Published in J Neurochem on September 01, 1996
Mutation in the tau gene in familial multiple system tauopathy with presenile dementia. Proc Natl Acad Sci U S A (1998) 6.13
Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure. Proc Natl Acad Sci U S A (2000) 3.49
Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments. Proc Natl Acad Sci U S A (2001) 2.97
The many faces of tau. Neuron (2011) 2.89
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation. Nature (2011) 2.46
Biochemistry and cell biology of tau protein in neurofibrillary degeneration. Cold Spring Harb Perspect Med (2012) 2.39
Mechanisms of tau-induced neurodegeneration. Acta Neuropathol (2009) 2.27
Tau in Alzheimer disease and related tauopathies. Curr Alzheimer Res (2010) 2.07
The acetylation of tau inhibits its function and promotes pathological tau aggregation. Nat Commun (2011) 2.00
A nucleated assembly mechanism of Alzheimer paired helical filaments. Proc Natl Acad Sci U S A (1998) 1.97
Template-assisted filament growth by parallel stacking of tau. Proc Natl Acad Sci U S A (2004) 1.89
Characterization of prefibrillar Tau oligomers in vitro and in Alzheimer disease. J Biol Chem (2011) 1.71
Stepwise proteolysis liberates tau fragments that nucleate the Alzheimer-like aggregation of full-length tau in a neuronal cell model. Proc Natl Acad Sci U S A (2007) 1.50
Nucleation-dependent tau filament formation: the importance of dimerization and an estimation of elementary rate constants. J Biol Chem (2008) 1.42
Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegeneration. Biochem J (1997) 1.42
Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity. Proc Natl Acad Sci U S A (2006) 1.33
Filamentous nerve cell inclusions in neurodegenerative diseases: tauopathies and alpha-synucleinopathies. Philos Trans R Soc Lond B Biol Sci (1999) 1.21
Prion-like properties of Tau protein: the importance of extracellular Tau as a therapeutic target. J Biol Chem (2014) 1.20
Phosphorylation of tau at Thr212, Thr231, and Ser262 combined causes neurodegeneration. J Biol Chem (2010) 1.16
Sulfates dramatically stabilize a salt-dependent type of glucagon fibrils. Biophys J (2006) 1.15
Tissue-nonspecific alkaline phosphatase promotes the neurotoxicity effect of extracellular tau. J Biol Chem (2010) 1.15
Tau and neurodegenerative disease: the story so far. Nat Rev Neurol (2015) 1.10
Tau-directed drug discovery for Alzheimer's disease and related tauopathies: a focus on tau assembly inhibitors. Exp Neurol (2009) 1.08
Are tau aggregates toxic or protective in tauopathies? Front Neurol (2013) 1.03
Human Tau isoforms assemble into ribbon-like fibrils that display polymorphic structure and stability. J Biol Chem (2010) 1.02
Quantitative characterization of heparin binding to Tau protein: implication for inducer-mediated Tau filament formation. J Biol Chem (2009) 1.01
Phosphorylation-mimicking glutamate clusters in the proline-rich region are sufficient to simulate the functional deficiencies of hyperphosphorylated tau protein. Biochem J (2001) 1.00
Tangles, Toxicity, and Tau Secretion in AD - New Approaches to a Vexing Problem. Front Neurol (2013) 0.96
Structure and pathology of tau protein in Alzheimer disease. Int J Alzheimers Dis (2012) 0.96
Conformation determines the seeding potencies of native and recombinant Tau aggregates. J Biol Chem (2014) 0.95
Fibers of tau fragments, but not full length tau, exhibit a cross beta-structure: implications for the formation of paired helical filaments. Protein Sci (2000) 0.92
Ferritin is associated with the aberrant tau filaments present in progressive supranuclear palsy. Am J Pathol (1998) 0.91
The tauopathies: toward an experimental animal model. Am J Pathol (1999) 0.91
Synergistic influence of phosphorylation and metal ions on tau oligomer formation and coaggregation with α-synuclein at the single molecule level. Mol Neurodegener (2012) 0.90
Competing interactions stabilize pro- and anti-aggregant conformations of human Tau. J Biol Chem (2011) 0.90
Sulphated glycosaminoglycans prevent the neurotoxicity of a human prion protein fragment. Biochem J (1998) 0.89
Understanding the kinetic roles of the inducer heparin and of rod-like protofibrils during amyloid fibril formation by Tau protein. J Biol Chem (2011) 0.89
Characteristics of tau oligomers. Front Neurol (2013) 0.89
Tau phosphorylation, aggregation, and cell toxicity. J Biomed Biotechnol (2006) 0.89
Role of glycosaminoglycans in determining the helicity of paired helical filaments. Am J Pathol (1997) 0.88
Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory. Sci Rep (2016) 0.86
Tramiprosate, a drug of potential interest for the treatment of Alzheimer's disease, promotes an abnormal aggregation of tau. Mol Neurodegener (2007) 0.86
Characterization by atomic force microscopy of Alzheimer paired helical filaments under physiological conditions. Biophys J (2004) 0.83
Thermodynamics of the interaction between Alzheimer's disease related tau protein and DNA. PLoS One (2014) 0.83
The glaucoma-associated olfactomedin domain of myocilin forms polymorphic fibrils that are constrained by partial unfolding and peptide sequence. J Mol Biol (2013) 0.82
Multiple mechanisms of extracellular tau spreading in a non-transgenic tauopathy model. Am J Neurodegener Dis (2012) 0.81
NMR Meets Tau: Insights into Its Function and Pathology. Biomolecules (2016) 0.81
Structural transitions in tau k18 on micelle binding suggest a hierarchy in the efficacy of individual microtubule-binding repeats in filament nucleation. Protein Sci (2013) 0.81
Tau Hyperphosphorylation and Oxidative Stress, a Critical Vicious Circle in Neurodegenerative Tauopathies? Oxid Med Cell Longev (2015) 0.80
Roles of tau protein in health and disease. Acta Neuropathol (2017) 0.80
Cellular factors modulating the mechanism of tau protein aggregation. Cell Mol Life Sci (2015) 0.79
In vitro aggregation assays using hyperphosphorylated tau protein. J Vis Exp (2015) 0.79
Effect of human neuronal tau on denaturation and reactivation of rabbit muscle D-glyceraldehyde-3-phosphate dehydrogenase. Biochem J (2000) 0.78
Sugar glues for broken neurons. Biomol Concepts (2013) 0.78
Tau pathology generated by overexpression of tau. Am J Pathol (1999) 0.77
Modulation and detection of tau aggregation with small-molecule ligands. Curr Alzheimer Res (2009) 0.77
RNA Binds to Tau Fibrils and Sustains Template-Assisted Growth. Biochemistry (2015) 0.77
Protein interaction module-assisted function X (PIMAX) approach to producing challenging proteins including hyperphosphorylated tau and active CDK5/p25 kinase complex. Mol Cell Proteomics (2014) 0.77
Prion-like Spreading in Tauopathies. Biol Psychiatry (2017) 0.75
Inferring Mechanistic Parameters from Amyloid Formation Kinetics by Approximate Bayesian Computation. Biophys J (2017) 0.75
Absence of a Role for Phosphorylation in the Tau Pathology of Alzheimer's Disease. Biomolecules (2016) 0.75
The role of crowded physiological environments in prion and prion-like protein aggregation. Int J Mol Sci (2013) 0.75
Tau Structures. Front Aging Neurosci (2016) 0.75
14-3-3ζ Mediates Tau Aggregation in Human Neuroblastoma M17 Cells. PLoS One (2016) 0.75
Absence of CX3CR1 impairs the internalization of Tau by microglia. Mol Neurodegener (2017) 0.75
RNA stores tau reversibly in complex coacervates. PLoS Biol (2017) 0.75
Viral DNA synthesis in cells infected by temperature-sensitive mutants of simian virus 40. J Virol (1974) 5.44
Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice. EMBO J (2001) 3.22
Functional recovery of paraplegic rats and motor axon regeneration in their spinal cords by olfactory ensheathing glia. Neuron (2000) 2.46
Controlled proteolysis of tubulin by subtilisin: localization of the site for MAP2 interaction. Biochemistry (1984) 2.30
WIP regulates N-WASP-mediated actin polymerization and filopodium formation. Nat Cell Biol (2001) 2.18
Involvement of the carboxyl-terminal domain of tubulin in the regulation of its assembly. Proc Natl Acad Sci U S A (1984) 2.11
delta-catenin, an adhesive junction-associated protein which promotes cell scattering. J Cell Biol (1999) 2.07
Differential gene expression during thermal stress and bleaching in the Caribbean coral Montastraea faveolata. Mol Ecol (2008) 2.05
The Borinquen ring: introduction of a new laparoscopic simulation surgery training instrument. J Laparoendosc Surg (1993) 1.99
Long-distance axonal regeneration in the transected adult rat spinal cord is promoted by olfactory ensheathing glia transplants. J Neurosci (1998) 1.98
Presenilin 1 interaction in the brain with a novel member of the Armadillo family. Neuroreport (1997) 1.97
Role of the PI3K regulatory subunit in the control of actin organization and cell migration. J Cell Biol (2000) 1.94
Dual DNA binding specificity of a petal epidermis-specific MYB transcription factor (MYB.Ph3) from Petunia hybrida. EMBO J (1995) 1.94
Eukaryotic type II chaperonin CCT interacts with actin through specific subunits. Nature (1999) 1.93
Ultrastructural and functional analyses of recombinant influenza virus ribonucleoproteins suggest dimerization of nucleoprotein during virus amplification. J Virol (2000) 1.86
Phosphorylation of microtubule-associated protein 2 (MAP2) and its relevance for the regulation of the neuronal cytoskeleton function. Prog Neurobiol (2000) 1.76
Eukaryotic chaperonin CCT stabilizes actin and tubulin folding intermediates in open quasi-native conformations. EMBO J (2000) 1.67
Study of the localization of iron, ferritin, and hemosiderin in Alzheimer's disease hippocampus by analytical microscopy at the subcellular level. J Struct Biol (2005) 1.55
Three-dimensional reconstruction of a recombinant influenza virus ribonucleoprotein particle. EMBO Rep (2001) 1.55
A cell division mutant of Drosophila with a functionally abnormal spindle. Cell (1985) 1.54
Review: postchaperonin tubulin folding cofactors and their role in microtubule dynamics. J Struct Biol (2001) 1.52
Initial studies with high resolution TEM and electron energy loss spectroscopy studies of ferritin cores extracted from brains of patients with progressive supranuclear palsy and Alzheimer disease. Cell Mol Biol (Noisy-le-grand) (2000) 1.51
Characterization of ATP and DNA binding activities of TrwB, the coupling protein essential in plasmid R388 conjugation. J Biol Chem (1999) 1.50
Extracellular tau promotes intracellular calcium increase through M1 and M3 muscarinic receptors in neuronal cells. Mol Cell Neurosci (2007) 1.50
Localization of the tubulin binding site for tau protein. Eur J Biochem (1985) 1.47
Tauopathies. Cell Mol Life Sci (2007) 1.47
Inflammatory fibroid polyps of the large intestine. Dig Dis Sci (1999) 1.46
Topology of the components of the DNA packaging machinery in the phage phi29 prohead. J Mol Biol (2000) 1.45
Lithium inhibits Alzheimer's disease-like tau protein phosphorylation in neurons. FEBS Lett (1997) 1.44
The semiautonomous replicon: a molecular model for the oncogenicity of SV40. Cold Spring Harb Symp Quant Biol (1975) 1.42
A novel GSK-3beta inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo. Neurobiol Dis (2009) 1.42
Purification and properties of DNA-dependent RNA polymerase from Bacillus subtilis vegetative cells. Eur J Biochem (1971) 1.41
The 'sequential allosteric ring' mechanism in the eukaryotic chaperonin-assisted folding of actin and tubulin. EMBO J (2001) 1.41
Modifications of the 5' untranslated region of foot-and-mouth disease virus after prolonged persistence in cell culture. Virus Res (1992) 1.40
Current advances on different kinases involved in tau phosphorylation, and implications in Alzheimer's disease and tauopathies. Curr Alzheimer Res (2005) 1.39
Olfactory ensheathing glia: properties and function. Brain Res Bull (1998) 1.38
Proteasomal-dependent aggregate reversal and absence of cell death in a conditional mouse model of Huntington's disease. J Neurosci (2001) 1.34
Depletion of casein kinase II by antisense oligonucleotide prevents neuritogenesis in neuroblastoma cells. EMBO J (1993) 1.31
Inherited congenital normofunctional testicular hyperplasia and mental deficiency. Hum Genet (1976) 1.27
Coral host transcriptomic states are correlated with Symbiodinium genotypes. Mol Ecol (2010) 1.26
delta-catenin is a nervous system-specific adherens junction protein which undergoes dynamic relocalization during development. J Comp Neurol (2000) 1.25
The neurite retraction induced by lysophosphatidic acid increases Alzheimer's disease-like Tau phosphorylation. J Biol Chem (1999) 1.24
Na+, K+-ATPase isozyme diversity; comparative biochemistry and physiological implications of novel functional interactions. Biosci Rep (2000) 1.24
Lithium protects cultured neurons against beta-amyloid-induced neurodegeneration. FEBS Lett (1999) 1.23
The marine compound spisulosine, an inhibitor of cell proliferation, promotes the disassembly of actin stress fibers. Cancer Lett (2000) 1.23
FTDP-17 mutations in tau transgenic mice provoke lysosomal abnormalities and Tau filaments in forebrain. Mol Cell Neurosci (2001) 1.22
Estradiol inhibits GSK3 and regulates interaction of estrogen receptors, GSK3, and beta-catenin in the hippocampus. Mol Cell Neurosci (2004) 1.20
Evidence for the role of MAP1B in axon formation. Mol Biol Cell (2001) 1.20
The temperature-sensitive defect in SV40 group D mutants. Virology (1976) 1.20
3D reconstruction of the ATP-bound form of CCT reveals the asymmetric folding conformation of a type II chaperonin. Nat Struct Biol (1999) 1.19
Measurement of distinct immunochemical presentations of tau protein in Alzheimer disease. Proc Natl Acad Sci U S A (1991) 1.19
Changes in microtubule protofilament number induced by Taxol binding to an easily accessible site. Internal microtubule dynamics. J Biol Chem (1998) 1.19
Implication of brain cdc2 and MAP2 kinases in the phosphorylation of tau protein in Alzheimer's disease. FEBS Lett (1992) 1.17
Self assembly of microtubule associated protein tau into filaments resembling those found in Alzheimer disease. Biochem Biophys Res Commun (1986) 1.16
Clinical vasospasm after subarachnoid hemorrhage: response to hypervolemic hemodilution and arterial hypertension. Stroke (1987) 1.16
Gut mucosal immunostimulation by lactic acid bacteria. Biocell (2000) 1.16
Physicochemical characterization of the heat-stable microtubule-associated protein MAP2. Eur J Biochem (1986) 1.15
Structure and thermal denaturation of crystalline and noncrystalline cytochrome oxidase as studied by infrared spectroscopy. Biochemistry (1994) 1.14
Cerebral venous malformations. J Neurosurg (1990) 1.14
Refined X-ray structures of the oxidized, at 1.3 A, and reduced, at 1.17 A, [2Fe-2S] ferredoxin from the cyanobacterium Anabaena PCC7119 show redox-linked conformational changes. Biochemistry (1999) 1.13
Perinatal lethality of microtubule-associated protein 1B-deficient mice expressing alternative isoforms of the protein at low levels. Mol Cell Neurosci (2000) 1.13
Crystallographic analysis reveals the 12-fold symmetry of the bacteriophage phi29 connector particle. J Mol Biol (1998) 1.13
Quantitation and characterization of the microtubule associated MAP2 in porcine tissues and its isolation from porcine (PK15) and human (HeLa) cell lines. Biochem Biophys Res Commun (1982) 1.11
The tubulin-binding sequence of brain microtubule-associated proteins, tau and MAP-2, is also involved in actin binding. Biochem J (1990) 1.11
X-ray structure of the ferredoxin:NADP+ reductase from the cyanobacterium Anabaena PCC 7119 at 1.8 A resolution, and crystallographic studies of NADP+ binding at 2.25 A resolution. J Mol Biol (1996) 1.11
A casein kinase II-related activity is involved in phosphorylation of microtubule-associated protein MAP-1B during neuroblastoma cell differentiation. J Cell Biol (1988) 1.10
Characterization of a double (amyloid precursor protein-tau) transgenic: tau phosphorylation and aggregation. Neuroscience (2005) 1.10
Analysis of microtubule-associated protein tau glycation in paired helical filaments. J Biol Chem (1994) 1.10
Point mutations in protein globular domains: contributions from function, stability and misfolding. J Mol Biol (2006) 1.09
The antitumoral compound Kahalalide F acts on cell lysosomes. Cancer Lett (1996) 1.08
Study of the possible mechanisms involved in the mucosal immune system activation by lactic acid bacteria. J Dairy Sci (1999) 1.07
Characterization and structural aspects of the enhanced assembly of tubulin after removal of its carboxyl-terminal domain. Eur J Biochem (1986) 1.07
A redox-dependent interaction between two electron-transfer partners involved in photosynthesis. EMBO Rep (2000) 1.06
HYDROMIC: prediction of hydrodynamic properties of rigid macromolecular structures obtained from electron microscopy images. Eur Biophys J (2001) 1.06
Amino acid residues in Anabaena ferredoxin crucial to interaction with ferredoxin-NADP+ reductase: site-directed mutagenesis and laser flash photolysis. Biochemistry (1993) 1.06
Phosphorylation of tubulin by a calmodulin-dependent protein kinase. J Biol Chem (1986) 1.06
Polymerization of tau peptides into fibrillar structures. The effect of FTDP-17 mutations. FEBS Lett (1999) 1.06
Islet xenotransplantation using gal-deficient neonatal donors improves engraftment and function. Am J Transplant (2011) 1.06
Brain armadillo protein delta-catenin interacts with Abl tyrosine kinase and modulates cellular morphogenesis in response to growth factors. J Neurosci Res (2002) 1.06
Interactions of the HIV-1 fusion peptide with large unilamellar vesicles and monolayers. A cryo-TEM and spectroscopic study. Biochim Biophys Acta (2000) 1.06
Antibodies to vimentin intermediate filaments in sera from patients with systemic lupus erythematosus. Arthritis Rheum (1984) 1.05
C455R notch3 mutation in a Colombian CADASIL kindred with early onset of stroke. Neurology (2002) 1.05
Immunomodulating effects of milks fermented by Lactobacillus helveticus and its non-proteolytic variant. J Dairy Res (2001) 1.05
Altered mitogen-activated protein kinase signaling, tau hyperphosphorylation and mild spatial learning dysfunction in transgenic rats expressing the beta-amyloid peptide intracellularly in hippocampal and cortical neurons. Neuroscience (2004) 1.05
GSK-3β overexpression causes reversible alterations on postsynaptic densities and dendritic morphology of hippocampal granule neurons in vivo. Mol Psychiatry (2013) 1.05
Differences in microtubule binding and self-association abilities of bovine brain tau isoforms. J Biol Chem (1993) 1.05
Tubulin phosphorylation by casein kinase II is similar to that found in vivo. J Cell Biol (1987) 1.04
Presenilin 1 interaction in the brain with a novel member of the Armadillo family. Neuroreport (1997) 1.04
Limited proteolysis of tubulin and the localization of the binding site for colchicine. J Biol Chem (1984) 1.04
The marine sphingolipid-derived compound ES 285 triggers an atypical cell death pathway. Apoptosis (2007) 1.04
The formation of symmetrical GroEL-GroES complexes in the presence of ATP. FEBS Lett (1994) 1.03
The relationship of time-dose fractionation factors to complications in the treatment of pituitary tumors by irradiation. Int J Radiat Oncol Biol Phys (1977) 1.02
Preferential binding of hog brain microtubule-associated proteins to mouse satellite versus bulk DNA preparations. Nature (1978) 1.02
Carcinoma of the pinna. Cancer (1977) 1.01
Presenilin affects arm/beta-catenin localization and function in Drosophila. Dev Biol (2000) 1.01
Domain architecture of the bacteriophage phi29 connector protein. J Mol Biol (1999) 1.01