TH2, allergy and group 2 innate lymphoid cells.

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Published in Nat Immunol on June 01, 2013

Authors

Paula Licona-Limón1, Lark Kyun Kim, Noah W Palm, Richard A Flavell

Author Affiliations

1: Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.

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The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR. Nat Immunol (2009) 2.73

Does Toll-like receptor 3 play a biological role in virus infections? Virology (2004) 2.73

Caspase activity mediates the differentiation of embryonic stem cells. Cell Stem Cell (2008) 2.68

Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing. Immunity (2009) 2.66

The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function. Nat Immunol (2006) 2.65

Molecular mechanism of NLRP3 inflammasome activation. J Clin Immunol (2010) 2.61

Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis. J Exp Med (2009) 2.61

Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation. J Exp Med (2002) 2.60

Humanized mice for modeling human infectious disease: challenges, progress, and outlook. Cell Host Microbe (2009) 2.58

Transcriptional regulation of th2 differentiation by inducible costimulator. Immunity (2003) 2.56

STAT3 is required for Flt3L-dependent dendritic cell differentiation. Immunity (2003) 2.54

Interleukin 23 production by intestinal CD103(+)CD11b(+) dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense. Immunity (2012) 2.54

JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species. Genes Dev (2004) 2.51

An antibiotic-responsive mouse model of fulminant ulcerative colitis. PLoS Med (2008) 2.50

A critical role of neural-specific JNK3 for ischemic apoptosis. Proc Natl Acad Sci U S A (2003) 2.47

Transforming growth factor-beta and the immune response: implications for anticancer therapy. Clin Cancer Res (2007) 2.44

Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo. Immunity (2009) 2.44

Hypersensitive site 7 of the TH2 locus control region is essential for expressing TH2 cytokine genes and for long-range intrachromosomal interactions. Nat Immunol (2004) 2.44

Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells. Nat Med (2013) 2.39