcinoma. Onco Targets Ther (2013) 0.86
Hedgehog signaling activation in the development of squamous cell carcinoma and adenocarcinoma of esophagus. Int J Biochem Mol Biol (2012) 0.86
Blockade of the sonic hedgehog pathway effectively inhibits the growth of hepatoma in mice: An in vivo study. Oncol Lett (2012) 0.86
Hedgehog Signaling in the Maintenance of Cancer Stem Cells. Cancers (Basel) (2015) 0.85
Development and homeostasis of the skin epidermis. Cold Spring Harb Perspect Biol (2012) 0.84
Molecular signalling in hepatocellular carcinoma: Role of and crosstalk among WNT/ß-catenin, Sonic Hedgehog, Notch and Dickkopf-1. Can J Gastroenterol Hepatol (2015) 0.82
Patched knockout mouse models of Basal cell carcinoma. J Skin Cancer (2012) 0.82
Tumor shrinkage by cyclopamine tartrate through inhibiting hedgehog signaling. Chin J Cancer (2011) 0.81
Patched 1 and patched 2 redundancy has a key role in regulating epidermal differentiation. J Invest Dermatol (2014) 0.81
A role for smoothened during murine lens and cornea development. PLoS One (2014) 0.80
Metastatic basal cell carcinoma with amplification of PD-L1: exceptional response to anti-PD1 therapy. NPJ Genom Med (2016) 0.78
Enhanced expression of the β4-galactosyltransferase 2 gene impairs mammalian tumor growth. Cancer Gene Ther (2014) 0.78
Distinct effects of the mesenchymal dysplasia gene variant of murine Patched-1 protein on canonical and non-canonical Hedgehog signaling pathways. J Biol Chem (2014) 0.78
Proliferation of murine midbrain neural stem cells depends upon an endogenous sonic hedgehog (Shh) source. PLoS One (2013) 0.78
RBP-J is not required for granule neuron progenitor development and medulloblastoma initiated by Hedgehog pathway activation in the external germinal layer. Neural Dev (2010) 0.77
The role of Sonic Hedgehog as a regulator of gastric function and differentiation. Vitam Horm (2012) 0.77
Targeted therapy for advanced Basal-cell carcinoma: vismodegib and beyond. Dermatol Ther (Heidelb) (2013) 0.76
Molecular docking approaches in identification of High affinity inhibitors of Human SMO receptor. Bioinformation (2014) 0.76
Small molecule inhibitors in acute myeloid leukemia: from the bench to the clinic. Expert Rev Hematol (2014) 0.76
The role of canonical and non-canonical Hedgehog signaling in tumor progression in a mouse model of small cell lung cancer. Oncogene (2017) 0.75
Itraconazole induces apoptosis and cell cycle arrest via inhibiting Hedgehog signaling in gastric cancer cells. J Exp Clin Cancer Res (2017) 0.75
Challenge to the suppression of tumor growth by the β4-galactosyltransferase genes. Proc Jpn Acad Ser B Phys Biol Sci (2015) 0.75
Activities of the Cytoplasmic Domains of Patched-1 Modulate but Are Not Essential for the Regulation of Canonical Hedgehog Signaling. J Biol Chem (2016) 0.75
New paradigms for the Hedgehog signaling network in mammary gland development and breast Cancer. Biochim Biophys Acta (2017) 0.75
Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. Cancer Cell (2008) 5.06
Mutations in SUFU predispose to medulloblastoma. Nat Genet (2002) 3.78
Fraser syndrome and mouse blebbed phenotype caused by mutations in FRAS1/Fras1 encoding a putative extracellular matrix protein. Nat Genet (2003) 1.71
Patched 1 conditional null allele in mice. Genesis (2003) 1.31
An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis. Development (2004) 1.30
Pax9 and Jagged1 act downstream of Gli3 in vertebrate limb development. Mech Dev (2005) 1.20
Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group. Acta Neuropathol (2013) 1.12
Sonic hedgehog and notch signaling can cooperate to regulate neurogenic divisions of neocortical progenitors. PLoS One (2011) 1.10
Failure of a medulloblastoma-derived mutant of SUFU to suppress WNT signaling. Oncogene (2004) 1.02
Ptch1-mediated dosage-dependent action of Shh signaling regulates neural progenitor development at late gestational stages. Dev Biol (2010) 0.91
Flagellin of Pseudomonas aeruginosa inhibits Na+ transport in airway epithelia. FASEB J (2006) 0.91
Pathways to improving skin regeneration. Expert Rev Mol Med (2005) 0.88
Wnt2 regulates progenitor proliferation in the developing ventral midbrain. J Biol Chem (2009) 0.87
Tumor shrinkage by cyclopamine tartrate through inhibiting hedgehog signaling. Chin J Cancer (2011) 0.81
Proliferation of murine midbrain neural stem cells depends upon an endogenous sonic hedgehog (Shh) source. PLoS One (2013) 0.78
Qualitative assessment of agritourism safety guidelines: a demonstration project. J Agromedicine (2013) 0.78
Genotyping Parkinson disease-associated mitochondrial polymorphisms. Clin Med Res (2004) 0.76
Krt6a-Cre transgenic mice direct LoxP-mediated recombination to the companion cell layer of the hair follicle and following induction by retinoic acid to the interfollicular epidermis. J Invest Dermatol (2004) 0.75
Targeted disruption of Brca1 in restricted compartments of the mouse mammary epithelia. Breast Cancer Res Treat (2007) 0.75