Published in Biomol Concepts on June 01, 2013
A synaptic model of memory: long-term potentiation in the hippocampus. Nature (1993) 29.13
Functions of cell surface heparan sulfate proteoglycans. Annu Rev Biochem (1999) 11.87
Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci (2001) 11.40
Regeneration beyond the glial scar. Nat Rev Neurosci (2004) 11.00
Chondroitinase ABC promotes functional recovery after spinal cord injury. Nature (2002) 8.22
Neurotrophin signal transduction in the nervous system. Curr Opin Neurobiol (2000) 6.31
Reactivation of ocular dominance plasticity in the adult visual cortex. Science (2002) 6.06
The glial scar and central nervous system repair. Brain Res Bull (1999) 4.80
Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome. Nat Genet (1996) 4.62
Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury. Nat Med (2006) 4.18
Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans. Nature (1996) 4.12
Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells. Proc Natl Acad Sci U S A (2002) 3.35
Perineuronal nets protect fear memories from erasure. Science (2009) 3.30
Combining an autologous peripheral nervous system "bridge" and matrix modification by chondroitinase allows robust, functional regeneration beyond a hemisection lesion of the adult rat spinal cord. J Neurosci (2006) 3.21
Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. Human-specific repeats, and additional alternatively spliced forms. J Biol Chem (1991) 3.01
Multiple domains of the large fibroblast proteoglycan, versican. EMBO J (1989) 2.86
PTPsigma is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regeneration. Science (2009) 2.84
Hyaluronan synthases. J Biol Chem (1997) 2.76
EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans. Science (2005) 2.50
The role of chondroitin sulfate proteoglycans in regeneration and plasticity in the central nervous system. Brain Res Rev (2007) 2.42
A p75(NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein. Nat Neurosci (2002) 2.30
Combining Schwann cell bridges and olfactory-ensheathing glia grafts with chondroitinase promotes locomotor recovery after complete transection of the spinal cord. J Neurosci (2005) 2.30
Sulfation patterns of glycosaminoglycans encode molecular recognition and activity. Nat Chem Biol (2006) 2.25
Sulfated proteoglycans in astroglial barriers inhibit neurite outgrowth in vitro. Exp Neurol (1990) 2.19
Combinatorial therapy with neurotrophins and cAMP promotes axonal regeneration beyond sites of spinal cord injury. J Neurosci (2004) 2.14
Generation of "neoheparin" from E. coli K5 capsular polysaccharide. J Med Chem (2005) 2.03
PKC mediates inhibitory effects of myelin and chondroitin sulfate proteoglycans on axonal regeneration. Nat Neurosci (2004) 2.01
Recent advances in the study of the biosynthesis and functions of sulfated glycosaminoglycans. Curr Opin Struct Biol (2000) 2.01
NgR1 and NgR3 are receptors for chondroitin sulfate proteoglycans. Nat Neurosci (2012) 1.94
Polymerization of tau into filaments in the presence of heparin: the minimal sequence required for tau-tau interaction. J Neurochem (1996) 1.88
Keratan sulfate: structure, biosynthesis, and function. Glycobiology (2000) 1.87
The chondroitin sulfate proteoglycans neurocan and phosphacan are expressed by reactive astrocytes in the chronic CNS glial scar. J Neurosci (1999) 1.87
Heparan sulfate proteoglycans are essential for FGF receptor signaling during Drosophila embryonic development. Development (1999) 1.86
Binding of the protease-sensitive form of PrP (prion protein) to sulfated glycosaminoglycan and congo red [corrected]. J Virol (1994) 1.85
Heparan sulphate proteoglycans in Alzheimer's disease and amyloid-related disorders. Lancet Neurol (2003) 1.84
The neuronal chondroitin sulfate proteoglycan neurocan binds to the neural cell adhesion molecules Ng-CAM/L1/NILE and N-CAM, and inhibits neuronal adhesion and neurite outgrowth. J Cell Biol (1994) 1.83
Fibrinogen triggers astrocyte scar formation by promoting the availability of active TGF-beta after vascular damage. J Neurosci (2010) 1.82
Proteoglycans in the developing brain: new conceptual insights for old proteins. Physiol Rev (2000) 1.81
Chondroitin proteoglycans are involved in cell division of Caenorhabditis elegans. Nature (2003) 1.79
Differential sulfations and epimerization define heparan sulfate specificity in nervous system development. Neuron (2004) 1.75
Injury-induced proteoglycans inhibit the potential for laminin-mediated axon growth on astrocytic scars. Exp Neurol (1995) 1.73
Caenorhabditis elegans early embryogenesis and vulval morphogenesis require chondroitin biosynthesis. Nature (2003) 1.73
The cell surface proteoglycan from mouse mammary epithelial cells bears chondroitin sulfate and heparan sulfate glycosaminoglycans. J Biol Chem (1985) 1.71
Specific molecular interactions of oversulfated chondroitin sulfate E with various heparin-binding growth factors. Implications as a physiological binding partner in the brain and other tissues. J Biol Chem (2002) 1.67
Chemoenzymatic design of heparan sulfate oligosaccharides. J Biol Chem (2010) 1.64
The division abnormally delayed (dally) gene: a putative integral membrane proteoglycan required for cell division patterning during postembryonic development of the nervous system in Drosophila. Development (1995) 1.61
Chondroitin-4-sulfation negatively regulates axonal guidance and growth. J Cell Sci (2008) 1.61
Proteoglycan-specific molecular switch for RPTPσ clustering and neuronal extension. Science (2011) 1.59
Cell-surface heparan sulfate is involved in the repulsive guidance activities of Slit2 protein. Nat Neurosci (2001) 1.59
Synergistic effects of transplanted adult neural stem/progenitor cells, chondroitinase, and growth factors promote functional repair and plasticity of the chronically injured spinal cord. J Neurosci (2010) 1.59
Polysialylated neural cell adhesion molecule promotes remodeling and formation of hippocampal synapses. J Neurosci (2004) 1.53
Leukocyte common antigen-related phosphatase is a functional receptor for chondroitin sulfate proteoglycan axon growth inhibitors. J Neurosci (2011) 1.52
Extinction memory is impaired in schizophrenia. Biol Psychiatry (2008) 1.50
Versican is selectively expressed in embryonic tissues that act as barriers to neural crest cell migration and axon outgrowth. Development (1995) 1.49
Regulated expression and subcellular localization of syndecan heparan sulfate proteoglycans and the syndecan-binding protein CASK/LIN-2 during rat brain development. J Neurosci (1999) 1.48
Sustained delivery of thermostabilized chABC enhances axonal sprouting and functional recovery after spinal cord injury. Proc Natl Acad Sci U S A (2009) 1.48
Oversulfated chondroitin/dermatan sulfates containing GlcAbeta1/IdoAalpha1-3GalNAc(4,6-O-disulfate) interact with L- and P-selectin and chemokines. J Biol Chem (2002) 1.46
A receptor-like protein-tyrosine phosphatase PTPzeta/RPTPbeta binds a heparin-binding growth factor midkine. Involvement of arginine 78 of midkine in the high affinity binding to PTPzeta. J Biol Chem (1999) 1.46
The transmembrane semaphorin Sema4D/CD100, an inhibitor of axonal growth, is expressed on oligodendrocytes and upregulated after CNS lesion. J Neurosci (2003) 1.46
Cortactin-Src kinase signaling pathway is involved in N-syndecan-dependent neurite outgrowth. J Biol Chem (1998) 1.46
Cloning and primary structure of neurocan, a developmentally regulated, aggregating chondroitin sulfate proteoglycan of brain. J Biol Chem (1992) 1.45
Molecular cloning of brevican, a novel brain proteoglycan of the aggrecan/versican family. J Biol Chem (1994) 1.44
Persistent cortical plasticity by upregulation of chondroitin 6-sulfation. Nat Neurosci (2012) 1.43
Heparan sulfate proteoglycans are ligands for receptor protein tyrosine phosphatase sigma. Mol Cell Biol (2002) 1.43
6B4 proteoglycan/phosphacan, an extracellular variant of receptor-like protein-tyrosine phosphatase zeta/RPTPbeta, binds pleiotrophin/heparin-binding growth-associated molecule (HB-GAM). J Biol Chem (1996) 1.40
Extracellular matrix and perineuronal nets in CNS repair. Dev Neurobiol (2011) 1.38
Down-regulation of apoptosis mediators by RNAi inhibits axotomy-induced retinal ganglion cell death in vivo. Brain (2005) 1.37
Increased chondroitin sulfate proteoglycan expression in denervated brainstem targets following spinal cord injury creates a barrier to axonal regeneration overcome by chondroitinase ABC and neurotrophin-3. Exp Neurol (2007) 1.35
From cradle to grave: the multiple roles of fibroblast growth factors in neural development. Neuron (2011) 1.33
Aggrecan glycoforms contribute to the molecular heterogeneity of perineuronal nets. J Neurosci (2002) 1.33
CS-4,6 is differentially upregulated in glial scar and is a potent inhibitor of neurite extension. Mol Cell Neurosci (2005) 1.32
When sugars guide axons: insights from heparan sulphate proteoglycan mutants. Nat Rev Genet (2004) 1.30
Involvement of receptor-like protein tyrosine phosphatase zeta/RPTPbeta and its ligand pleiotrophin/heparin-binding growth-associated molecule (HB-GAM) in neuronal migration. J Cell Biol (1998) 1.30
The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety. Proc Natl Acad Sci U S A (1997) 1.29
Transplanted adult spinal cord-derived neural stem/progenitor cells promote early functional recovery after rat spinal cord injury. Neuroscience (2008) 1.28
Heparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-beta uptake. J Neurosci (2011) 1.28
Expression of neural proteoglycans correlates with the acquisition of mature neuronal properties in the mammalian brain. Cold Spring Harb Symp Quant Biol (1990) 1.28
Extracellular matrix-glial abnormalities in the amygdala and entorhinal cortex of subjects diagnosed with schizophrenia. Arch Gen Psychiatry (2010) 1.27
K-glypican: a novel GPI-anchored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney. J Cell Biol (1995) 1.26
The sulfate moieties of glycosaminoglycans are critical for the enhancement of beta-amyloid protein fibril formation. J Neurochem (1999) 1.25
Expression of the cell surface proteoglycan glypican-5 is developmentally regulated in kidney, limb, and brain. Dev Biol (1997) 1.25
Structural modification of fibroblast growth factor-binding heparan sulfate at a determinative stage of neural development. J Biol Chem (1998) 1.24
Chemoenzymatic synthesis of classical and non-classical anticoagulant heparan sulfate polysaccharides. J Biol Chem (2003) 1.23
A chondroitin sulfate small molecule that stimulates neuronal growth. J Am Chem Soc (2004) 1.21
Glypican-1 is frequently overexpressed in human gliomas and enhances FGF-2 signaling in glioma cells. Am J Pathol (2006) 1.21
Structure of a heparan sulphate oligosaccharide that binds to basic fibroblast growth factor. Biochem J (1992) 1.20
Effects of transforming growth factor beta 1 on scar production in the injured central nervous system of the rat. Eur J Neurosci (1994) 1.20
Chemical approaches to deciphering the glycosaminoglycan code. Curr Opin Chem Biol (2005) 1.19
Mammalian homologues of the Drosophila slit protein are ligands of the heparan sulfate proteoglycan glypican-1 in brain. J Biol Chem (1999) 1.19
A star-PEG-heparin hydrogel platform to aid cell replacement therapies for neurodegenerative diseases. Biomaterials (2009) 1.19
Effects of sulfate ions on Alzheimer beta/A4 peptide assemblies: implications for amyloid fibril-proteoglycan interactions. J Neurochem (1992) 1.18
Modification of extracellular matrix by enzymatic removal of chondroitin sulfate and by lack of tenascin-R differentially affects several forms of synaptic plasticity in the hippocampus. Neuroscience (2001) 1.18
BEHAB/brevican requires ADAMTS-mediated proteolytic cleavage to promote glioma invasion. J Neurooncol (2008) 1.17
Midkine, a heparin-binding cytokine with multiple roles in development, repair and diseases. Proc Jpn Acad Ser B Phys Biol Sci (2010) 1.16
The proteoglycan brevican binds to fibronectin after proteolytic cleavage and promotes glioma cell motility. J Biol Chem (2008) 1.16
Developmental regulation of the sulfation profile of chondroitin sulfate chains in the chicken embryo brain. J Biol Chem (1997) 1.15
Myelin-associated inhibitors regulate cofilin phosphorylation and neuronal inhibition through LIM kinase and Slingshot phosphatase. J Neurosci (2006) 1.13
Expression of the heparan sulfate proteoglycan glypican-1 in the developing rodent. Dev Dyn (1998) 1.13
Natural Underwater Adhesives. J Polym Sci B Polym Phys (2011) 1.41
From 3D to 2D: a review of the molecular imprinting of proteins. Biotechnol Prog (2006) 1.25
Multiscale structure of the underwater adhesive of Phragmatopoma californica: a nanostructured latex with a steep microporosity gradient. Langmuir (2007) 1.24
Chemical Tumor Biology of Heparan Sulfate Proteoglycans. Curr Chem Biol (2010) 1.17
Fluorescence correlation spectroscopy can probe albumin dynamics inside lung endothelial glycocalyx. Am J Physiol Lung Cell Mol Physiol (2007) 1.10
Investigating the elusive mechanism of glycosaminoglycan biosynthesis. J Biol Chem (2009) 1.10
Using microcontact printing of fibrinogen to control surface-induced platelet adhesion and activation. Langmuir (2011) 1.02
Mapping critical biological motifs and biosynthetic pathways of heparan sulfate. Glycobiology (2004) 1.00
Stiffness and heterogeneity of the pulmonary endothelial glycocalyx measured by atomic force microscopy. Am J Physiol Lung Cell Mol Physiol (2011) 0.99
Preparation and characterization of (15)N-enriched, size-defined heparan sulfate precursor oligosaccharides. Carbohydr Res (2009) 0.96
Screening platelet-surface interactions using negative surface charge gradients. Biomaterials (2010) 0.93
A serotonin-induced N-glycan switch regulates platelet aggregation. Sci Rep (2013) 0.92
Langmuir monolayer approaches to protein recognition through molecular imprinting. Biosens Bioelectron (2005) 0.92
Inducing alignment in astrocyte tissue constructs by surface ligands patterned on biomaterials. Biomaterials (2011) 0.89
Inhibition of heparan sulfate and chondroitin sulfate proteoglycan biosynthesis. J Biol Chem (2008) 0.89
Fluorescent-tagged heparan sulfate precursor oligosaccharides to probe the enzymatic action of heparitinase I. Anal Biochem (2009) 0.87
Novel glycosaminoglycan biosynthetic inhibitors affect tumor-associated angiogenesis. Biochem Biophys Res Commun (2010) 0.86
Hydrogen/deuterium exchange-LC-MS approach to characterize the action of heparan sulfate C5-epimerase. Anal Bioanal Chem (2011) 0.85
Multiprotein microcontact printing with micrometer resolution. Langmuir (2012) 0.84
Astrocytes specifically remove surface-adsorbed fibrinogen and locally express chondroitin sulfate proteoglycans. Acta Biomater (2013) 0.83
Chemoenzymatically prepared heparan sulfate containing rare 2-O-sulfonated glucuronic acid residues. ACS Chem Biol (2015) 0.83
Relating material surface heterogeneity to protein adsorption: the effect of annealing of micro-contact-printed OTS patterns. J Adhes Sci Technol (2008) 0.83
Characterization of uniformly and atom-specifically (13)C-labeled heparin and heparan sulfate polysaccharide precursors using (13)C NMR spectroscopy and ESI mass spectrometry. Carbohydr Res (2010) 0.83
The differential influence of colocalized and segregated dual protein signals on neurite outgrowth on surfaces. Biomaterials (2007) 0.83
The effect of upstream platelet-fibrinogen interactions on downstream adhesion and activation. Biomaterials (2011) 0.82
The influence of sub-micron inhibitory clusters on growth cone substratum attachments and CD44 expression. Biomaterials (2008) 0.82
4-deoxy-4-fluoro-xyloside derivatives as inhibitors of glycosaminoglycan biosynthesis. Bioorg Med Chem Lett (2010) 0.81
Is N-sulfation just a gateway modification during heparan sulfate biosynthesis? FEBS Lett (2011) 0.81
RGD-xyloside conjugates prime glycosaminoglycans. Glycoconj J (2010) 0.81
Applications of isotopes in advancing structural and functional heparanomics. Anal Bioanal Chem (2010) 0.81
A synthetic heparan sulfate oligosaccharide library reveals the novel enzymatic action of D-glucosaminyl 3-O-sulfotransferase-3a. Mol Biosyst (2011) 0.80
Discovery of novel sulfonated small molecules that inhibit vascular tube formation. Bioorg Med Chem Lett (2012) 0.80
Differential effects of Heparitinase I and Heparitinase III on endothelial tube formation in vitro. Biochem Biophys Res Commun (2010) 0.80
Sulfation patterns determine cellular internalization of heparin-like polysaccharides. Mol Pharm (2013) 0.80
Dimerized glycosaminoglycan chains increase FGF signaling during zebrafish development. ACS Chem Biol (2013) 0.79
A nanosensor for ultrasensitive detection of oversulfated chondroitin sulfate contaminant in heparin. J Am Chem Soc (2014) 0.79
The role of well-defined patterned substrata on the regeneration of DRG neuron pathfinding and integrin expression dynamics using chondroitin sulfate proteoglycans. Biomaterials (2012) 0.79
Formation of protein molecular imprints within Langmuir monolayers: a quartz crystal microbalance study. J Colloid Interface Sci (2006) 0.79
Spatial variation of the charge and sulfur oxidation state in a surface gradient affects plasma protein adsorption. Langmuir (2010) 0.79
Use of reflectance interference contrast microscopy to characterize the endothelial glycocalyx stiffness. Am J Physiol Lung Cell Mol Physiol (2012) 0.78
Competitive Adsorption of Three Human Plasma Proteins onto Sulfhydryl-to-sulfonate Gradient Surfaces. Croat Chem Acta (2011) 0.78
Click-xylosides mitigate glioma cell invasion in vitro. Mol Biosyst (2010) 0.78
Polyunsaturated fatty acyl-coenzyme As are inhibitors of cholesterol biosynthesis in zebrafish and mice. Dis Model Mech (2013) 0.78
How Surface Heterogeneity Affects Protein Adsorption: Annealing of OTS Patterns and Albumin Adsorption Kinetics. Croat Chem Acta (2007) 0.78
A rapid, nonradioactive assay for measuring heparan sulfate C-5 epimerase activity using hydrogen/deuterium exchange-mass spectrometry. Methods Mol Biol (2015) 0.77
Investigating the mechanism of the assembly of FGF1-binding heparan sulfate motifs. FEBS Lett (2011) 0.77
Synthesis and biomedical applications of xylosides. Methods Mol Biol (2015) 0.77
Exploiting differential surface display of chondroitin sulfate variants for directing neuronal outgrowth. J Am Chem Soc (2013) 0.77
Recognition of conformational changes in beta-lactoglobulin by molecularly imprinted thin films. Biomacromolecules (2007) 0.76
Giant micelles of organoplatinum(II) gemini amphiphiles. Langmuir (2008) 0.76
Synthesis of fluorophore-tagged xylosides that prime glycosaminoglycan chains. Bioconjug Chem (2014) 0.75
Monolayer Formation on Silicon and Mica Surfaces Rearranged from N-Hexadecanoyl-l-alanine Supramolecular Structures. J Phys Chem B (2002) 0.75
The Biomechanical Effects of Resuscitation Colloids on the Compromised Lung Endothelial Glycocalyx. Anesth Analg (2016) 0.75
Synthesis of selective inhibitors of heparan sulfate and chondroitin sulfate proteoglycan biosynthesis. Methods Mol Biol (2015) 0.75
Preparation of isotope-enriched heparan sulfate precursors for structural biology studies. Methods Mol Biol (2015) 0.75
Cell substrate patterning with glycosaminoglycans to study their biological roles in the central nervous system. Methods Mol Biol (2015) 0.75
A method for obtaining equilibrium tautomeric mixtures of reducing sugars via glycosylamines using nonaqueous media. Carbohydr Res (2002) 0.75
Synthesis of sulfur isotope-labeled sulfate donor, 3'-phosphoadenosine-5'-phosphosulfate, for studying glycosaminoglycan functions. Methods Mol Biol (2015) 0.75
Production of size-defined heparosan, heparan sulfate, and heparin oligosaccharides by enzymatic depolymerization. Methods Mol Biol (2015) 0.75
Enzymatic synthesis of heparan sulfate and heparin. Methods Mol Biol (2015) 0.75
Chemical modification of heparin and heparosan. Methods Mol Biol (2015) 0.75
Synthesis and assessment of glycosaminoglycan priming activity of cluster-xylosides for potential use as proteoglycan mimetics. ACS Chem Biol (2013) 0.75