Distinct dendritic cell subsets actively induce Th2 polarization.

PubWeight™: 0.78‹?›

🔗 View Article (PMID 25290173)

Published in Curr Opin Immunol on October 04, 2014

Authors

Melissa Y Tjota1, Anne I Sperling2

Author Affiliations

1: Committee on Immunology, University of Chicago, Chicago, IL, USA; Medical Scientist Training Program, University of Chicago, Chicago, IL, USA.
2: Committee on Immunology, University of Chicago, Chicago, IL, USA; Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL, USA. Electronic address: asperlin@uchicago.edu.

Articles cited by this

Differentiation of effector CD4 T cell populations (*). Annu Rev Immunol (2010) 11.80

Toll-like receptors control activation of adaptive immune responses. Nat Immunol (2001) 7.54

CD8alpha+ and CD8alpha- subclasses of dendritic cells direct the development of distinct T helper cells in vivo. J Exp Med (1999) 6.06

Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response. J Exp Med (1993) 5.71

House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells. Nat Med (2009) 5.55

Monocyte-derived dendritic cells formed at the infection site control the induction of protective T helper 1 responses against Leishmania. Immunity (2007) 4.65

TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation. Annu Rev Immunol (2007) 4.39

In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma. J Exp Med (2005) 4.34

The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model. J Exp Med (1995) 4.21

Deciphering the transcriptional network of the dendritic cell lineage. Nat Immunol (2012) 4.17

Conventional and monocyte-derived CD11b(+) dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen. Immunity (2013) 3.07

CD4+ effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major. J Exp Med (1994) 2.88

Resting respiratory tract dendritic cells preferentially stimulate T helper cell type 2 (Th2) responses and require obligatory cytokine signals for induction of Th1 immunity. J Exp Med (1998) 2.85

Inflammatory monocytes facilitate adaptive CD4 T cell responses during respiratory fungal infection. Cell Host Microbe (2009) 2.81

IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses. Immunity (2013) 2.69

Dectin-2 recognition of house dust mite triggers cysteinyl leukotriene generation by dendritic cells. J Immunol (2009) 2.63

Minimal differentiation of classical monocytes as they survey steady-state tissues and transport antigen to lymph nodes. Immunity (2013) 2.61

TH2, allergy and group 2 innate lymphoid cells. Nat Immunol (2013) 2.52

CD301b⁺ dermal dendritic cells drive T helper 2 cell-mediated immunity. Immunity (2013) 2.31

Programming dendritic cells to induce T(H)2 and tolerogenic responses. Nat Immunol (2010) 2.29

IRF4 transcription-factor-dependent CD103(+)CD11b(+) dendritic cells drive mucosal T helper 17 cell differentiation. Immunity (2013) 2.27

Origins and functional specialization of macrophages and of conventional and monocyte-derived dendritic cells in mouse skin. Immunity (2013) 2.20

Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung. J Exp Med (2012) 2.03

Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells. Immunity (2013) 1.88

CD28 costimulation promotes the production of Th2 cytokines. J Immunol (1997) 1.78

Alarming dendritic cells for Th2 induction. J Exp Med (2008) 1.75

Optimization of methods to study pulmonary dendritic cell migration reveals distinct capacities of DC subsets to acquire soluble versus particulate antigen. J Immunol Methods (2008) 1.69

Helminth products bypass the need for TSLP in Th2 immune responses by directly modulating dendritic cell function. Proc Natl Acad Sci U S A (2009) 1.63

Regulation of dendritic cell development by GM-CSF: molecular control and implications for immune homeostasis and therapy. Blood (2012) 1.61

Endogenous IL-12 is required for control of Th2 cytokine responses capable of exacerbating leishmaniasis in normally resistant mice. J Immunol (1995) 1.53

CD64 expression distinguishes monocyte-derived and conventional dendritic cells and reveals their distinct role during intramuscular immunization. J Immunol (2012) 1.50

Transcriptional programming of dendritic cells for enhanced MHC class II antigen presentation. Nat Immunol (2013) 1.50

Inflammatory monocytes orchestrate innate antifungal immunity in the lung. PLoS Pathog (2014) 1.39

Dectin-1 diversifies Aspergillus fumigatus-specific T cell responses by inhibiting T helper type 1 CD4 T cell differentiation. J Exp Med (2011) 1.38

Pulmonary CD103(+) dendritic cells prime Th2 responses to inhaled allergens. Mucosal Immunol (2011) 1.32

Transcription factor IRF4 drives dendritic cells to promote Th2 differentiation. Nat Commun (2013) 1.29

T-cell-receptor-dependent signal intensity dominantly controls CD4(+) T cell polarization In Vivo. Immunity (2014) 1.28

The mannose receptor mediates the uptake of diverse native allergens by dendritic cells and determines allergen-induced T cell polarization through modulation of IDO activity. J Immunol (2010) 1.25

The expanding roles of ITAM adapters FcRgamma and DAP12 in myeloid cells. Immunol Rev (2009) 1.23

Neutrophil differentiation into a unique hybrid population exhibiting dual phenotype and functionality of neutrophils and dendritic cells. Blood (2013) 1.23

The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses. Nat Immunol (2013) 1.21

IRF4 promotes cutaneous dendritic cell migration to lymph nodes during homeostasis and inflammation. J Immunol (2012) 1.18

A unique dermal dendritic cell subset that skews the immune response toward Th2. PLoS One (2013) 1.17

Essential role of the IRF8-KLF4 transcription factor cascade in murine monocyte differentiation. Blood (2013) 1.16

Dendritic cells and other innate determinants of T helper cell polarisation. Trends Immunol (2013) 1.13

Interleukin-12 is indispensable for protective immunity against Leishmania major. Infect Immun (1997) 1.10

Signaling through Fc gamma RIII is required for optimal T helper type (Th)2 responses and Th2-mediated airway inflammation. J Exp Med (2007) 1.09

IL-33-dependent induction of allergic lung inflammation by FcγRIII signaling. J Clin Invest (2013) 1.08

Monocyte-derived dendritic cells perform hemophagocytosis to fine-tune excessive immune responses. Immunity (2013) 1.07

Distinct biochemical signals characterize agonist- and altered peptide ligand-induced differentiation of naive CD4+ T cells into Th1 and Th2 subsets. J Immunol (1997) 1.03

Selective control of SIRP-alpha-positive airway dendritic cell trafficking through CD47 is critical for the development of T(H)2-mediated allergic inflammation. J Allergy Clin Immunol (2009) 1.01

Cutting edge: inhaled antigen upregulates retinaldehyde dehydrogenase in lung CD103+ but not plasmacytoid dendritic cells to induce Foxp3 de novo in CD4+ T cells and promote airway tolerance. J Immunol (2013) 1.00

Effective treatment of allergic airway inflammation with Helicobacter pylori immunomodulators requires BATF3-dependent dendritic cells and IL-10. Proc Natl Acad Sci U S A (2014) 0.97

Migratory properties of pulmonary dendritic cells are determined by their developmental lineage. Mucosal Immunol (2012) 0.93

Critical role of the Fc receptor gamma-chain on APCs in the development of allergen-induced airway hyperresponsiveness and inflammation. J Immunol (2007) 0.91

Resident CD11b(+)Ly6C(-) lung dendritic cells are responsible for allergic airway sensitization to house dust mite in mice. PLoS One (2012) 0.90

Dectin-2 regulates the effector phase of house dust mite-elicited pulmonary inflammation independently from its role in sensitization. J Immunol (2014) 0.89

Cutting edge: identification of the thymic stromal lymphopoietin-responsive dendritic cell subset critical for initiation of type 2 contact hypersensitivity. J Immunol (2013) 0.88

Th1/Th2 cross-regulation and the discovery of IL-10. J Exp Med (2007) 0.88

TSLP promotes induction of Th2 differentiation but is not necessary during established allergen-induced pulmonary disease. PLoS One (2013) 0.87

Signaling through FcRγ-associated receptors on dendritic cells drives IL-33-dependent TH2-type responses. J Allergy Clin Immunol (2014) 0.87

Skin thymic stromal lymphopoietin initiates Th2 responses through an orchestrated immune cascade. Nat Commun (2013) 0.87

A thymic stromal lymphopoietin-responsive dendritic cell subset mediates allergic responses in the upper airway mucosa. J Allergy Clin Immunol (2014) 0.87

Cutting edge: allergen-specific CD4 T cells respond indirectly to thymic stromal lymphopoietin to promote allergic responses in the skin. J Immunol (2013) 0.86

Monocyte-derived dendritic cell recruitment and allergic T(H)2 responses after exposure to diesel particles are CCR2 dependent. J Allergy Clin Immunol (2011) 0.85

Allergens. Immunol Allergy Clin North Am (2005) 0.83

OX40 ligand and programmed cell death 1 ligand 2 expression on inflammatory dendritic cells regulates CD4 T cell cytokine production in the lung during viral disease. J Immunol (2012) 0.81

Dysregulation of alveolar macrophages unleashes dendritic cell-mediated mechanisms of allergic airway inflammation. Mucosal Immunol (2013) 0.79